4.4 Article

A finite strain nonlinear human mitral valve model with fluid-structure interaction

出版社

WILEY
DOI: 10.1002/cnm.2691

关键词

human mitral valve; clinical imaging; magnetic resonance imaging; fluid-structure interaction; finite element immersed boundary method; nonlinear finite strain; fibre-reinforced constitutive law

资金

  1. UK EPSRC [EP/I1029990]
  2. British Heart Foundation [PG/11/2/28474]
  3. Medical Research Scotland
  4. Chinese Scholarship Council
  5. University of Glasgow
  6. American Heart Association [10SDG4320049]
  7. National Institutes of Health [HL117063]
  8. National Science Foundation [DMS 1016554, ACI 1047734]
  9. EPSRC [EP/I029990/1] Funding Source: UKRI
  10. British Heart Foundation [PG/11/2/28474] Funding Source: researchfish
  11. Engineering and Physical Sciences Research Council [EP/I029990/1] Funding Source: researchfish

向作者/读者索取更多资源

A computational human mitral valve (MV) model under physiological pressure loading is developed using a hybrid finite element immersed boundary method, which incorporates experimentally-based constitutive laws in a three-dimensional fluid-structure interaction framework. A transversely isotropic material constitutive model is used to characterize the mechanical behaviour of the MV tissue based on recent mechanical tests of healthy human mitral leaflets. Our results show good agreement, in terms of the flow rate and the closing and opening configurations, with measurements from in vivo magnetic resonance images. The stresses in the anterior leaflet are found to be higher than those in the posterior leaflet and are concentrated around the annulus trigons and the belly of the leaflet. The results also show that the chordae play an important role in providing a secondary orifice for the flow when the valve opens. Although there are some discrepancies to be overcome in future work, our simulations show that the developed computational model is promising in mimicking the in vivo MV dynamics and providing important information that are not obtainable by in vivo measurements. (c) 2014 The Authors. International Journal for Numerical Methods in Biomedical Engineering published by John Wiley & Sons Ltd.

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