Review
Immunology
Fang He, Xiaoyan Wu, Qingzhuo Zhang, Yikun Li, Yuyi Ye, Pan Li, Shuai Chen, Yuanyi Peng, Rudiger Hardeland, Yaoyao Xia
Summary: Melatonin exhibits antibacterial effects on various pathogenic bacteria in animals and plants, acting through multiple mechanisms such as direct actions at high concentrations, activation of hosts' defense mechanisms, attenuation of inflammation, and modulation of signaling pathways. Its protective functions involve inhibition of reactive oxygen and nitrogen species, detoxification, and protection against mitochondrial damage, suggesting melatonin as a potential effective approach against bacterial infections.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Xue-Fei Wu, Chun Li, Guang Yang, Ying-Zi Wang, Yan Peng, Dan-Dan Zhu, Ao-Ran Sui, Qiong Wu, Qi-Fa Li, Bin Wang, Na Li, Yue Zhang, Bi-Ying Ge, Jie Zhao, Shao Li
Summary: The study demonstrates that SVHRP can inhibit neuroinflammation and microglia activation, potentially explaining the therapeutic effects of BmK-derived materials and suggesting that BmK venom could be a potential source for CNS drug development.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Plant Sciences
Zhuangwei Zhang, Shuoqi Jiang, Hengqun Tian, Yu Zeng, Kang He, Lin Lin, Fangmiao Yu
Summary: The study aimed to investigate the anti-inflammatory effects of Nymphaea hybrida ethanol extract and its polar fractions. The results showed that the ethyl acetate fraction of NHE exhibited significant inhibitory effects on inflammation by suppressing the activation of NF-kappa B and MAPK pathways in LPS-induced inflammation.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Review
Immunology
Lang Pan, Spiros Vlahopoulos, Lloyd Tanner, Jesper Bergwik, Attila Bacsi, Zsolt Radak, Arne Egesten, Xueqing Ba, Allan R. Brasier, Istvan Boldogh
Summary: Recent research has revealed the non-random distribution of 8-oxoguanine induced by reactive oxygen species, suggesting its epigenetic effects. 8-oxoguanine DNA glycosylase 1 (OGG1), the repair protein for 8-oxoGua, has been found to participate in transcriptional initiation and transmit acute inflammatory signals in airway epithelial cells. The interactions between epithelial-mesenchymal and epithelial-immune contribute to the development of chronic pulmonary diseases through inflammatory remodeling.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Food Science & Technology
Zeyuan Wang, Lehao Wu, Dongmei Fu, Yan Zhang, Chunzhi Zhang
Summary: Fermented hemp seed exhibited enhanced anti-neuroinflammatory ability by suppressing ROS production and decreasing the expression levels of inflammatory mediators and cytokines.
Article
Biochemistry & Molecular Biology
Jingjie Sun, Xiaodong Qin, Xinyan Zhang, Qi Wang, Wei Zhang, Manxia Wang
Summary: The study found that FBXW11 may regulate neuroinflammation in Alzheimer's disease (AD) by suppressing the NF-kappa B signaling pathway. Through interaction with ASK1, FBXW11 promotes its ubiquitination, leading to aberrant activation of the NF-kappa B and MAPK signaling pathways.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Chemistry, Medicinal
Xinxin Zhang, Yating Qin, Weibin Ruan, Xiaoning Wan, Chao Lv, Lin He, Li Lu, Xiaomei Guo
Summary: Baicalein, a flavonoid phytochemical, demonstrates anti-inflammatory properties in macrophages, endothelial cells, and vascular smooth muscle cells by activating the AMPK/Mfn-2 axis and inhibiting MAPKs/NF-kappa B signaling transduction pathway. Baicalein effectively reduces proinflammatory cytokine levels, suggesting its potential role in atherosclerosis treatment. Further studies may be needed to fully understand the mechanisms of baicalein's anti-inflammatory effects.
PHYTOTHERAPY RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Huakang Zhou, Dilaware Khan, Norbert Gerdes, Carsten Hagenbeck, Majeed Rana, Jan Frederick Cornelius, Sajjad Muhammad
Summary: Inflammaging is a potential risk factor for cardiovascular diseases, leading to the development of thrombosis and atherosclerosis. Ethanol can induce inflammation and senescence, which are both implicated in cardiovascular diseases. In this study, colchicine was used to mitigate the damaging effects of ethanol on endothelial cells. It prevented senescence, reduced oxidative stress, and inhibited the activation of NF-κB and MAPKs in ethanol-treated endothelial cells. Colchicine ameliorated the ethanol-induced molecular events, resulting in attenuated senescence and senescence-associated secretory phenotype in endothelial cells.
Article
Environmental Sciences
Hui Zhao, Lin Fu, Hui-Xian Xiang, Ying Xiang, Meng-Die Li, Bian-Bian Lv, Zhu-Xia Tan, Lan Gao, Cheng Zhang, De-Xiang Xu
Summary: The study found that Benzo[a]pyrene can cause acute lung injury and inflammation, while the antioxidant N-acetylcysteine (NAC) can alleviate the pulmonary inflammatory response induced by Benzo[a]pyrene.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Immunology
Ying Tang, Shiyi Yang, Minshan Yao, Minxuan Yang, Lixiang Wei, Hong Chen, Junyan Lin, Yao Huang, Li Lin, Zhendong Qin
Summary: Hemolytic disease in grass carp leads to oxidative damage and cell death, mediated by the release of cell-free hemoglobin and activation of inflammatory pathways.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Chemistry, Analytical
Xinyue Zhao, Lulu Ning, Xiaoman Zhou, Zhihui Song, Jianjian Zhang, Feng Guan, Xiao-Feng Yang
Summary: Hydrogen sulfide (H2S) is a vital endogenous signal molecule with critical physiological functions, but its site-specific delivery and release in biological systems remains a challenge. The newly developed Pro-S donor shows excellent release efficiency and live-cell compatibility, allowing real-time capturing of H2S and demonstrating anti-inflammatory effects in cells.
ANALYTICAL CHEMISTRY
(2021)
Article
Plant Sciences
Shou-Kai Wang, Ting-Xiao Chen, Wei Wang, Ling-Ling Xu, Yu-Qing Zhang, Zhen Jin, You -Bin Liu, You-Zhi Tang
Summary: Aesculetin exhibits potent anti-inflammatory effect both in vitro and in vivo by inhibiting the production of inflammatory mediators and the activation of NF-Kappa B and MAPKs signaling pathways. In a DSS-induced colitis model, aesculetin can alleviate clinical symptoms and reduce the secretion of inflammatory mediators.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Min Jo Kim, Dae Hyun Kim, EunJin Bang, Sang Gyun Noh, Pusoon Chun, Takako Yokozawa, Hyung Ryong Moon, Hae Young Chung
Summary: MHY3200 shows beneficial effects on oxidative stress and inflammation in aging rats, by reducing ROS levels, inhibiting NF-κB activation, and regulating the FoxO1 signaling pathway.
Article
Cell Biology
Changkai Zhou, Jing Gao, Hongyan Ji, Wenjing Li, Xiaomin Xing, Donghua Liu, Qie Guo, Lihua Zhou, Fanbo Jing
Summary: The study showed that BAC exhibits anti-inflammatory effects by inhibiting TLR-induced MAPK and NF-kappa B pathways, indicating its potential use in treating inflammatory diseases.
Article
Biochemistry & Molecular Biology
Yuan-ru Zheng, Chun-lin Fan, Ye Chen, Jing-yu Quan, Ling-zhu Shi, Chun-yang Tian, Xiao Shang, Ni-shan Xu, Wen-cai Ye, Lin-zhong Yu, Jun-shan Liu
Summary: This study discovered that dammarane-type triterpenoid saponins from Panax notoginseng have anti-inflammatory, anti-angiogenetic, and anti-dengue virus effects. They may be developed as potential functional foods for treating inflammation, angiogenesis, and dengue-related diseases.
Article
Immunology
Jun Cui, Cheng Chen, Xiao Zhou, Wenju Shan, Yuhong Jian, Panpan Li, Yang Sun, Wei Yi
Summary: Bone marrow mesenchymal stem cells (BMSCs) are a promising therapy for sepsis, but metabolic syndromes threaten their effectiveness. This study investigated the potential of small extracellular vesicles from high-fat diet BMSCs in sepsis-induced liver-heart axis injury.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Binbin Zhu, Angyang Cao, Chunqu Chen, Weijian Zhou, Wenjun Luo, Yu Gui, Qinwen Wang, Zhipeng Xu, Jianhua Wang
Summary: GM6001 alleviates postoperative cognitive deficits and neuroinflammation, preserves blood-brain barrier integrity, and rescues aquaporin-4 mislocalization. MMP-9 inhibition plays a dual role in cognitive protection through direct anti-neuroinflammatory effects and regulation of aquaporin-4 membrane distribution.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Anika Sood, Valencia Fernandes, Kumari Preeti, Shruti Rajan, Dharmendra Kumar Khatri, Shashi Bala Singh
Summary: S1PR2 inhibitor improves cognitive function and skews microglia toward anti-inflammatory phenotype in type 2 diabetic mice, promising to be a potential therapy for neuroinflammation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Haochun Guo, Ran Yu, Haijun Zhang, Wanpeng Wang
Summary: Radiation therapy is an effective treatment for thoracic malignancies, but it can cause radiation-induced lung injury (RILI), including radiation pneumonitis (RP) and radiation pulmonary fibrosis (RPF). The damage to normal lung cells during radiation treatment leads to a pulmonary inflammatory response, resulting in RP and RPF.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Guanghui Wang, Haotian Zheng, Yunzhi Xiang, Yadong Wang, Kai Wang, Xiaoyang Ren, Jiajun Du
Summary: This study identified a T-cell synthetic driver-associated prognostic model that accurately predicted prognosis and effectiveness of immunotherapy in LUAD patients. It also highlighted the role of LDHA in promoting tumor cell proliferation, invasion, and resistance to treatment, as well as its involvement in immune escape within the tumor microenvironment. These findings provide a promising new therapeutic strategy for LUAD.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Bowen Wei, Aihua Wang, Wei Liu, Qingyun Yue, Yihua Fan, Bin Xue, Siwei Wang
Summary: This study systematically analyzed the association between pSS and cuproptosis, established a predictive model based on 5 genes, explored the pathogenic mechanisms and novel therapeutic strategies for pSS, and identified EED, CBL, and NFU1 as potential targets for treatment.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Nusrit Iqbal Andrabi, Aminur R. Sarkar, Syed Assim Haq, Diljeet Kumar, Dilpreet Kour, Diksha Saroch, Sanket Kumar Shukla, Ajay Kumar, Asha Bhagat, Asif Ali, Gurleen Kour, Zabeer Ahmed
Summary: Koenimbine and its novel semi-synthetic derivative 1G demonstrate significant anti-inflammatory effects by downregulating the nuclear factor kappa-B (NF-kappa B) signaling pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Jing-Mei Lu, Xiang Xu, Fumie Aosai, Ming-Yue Zhang, Lian-Xun Piao
Summary: This study found that arctiin can improve allergic acute liver injury caused by T.g.HSP70 by inhibiting TLR4 signaling and reducing the production of inflammatory mediators.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Minxuan Xu, Fang Shi, Yongshen Gao, Shumei Han, Chensuo Huang, Qinsheng Hou, Xiaoweng Wen, Bengshi Wang, Zhenyu Zhu, Lei Zou, Mingxin Xiong, Wei Dong, Jun Tan
Summary: There is a growing body of research highlighting the involvement of metabolic imbalance and the inflammatory response in the advancement of colitis. This study recognizes arabinose as a significant protector of the intestinal mucosal barrier, reducing damage to the intestines. In addition, lower levels of arabinose in the bloodstream are associated with a higher severity of inflammatory bowel disease and colorectal cancer.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yueqing Han, Haoxin Song, Yanshan Li, Rongxin Li, Ling Chen, Bo Gao, Yijun Chen, Shuzhen Wang
Summary: The combination of tetracycline antibiotics, demeclocycline (D), chlortetracycline (C), and minocycline (M), showed therapeutic potential against liver fibrosis by inhibiting the activation of hepatic stellate cells and the MAPK signaling. This study suggests that tetracyclines may be repurposed for the treatment of liver fibrosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yu Li, Hailing Liu, Danwen Zhao, Danjie Zhang
Summary: Chronic stress can lead to lung injury, with the spleen playing a crucial role. This study found that the spleen contributes to chronic restraint stress-induced lung injury, and splenic CD11b+ cells may be an important factor in this process.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yingqian Mi, Mengyan Tang, Qiong Wu, Yinan Wang, Qihui Liu, Pei Zhu, Xiaoyang Xue, Yuntong Liu, Xinyu Chai, Yuyang Hou, Dongmei Yan
Summary: BCG therapy can induce macrophage polarization to the M1 type, and NMAAP1 plays a crucial role in this process by regulating glycolysis and HIF-1α expression. This promotes the antitumor effect of macrophages.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Xiaosheng Liu, Tingxia Lv, Xiuxia Li, Jing Xue, Ling Lin, Lianfeng Lu, Xiaodi Li, Yang Yang, Yuanni Wu, Qiang Wei, Wei Cao, Taisheng Li
Summary: LLDT-8 exhibits notable efficacy in alleviating immune activation in both an in vivo animal model and in vitro human cell experiments, suggesting its potential as a drug for managing systemic immune activation associated with SIV/HIV infection.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Honghong Yu, Qi Li, Huimin Zhu, Chang Liu, Weiwei Chen, Lingyun Sun
Summary: The activation of the inflammasome plays a critical role in the pathogenesis of systemic lupus erythematosus (SLE), and mesenchymal stem cells (MSC) have been shown to alleviate SLE by suppressing inflammasome activation. This study found that the NLRP3 inflammasome was activated in macrophages from SLE patients and mice, and its activation correlated with disease activity. After MSC transplantation, the severity of SLE was reduced, and NLRP3 inflammasome activation was inhibited. These findings suggest that MSC suppress inflammasome activation and provide a potential therapeutic target for SLE.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Wei Zhou, Dan Zeng, Shunan Liu, Yunxia Huang, Fenglin Lv, Weikang Zhou
Summary: This study found that inhibiting HDAC3 can protect the skin from atopic dermatitis by activating the Nrf2 transcription to upregulate Nrf2/HO-1 signaling pathway activity.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)