Article
Immunology
Carlos Blanco-Camarillo, Omar Rafael Aleman, Carlos Rosales
Summary: The article discusses the different phenotypes and functional states of neutrophils in healthy and pathological conditions, with a focus on the presence and cellular functions of low-density neutrophils (LDN) in the blood of healthy individuals.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Endocrinology & Metabolism
Daniella Bianchi Reis Insuela, Maximiliano Ruben Ferrero, Amanda da Silva Chaves, Diego de Sa Coutinho, Nathalia dos Santos Magalhaes, Ana Carolina Santos de Arantes, Adriana Ribeiro Silva, Patricia Machado Rodrigues e Silva, Marco Aurelio Martins, Vinicius Frias Carvalho
Summary: Glucagon has pro-resolving potential on neutrophilic inflammation, reducing neutrophil numbers and promoting neutrophil apoptosis while increasing the levels of pro-resolving mediators. It also inhibits inflammatory cell activity.
JOURNAL OF ENDOCRINOLOGY
(2023)
Review
Immunology
Jingjing Ji, Jie Fan
Summary: This article provides an overview of the current understanding of the mechanism and roles of PMN reverse migration (rM) in inflammation and sepsis. Evidence suggests that PMN rM can be both a protective response and a tissue-damaging event, highlighting its importance in the development of novel prophylactic and therapeutic strategies for sepsis.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Sladjana Skopelja-Gardner, Joyce Tai, Xizhang Sun, Lena Tanaka, James A. Kuchenbecker, Jessica M. Snyder, Paul Kubes, Tomas Mustelin, Keith B. Elkon
Summary: Exposure to UV light triggers a neutrophil-dependent injury response in the kidney, leading to subclinical renal inflammation and injury. Neutrophils not only migrate to the skin but also to the kidney post UV light exposure, contributing to the renal induction of inflammation and injury genes. Patients with lupus have blood neutrophils similar to those observed in mice post-UV exposure, suggesting a potential role of these cells in mediating inflammation and injury.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Oncology
Aiping Ma, Guangdong Wang, Yan Du, Weixi Guo, Jiaxi Guo, Yi Hu, Dongyu Bai, Huiping Huang, Lianjin Zhuang, Jinhan Chen, Qun Liu
Summary: This study found that NLR and PLR are associated with the clinical characteristics of COPD patients with lung cancer. Elevated levels of NLR or PLR are related to age over 70, current smoking status, and ineligible surgery, serving as important inflammation biomarkers for predicting diagnosis and disease severity.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Aurelie Moniot, Julien Braux, Renaud Siboni, Christine Guillaume, Sandra Audonnet, Ingrid Allart-Simon, Janos Sapi, Rabindra Tirouvanziam, Stephane Gerard, Sophie C. Gangloff, Frederic Velard
Summary: In inflammatory diseases, the excessive activation of polymorphonuclear neutrophils (PMNs) can lead to tissue damage. This study investigated the effects of two novel compounds, 4aa and 4ba, on PMNs activation and found that they can reduce the release of inflammatory cytokines, decrease PMNs phagocytic ability, and limit the recruitment of PMNs in tissues. These findings suggest the therapeutic potential of these compounds in the treatment of inflammatory diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Ke Wang, Yue Liao, Xiaoou Li, Ran Wang, Zijian Zeng, Mengxin Cheng, Lijuan Gao, Dan Xu, Fuqiang Wen, Tao Wang, Jun Chen
Summary: Chronic obstructive pulmonary disease (COPD) is a global public health challenge caused by significant exposure to noxious agents, especially cigarette smoke. Excessive production of neutrophil extracellular traps (NETs) in the airways is associated with the severity of COPD. In this study, the inhibitor GW311616A was found to effectively prevent cigarette smoke-induced NET formation in human neutrophil cells by blocking the nuclear translocation of neutrophil elastase (NE) and subsequent chromatin decondensation. Inhibition of NE also improved lung function and attenuated COPD-related pathological changes in a mouse model.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Cell Biology
Sofie Vandendriessche, Seppe Cambier, Paul Proost, Pedro E. Marques
Summary: The complement system plays a crucial role in controlling microorganisms and removing dead cells, while also stimulating adaptive immune responses and tissue regeneration. Complement receptors on leukocytes and parenchymal cells are essential for recognizing complement-derived molecules and promoting immune responses.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Maya F. Amjadi, Benjamin S. Avner, Mallary C. Greenlee-Wacker, Alexander R. Horswill, William M. Nauseef
Summary: Neutrophils regulate inflammation by releasing extracellular vesicles (EVs) containing important proteins to alter the phenotype of other immune cells, ultimately enhancing NADPH oxidase activity and promoting phagocytosis.
JOURNAL OF LEUKOCYTE BIOLOGY
(2021)
Article
Cell Biology
Zhixiang Fu, Jie Chen, Ran Zhang, Juliang Qin, Jueping Shi, Xiaoyu Zhang, Bing Du, Min Qian, Hua Ren
Summary: Neutrophils play a critical role in the inflammatory response and pathogenesis of acute lung injury (ALI). However, the regulatory mechanism of neutrophil recruitment in ALI is still unclear. This study explored the functions and signaling pathways of the purinergic receptor P2Y(6) in mediating the innate immune response in ALI. The results showed that P2Y(6) activation by the extracellular nucleotide UDP promotes the inflammatory response and pulmonary damage during ALI. P2Y(6) deficiency mitigates the progression of ALI, including reduced inflammatory factor release and immune cell invasion. Additionally, P2Y(6) regulates neutrophil migration through the ErK signaling pathway.
CELLULAR IMMUNOLOGY
(2022)
Article
Environmental Sciences
Chen Zhao, Wenyuan Pu, Mengyuan Niu, Junaid Wazir, Shiyu Song, Lulu Wei, Li Li, Zhonglan Su, Hongwei Wang
Summary: Exposure to PM2.5 soluble extract activates NF-κB and MAPK signaling pathways, induces the production of pro-inflammatory cytokines, alters transcription profiles of genes, and leads to phagocytic dysfunction, potentially exacerbating lung injury.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Cell Biology
Ruth A. Houseright, Veronika Miskolci, Oscar Mulvaney, Valeriu Bortnov, Deane F. Mosher, Julie Rindy, David A. Bennin, Anna Huttenlocher
Summary: MYDGF, induced by tissue damage, regulates neutrophil motility to damaged tissues through the HIF-1α pathway. Depletion of MYDGF impairs wound healing and inflammation resolution, while persistent neutrophil inflammation in MYDGF mutants is dependent on HIF-1α pathway.
JOURNAL OF CELL BIOLOGY
(2021)
Article
Immunology
Yonggang Ma, Scott S. Kemp, Xiaoyuan Yang, Mack H. Wu, Sarah Y. Yuan
Summary: Phagocytosis and clearance of dying cells by macrophages, known as efferocytosis, play crucial roles in maintaining homeostasis and promoting tissue repair. Defects in efferocytosis are implicated in various inflammatory and autoimmune diseases. This review highlights the signaling and metabolic processes of macrophage efferocytosis, its importance in tissue homeostasis and repair, and the mechanisms underlying efferocytotic abnormalities in disease or injury conditions. Potential molecular targets for enhanced efferocytosis in animal models of disease are also discussed.
IMMUNOLOGY LETTERS
(2023)
Review
Immunology
Andrea Herrero-Cervera, Oliver Soehnlein, Ellinor Kenne
Summary: Chronic inflammation is a common feature of many diseases and is especially prevalent in the aging population. The role of neutrophils in chronic inflammation is still not well understood, with conflicting evidence suggesting both beneficial and detrimental effects. However, emerging evidence indicates that neutrophils play a significant role in several chronic diseases.
CELLULAR & MOLECULAR IMMUNOLOGY
(2022)
Article
Immunology
Amena Aktar, Lianyu Shan, Latifa Koussih, Mohamed S. Almiski, Sujata Basu, Andrew Halayko, Ifeoma Okwor, Jude E. Uzonna, Abdelilah S. Gounni
Summary: The Sema3E/plexinD1 signaling pathway in interstitial macrophages regulates airway inflammation, airway resistance, and tissue remodeling in house dust mite-induced allergic asthma. Reduced IL-10 expression by plexinD1-deficient macrophages may contribute to the exacerbation of these allergic asthma features.
JOURNAL OF IMMUNOLOGY
(2022)
Article
Respiratory System
Luke Daines, Bang Zheng, Omer Elneima, Ewen Harrison, Nazir I. Lone, John R. Hurst, Jeremy S. Brown, Elizabeth Sapey, James D. Chalmers, Jennifer K. Quint, Paul Pfeffer, Salman Siddiqui, Samantha Walker, Krisnah Poinasamy, Hamish McAuley, Marco Sereno, Aarti Shikotra, Amisha Singapuri, Annemarie B. Docherty, Michael Marks, Mark Toshner, Luke S. Howard, Alex Horsley, Gisli Jenkins, Joanna C. Porter, Ling-Pei Ho, Betty Raman, Louise V. Wain, Christopher E. Brightling, Rachael A. Evans, Liam G. Heaney, Anthony De Soyza, Aziz Sheikh
Summary: This study aimed to characterize and identify risk factors for patients with persistent breathlessness following COVID-19 hospitalization and develop a prediction model. The results showed that lower socioeconomic status, preexisting depression/anxiety, female sex, and longer hospital stay were risk factors for post-COVID-19 breathlessness. In contrast, Black ethnicity and older age groups were less likely to experience post-COVID-19 breathlessness. Breathlessness was associated with decreased exercise capacity and lung function, but not with obstructive airflow limitation.
Article
Endocrinology & Metabolism
Conor Bentley, Jon Hazeldine, Laura Bravo, Angela E. Taylor, Lorna C. Gilligan, Fozia Shaheen, Animesh Acharjee, George Gkoutos, Mark A. Foster, Wiebke Arlt, Janet M. Lord
Summary: This study aimed to understand the speed and extent of the immediate endocrine response to traumatic injury. The results showed an increase in glucocorticoid and adrenal androgen biosynthesis within 1 hour of injury, while classic gonadal androgens decreased. Further studies are needed to investigate the association between these early changes in steroid metabolism and patient outcomes.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2023)
Article
Physiology
Jonathan I. Quinlan, Amritpal Dhaliwal, Felicity R. Williams, Sophie L. Allen, Surabhi Choudhary, Alex Rowlands, Leigh Breen, Gareth G. Lavery, Janet M. Lord, Ahmed M. Elsharkawy, Matthew J. Armstrong, Carolyn A. Greig
Summary: The central question of this study is to determine to what extent musculoskeletal impairment occurs in patients with end stage liver disease (ESLD) compared to a healthy control group. The main finding is that muscle mass, quality, and function are impaired in patients with ESLD, particularly in the lower limb muscle groups. This highlights the importance of considering muscle health in the lower limbs, as sarcopenia is associated with reduced quality of life and increased mortality in ESLD patients.
EXPERIMENTAL PHYSIOLOGY
(2023)
Article
Cell Biology
Maxim B. Freidin, Nathan Cheetham, Emma L. Duncan, Claire J. Steves, Katherine J. Doores, Michael H. Malim, Niccolo Rossi, Janet M. Lord, Paul W. Franks, Alessandra Borsini, Isabelle Granville Smith, Mario Falchi, Carmine Pariante, Frances M. K. Williams
Summary: Chronic fatigue is a common symptom of post-COVID syndrome, and this study suggests that elevated levels of IL-6 prior to COVID-19 infection may contribute to the development of chronic fatigue.
INFLAMMATION RESEARCH
(2023)
Article
Critical Care Medicine
Callum Jackson, Iain Stewart, Tatiana Plekhanova, Peter S. Cunningham, Andrew L. Hazel, Bashar Al-Sheklly, Raminder Aul, Charlotte E. Bolton, Trudie Chalder, James D. Chalmers, Nazia Chaudhuri, Annemarie B. Docherty, Gavin Donaldson, Charlotte L. Edwardson, Omer Elneima, Neil J. Greening, Neil A. Hanley, Victoria C. Harris, Ewen M. Harrison, Ling-Pei Ho, Linzy Houchen-Wolloff, Luke S. Howard, Caroline J. Jolley, Mark G. Jones, Olivia C. Leavy, Keir E. Lewis, Nazir Lone, Michael Marks, Hamish J. C. McAuley, Melitta A. McNarry, Brijesh Patel, Karen Piper-Hanley, Krisnah Poinasamy, Betty Raman, Matthew Richardson, Pilar Rivera-Ortega, Sarah L. Rowland-Jones, Alex Rowlands, Ruth M. Saunders, Janet T. Scott, Marco Sereno, Ajay M. Shah, Aarti Shikotra, Amisha Singapuri, Stefan C. Stanel, Mathew Thorpe, Daniel G. Wootton, Thomas Yates, R. Gisli Jenkins, Sally J. Singh, William D-C Man, Christopher E. Brightling, Louise Wain, Joanna C. Porter, A. A. Roger Thompson, Alex Horsley, Philip L. Molyneaux, Rachael A. Evans, Samuel E. Jones, Martin K. Rutter, John F. Blaikley, PHOSP-COVID Study Collaborative Grp
Summary: This study investigated the prevalence and nature of sleep disturbance after discharge following hospital admission for COVID-19 and found that sleep disturbance is associated with dyspnoea, anxiety, and muscle weakness. Targeting sleep disturbance might be beneficial in treating the post-COVID-19 condition.
LANCET RESPIRATORY MEDICINE
(2023)
Article
Immunology
Frances S. Grudzinska, Alice Jasper, Elizabeth Sapey, David R. Thickett, Claudio Mauro, Aaron Scott, Jonathan Barlow
Summary: Neutrophil responses are crucial in inflammatory and infective events, but their dysregulation is linked to poor patient outcomes. Immunometabolism has provided insights into cellular functions in health and disease. This study presents optimized protocols for using XF analysis to probe glycolysis and oxidative burst in neutrophils and highlights the challenges of examining mitochondrial function using this technology. XF technology is a powerful platform with a user-friendly interface, but caution is advised when assessing neutrophil mitochondrial respiration.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Health Care Sciences & Services
Bang Zheng, Giulia Vivaldi, Luke Daines, Olivia C. Leavy, Matthew Richardson, Omer Elneima, Hamish J. C. McAuley, Aarti Shikotra, Amisha Singapuri, Marco Sereno, Ruth M. Saunders, Victoria C. Harris, Linzy Houchen-Wolloff, Neil J. Greening, Paul E. Pfeffer, John R. Hurst, Jeremy S. Brown, Manu Shankar-Hari, Carlos Echevarria, Anthony De Soyza, Ewen M. Harrison, Annemarie B. Docherty, Nazir Lone, Jennifer K. Quint, James D. Chalmers, Ling-Pei Ho, Alex Horsley, Michael Marks, Krishna Poinasamy, Betty Raman, Liam G. Heaney, Louise V. Wain, Rachael A. Evans, Christopher E. Brightling, Adrian Martineau, Aziz Sheikh
Summary: This study investigated the determinants of recovery from dyspnoea in adults with COVID-19 and compared them to non-COVID-19 patients. The results showed that the factors associated with dyspnoea recovery in COVID-19 patients were similar to those in non-COVID-19 patients. These factors included age, gender, obesity status, mental health, cardiovascular disease, and length of hospital admission.
LANCET REGIONAL HEALTH-EUROPE
(2023)
Article
Medicine, General & Internal
Umer Syed, Anuradhaa Subramanian, David C. Wraith, Janet M. Lord, Kirsty McGee, Krishna Ghokale, Krishnarajah Nirantharakumar, Shamil Haroon
Summary: This study found an association between SARS-CoV-2 infection and an increased incidence of IMIDs such as T1DM, IBD, and psoriasis. However, these findings may be influenced by ascertainment bias, and further research is needed to replicate and investigate these results in other populations.
Article
Emergency Medicine
Yuanwei Xu, Nabeela Malik, Saisakul Chernbumroong, James Vassallo, Damian Keene, Mark Foster, Janet Lord, Antonio Belli, Timothy Hodgetts, Douglas Bowley, George Gkoutos
Summary: Novel triage tools developed using machine learning outperform existing tools in a nationally representative trauma population. The proposed primary tool requires external validation prior to consideration for practical use. The secondary tool demonstrates good external validity and may be used to support decision-making by healthcare workers responding to major incidents.
EMERGENCY MEDICINE JOURNAL
(2023)
Article
Neurosciences
Benoit Smeuninx, Yasir S. Elhassan, Elizabeth Sapey, Alison B. Rushton, Paul T. Morgan, Marie Korzepa, Archie E. Belfield, Andrew Philp, Matthew S. Brook, Nima Gharahdaghi, Daniel Wilkinson, Kenneth Smith, Philip J. Atherton, Leigh Breen
Summary: This study found that prior resistance exercise can attenuate the impairment of myofibrillar protein synthesis during bed rest in older adults, reducing muscle loss and improving overall health outcomes.
JOURNAL OF PHYSIOLOGY-LONDON
(2023)
Article
Biochemistry & Molecular Biology
Anmol Arora, Joseph E. Alderman, Joanne Palmer, Shaswath Ganapathi, Elinor Laws, Melissa D. Mccradden, Lauren Oakden-Rayner, Stephen R. Pfohl, Marzyeh Ghassemi, Francis Mckay, Darren Treanor, Negar Rostamzadeh, Bilal Mateen, Jacqui Gath, Adewole O. Adebajo, Stephanie Kuku, Rubeta Matin, Katherine Heller, Elizabeth Sapey, Neil J. Sebire, Heather Cole-Lewis, Melanie Calvert, Alastair Denniston, Xiaoxuan Liu
Summary: Artificial intelligence as a medical device is increasingly being used in healthcare for various purposes. However, there is a risk of algorithmic bias, which may exacerbate existing health disparities. This study aims to explore existing standards and best practices for ensuring data diversity in healthcare datasets.
Article
Multidisciplinary Sciences
Yung-Yi Chen, Krupali M. Patel, Rizwana Imran, Tarek Hassouna, Ezekwe Amirize, Abdulrazak Abdulsalam, Jonathan Bishop, Anita Slade, Maximina Ventura, Jeremy Yarrow, Janet M. Lord, Yvonne Wilson, Naiem S. Moiemen
Summary: This study aims to investigate the cellular kinetics in HTS after laser therapy, focusing on the association of scar reduction with the presence of senescent cells. The findings will provide a better understanding of the mechanisms involved in scar reduction with laser treatment and help improve treatment regimens for HTS patients.
Article
Multidisciplinary Sciences
Vicky Kamwa, Thomas Jackson, Zaki Hassan-Smith, Elizabeth Sapey
Summary: The TYSON study aims to assess the feasibility and acceptability of frailty and sarcopenia assessments in older adults admitted to acute medical units and explore their trajectory and associated outcomes. Additionally, the study will investigate the inflammatory and metabolic mediators associated with frailty and sarcopenia.
Editorial Material
Medicine, General & Internal
Tim Cooksley, Mark Holland, Elizabeth Sapey
BMJ-BRITISH MEDICAL JOURNAL
(2023)
Letter
Critical Care Medicine
Christopher E. Brightling, Rachael A. Evans, Amisha Singapuri, Nikki Smith, Louise Wain
LANCET RESPIRATORY MEDICINE
(2023)
Article
Immunology
Jun Cui, Cheng Chen, Xiao Zhou, Wenju Shan, Yuhong Jian, Panpan Li, Yang Sun, Wei Yi
Summary: Bone marrow mesenchymal stem cells (BMSCs) are a promising therapy for sepsis, but metabolic syndromes threaten their effectiveness. This study investigated the potential of small extracellular vesicles from high-fat diet BMSCs in sepsis-induced liver-heart axis injury.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Binbin Zhu, Angyang Cao, Chunqu Chen, Weijian Zhou, Wenjun Luo, Yu Gui, Qinwen Wang, Zhipeng Xu, Jianhua Wang
Summary: GM6001 alleviates postoperative cognitive deficits and neuroinflammation, preserves blood-brain barrier integrity, and rescues aquaporin-4 mislocalization. MMP-9 inhibition plays a dual role in cognitive protection through direct anti-neuroinflammatory effects and regulation of aquaporin-4 membrane distribution.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Anika Sood, Valencia Fernandes, Kumari Preeti, Shruti Rajan, Dharmendra Kumar Khatri, Shashi Bala Singh
Summary: S1PR2 inhibitor improves cognitive function and skews microglia toward anti-inflammatory phenotype in type 2 diabetic mice, promising to be a potential therapy for neuroinflammation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Haochun Guo, Ran Yu, Haijun Zhang, Wanpeng Wang
Summary: Radiation therapy is an effective treatment for thoracic malignancies, but it can cause radiation-induced lung injury (RILI), including radiation pneumonitis (RP) and radiation pulmonary fibrosis (RPF). The damage to normal lung cells during radiation treatment leads to a pulmonary inflammatory response, resulting in RP and RPF.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Guanghui Wang, Haotian Zheng, Yunzhi Xiang, Yadong Wang, Kai Wang, Xiaoyang Ren, Jiajun Du
Summary: This study identified a T-cell synthetic driver-associated prognostic model that accurately predicted prognosis and effectiveness of immunotherapy in LUAD patients. It also highlighted the role of LDHA in promoting tumor cell proliferation, invasion, and resistance to treatment, as well as its involvement in immune escape within the tumor microenvironment. These findings provide a promising new therapeutic strategy for LUAD.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Bowen Wei, Aihua Wang, Wei Liu, Qingyun Yue, Yihua Fan, Bin Xue, Siwei Wang
Summary: This study systematically analyzed the association between pSS and cuproptosis, established a predictive model based on 5 genes, explored the pathogenic mechanisms and novel therapeutic strategies for pSS, and identified EED, CBL, and NFU1 as potential targets for treatment.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Nusrit Iqbal Andrabi, Aminur R. Sarkar, Syed Assim Haq, Diljeet Kumar, Dilpreet Kour, Diksha Saroch, Sanket Kumar Shukla, Ajay Kumar, Asha Bhagat, Asif Ali, Gurleen Kour, Zabeer Ahmed
Summary: Koenimbine and its novel semi-synthetic derivative 1G demonstrate significant anti-inflammatory effects by downregulating the nuclear factor kappa-B (NF-kappa B) signaling pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Jing-Mei Lu, Xiang Xu, Fumie Aosai, Ming-Yue Zhang, Lian-Xun Piao
Summary: This study found that arctiin can improve allergic acute liver injury caused by T.g.HSP70 by inhibiting TLR4 signaling and reducing the production of inflammatory mediators.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Minxuan Xu, Fang Shi, Yongshen Gao, Shumei Han, Chensuo Huang, Qinsheng Hou, Xiaoweng Wen, Bengshi Wang, Zhenyu Zhu, Lei Zou, Mingxin Xiong, Wei Dong, Jun Tan
Summary: There is a growing body of research highlighting the involvement of metabolic imbalance and the inflammatory response in the advancement of colitis. This study recognizes arabinose as a significant protector of the intestinal mucosal barrier, reducing damage to the intestines. In addition, lower levels of arabinose in the bloodstream are associated with a higher severity of inflammatory bowel disease and colorectal cancer.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yueqing Han, Haoxin Song, Yanshan Li, Rongxin Li, Ling Chen, Bo Gao, Yijun Chen, Shuzhen Wang
Summary: The combination of tetracycline antibiotics, demeclocycline (D), chlortetracycline (C), and minocycline (M), showed therapeutic potential against liver fibrosis by inhibiting the activation of hepatic stellate cells and the MAPK signaling. This study suggests that tetracyclines may be repurposed for the treatment of liver fibrosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yu Li, Hailing Liu, Danwen Zhao, Danjie Zhang
Summary: Chronic stress can lead to lung injury, with the spleen playing a crucial role. This study found that the spleen contributes to chronic restraint stress-induced lung injury, and splenic CD11b+ cells may be an important factor in this process.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yingqian Mi, Mengyan Tang, Qiong Wu, Yinan Wang, Qihui Liu, Pei Zhu, Xiaoyang Xue, Yuntong Liu, Xinyu Chai, Yuyang Hou, Dongmei Yan
Summary: BCG therapy can induce macrophage polarization to the M1 type, and NMAAP1 plays a crucial role in this process by regulating glycolysis and HIF-1α expression. This promotes the antitumor effect of macrophages.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Xiaosheng Liu, Tingxia Lv, Xiuxia Li, Jing Xue, Ling Lin, Lianfeng Lu, Xiaodi Li, Yang Yang, Yuanni Wu, Qiang Wei, Wei Cao, Taisheng Li
Summary: LLDT-8 exhibits notable efficacy in alleviating immune activation in both an in vivo animal model and in vitro human cell experiments, suggesting its potential as a drug for managing systemic immune activation associated with SIV/HIV infection.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Honghong Yu, Qi Li, Huimin Zhu, Chang Liu, Weiwei Chen, Lingyun Sun
Summary: The activation of the inflammasome plays a critical role in the pathogenesis of systemic lupus erythematosus (SLE), and mesenchymal stem cells (MSC) have been shown to alleviate SLE by suppressing inflammasome activation. This study found that the NLRP3 inflammasome was activated in macrophages from SLE patients and mice, and its activation correlated with disease activity. After MSC transplantation, the severity of SLE was reduced, and NLRP3 inflammasome activation was inhibited. These findings suggest that MSC suppress inflammasome activation and provide a potential therapeutic target for SLE.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Wei Zhou, Dan Zeng, Shunan Liu, Yunxia Huang, Fenglin Lv, Weikang Zhou
Summary: This study found that inhibiting HDAC3 can protect the skin from atopic dermatitis by activating the Nrf2 transcription to upregulate Nrf2/HO-1 signaling pathway activity.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)