Article
Immunology
Xiang Nie, Huihui Li, Jin Wang, Yuanyuan Cai, Jiahui Fan, Beibei Dai, Chen Chen, Dao Wen Wang
Summary: The study revealed that the expression of lncRNAs is significantly dysregulated in acute myocarditis, potentially playing different roles in the progression of AM.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Oncology
Qingxiang Li, Yuke Li, Yifei Wang, Le Xu, Yuxing Guo, Yixiang Wang, Lin Wang, Chuanbin Guo
Summary: The intestinal microbiota, particularly through the probiotic B. breve, can enhance the efficacy of cancer immunotherapy, promoting tumor cell apoptosis; the mechanism of B. breve may involve the regulation of DC-related chemokines and the promotion of IL-12 secretion; the study suggests that exogenous B. breve can alter the intestinal microbiota and enhance its antitumor effect.
Article
Medicine, General & Internal
Ashish Jain, Rahul P. Rane, Maha Mumtaz, Asfand Y. Butt, Mahmoud Abdelsalam, Saba Waseem
Summary: Myocarditis is an inflammatory condition primarily caused by viruses, which affects cardiac myocytes. It can lead to various symptoms such as chest pain, dyspnea, and palpitations. The diagnosis of myocarditis can be challenging, resulting in delayed treatment.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2022)
Article
Cardiac & Cardiovascular Systems
Vipul Sharma, Lisa S. Goessling, Anoop K. Brar, Chetanchandra S. Joshi, Indira U. Mysorekar, Pirooz Eghtesady
Summary: Prenatal infection with CVB3 can induce congenital heart defects in fetuses, with a dose-response relationship observed between viral titers and defect severity. Following exposure to CVB3, a significant decrease in cardiomyocyte proliferation was identified as the main cause for alterations in cardiac architecture and trabeculation.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Food Science & Technology
Kan Gao, Xueliang Ren, Cailing Chen, Qiuling Fan, Yanjun Li, Haifeng Wang, Su Chen
Summary: The probiotic strain Bifidobacterium longum WHH2270 exhibits hypoglycemic effects on type 2 diabetes by inhibiting α-glucosidase activity and reshaping the gut microbiome. It improves glucose tolerance and insulin resistance by increasing the abundance of beneficial bacteria and short-chain fatty acid production.
JOURNAL OF FOOD SCIENCE
(2023)
Article
Immunology
Mahadappa Priyanka, H. B. Ranjitha, M. Karikalan, S. Chandramohan, Subhasmitha Behera, V. Gnanavel, Tamil Selvan Ramasamy Periyasamy, V. Umapathi, H. J. Dechamma, Narayanan Krishnaswamy
Summary: It was found that FMDV infection leads to overexpression of CAR in the myocardium of suckling mice, which may be the reason for their susceptibility to viral myocarditis.
MICROBIAL PATHOGENESIS
(2023)
Article
Immunology
Baona Li, Xinran Cao, Guo Ai, Yuanyuan Liu, Chanyuan Lv, Luoqing Jin, Rong Xu, Gang Zhao, Haitao Yuan
Summary: This study investigated the potential mechanisms of interleukin-37 (IL-37) in inhibiting the formation of neutrophil extracellular traps (NETs) in acute viral myocarditis (VMC). The results showed that IL-37 could reduce inflammatory cell infiltration, improve cardiac function, and inhibit NETs formation in the myocardium. Furthermore, IL-37 effectively suppressed the activation of NF Kappa b /I Kappa B alpha in isolated neutrophils.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Immunology
Qingru Yang, Yuhan Li, Yan Wang, Xiaorong Qiao, Tingjun Liu, Hua Wang, Hongxing Shen
Summary: This study found that circSIAE can target TAOK2 through sponge adsorption of miR-331-3p to inhibit the replication and proliferation of CVB3 virus.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Wei Peng, Ying-Hui Li, Guan Yang, Jie-Lin Duan, Ling-Yuan Yang, Li-Xiang Chen, Shu-Ling Hou, Xing-Guo Huang
Summary: In this study, it was found that supplementation of Lactobacillus delbrueckii (LAB) can regulate intestinal immunity in piglets by increasing inflammatory factors and modulating gut microbial communities. LAB was shown to induce dendritic cell maturation and activation, possibly through the activation of NF-κB and MAPK signaling pathways. Oral supplementation of LAB was also found to have long-lasting immunomodulatory effects on intestinal immunity after weaning.
Article
Microbiology
Soo Jin A. Park, Uram T. Jin, Sang Myun A. Park
Summary: This study elucidated the mechanism of Lewy body formation and the pathogenesis of PD associated with CVB3 infection. CVB3 infection can induce α-syn-associated inclusion body formation in neurons, acting as a trigger for PD. α-Syn overexpression in CVB3-infected mice brains favored virus replication, leading to neuronal cell death and a low survival rate.
Article
Virology
Yafeng Wang, Xiaokai Zhuan, Youmei Peng, Qing Li, Chenzheng Huang, He Huang, Zongxian Liang, Qingduan Wang, Junbiao Chang
Summary: The novel fluoronucleoside analogue NCC demonstrated significant antiviral activities against CVB3, inhibiting virus replication, alleviating myocardial injury, and suppressing apoptosis in HeLa cells and infected mice. It shows potential as a therapeutic agent for viral myocarditis.
Article
Dermatology
Ana Soler-Cardona, Adrian Tanew, Sonja Radakovic
Summary: AHEI is a cutaneous leukocytoclastic small vessel vasculitis that mostly affects infants aged 4 to 24 months, characterized by targetoid purpuric edematous lesions that typically resolve within 3 weeks without late sequelae. The main differential diagnosis is HSP and purpura fulminans should be ruled out initially.
ACTA DERMATOVENEROLOGICA CROATICA
(2021)
Article
Microbiology
Carlotta Vizioli, Rosario Jaime-Lara, Scott G. Daniel, Alexis Franks, Ana F. Diallo, Kyle Bittinger, Tina P. Tan, Daniel J. Merenstein, Brianna Brooks, Paule V. Joseph, Katherine A. Maki
Summary: This study aimed to investigate the effects of probiotic consumption on the gut microbiome and metabolome of children. The results showed no significant changes in the global metagenomic or metabolomic profiles between the two intervention groups. However, there was a measurable impact on the relative abundance of the probiotics of interest in the gut microbiome. Future research should explore longer probiotic interventions and focus on children at risk for gastrointestinal disorders to further understand the potential protective effects of functional metabolite changes.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Rwaa H. Abdulal, Jana S. Malki, Ezdehar Ghazal, Ahdab A. Alsaieedi, Sarah A. Almahboub, Muhammad Yasir Khan, Reem M. Alsulaiman, Mazen M. Ghaith, Turki S. Abujamel, Magdah Ganash, Ahmad Bakur Mahmoud, Almohanad A. Alkayyal, Anwar M. Hashem
Summary: The combination of oncolytic viruses (OVs) and cytokines, like IL-12, is a promising approach for cancer treatment, addressing the limitations of current standard treatments. IL-12 triggers intracellular signaling pathways that enhance apoptosis of tumor cells and antitumor activity of immune cells, making it a promising candidate for cancer therapy. Targeted expression of IL-12 within tumors plays a crucial role in tumor eradication, and the recent development of oncolytic viruses allows for targeted delivery and expression of IL-12 at the tumor site, reducing systemic toxicities.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2023)
Article
Microbiology
Yuanyuan Yan, Jia Li, Zhe Jiao, Mengfang Yang, Lisha Li, Gang Wang, Yixi Chen, Mengxia Li, Zhou Shen, Yuejun Shi, Guiqing Peng
Summary: This study evaluated the efficacy of oral administration of GS441524 and GC376 against FIPV and determined the effective oral doses through in vivo pharmacokinetics. The findings showed that GS441524 effectively reduced the mortality rate of FIP patients, while GC376 only reduced mortality at high doses. In addition, there was no significant difference in pharmacokinetic parameters between oral and subcutaneous administration.
VETERINARY MICROBIOLOGY
(2023)
Article
Immunology
Jun Cui, Cheng Chen, Xiao Zhou, Wenju Shan, Yuhong Jian, Panpan Li, Yang Sun, Wei Yi
Summary: Bone marrow mesenchymal stem cells (BMSCs) are a promising therapy for sepsis, but metabolic syndromes threaten their effectiveness. This study investigated the potential of small extracellular vesicles from high-fat diet BMSCs in sepsis-induced liver-heart axis injury.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Binbin Zhu, Angyang Cao, Chunqu Chen, Weijian Zhou, Wenjun Luo, Yu Gui, Qinwen Wang, Zhipeng Xu, Jianhua Wang
Summary: GM6001 alleviates postoperative cognitive deficits and neuroinflammation, preserves blood-brain barrier integrity, and rescues aquaporin-4 mislocalization. MMP-9 inhibition plays a dual role in cognitive protection through direct anti-neuroinflammatory effects and regulation of aquaporin-4 membrane distribution.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Anika Sood, Valencia Fernandes, Kumari Preeti, Shruti Rajan, Dharmendra Kumar Khatri, Shashi Bala Singh
Summary: S1PR2 inhibitor improves cognitive function and skews microglia toward anti-inflammatory phenotype in type 2 diabetic mice, promising to be a potential therapy for neuroinflammation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Haochun Guo, Ran Yu, Haijun Zhang, Wanpeng Wang
Summary: Radiation therapy is an effective treatment for thoracic malignancies, but it can cause radiation-induced lung injury (RILI), including radiation pneumonitis (RP) and radiation pulmonary fibrosis (RPF). The damage to normal lung cells during radiation treatment leads to a pulmonary inflammatory response, resulting in RP and RPF.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Guanghui Wang, Haotian Zheng, Yunzhi Xiang, Yadong Wang, Kai Wang, Xiaoyang Ren, Jiajun Du
Summary: This study identified a T-cell synthetic driver-associated prognostic model that accurately predicted prognosis and effectiveness of immunotherapy in LUAD patients. It also highlighted the role of LDHA in promoting tumor cell proliferation, invasion, and resistance to treatment, as well as its involvement in immune escape within the tumor microenvironment. These findings provide a promising new therapeutic strategy for LUAD.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Bowen Wei, Aihua Wang, Wei Liu, Qingyun Yue, Yihua Fan, Bin Xue, Siwei Wang
Summary: This study systematically analyzed the association between pSS and cuproptosis, established a predictive model based on 5 genes, explored the pathogenic mechanisms and novel therapeutic strategies for pSS, and identified EED, CBL, and NFU1 as potential targets for treatment.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Nusrit Iqbal Andrabi, Aminur R. Sarkar, Syed Assim Haq, Diljeet Kumar, Dilpreet Kour, Diksha Saroch, Sanket Kumar Shukla, Ajay Kumar, Asha Bhagat, Asif Ali, Gurleen Kour, Zabeer Ahmed
Summary: Koenimbine and its novel semi-synthetic derivative 1G demonstrate significant anti-inflammatory effects by downregulating the nuclear factor kappa-B (NF-kappa B) signaling pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Jing-Mei Lu, Xiang Xu, Fumie Aosai, Ming-Yue Zhang, Lian-Xun Piao
Summary: This study found that arctiin can improve allergic acute liver injury caused by T.g.HSP70 by inhibiting TLR4 signaling and reducing the production of inflammatory mediators.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Minxuan Xu, Fang Shi, Yongshen Gao, Shumei Han, Chensuo Huang, Qinsheng Hou, Xiaoweng Wen, Bengshi Wang, Zhenyu Zhu, Lei Zou, Mingxin Xiong, Wei Dong, Jun Tan
Summary: There is a growing body of research highlighting the involvement of metabolic imbalance and the inflammatory response in the advancement of colitis. This study recognizes arabinose as a significant protector of the intestinal mucosal barrier, reducing damage to the intestines. In addition, lower levels of arabinose in the bloodstream are associated with a higher severity of inflammatory bowel disease and colorectal cancer.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yueqing Han, Haoxin Song, Yanshan Li, Rongxin Li, Ling Chen, Bo Gao, Yijun Chen, Shuzhen Wang
Summary: The combination of tetracycline antibiotics, demeclocycline (D), chlortetracycline (C), and minocycline (M), showed therapeutic potential against liver fibrosis by inhibiting the activation of hepatic stellate cells and the MAPK signaling. This study suggests that tetracyclines may be repurposed for the treatment of liver fibrosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yu Li, Hailing Liu, Danwen Zhao, Danjie Zhang
Summary: Chronic stress can lead to lung injury, with the spleen playing a crucial role. This study found that the spleen contributes to chronic restraint stress-induced lung injury, and splenic CD11b+ cells may be an important factor in this process.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yingqian Mi, Mengyan Tang, Qiong Wu, Yinan Wang, Qihui Liu, Pei Zhu, Xiaoyang Xue, Yuntong Liu, Xinyu Chai, Yuyang Hou, Dongmei Yan
Summary: BCG therapy can induce macrophage polarization to the M1 type, and NMAAP1 plays a crucial role in this process by regulating glycolysis and HIF-1α expression. This promotes the antitumor effect of macrophages.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Xiaosheng Liu, Tingxia Lv, Xiuxia Li, Jing Xue, Ling Lin, Lianfeng Lu, Xiaodi Li, Yang Yang, Yuanni Wu, Qiang Wei, Wei Cao, Taisheng Li
Summary: LLDT-8 exhibits notable efficacy in alleviating immune activation in both an in vivo animal model and in vitro human cell experiments, suggesting its potential as a drug for managing systemic immune activation associated with SIV/HIV infection.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Honghong Yu, Qi Li, Huimin Zhu, Chang Liu, Weiwei Chen, Lingyun Sun
Summary: The activation of the inflammasome plays a critical role in the pathogenesis of systemic lupus erythematosus (SLE), and mesenchymal stem cells (MSC) have been shown to alleviate SLE by suppressing inflammasome activation. This study found that the NLRP3 inflammasome was activated in macrophages from SLE patients and mice, and its activation correlated with disease activity. After MSC transplantation, the severity of SLE was reduced, and NLRP3 inflammasome activation was inhibited. These findings suggest that MSC suppress inflammasome activation and provide a potential therapeutic target for SLE.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Wei Zhou, Dan Zeng, Shunan Liu, Yunxia Huang, Fenglin Lv, Weikang Zhou
Summary: This study found that inhibiting HDAC3 can protect the skin from atopic dermatitis by activating the Nrf2 transcription to upregulate Nrf2/HO-1 signaling pathway activity.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)