Review
Pharmacology & Pharmacy
Pengyu Tao, Jing Ji, Simeng Gu, Qian Wang, Yuzhen Xu
Summary: This article summarizes the potential and mechanisms of herbal medicine in the treatment of dementia. It highlights the regulatory effect of herbal extracts on autophagy, as well as their effects in reducing oxidative stress, inhibiting inflammation, and neurotoxicity.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Medicine, General & Internal
Nan Zheng, Shan Liu, Huiting Zeng, Huajun Zhao, Lixu Jin
Summary: This study found that WZ10 can significantly inhibit the proliferation and invasion of ovarian cancer OVCAR3 cells by downregulating the activation of the Hippo-YAP pathway, and induce cell apoptosis.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, Research & Experimental
Lilik Duwi Wahyudi, Seon Hui Yu, Min Kyung Cho
Summary: In this study, the effects of curcumin on Cd-induced apoptosis in keratinocytes and the underlying molecular mechanisms were investigated. The results showed that curcumin could inhibit apoptosis caused by Cd in keratinocytes by modulating the expression of MT2A.
Article
Engineering, Biomedical
Junjie Chi, Lingyu Sun, Lijun Cai, Lu Fan, Changmin Shao, Luoran Shang, Yuanjin Zhao
Summary: The study introduces a novel Chinese herb microneedle patch, which promotes wound healing and has various medicinal effects such as heat clearing, detoxicating, and antibacterial properties. By integrating pure herbal compositions with advanced technologies, the research demonstrates the potential development and promotion of traditional Chinese medicine in modern society.
BIOACTIVE MATERIALS
(2021)
Article
Cell Biology
Eric Seidel, Silvia von Karstedt
Summary: Cancer cells show adaptive behavior during early transformation, and specific mutations optimize cellular fitness. However, the influence of the immune system on cellular adaptation during early carcinogenesis and the role of cell death pathways are still unclear.
CELL DEATH DISCOVERY
(2022)
Article
Pharmacology & Pharmacy
Feng Zhang, Tiantian Zhang, Jiahao Gong, Qinqin Fang, Shenglan Qi, Mengting Li, Yan Han, Wei Liu, Guangbo Ge
Summary: This study demonstrates that the Chinese herb Styrax can efficiently inhibit hCYP3A4 enzyme and modulate the pharmacokinetic behavior of CYP3A-substrate drugs. It provides valuable insights for clinical pharmacologists to assess the potential herb-drug interactions triggered by Styrax or Styrax-related herbal products.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Zhihui Liu, Bendong Shi, Yu Wang, Qingyang Xu, Hongxin Gao, Jun Ma, Xiaowen Jiang, Wenhui Yu
Summary: Curcumin has been shown to alleviate aristolochic acid I-induced renal injury in rats by activating the SIRT1/Nrf2/HO-1 signaling pathway.
Review
Biochemistry & Molecular Biology
Parnia Rahnamay Farnood, Romina Danesh Pazhooh, Zatollah Asemi, Bahman Yousefi
Summary: Osteosarcoma is the most common primary bone malignancy among children and adolescents, and its high mortality rate is mainly due to lung metastasis. Traditional chemotherapy and surgical treatment have limited efficacy in reducing metastasis rate and improving prognosis. Therefore, it is necessary to explore new therapeutic strategies to enhance the survival rate of osteosarcoma patients. Curcumin, a compound derived from Curcuma longa, has been shown to have multiple anti-cancer effects. Studies have demonstrated that curcumin can inhibit cell proliferation and induce apoptosis in osteosarcoma cells. Additionally, research has identified several signaling pathways involved in the pathogenesis of osteosarcoma, and curcumin has been evaluated for its potential to regulate these pathways and improve treatment outcomes.
CURRENT MOLECULAR PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Zhaohui Cao, Zhuan Wu, Tingting Duan, Cifei Tang, Di Huang, Xiaobo Hu
Summary: This study found that curcumin improves oxidative stress-induced apoptosis in pancreatic beta cells by inhibiting the PERK-CHOP pathway of ER stress. Curcumin acts by activating SIRT1 expression and reducing the expression of CHOP. These findings suggest that curcumin and SIRT1 may serve as a potential therapeutic approach for T1DM.
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
(2022)
Article
Pharmacology & Pharmacy
Yifan Huang, Minghan Cheng, Xiaoye Wang, Hongliang Dong, Jian Gao
Summary: In this study, the protective effect of DBT on radiation-induced heart disease (RIHD) was investigated. The results showed that DBT can improve cardiac dysfunction, myocardial fibrosis, and cardiac injury caused by RIHD, possibly through modulation of myocardial Nrf2 and HMGB1 protein levels.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Cell Biology
Yu Zhang, Jingjing Xiang, Ni Zhu, Hangping Ge, Xianfu Sheng, Shu Deng, Junfa Chen, Lihong Yu, Yan Zhou, Jianping Shen
Summary: The combination of HHT and curcumin synergistically inhibits lymphoma cell proliferation and invasion, increases apoptosis, and promotes anti-tumor mechanisms via modulation of cell signaling pathways. This suggests that the combination therapy may be a promising approach for lymphoma treatment.
Article
Biochemistry & Molecular Biology
Gulcin Yavuz Turel, Nilufer Sahin Calapoglu, Dilek Bayram, Meltem Ozgocmen, Vehbi Atahan Togay, Eda Evgen Tuluceoglu
Summary: The study demonstrated that curcumin has inhibitory effects on cell proliferation and induces apoptosis in colon carcinoma cells. It suggests that curcumin could be a potential protective or treatment agent against colon cancer, but further research on curcumin-rich diets and bioavailability is needed.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Plant Sciences
Dahae Lee, Hee Jae Kwak, Byoung Ha Kim, Dong-Wook Kim, Hyun Young Kim, Seung Hyun Kim, Ki Sung Kang
Summary: This study evaluated the anticancer activities of Centipeda minima (CMX) extracts and brevilin A against human gastric cancer cells and identified key anticancer genes targeted by brevilin A. The findings suggest that CMX and brevilin A may be novel sources of herbal medicine effective for the treatment of gastric cancer.
Article
Environmental Sciences
Xintong Zhang, Yuan Cui, Xiaopeng Song, Xiaodi Jin, Xuanbo Sheng, Xinyu Xu, Ting Li, Hong Chen, Li Gao
Summary: This study investigates the protective effect of curcumin on nerve damage caused by ketamine anesthesia through the Nrf2 signaling pathway. The results suggest that curcumin may alleviate oxidative stress and apoptosis by targeting the Nrf2 pathway, reducing the nerve injury caused by ketamine.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Chao Song, Dongmei Shi, Kaiwen Chang, Xianghui Li, Qing Dong, Xia Ma, Xuefei Wang, Zhenhuan Guo, Yonglu Liu, Jundong Wang
Summary: Fluoride-induced pulmonary toxicity is related to cell apoptosis, with activation of caspase-8 and induction of DR5 playing critical roles. NOX4 and p53 mediate the expression of DR5 induced by NaF, influencing pulmonary apoptosis.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Shih-Ya Hung, Chih-Yang Lin, Cheng-Chieh Yu, Hsien-Te Chen, Ming-Yu Lien, Yu-Wen Huang, Yi-Chin Fong, Ju-Fang Liu, Shih-Wei Wang, Wei-Cheng Chen, Chih-Hsin Tang
Summary: Chondrosarcoma is a malignant bone tumor with high metastatic potential and resistance to conventional treatments. Visfatin, an adipokine, has been found to promote chondrosarcoma cell migration and lung metastasis through the induction of MMP-2 and activation of the AP-1 transcription factor. Targeting visfatin may be a promising strategy for treating metastatic chondrosarcoma.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Iona J. MacDonald, Hsiao-Chi Tsai, An-Chen Chang, Chien-Chung Huang, Shun-Fa Yang, Chih-Hsin Tang
Summary: Osteoblasts and osteoclasts are crucial in the bone turnover cycle, and melatonin shows promising therapeutic potential for both osteoporosis and osteolytic bone metastasis by regulating bone metabolism, bone cell differentiation, and bone resorption.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Nutrition & Dietetics
Fang-Ju Cheng, Thanh-Kieu Huynh, Chia-Shin Yang, Dai-Wei Hu, Yi-Cheng Shen, Chih-Yen Tu, Yang-Chang Wu, Chih-Hsin Tang, Wei-Chien Huang, Yeh Chen, Chien-Yi Ho
Summary: The study demonstrates that hesperetin and hesperidin have the potential to inhibit SARS-CoV-2 infection by blocking the cellular entry process. They can reduce the binding of the S protein to the cellular receptor and decrease the expression of related proteins, thereby inhibiting the viral infection.
Article
Environmental Sciences
Jing-Yang Huang, Shun-Fa Yang, Pei-Ju Wu, Chun-Hao Wang, Chih-Hsin Tang, Po-Hui Wang
Summary: A nationwide population cohort research compared the risk of ovarian cancer in patients with endometriosis or pelvic inflammatory disease (PID), finding that patients with endometriosis were more likely to develop ovarian cancer.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Biochemistry & Molecular Biology
Tsung-Ju Wu, Sunny Li-Yun Chang, Chih-Yang Lin, Chao-Yang Lai, Xiu-Yuan He, Chun-Hao Tsai, Chih-Yuan Ko, Yi-Chin Fong, Chen-Ming Su, Chih-Hsin Tang
Summary: IL-17 increases monocyte adhesion in OA synovium by reducing miR-5701 expression and enhancing VCAM-1 production. These findings improve our understanding of IL-17's impact on OA progression and provide insights for the design of more effective OA treatments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Chien-Chi Lu, Hsiao-Chi Tsai, Dong-Ying Yang, Shih-Wei Wang, Ming-Hsui Tsai, Chun-Hung Hua, Kwei-Jing Chen, Michael Yuan-Chien Chen, Ming-Yu Lien, Chih-Hsin Tang
Summary: The inflammatory chemokine CCL4 promotes angiogenesis and metastasis in oral squamous cell carcinoma (OSCC) by upregulating Angpt2 expression and activating MEK, ERK, and STAT3 signaling pathways. Inhibiting CCL4 may be a potential strategy for treating OSCC by targeting angiogenesis and metastasis.
Article
Cell Biology
Tien-Huang Lin, Sunny Li-Yun Chang, Pham Minh Khanh, Nguyen Thi Nha Trang, Shan-Chi Liu, Hsiao-Chi Tsai, An-Chen Chang, Jo-Yu Lin, Po-Chun Chen, Ju-Fang Liu, Jeng-Hung Guo, Chun-Lin Liu, Hsi-Chin Wu, Chih-Hsin Tang
Summary: Apelin plays a positive role in prostate cancer metastasis and is positively correlated with tumor progression and metastasis. It promotes cell migration and invasion by inhibiting TIMP2 expression. The signaling pathway of c-Src/PI3K/Akt and the synthesis of miR-106a-5p are controlled by apelin to regulate TIMP2 production and cell motility. Blocking apelin can inhibit prostate cancer metastasis in a mouse model.
Article
Cell Biology
Chang-Yu Song, Sunny Li-Yun Chang, Chih-Yang Lin, Chun-Hao Tsai, Shang-Yu Yang, Yi-Chin Fong, Yu-Wen Huang, Shih-Wei Wang, Wei-Cheng Chen, Chih-Hsin Tang
Summary: New treatments for chondrosarcoma are crucial due to its poor prognosis, and factors like PDGF and visfatin play significant roles in tumor development and angiogenesis. Research has shown that visfatin promotes chondrosarcoma angiogenesis by modulating miR-1264 expression, potentially offering a new therapeutic approach for the treatment of chondrosarcoma.
Article
Biochemistry & Molecular Biology
Sheng-Yen Hsiao, Chih-Hsin Tang, Po-Chun Chen, Tien-Huang Lin, Chia-Chia Chao
Summary: Melatonin exhibits antitumor activities against bladder cancer by inhibiting the epithelial-mesenchymal transition process and autophagy of bladder cancer cells. Melatonin treatment also slightly prolongs the survival of tumor-bearing mice.
Article
Cell Biology
Trung-Loc Ho, Chih-Hsin Tang, Sunny Li-Yun Chang, Chun-Hao Tsai, Hsien-Te Chen, Chen-Ming Su
Summary: Skeletal muscle atrophy is caused by muscle wasting or reductions in protein associated with aging, injury, and inflammatory processes. The study found an association between HMGB1 and IL-18 signaling in skeletal muscle atrophy, and the HMGB1/IL-18 axis may be a potential target for the treatment of this condition.
Editorial Material
Biochemistry & Molecular Biology
Chih-Hsin Tang
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Liang-Wei Lin, Shih-Wei Wang, Wei-Chien Huang, Thanh Kieu Huynh, Chao-Yang Lai, Chih-Yuan Ko, Yi-Chin Fong, Jie-Jen Lee, Shun-Fa Yang, Chih-Hsin Tang
Summary: Neovascular age-related macular degeneration (AMD) is a disease characterized by abnormal blood vessel growth in the retina, leading to severe vision loss. The presence of certain markers in the retinas of AMD patients suggests a contribution of endothelial progenitor cells (EPCs) in this pathogenesis. This study explores the potential of melatonin, a hormone produced in the retina, to inhibit EPC angiogenesis in neovascular AMD. The results demonstrate that melatonin can effectively inhibit the formation of EPC blood vessels and shows promise as a potential treatment for neovascular AMD.
Article
Biochemistry & Molecular Biology
Yu-Hsiang Chang, Yuan-Li Huang, Hsiao-Chi Tsai, An-Chen Chang, Chih-Yuan Ko, Yi-Chin Fong, Chih-Hsin Tang
Summary: This study aims to investigate the role of miRNAs in CCL2-mediated MMP expression and cell motility in human osteosarcoma. The results demonstrate a positive correlation between CCL2 or MMP-3 levels and osteosarcoma metastasis, and stimulation of osteosarcoma cells with CCL2 enhances migration and invasion abilities. Additionally, CCL2 enhances MMP-3-dependent cell motility by inhibiting miR-3659 synthesis.
Article
Biochemistry & Molecular Biology
Jui-Chieh Chen, Hsun-Chang Shih, Chih-Yang Lin, Jeng-Hung Guo, Cheng Huang, Hsiu-Chen Huang, Zhi-Yong Chong, Chih-Hsin Tang
Summary: Chondrosarcoma, the second most common bone cancer, is difficult to treat surgically when it is high-grade and metastatic. Doxorubicin (Dox) is commonly used in chemotherapy, but drug resistance hampers its effectiveness. This study found that the apelin (APLN) pathway is highly activated in Dox-resistant cells and in high-grade chondrosarcoma tissues. Inhibition of the APLN axis has shown therapeutic benefits in other cancers, and this study suggests that targeting APLN may improve the treatment of chondrosarcoma by overcoming drug resistance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Environmental Sciences
Chih-Chun Chuang, Kai Wang, Yi-Sun Yang, Edy Kornelius, Chih-Hsin Tang, Chia-Yi Lee, Hsiang-Wen Chien, Shun-Fa Yang
Summary: The study investigates the correlation between single-nucleotide polymorphisms (SNP) of HOX transcript antisense intergenic RNA (HOTAIR) and the clinical characteristics of diabetic retinopathy (DR). The results indicate that HOTAIR SNP rs12427129 and rs1899663 are strongly associated with the presence of DR, especially in female patients with proliferative diabetic retinopathy (PDR).
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Immunology
Jun Cui, Cheng Chen, Xiao Zhou, Wenju Shan, Yuhong Jian, Panpan Li, Yang Sun, Wei Yi
Summary: Bone marrow mesenchymal stem cells (BMSCs) are a promising therapy for sepsis, but metabolic syndromes threaten their effectiveness. This study investigated the potential of small extracellular vesicles from high-fat diet BMSCs in sepsis-induced liver-heart axis injury.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Binbin Zhu, Angyang Cao, Chunqu Chen, Weijian Zhou, Wenjun Luo, Yu Gui, Qinwen Wang, Zhipeng Xu, Jianhua Wang
Summary: GM6001 alleviates postoperative cognitive deficits and neuroinflammation, preserves blood-brain barrier integrity, and rescues aquaporin-4 mislocalization. MMP-9 inhibition plays a dual role in cognitive protection through direct anti-neuroinflammatory effects and regulation of aquaporin-4 membrane distribution.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Anika Sood, Valencia Fernandes, Kumari Preeti, Shruti Rajan, Dharmendra Kumar Khatri, Shashi Bala Singh
Summary: S1PR2 inhibitor improves cognitive function and skews microglia toward anti-inflammatory phenotype in type 2 diabetic mice, promising to be a potential therapy for neuroinflammation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Haochun Guo, Ran Yu, Haijun Zhang, Wanpeng Wang
Summary: Radiation therapy is an effective treatment for thoracic malignancies, but it can cause radiation-induced lung injury (RILI), including radiation pneumonitis (RP) and radiation pulmonary fibrosis (RPF). The damage to normal lung cells during radiation treatment leads to a pulmonary inflammatory response, resulting in RP and RPF.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Guanghui Wang, Haotian Zheng, Yunzhi Xiang, Yadong Wang, Kai Wang, Xiaoyang Ren, Jiajun Du
Summary: This study identified a T-cell synthetic driver-associated prognostic model that accurately predicted prognosis and effectiveness of immunotherapy in LUAD patients. It also highlighted the role of LDHA in promoting tumor cell proliferation, invasion, and resistance to treatment, as well as its involvement in immune escape within the tumor microenvironment. These findings provide a promising new therapeutic strategy for LUAD.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Bowen Wei, Aihua Wang, Wei Liu, Qingyun Yue, Yihua Fan, Bin Xue, Siwei Wang
Summary: This study systematically analyzed the association between pSS and cuproptosis, established a predictive model based on 5 genes, explored the pathogenic mechanisms and novel therapeutic strategies for pSS, and identified EED, CBL, and NFU1 as potential targets for treatment.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Nusrit Iqbal Andrabi, Aminur R. Sarkar, Syed Assim Haq, Diljeet Kumar, Dilpreet Kour, Diksha Saroch, Sanket Kumar Shukla, Ajay Kumar, Asha Bhagat, Asif Ali, Gurleen Kour, Zabeer Ahmed
Summary: Koenimbine and its novel semi-synthetic derivative 1G demonstrate significant anti-inflammatory effects by downregulating the nuclear factor kappa-B (NF-kappa B) signaling pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Jing-Mei Lu, Xiang Xu, Fumie Aosai, Ming-Yue Zhang, Lian-Xun Piao
Summary: This study found that arctiin can improve allergic acute liver injury caused by T.g.HSP70 by inhibiting TLR4 signaling and reducing the production of inflammatory mediators.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Minxuan Xu, Fang Shi, Yongshen Gao, Shumei Han, Chensuo Huang, Qinsheng Hou, Xiaoweng Wen, Bengshi Wang, Zhenyu Zhu, Lei Zou, Mingxin Xiong, Wei Dong, Jun Tan
Summary: There is a growing body of research highlighting the involvement of metabolic imbalance and the inflammatory response in the advancement of colitis. This study recognizes arabinose as a significant protector of the intestinal mucosal barrier, reducing damage to the intestines. In addition, lower levels of arabinose in the bloodstream are associated with a higher severity of inflammatory bowel disease and colorectal cancer.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yueqing Han, Haoxin Song, Yanshan Li, Rongxin Li, Ling Chen, Bo Gao, Yijun Chen, Shuzhen Wang
Summary: The combination of tetracycline antibiotics, demeclocycline (D), chlortetracycline (C), and minocycline (M), showed therapeutic potential against liver fibrosis by inhibiting the activation of hepatic stellate cells and the MAPK signaling. This study suggests that tetracyclines may be repurposed for the treatment of liver fibrosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yu Li, Hailing Liu, Danwen Zhao, Danjie Zhang
Summary: Chronic stress can lead to lung injury, with the spleen playing a crucial role. This study found that the spleen contributes to chronic restraint stress-induced lung injury, and splenic CD11b+ cells may be an important factor in this process.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yingqian Mi, Mengyan Tang, Qiong Wu, Yinan Wang, Qihui Liu, Pei Zhu, Xiaoyang Xue, Yuntong Liu, Xinyu Chai, Yuyang Hou, Dongmei Yan
Summary: BCG therapy can induce macrophage polarization to the M1 type, and NMAAP1 plays a crucial role in this process by regulating glycolysis and HIF-1α expression. This promotes the antitumor effect of macrophages.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Xiaosheng Liu, Tingxia Lv, Xiuxia Li, Jing Xue, Ling Lin, Lianfeng Lu, Xiaodi Li, Yang Yang, Yuanni Wu, Qiang Wei, Wei Cao, Taisheng Li
Summary: LLDT-8 exhibits notable efficacy in alleviating immune activation in both an in vivo animal model and in vitro human cell experiments, suggesting its potential as a drug for managing systemic immune activation associated with SIV/HIV infection.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Honghong Yu, Qi Li, Huimin Zhu, Chang Liu, Weiwei Chen, Lingyun Sun
Summary: The activation of the inflammasome plays a critical role in the pathogenesis of systemic lupus erythematosus (SLE), and mesenchymal stem cells (MSC) have been shown to alleviate SLE by suppressing inflammasome activation. This study found that the NLRP3 inflammasome was activated in macrophages from SLE patients and mice, and its activation correlated with disease activity. After MSC transplantation, the severity of SLE was reduced, and NLRP3 inflammasome activation was inhibited. These findings suggest that MSC suppress inflammasome activation and provide a potential therapeutic target for SLE.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Wei Zhou, Dan Zeng, Shunan Liu, Yunxia Huang, Fenglin Lv, Weikang Zhou
Summary: This study found that inhibiting HDAC3 can protect the skin from atopic dermatitis by activating the Nrf2 transcription to upregulate Nrf2/HO-1 signaling pathway activity.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)