Article
Food Science & Technology
Jeongun Choi, Weerawan Rod-in, A-yeong Jang, Woo Jung Park
Summary: This study investigated the immunostimulatory effects of A. japonicus lipids incorporated with PEG6000 (AJ-PEG) on immunosuppressed mice. The results showed that AJ-PEG enhanced immune function in mice by increasing spleen index, promoting lymphocyte and natural killer (NK) cell proliferation, and improving the function of peritoneal macrophages.
Article
Immunology
Yunping Tang, Qiuyan Pu, Qiaoling Zhao, Yafeng Zhou, Xiaoxia Jiang, Tao Han
Summary: The study found that Laminaria japonica fucoidan (LF) can enhance immunity and regulate the composition of intestinal microflora in mice.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Bindan Guo, Wenting Dong, Jinhai Huo, Guodong Sun, Zhiwei Qin, Xiaodong Liu, Bihai Zhang, Weiming Wang
Summary: Qifenggubiao granules (QFGBG) is a new Chinese medicine that has shown immunomodulatory effects in pharmacological studies. Through experiments on mouse models, it was found that QFGBG can increase body weight, organ index, and repair immune organ damage caused by cyclophosphamide. Metabonomics analysis identified 13 metabolites with significant changes, with QFGBG acting through multiple targets and pathways to exert its immunomodulatory effects.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Food Science & Technology
Anqi Xie, Hao Wan, Lei Feng, Boyun Yang, Yiqun Wan
Summary: In this study, Anoectochilus formosanus polysaccharide (AFP) was obtained through water extraction and alcohol precipitation. The immunoregulatory activity of AFP was evaluated through various experiments, showing its potential as a natural immunomodulator. AFP exhibited the ability to stimulate cytokine production and enhance immunity in mice. Furthermore, it alleviated immune toxicity and showed promising results for further application and utilization.
Article
Biochemistry & Molecular Biology
Yanan Li, Junping Zheng, Yao Wang, Huabing Yang, Lu Cao, Shuiyong Gan, Jun Ma, Hongtao Liu
Summary: This study investigates the role of gut microbiota in the immune-enhancing activity of Astragalus polysaccharides (APS) in mice. The results show that APS can ameliorate immunosuppression in mice and activate Toll-like receptor 4 (TLR4) and mitogen-activated protein kinase (MAPK) pathways. APS treatment also reverses gut microbiota dysbiosis in immunocompromised mice.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Tae Hoon Kim, Nayoung Bae, Taeho Kim, Albert L. Hsu, Mark Hunter, Jung-Ho Shin, Jae-Wook Jeong
Summary: Endometriosis is positively associated with obesity, but negatively associated with low BMI. High-fat diet-induced obesity can increase the development of endometriosis, while obesity with leptin deficiency and leptin receptor deficiency can suppress the development of endometriosis. These findings suggest that leptin and its receptor play a critical role in the development of endometriosis.
Article
Virology
Jichen Li, Guoyan Zhang, Qiang Sun, Keyi Zhang, Huanhuan Lu, Jinbo Xiao, Zhenzhi Han, Hehe Zhao, Wenbo Xu, Yong Zhang, Zhijun Liu
Summary: Echovirus 30 (E30) infection causes a range of diseases and affects the nervous system, and a mouse model was established in this study to explore its pathogenesis.
JOURNAL OF VIROLOGY
(2022)
Article
Agriculture, Multidisciplinary
Xu Song, Lin Liu, Shuwei Peng, Tao Liu, Yaqin Chen, Renyong Jia, Yuanfeng Zou, Lixia Li, Xinghong Zhao, Xiaoxia Liang, Huaqiao Tang, Zhongqiong Yin
Summary: Resveratrol can improve intestinal microbiota diversity and structure, increase abundance of probiotics, upregulate secretion of immunoglobulin A, and promote transcriptional levels of cytokines to enhance intestinal immunity under immunosuppression. Additionally, resveratrol can increase levels of tight junction proteins, while decreasing levels of TLR4/NF-kappa B signaling pathway proteins, improving intestinal barrier function.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2022)
Article
Veterinary Sciences
Dongshuai Qu, Hongjie Hu, Shuaitao Lian, Wenjing Sun, Hongbin Si
Summary: This study systematically investigated the immunomodulatory and antioxidant effects of three polysaccharide fractions from Abrus cantoniensis on immunosuppressive mice. The results showed that the polysaccharides could recover immune function and improve antioxidant capacity, with ACP(t2) exhibiting the highest activities. These findings suggest that the polysaccharides can be utilized as potential immunomodulators and antioxidants in the food and pharmaceutical industries.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Pharmacology & Pharmacy
Siwen Zheng, Housheng Zheng, Rui Zhang, Xiangmin Piao, Junnan Hu, Yanzhu Zhu, Yingping Wang
Summary: This study demonstrates that ginsenoside Rb2 can improve the immune function that is declined in CTX-induced immunosuppressed mice, possibly through the regulation of cytokines and mRNA expression.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Lei Chen, Ai Ren, Yushi Wang, Yunhe Qu, Hesong Gong, Kevin H. Mayo, Yifa Zhou, Hairong Cheng
Summary: This study demonstrates that WPEP-N-b, a heterogalactan from Pleurotus eryngii, enhances immunity in immunosuppressed mice. WPEP-N-b improves immune organ index, peripheral blood immune cell content, splenocyte proliferation, NK cell activity, and T lymphocyte subpopulations. Additionally, WPEP-N-b restores cytokine levels and macrophage activity, and its mechanisms involve Toll-like receptor and signaling pathways.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Biochemistry & Molecular Biology
Aiko Robert, Michael Scholl, Thomas Vogels
Summary: Recent research has shown that injecting purified tau aggregates from human tauopathy patients can replicate the structural features and cell type specificity of the original tau pathology. These models may have unique translational value in studying the functional consequences of tau pathology, tau-based diagnostics, and tau-targeting therapeutics.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Virology
Helen E. Farrell, Kimberley Bruce, Philip G. Stevenson
Summary: Vaccination against HCMV is a public health goal but has proven challenging. Deleting specific viral genes may provide a safe and effective alternative for vaccination. Insights from animal models of experimental infection contribute to understanding and developing potential vaccines.
JOURNAL OF VIROLOGY
(2021)
Review
Oncology
Roxanne Wouters, Sien Bevers, Matteo Riva, Frederik De Smet, An Coosemans
Summary: Glioblastoma remains a highly aggressive brain tumor with limited treatment options, despite the advancements in preclinical immunotherapeutic approaches. The discrepancy between successful animal experiments and clinical trials may be attributed to the inability of current mouse models to fully replicate the complexity and heterogeneity of the disease. Understanding and combining different mouse models may be crucial in capturing the full spectrum of GBM for effective research and drug testing.
Article
Immunology
Zhi-Chun Ding, Nada S. Aboelella, Locke Bryan, Huidong Shi, Gang Zhou
Summary: The expansion of myeloid cells induced by cyclophosphamide (CTX) is an intrinsic process of hematopoietic recovery after chemotherapy. The repopulated monocytes acquire long-lasting immunosuppressive activity and gene signature characteristic of neutrophil precursors. The expansion is regulated by DNA methyltransferase 1 (Dnmt1) and dependent on chemotherapy-induced microbial translocation.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Fang-Gu Li, Wen-Bin Huang, Hao-Song Chen, Tian Wang, Yi-Ming Fan
INTERNATIONAL JOURNAL OF STD & AIDS
(2020)
Letter
Dermatology
Y. -J. Wang, Q. Wang, X. -X. Pi, Y. -M. Fan
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2021)
Article
Infectious Diseases
Qi Wang, Hao Wu, Zheng Huang, Yi-Ming Fan
Summary: This case report presents a 17-year-old male with penile annular and scrotal eczematoid syphilids, along with penile chancre redux. Dermoscopy and histopathology findings were consistent with the diagnosis, which was confirmed by positive Rapid plasma reagin and Treponema pallidum assays. Treatment with intramuscular benzathine penicillin resulted in resolution of the lesions.
SEXUALLY TRANSMITTED INFECTIONS
(2021)
Letter
Dermatology
Q. Wang, F. Qiu, H. Wu, Y. -M. Fan
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2021)
Editorial Material
Geriatrics & Gerontology
Ling-Li Chen, Ying Jiang, Fang Qiu, Yi-Ming Fan
Letter
Dermatology
Zi-Wei Zhang, Hao Wu, Ke-Feng Tang, Yi-Ming Fan
ANAIS BRASILEIROS DE DERMATOLOGIA
(2021)
Editorial Material
Allergy
Qi Wang, An-Ting Zhan, Fang Qiu, Yi-Ming Fan
CONTACT DERMATITIS
(2022)
Editorial Material
Dermatology
Wei Li, Tian Wang, Wen-Bin Huang, Fang-Gu Li, Juan-Hua Quan, Ge Shi, Christos C. Zouboulis, Yi-Ming Fan
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2022)
Letter
Dermatology
Y. Jiang, A. T. Zhan, F. Qiu, Y. M. Fan
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2022)
Article
Infectious Diseases
Yu Chen, Yan-Ping Yang, Fang Qiu, Yu-Jie Wang, Yi-Ming Fan
Summary: The immunophenotyping of inflammatory dermal infiltrates in Malassezia folliculitis (MF) and pityriasis versicolor (PV) lesions showed differences in the distribution of immune cells, which may contribute to the clinicopathological differences between the two disorders.
Letter
Dermatology
F. Qiu, C. -H. Zhang, J. -D. Wang, Y. -M. Fan
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2022)
Editorial Material
Geriatrics & Gerontology
Chuan-Ting Ma, Si Liu, Yi-Ming Fan
Letter
Dermatology
Xuan Song, Wei Dai, Yong-Jun Wu, Yan-Xia Wu, Yi-Ming Fan
INTERNATIONAL JOURNAL OF DERMATOLOGY
(2023)
Editorial Material
Mycology
Yan-Ping Yang, Ci-Juan Zhong, Shu-Jun Yin, Yi-Ming Fan
Letter
Dermatology
Hao-Song Chen, Fang-Gu Li, Yi Zhu, Tian Wang, Yi-Ming Fan
EUROPEAN JOURNAL OF DERMATOLOGY
(2019)
Article
Immunology
Jun Cui, Cheng Chen, Xiao Zhou, Wenju Shan, Yuhong Jian, Panpan Li, Yang Sun, Wei Yi
Summary: Bone marrow mesenchymal stem cells (BMSCs) are a promising therapy for sepsis, but metabolic syndromes threaten their effectiveness. This study investigated the potential of small extracellular vesicles from high-fat diet BMSCs in sepsis-induced liver-heart axis injury.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Binbin Zhu, Angyang Cao, Chunqu Chen, Weijian Zhou, Wenjun Luo, Yu Gui, Qinwen Wang, Zhipeng Xu, Jianhua Wang
Summary: GM6001 alleviates postoperative cognitive deficits and neuroinflammation, preserves blood-brain barrier integrity, and rescues aquaporin-4 mislocalization. MMP-9 inhibition plays a dual role in cognitive protection through direct anti-neuroinflammatory effects and regulation of aquaporin-4 membrane distribution.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Anika Sood, Valencia Fernandes, Kumari Preeti, Shruti Rajan, Dharmendra Kumar Khatri, Shashi Bala Singh
Summary: S1PR2 inhibitor improves cognitive function and skews microglia toward anti-inflammatory phenotype in type 2 diabetic mice, promising to be a potential therapy for neuroinflammation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Haochun Guo, Ran Yu, Haijun Zhang, Wanpeng Wang
Summary: Radiation therapy is an effective treatment for thoracic malignancies, but it can cause radiation-induced lung injury (RILI), including radiation pneumonitis (RP) and radiation pulmonary fibrosis (RPF). The damage to normal lung cells during radiation treatment leads to a pulmonary inflammatory response, resulting in RP and RPF.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Guanghui Wang, Haotian Zheng, Yunzhi Xiang, Yadong Wang, Kai Wang, Xiaoyang Ren, Jiajun Du
Summary: This study identified a T-cell synthetic driver-associated prognostic model that accurately predicted prognosis and effectiveness of immunotherapy in LUAD patients. It also highlighted the role of LDHA in promoting tumor cell proliferation, invasion, and resistance to treatment, as well as its involvement in immune escape within the tumor microenvironment. These findings provide a promising new therapeutic strategy for LUAD.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Bowen Wei, Aihua Wang, Wei Liu, Qingyun Yue, Yihua Fan, Bin Xue, Siwei Wang
Summary: This study systematically analyzed the association between pSS and cuproptosis, established a predictive model based on 5 genes, explored the pathogenic mechanisms and novel therapeutic strategies for pSS, and identified EED, CBL, and NFU1 as potential targets for treatment.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Nusrit Iqbal Andrabi, Aminur R. Sarkar, Syed Assim Haq, Diljeet Kumar, Dilpreet Kour, Diksha Saroch, Sanket Kumar Shukla, Ajay Kumar, Asha Bhagat, Asif Ali, Gurleen Kour, Zabeer Ahmed
Summary: Koenimbine and its novel semi-synthetic derivative 1G demonstrate significant anti-inflammatory effects by downregulating the nuclear factor kappa-B (NF-kappa B) signaling pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Jing-Mei Lu, Xiang Xu, Fumie Aosai, Ming-Yue Zhang, Lian-Xun Piao
Summary: This study found that arctiin can improve allergic acute liver injury caused by T.g.HSP70 by inhibiting TLR4 signaling and reducing the production of inflammatory mediators.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Minxuan Xu, Fang Shi, Yongshen Gao, Shumei Han, Chensuo Huang, Qinsheng Hou, Xiaoweng Wen, Bengshi Wang, Zhenyu Zhu, Lei Zou, Mingxin Xiong, Wei Dong, Jun Tan
Summary: There is a growing body of research highlighting the involvement of metabolic imbalance and the inflammatory response in the advancement of colitis. This study recognizes arabinose as a significant protector of the intestinal mucosal barrier, reducing damage to the intestines. In addition, lower levels of arabinose in the bloodstream are associated with a higher severity of inflammatory bowel disease and colorectal cancer.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yueqing Han, Haoxin Song, Yanshan Li, Rongxin Li, Ling Chen, Bo Gao, Yijun Chen, Shuzhen Wang
Summary: The combination of tetracycline antibiotics, demeclocycline (D), chlortetracycline (C), and minocycline (M), showed therapeutic potential against liver fibrosis by inhibiting the activation of hepatic stellate cells and the MAPK signaling. This study suggests that tetracyclines may be repurposed for the treatment of liver fibrosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yu Li, Hailing Liu, Danwen Zhao, Danjie Zhang
Summary: Chronic stress can lead to lung injury, with the spleen playing a crucial role. This study found that the spleen contributes to chronic restraint stress-induced lung injury, and splenic CD11b+ cells may be an important factor in this process.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yingqian Mi, Mengyan Tang, Qiong Wu, Yinan Wang, Qihui Liu, Pei Zhu, Xiaoyang Xue, Yuntong Liu, Xinyu Chai, Yuyang Hou, Dongmei Yan
Summary: BCG therapy can induce macrophage polarization to the M1 type, and NMAAP1 plays a crucial role in this process by regulating glycolysis and HIF-1α expression. This promotes the antitumor effect of macrophages.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Xiaosheng Liu, Tingxia Lv, Xiuxia Li, Jing Xue, Ling Lin, Lianfeng Lu, Xiaodi Li, Yang Yang, Yuanni Wu, Qiang Wei, Wei Cao, Taisheng Li
Summary: LLDT-8 exhibits notable efficacy in alleviating immune activation in both an in vivo animal model and in vitro human cell experiments, suggesting its potential as a drug for managing systemic immune activation associated with SIV/HIV infection.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Honghong Yu, Qi Li, Huimin Zhu, Chang Liu, Weiwei Chen, Lingyun Sun
Summary: The activation of the inflammasome plays a critical role in the pathogenesis of systemic lupus erythematosus (SLE), and mesenchymal stem cells (MSC) have been shown to alleviate SLE by suppressing inflammasome activation. This study found that the NLRP3 inflammasome was activated in macrophages from SLE patients and mice, and its activation correlated with disease activity. After MSC transplantation, the severity of SLE was reduced, and NLRP3 inflammasome activation was inhibited. These findings suggest that MSC suppress inflammasome activation and provide a potential therapeutic target for SLE.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Wei Zhou, Dan Zeng, Shunan Liu, Yunxia Huang, Fenglin Lv, Weikang Zhou
Summary: This study found that inhibiting HDAC3 can protect the skin from atopic dermatitis by activating the Nrf2 transcription to upregulate Nrf2/HO-1 signaling pathway activity.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)