期刊
INTERNATIONAL IMMUNOPHARMACOLOGY
卷 11, 期 3, 页码 295-309出版社
ELSEVIER
DOI: 10.1016/j.intimp.2010.12.006
关键词
Chalcone; Nuclear factor-kappa B; Inflammation; Tumor cell proliferation; Invasion and angiogenesis; Apoptosis
资金
- National Institutes of Health [NIH CA-124787-01A2]
- Clayton Foundation for Research, USA
Although consumption of fruits, vegetables, spices, cereals and pulses has been associated with lower incidence of cancer and other chronic diseases, how these dietary agents and their active ingredients minimize these diseases, is not fully understood. Whether it is oranges, kawa, hops, water-lilly, locorice, wax apple or mulberry, they are all connected by a group of aromatic ketones, called chalcones (1,3-diaryl-2-propen-1-ones). Some of the most significant chalcones identified from these plants include flavokawin, butein, xanthoangelol, 4-hydroxyderricin, cardamonin, 2`,4`-dihydroxychalcone, isoliquiritigenin, isosalipurposide, and naringenin chalcone. These chalcones have been linked with immunomodulation, antibacterial, antifungal, antiviral, anti-inflammatory, antioxidant, anticancer, and antidiabetic activities. The current review, however, deals with the role of various chalcones in inflammation that controls both the immune system and tumorigenesis. Inflammatory pathways have been shown to mediate the survival, proliferation, invasion, angiogenesis and metastasis of tumors. How these chalcones modulate inflammatory pathways, tumorigenesis and immune system is the focus of this review. (c) 2010 Elsevier B.V. All rights reserved.
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