期刊
INTERNATIONAL IMMUNOPHARMACOLOGY
卷 11, 期 7, 页码 789-793出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.intimp.2011.01.026
关键词
MDSC; Autoimmunity; Autoimmune hepatitis; EAE; IBD; Nitric oxide
资金
- NCI NIH HHS [P30 CA023108] Funding Source: Medline
- NIAID NIH HHS [R01 AI078195-03, R01 AI078195] Funding Source: Medline
Myeloid derived suppressor cells (MDSC) were first described nearly two decades ago. Until recently, however, descriptions of MDSC populations were found almost exclusively in animal models of cancer or in cancer patients. Over the last few years, an increasing number of reports have been published describing populations of myeloid cells with MDSC-like properties in murine models of autoimmune disease. In contrast to the proposed deleterious role of MDSC in cancer - where these cells likely inhibit tumor immunity - in the context of autoimmunity, MDSC have the potential to suppress the autoimmune response, thereby limiting tissue injury. A logical corollary of this hypothesis is that a failure of endogenous MDSC to appropriately control autoimmune T cell responses in vivo may actually contribute to the pathogenesis of autoimmune disease. (c) 2011 Elsevier B.V. All rights reserved.
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