期刊
INTERNATIONAL IMMUNOPHARMACOLOGY
卷 11, 期 10, 页码 1407-1414出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.intimp.2011.04.025
关键词
Toll-like receptors; Central nervous system; Inflammation; Infection; Injury; Autoimmune diseases
资金
- National Basic Research Program of China [2010CB529701]
- National Natural Science Foundation of China [30970917]
Toll-like receptors (TLRs) belong to pattern-recognition receptor family that could recognize exogenous pathogen-associated molecular patterns and endogenous damage-associated molecular patterns. TLRs play pivotal roles in innate and adaptive immune responses. In this review we summarize the ligands and signal transduction pathways of TLRs and highlight recent progress of the involvement of TLRs in neuroinflammation related disorders, including cerebral ischemia/stroke, brain trauma and hemorrhage, pathogen infection and autoimmune diseases, and explore the potential of TLR signaling as therapeutic targets against these disorders. (C) 2011 Elsevier B.V. All rights reserved.
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