Article
Endocrinology & Metabolism
Yongwang Yan, Qing Li, Ling Shen, Kangxiao Guo, Xu Zhou
Summary: CGA can improve the antidiabetic effects, and microbes may critically mediate these beneficial effects.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Chemistry, Medicinal
Razieh Choghakhori, Amir Abbasnezhad, Mohammad Yazdi, Hassan Ahmadvand
Summary: This meta-analysis examined the pharmaceutical applications of Pistacia atlantica (PA) in diabetes prevention and treatment by assessing preclinical studies. The findings indicated that PA supplementation significantly decreased blood glucose, insulin resistance, total cholesterol, triglyceride, and malondialdehyde levels, while increasing insulin and superoxide dismutase levels in diabetic animals. However, HDL-cholesterol levels were not significantly affected. Subgroup analysis supported the beneficial effects of longer duration and higher doses of PA supplementation, as well as the use of extracts. Methodological diversity and concerns about bias were noted in the studies. Further high-quality studies are needed to confirm the clinical efficacy of PA.
PHYTOTHERAPY RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Rajasekar Janani, Rani Elavarasan Anitha, Peethambaran Divya, Muzaffar Chonche, Vallikannan Baskaran
Summary: Astaxanthin protects retinal cells from inflammation induced by hyperglycemia by modulating NF-kappa B through the ROS-PI3K/Akt signaling cascade.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yin Qin, Ruyan Fan, Yingxin Liu, Shuyi Qiu, Lu Wang
Summary: This study investigated the liver protective effect of Rubus corchorifolius fruit extract (RCE) on mice with high-fat-diet-induced NAFLD and explored the potential mechanisms through transcriptomics and metabolomics analysis. The results showed that RCE contains polyphenolic compounds and has a modulatory effect on oxidative stress and inflammatory responses in the liver. Additionally, RCE intervention significantly affected metabolic pathways associated with glycolipid metabolism. Therefore, intake of RCE may be an effective strategy to alleviate liver damage.
Article
Engineering, Environmental
You Zhang, Wenhong Fan, Xiaomin Li, Wen-Xiong Wang, Shu Liu
Summary: In this study, nanobubble technology and hydrogen water were combined for the first time to remove reactive oxygen species caused by environmental stress. Hydrogen nanobubbles showed remarkable capability in removing H2O2 and O(2)(center dot- ), and increasing the activity and expression of antioxidant enzymes.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Leanne E. Mocniak, Zachary T. Bitzer, Neil Trushin, John P. Richie
Summary: Tobacco smoke free radicals, which depend on the intrinsic nitrate levels in tobacco, are closely associated with adverse health effects. The levels of gas phase radicals are highly correlated with nitrate levels in different tobacco types and brands. Nitrate addition to tobacco leaves increases the production of gas phase radicals and NNK in smoke. Tobacco nitrate plays a key role in the production of gas phase radicals and has implications for health regulation.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Review
Medicine, Research & Experimental
Zeynab Kohandel, Tahereh Farkhondeh, Michael Aschner, Ali Mohammad Pourbagher-Shahri, Saeed Samarghandian
Summary: This study summarizes the anti-inflammatory efficacy of astaxanthin in various chronic and acute disorders, as well as the pathways through which it mediates its effects. Further experimental and clinical studies are needed to confirm the anti-inflammatory and protective effects of astaxanthin in humans. The review suggests that astaxanthin, with its demonstrated anti-inflammatory properties, may be a suitable candidate for drug design with novel technology.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Medicine, Research & Experimental
Zeynab Kohandel, Tahereh Farkhondeh, Michael Aschner, Saeed Samarghandian
Summary: Astaxanthin (ATX) is a red pigment carotenoid found in shrimp, salmon, crab, and asteroidean, with proven antioxidant efficacy. Nrf2 plays a crucial role in mediating the various protective effects of ATX.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Medicine, Research & Experimental
Ayaho Yamamoto, Peter D. Sly, Keng Yih Chew, Lavrent Khachatryan, Nelufa Begum, Abrey J. Yeo, Luan D. Vu, Kirsty R. Short, Stephania A. Cormier, Emmanuelle Fantino
Summary: Epidemiological evidence shows a link between lower air quality and increased severity of COVID-19, but the mechanism is not yet understood. This study suggests that oxidative stress caused by air pollution could increase viral replication and inflammation in the nasal epithelium. The researchers found that exposure to an oxidant found in air pollution increased SARS-CoV-2 replication and inflammation-related gene expression, while antioxidant treatment reduced viral replication and inflammation. These findings indicate that oxidant damage to the respiratory epithelium may contribute to the association between poor air quality and increased COVID-19 severity.
EXPERIMENTAL BIOLOGY AND MEDICINE
(2023)
Article
Multidisciplinary Sciences
Ahmed H. Abdelazeem, Abdelaziz S. A. Abuelsaad, Adel Abdel-Moniem, Mohammed Abdel-Gabbar
Summary: Metabolic syndrome is associated with chronic inflammation, with decreased antioxidant enzyme activities and elevated inflammatory markers in patients. Biomarkers such as IL-8, IL-23, IL-33 are positively correlated with triglyceride and LDL-cholesterol levels.
JOURNAL OF TAIBAH UNIVERSITY FOR SCIENCE
(2021)
Review
Multidisciplinary Sciences
Tanzina Akter, Md. Sarwar Zahan, Nafisa Nawal, Md. Hasanur Rahman, Tayyabatun Nur Tanjum, Kazi Ifthi Arafat, Akhi Moni, Mohammad Nazrul Islam, Md Jamal Uddin
Summary: Polycystic ovary syndrome (PCOS) is a common hormonal disorder among women (4%-20%), characterized by high levels of male sex hormones called androgens. PCOS is associated with oxidative stress, inflammation, hyperglycemia, hyperlipidemia, hyperandrogenism, and insulin resistance. Curcumin, a natural compound found in turmeric, has shown potential in treating PCOS due to its anti-inflammatory, anti-oxidative stress, antibacterial, and anti-apoptotic properties. This review focuses on the therapeutic aspects of curcumin against the pathophysiology of PCOS and proposes the development of curcumin-based medicines for PCOS.
Review
Biochemistry & Molecular Biology
Kozo Nakai, Daisuke Tsuruta
Summary: Oxygen in the atmosphere is vital for human life, but the metabolites ROS, produced in excess, can exacerbate skin aging and inflammation. Excessive exposure to air pollutants and other harmful substances can stimulate the production of ROS.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Environmental Sciences
Yuyang Peng, Min Li, Yong Huang, Bo Cheng, Zigang Cao, Xinjun Liao, Guanghua Xiong, Fasheng Liu, Chengyu Hu, Huiqiang Lu
Summary: Exposure to bifenazate has immunotoxicity and oxidative stress effects on zebrafish larvae, affecting growth and development, decreasing immune cells, and inhibiting antioxidant activity. Astaxanthin can effectively alleviate this developmental toxicity.
Article
Nutrition & Dietetics
Luchuanyang Sun, Nobuyuki Miyaji, Min Yang, Edward M. Mills, Shigeto Taniyama, Takayuki Uchida, Takeshi Nikawa, Jifeng Li, Jie Shi, Katsuyasu Tachibana, Katsuya Hirasaka
Summary: The study demonstrated that astaxanthin (AX) has protective effects on muscle atrophy by preventing loss of muscle weight and suppressing muscle fiber size decrease, hydrogen peroxide production increase, and downregulation of mitochondrial respiratory chain complexes. AX also promoted mitochondrial biogenesis and inhibited mitochondrial reactive oxygen species production and apoptosis, ultimately preventing muscle atrophy.
Review
Biochemistry & Molecular Biology
Jaeeun Lee, Min-Hyun Kim, Hyeyoung Kim
Summary: A moderate amount of ROS plays an important role in cell signaling and immune response, while excessive production can lead to inflammation and pathological conditions. The gastrointestinal mucosa is continuously exposed to ROS, increasing the risk of GI disorders. AST, a compound with antioxidant and anti-inflammatory properties, has shown protective effects against GI diseases through various mechanisms, including ROS neutralization, enhancement of antioxidant enzyme activity, and suppression of inflammation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Eduardo Fernandes Bondan, Carolina Vieira Cardoso, Maria de Fatima Monteiro Martins, Rosemari Otton
ARQUIVOS DE NEURO-PSIQUIATRIA
(2019)
Article
Psychology, Biological
Douglas Popp Marin, Todd Anthony Astorino, Felipe Martinatto, Filipe Teixeira Ragazzini, Rafael Eduardo Bispo, Denis Foschini, Rosemari Otton
PHYSIOLOGY & BEHAVIOR
(2019)
Article
Food Science & Technology
Leticia Torres Ferreira, Celso Pereira Batista de Sousa Filho, Marcelo Paradiso Marinovic, Alice Cristina Rodrigues, Rosemari Otton
JOURNAL OF FUNCTIONAL FOODS
(2020)
Article
Cell Biology
L. F. Torres, B. Cogliati, R. Otton
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2019)
Article
Biochemistry & Molecular Biology
Anaysa Paola Bolin, Celso Pereira Batista Sousa-Filho, Marcelo Paradiso Marinovic, Alice Cristina Rodrigues, Rosemari Otton
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2020)
Article
Biochemistry & Molecular Biology
Anaysa Paola Bolin, Celso Pereira Batista Sousa-Filho, Gustavo Tolentino Nascimento dos Santos, Leticia Torres Ferreira, Paula Bresciani Martins de Andrade, Ana Carolina Migliorini Figueira, Fernanda Aparecida Heleno Batista, Rosemari Otton
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2020)
Article
Pharmacology & Pharmacy
Celso Pereira Batista Sousa-Filho, Hector Oreliana Fernandes Faria, Juliana Carvalho Esposito, Alessandra Melo, Miriam Oliveira Ribeiro, Rosemari Otton
PHARMACOLOGICAL RESEARCH
(2020)
Article
Multidisciplinary Sciences
Bruna B. Brandao, Soren Madsen, Atefeh Rabiee, Matteo Oliverio, Gabriel P. Ruiz, Danilo L. Ferrucci, Jessica L. Branquinho, Daniela Razolli, Silas Pinto, Thomas S. Nielsen, William T. Festuccia, Adriano S. Martins, Beatriz A. Guerra, Thiago L. Knittel, Ditte Sogaard, Steen Larsen, Jorn W. Helge, Josef Brandauer, Licio A. Velloso, Brice Emanuelli, Jan-Wilhelm Kornfeld, C. Ronald Kahn, Sara G. Vienberg, Juleen R. Zierath, Jonas T. Treebak, Marcelo A. Mori
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2020)
Article
Physiology
Fabio Rocha de Lima, Douglas Popp Marin, Leticia Torres Ferreira, Celso Pereira Batista Sousa Filho, Todd Anthony Astorino, Jonato Prestes, Marcelo Luis Marquezi, Rosemari Otton
Summary: The study found that partial BFR can increase muscular strength without increasing oxidative stress biomarkers in untrained men. Additionally, total BFR promoted similar responses of oxidative stress and markers of immune cell apoptosis compared to traditional RT.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Nutrition & Dietetics
Rosemari Otton, Natasa Petrovic, Barbara Cannon, Jan Nedergaard
Summary: Green tea compounds have a negative effect on basal UCP1 gene expression in both primary brown and white adipocytes, contrary to reported positive effects in adipogenic cell lines. These compounds also suppress cell differentiation, reduce lipid accumulation, and do not directly interact with the PPAR gamma pathway.
FRONTIERS IN NUTRITION
(2021)
Article
Biochemistry & Molecular Biology
Marcelo Paradiso Marinovic, Celso Pereira Batista Sousa-Filho, Fernanda Aparecida Heleno Batista, Thayna Mendonca Avelino, Bruno Cogliati, Ana Carolina Migliorini Figueira, Rosemari Otton, Alice Cristina Rodrigues
Summary: This study demonstrates that green tea can improve non-alcoholic fatty liver disease (NAFLD), and this improvement is dependent on the action of adiponectin in the liver. The researchers found that catechins in green tea can reduce hepatic steatosis in a PPAR alpha-dependent manner.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2022)
Article
Nutrition & Dietetics
Kaue Tognolli, Victoria Silva, Celso Pereira Batista Sousa-Filho, Claudia Andrea Lima Cardoso, Renata Gorjao, Rosemari Otton
Summary: This study aims to investigate the immune cell population in the subcutaneous and epididymal white adipose tissue (WAT) of obese mice, as well as the effects of green tea. The results suggest that a high-fat diet and thermoneutrality can induce chronic inflammation and insulin resistance. However, green tea can prevent weight gain, inflammation, and tissue fibrosis, while maintaining a similar immune cell profile to that of lean mice.
EUROPEAN JOURNAL OF NUTRITION
(2023)
Review
Biochemistry & Molecular Biology
Celso Pereira Batista Sousa-Filho, Victoria Silva, Anaysa Paola Bolin, Andrea Livia Silva Rocha, Rosemari Otton
Summary: This article presents studies on the modulation of miRNA expression by the main compounds of green tea in inflammation, adipose tissue, skeletal muscle, and liver. It emphasizes the need for further research on the role of miRNAs in the extensive beneficial health effects of green tea compounds already described, indicating miRNAs as potential mediators of polyphenols.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Biochemistry & Molecular Biology
Victoria Silva, Hector Oreliana Fernandes Faria, Celso Pereira Batista Sousa-Filho, Jose Fernando Rinaldi de Alvarenga, Jarlei Fiamoncini, Rosemari Otton
Summary: Metabolic-associated fatty liver disease (MAFLD) is characterized by excessive accumulation of triglycerides in hepatocytes and is considered the leading cause of chronic liver disease. It is closely associated with obesity, type 2 diabetes, hyperlipidemia, and hypertension. This study investigates the effects of green tea (GT) on MAFLD and shows that GT has beneficial effects on the liver phenotype and gene expression involved in lipogenesis, regardless of housing temperature.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2023)
Article
Biology
Andrea Livia Rocha, Beatriz Alves Guerra, Jeremie Boucher, Marcelo A. Mori
Summary: Adipocytes exhibit different characteristics and functions depending on their location, origin, and stimuli. Differentiation protocols involving pharmacological stimuli can induce distinct characteristics in differentiating adipocytes, providing insight into mechanisms of adipogenesis and thermogenesis in adipocytes.
Article
Immunology
Jun Cui, Cheng Chen, Xiao Zhou, Wenju Shan, Yuhong Jian, Panpan Li, Yang Sun, Wei Yi
Summary: Bone marrow mesenchymal stem cells (BMSCs) are a promising therapy for sepsis, but metabolic syndromes threaten their effectiveness. This study investigated the potential of small extracellular vesicles from high-fat diet BMSCs in sepsis-induced liver-heart axis injury.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Binbin Zhu, Angyang Cao, Chunqu Chen, Weijian Zhou, Wenjun Luo, Yu Gui, Qinwen Wang, Zhipeng Xu, Jianhua Wang
Summary: GM6001 alleviates postoperative cognitive deficits and neuroinflammation, preserves blood-brain barrier integrity, and rescues aquaporin-4 mislocalization. MMP-9 inhibition plays a dual role in cognitive protection through direct anti-neuroinflammatory effects and regulation of aquaporin-4 membrane distribution.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Anika Sood, Valencia Fernandes, Kumari Preeti, Shruti Rajan, Dharmendra Kumar Khatri, Shashi Bala Singh
Summary: S1PR2 inhibitor improves cognitive function and skews microglia toward anti-inflammatory phenotype in type 2 diabetic mice, promising to be a potential therapy for neuroinflammation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Haochun Guo, Ran Yu, Haijun Zhang, Wanpeng Wang
Summary: Radiation therapy is an effective treatment for thoracic malignancies, but it can cause radiation-induced lung injury (RILI), including radiation pneumonitis (RP) and radiation pulmonary fibrosis (RPF). The damage to normal lung cells during radiation treatment leads to a pulmonary inflammatory response, resulting in RP and RPF.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Guanghui Wang, Haotian Zheng, Yunzhi Xiang, Yadong Wang, Kai Wang, Xiaoyang Ren, Jiajun Du
Summary: This study identified a T-cell synthetic driver-associated prognostic model that accurately predicted prognosis and effectiveness of immunotherapy in LUAD patients. It also highlighted the role of LDHA in promoting tumor cell proliferation, invasion, and resistance to treatment, as well as its involvement in immune escape within the tumor microenvironment. These findings provide a promising new therapeutic strategy for LUAD.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Bowen Wei, Aihua Wang, Wei Liu, Qingyun Yue, Yihua Fan, Bin Xue, Siwei Wang
Summary: This study systematically analyzed the association between pSS and cuproptosis, established a predictive model based on 5 genes, explored the pathogenic mechanisms and novel therapeutic strategies for pSS, and identified EED, CBL, and NFU1 as potential targets for treatment.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Nusrit Iqbal Andrabi, Aminur R. Sarkar, Syed Assim Haq, Diljeet Kumar, Dilpreet Kour, Diksha Saroch, Sanket Kumar Shukla, Ajay Kumar, Asha Bhagat, Asif Ali, Gurleen Kour, Zabeer Ahmed
Summary: Koenimbine and its novel semi-synthetic derivative 1G demonstrate significant anti-inflammatory effects by downregulating the nuclear factor kappa-B (NF-kappa B) signaling pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Jing-Mei Lu, Xiang Xu, Fumie Aosai, Ming-Yue Zhang, Lian-Xun Piao
Summary: This study found that arctiin can improve allergic acute liver injury caused by T.g.HSP70 by inhibiting TLR4 signaling and reducing the production of inflammatory mediators.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Minxuan Xu, Fang Shi, Yongshen Gao, Shumei Han, Chensuo Huang, Qinsheng Hou, Xiaoweng Wen, Bengshi Wang, Zhenyu Zhu, Lei Zou, Mingxin Xiong, Wei Dong, Jun Tan
Summary: There is a growing body of research highlighting the involvement of metabolic imbalance and the inflammatory response in the advancement of colitis. This study recognizes arabinose as a significant protector of the intestinal mucosal barrier, reducing damage to the intestines. In addition, lower levels of arabinose in the bloodstream are associated with a higher severity of inflammatory bowel disease and colorectal cancer.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yueqing Han, Haoxin Song, Yanshan Li, Rongxin Li, Ling Chen, Bo Gao, Yijun Chen, Shuzhen Wang
Summary: The combination of tetracycline antibiotics, demeclocycline (D), chlortetracycline (C), and minocycline (M), showed therapeutic potential against liver fibrosis by inhibiting the activation of hepatic stellate cells and the MAPK signaling. This study suggests that tetracyclines may be repurposed for the treatment of liver fibrosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yu Li, Hailing Liu, Danwen Zhao, Danjie Zhang
Summary: Chronic stress can lead to lung injury, with the spleen playing a crucial role. This study found that the spleen contributes to chronic restraint stress-induced lung injury, and splenic CD11b+ cells may be an important factor in this process.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yingqian Mi, Mengyan Tang, Qiong Wu, Yinan Wang, Qihui Liu, Pei Zhu, Xiaoyang Xue, Yuntong Liu, Xinyu Chai, Yuyang Hou, Dongmei Yan
Summary: BCG therapy can induce macrophage polarization to the M1 type, and NMAAP1 plays a crucial role in this process by regulating glycolysis and HIF-1α expression. This promotes the antitumor effect of macrophages.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Xiaosheng Liu, Tingxia Lv, Xiuxia Li, Jing Xue, Ling Lin, Lianfeng Lu, Xiaodi Li, Yang Yang, Yuanni Wu, Qiang Wei, Wei Cao, Taisheng Li
Summary: LLDT-8 exhibits notable efficacy in alleviating immune activation in both an in vivo animal model and in vitro human cell experiments, suggesting its potential as a drug for managing systemic immune activation associated with SIV/HIV infection.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Honghong Yu, Qi Li, Huimin Zhu, Chang Liu, Weiwei Chen, Lingyun Sun
Summary: The activation of the inflammasome plays a critical role in the pathogenesis of systemic lupus erythematosus (SLE), and mesenchymal stem cells (MSC) have been shown to alleviate SLE by suppressing inflammasome activation. This study found that the NLRP3 inflammasome was activated in macrophages from SLE patients and mice, and its activation correlated with disease activity. After MSC transplantation, the severity of SLE was reduced, and NLRP3 inflammasome activation was inhibited. These findings suggest that MSC suppress inflammasome activation and provide a potential therapeutic target for SLE.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Wei Zhou, Dan Zeng, Shunan Liu, Yunxia Huang, Fenglin Lv, Weikang Zhou
Summary: This study found that inhibiting HDAC3 can protect the skin from atopic dermatitis by activating the Nrf2 transcription to upregulate Nrf2/HO-1 signaling pathway activity.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
