Article
Agronomy
Yuxuan Zhao, Jianmin Yun, Gengxin Guo, Wenhui Li, Biao Wang, Fengyun Zhao, Yang Bi
Summary: This study investigated the effects of polyethylene nano-packaging on postharvest stipe elongation of Flammulina velutipes and explored its regulatory mechanisms. The results showed that nano-packaging reduced respiration, inhibited stipe elongation rate and cell wall component increase, and decreased the levels of plant hormones. Nano-packaging effectively inhibited stipe elongation and prolonged the shelf life of F. velutipes.
Review
Immunology
Yang Ying, Wu Hao
Summary: Polysaccharides extracted from natural resources have significant potential in biomedical research and pharmaceutical fields due to their medical values in anti-tumor, immunomodulation, drug delivery, and other aspects. They can exert direct anti-tumor effects or regulate the host immune system to indirectly inhibit tumors. Some polysaccharides also modulate the tumoral niche to inhibit the proliferation and metastasis of tumor cells. This article focuses on the biomedical application potential of natural polysaccharides, reviews their immunomodulation function, and highlights the importance of their signaling transduction feature for antitumor drug development.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yuting Hao, Xiangdong Wang, Sijie Yuan, Yingyi Wang, Xiaoshan Liao, Meiling Zhong, Qiangnan He, Haibin Shen, Wenzhen Liao, Jie Shen
Summary: Flammulina velutipes polysaccharides (FVP) have the potential to improve gut health by regulating gut microbiota and metabolism. The study reveals changes in intestinal tissue structure, microbiota composition, and metabolic profiling induced by FVP treatment, suggesting it as a promising dietary supplement for promoting intestinal health.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Biochemistry & Molecular Biology
Sheng Ma, Hongcai Zhang, Jianxiong Xu
Summary: The study found that fermented Flammulina velutipes polyphenols (FFVP) exhibit higher antioxidant and anti-inflammatory activities compared to non-fermented FVP, enhancing immune function in cells and reducing inflammatory responses.
Article
Biochemistry & Molecular Biology
Yuting Hao, Xiaoshan Liao, Xiangdong Wang, Shenghui Lao, Wenzhen Liao
Summary: The novel Flammulina velutipes polysaccharide (FVP) was found to effectively regulate colonic microbiota and exhibit significant immunoregulatory effects. Additionally, FVP treatment led to significant changes in the heart transcriptome, with up-regulated mRNA enriched in multiple pathways and downregulated mRNA clustered in various signaling pathways related to metabolism and cardiac function. The findings suggest that FVP has great potential as a complementary medicine or functional food for health promotion.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Biotechnology & Applied Microbiology
Mikal El-Hajjar, Lara Gerhardt, Megan M. Y. Hong, Mithunah Krishnamoorthy, Rene Figueredo, Xiufen Zheng, James Koropatnick, Saman Maleki Vareki
Summary: Immune checkpoint blockade is effective against highly immunogenic mismatch repair-deficient tumors but not neuroblastoma. However, stimulating T cell-based therapy and memory T cell-dependent gene expression can improve survival in high-risk neuroblastoma patients. Inducing mismatch repair deficiency and combining it with anti-CTLA4 therapy can serve as a novel T cell-based treatment strategy for neuroblastoma.
Article
Oncology
Rilan Bai, Jiuwei Cui
Summary: Cancer cells adapt to increasing energy and biosynthetic demands by reprogramming their metabolic pathways via mitochondria, which play crucial roles in the survival, immune evasion, tumor progression, and treatment resistance of the hypoxic tumor microenvironment. Targeting the mitochondria-related pathway with anticancer drugs can enhance the immune recognition of cancer cells, tumor antigen presentation ability, and anti-tumor function of immune cells. This review focuses on the effects of mitochondrial morphology and function on immune cells, the impact of mitochondrial changes on tumor immune escape and immune cell function, and the research progress and challenges of novel anti-tumor immunotherapy strategies targeting mitochondria.
Review
Immunology
Chen Shen, Mei Li, Yujuan Duan, Xin Jiang, Xiaoming Hou, Fulai Xue, Yinan Zhang, Yao Luo
Summary: Hepatocellular carcinoma (HCC) is a common liver cancer with poor prognosis and increasing incidence globally. Immunotherapy has been considered as an ideal approach for HCC treatment and is changing patient management. However, immunotherapy resistance hinders the effectiveness of current therapies for some HCC patients. Recent studies have shown that histone deacetylase inhibitors (HDACis) can enhance the efficacy of immunotherapy in various tumors, including HCC. This review discusses the current understanding and recent advances in immunotherapy-based and HDACi-based treatments for HCC, highlighting the synergistic effects of these therapies and efforts to translate this knowledge into clinical benefits. Additionally, the potential of nano-based drug delivery systems (NDDS) as a novel strategy to enhance HCC treatment is explored.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Sabrina Nicolo, Michele Tanturli, Giorgio Mattiuz, Alberto Antonelli, Ilaria Baccani, Chiara Bonaiuto, Simone Baldi, Giulia Nannini, Marta Menicatti, Gianluca Bartolucci, Gian Maria Rossolini, Amedeo Amedei, Maria Gabriella Torcia
Summary: Persistent infection with High Risk-Human Papilloma Viruses (HR-HPVs) is a primary cause of cervical cancer worldwide. Vaginal-dysbiosis-associated bacteria were correlated with the persistence of HR-HPVs infection and with increased cancer risk. Lactobacilli, especially L. gasseri or L. jensenii, may assist immune cells in clearing HPV infection and restore immune homeostasis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Jiadi Lv, Yabo Zhou, Nannan Zhou, Zhenfeng Wang, Jie Chen, Haoran Chen, Dianheng Wang, Li Zhou, Keke Wei, Huafeng Zhang, Ke Tang, Jingwei Ma, Yuying Liu, Yonghong Wan, Yi Zhang, Haizeng Zhang, Bo Huang
Summary: Weak immunogenicity of tumor cells is a major obstacle in immunosurveillance and immunotherapy. The mechanisms determining the initial immunogenicity of tumor cells remain unclear. This study found that the activation status of STAT1 protein and the RNA binding protein CSDE1 play a role in determining the immunogenic heterogeneity of tumorigenic cells. The identified SMYD3-CSDE1 pathway may serve as a prognostic marker for cancer immunotherapy effectiveness.
SCIENCE TRANSLATIONAL MEDICINE
(2023)
Review
Immunology
Ping-Heng Tan, Jasmine Ji, Chun-Chang Yeh, Ru-Rong Ji
Summary: IFNs exert antiviral, antiproliferative, and immunomodulatory actions, with type-I IFNs like IFN-alpha and IFN-beta used in treating diseases such as hepatitis and multiple sclerosis. Emerging evidence indicates non-genomic regulation by IFN-alpha and IFN-beta in addition to canonical transcriptional regulations, leading to rapid suppression of neuronal activity and synaptic transmission. Type-I and type-II IFNs modulate pain and infection via neuro-immune interactions, with IFN-gamma inducing central sensitization and microglia activation in persistent pain. Insights into IFN signaling in nociceptors and their roles in distinct physiological vs. pathological conditions will enhance pain treatments after surgeries, traumas, and infections.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Paulina Mertowska, Konrad Smolak, Sebastian Mertowski, Ewelina Grywalska
Summary: Interferons are immunomodulatory substances produced by the human immune system to fight infections. This review focuses on the interplay between the IFN system and medically important viruses such as HSV, influenza, HCV, LCMV, HIV, EBV, and SARS-CoV coronavirus, highlighting viral diversity. Research is ongoing to identify the specific genes and pathways involved in the antimicrobial response mediated by IFNs. Further interdisciplinary studies are needed to optimize their use in personalized therapeutics.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Lulu Xie, Mingyu Liu, Mingyue Cai, Wensou Huang, Yongjian Guo, Licong Liang, Weiguo Cai, Jianxin Liu, Wei Liang, Yitong Tan, Miaoling Lai, Liteng Lin, Kangshun Zhu
Summary: ICI resistance in hepatocellular carcinoma (HCC) is poorly understood. This study investigated the role of IFN-gamma-induced TGF-beta 1 in mediating ICI resistance and the potential of regorafenib as a treatment strategy.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Tomislav Ivanovic, Dorotea Bozic, Benjamin Benzon, Vesna Capkun, Katarina Vukojevic, Merica Glavina Durdov
Summary: Gastric cancer (GC) therapies include gastrectomy and chemoradiotherapy. The tumor immune microenvironment (TME) has implications for potential immunotherapy. We analyzed the expression of PD-L1, CD8, CTLA-4, and IFN-? in the tumor and regional lymph node (LN) of patients with GC and found correlations between PD-L1 expression and tumor type, CD8+ T cells, and macrophages, as well as between IFN-? expression and CTLA4(+) lymphocytes. Overall survival was negatively correlated with IFN-? expression in metastases. Rating: 8/10.
Review
Immunology
Kai Wang, Zixue Xuan, Xiaoyan Liu, Meiling Zheng, Chao Yang, Haiyong Wang
Summary: ADAM17 is a transmembrane protease involved in cell membrane protein shedding and signal pathway regulation. It has been shown to regulate over 90 substrates, some of which play important roles in tumor formation and development. ADAM17 also has immunomodulatory roles, although the mechanisms are still not well understood. This paper provides a summary of the structure, regulatory roles, and immunomodulatory functions of ADAM17, as well as the potential use of small molecule inhibitors and monoclonal antibodies for targeting ADAM17.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Pin-Yi Lin, Hsiao-Yu Jen, Bor-Luen Chiang, Fuu Sheu, Ya-Hui Chuang
Article
Immunology
Yu-Lin Su, Jyh-Chin Yang, Haur Lee, Fuu Sheu, Chun-Hua Hsu, Shuei-Liong Lin, Lu-Ping Chow
JOURNAL OF IMMUNOLOGY
(2015)
Article
Immunology
Kuei-Ying Su, Akiko Watanabe, Chen-Hao Yeh, Garnett Kelsoe, Masayuki Kuraoka
JOURNAL OF IMMUNOLOGY
(2016)
Article
Immunology
Joshua D. Wheaton, Chen-Hao Yeh, Maria Ciofani
JOURNAL OF IMMUNOLOGY
(2017)
Review
Immunology
Joel Finney, Chen-Hao Yeh, Garnett Kelsoe, Masayuki Kuraoka
IMMUNOLOGICAL REVIEWS
(2018)
Article
Multidisciplinary Sciences
Chen-Hao Yeh, Takuya Nojima, Masayuki Kuraoka, Garnett Kelsoe
NATURE COMMUNICATIONS
(2018)
Article
Integrative & Complementary Medicine
Hsien-Yeh Hsu, Yen-Chou Kuan, Tung-Yi Lin, Shu-Ming Tsao, Jason Hsu, Li-Juan Ma, Fuu Sheu
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2013)
Article
Fisheries
Yen-Chou Kuan, Fuu Sheu, Guo-Chi Lee, Ming-Wei Tsai, Chih-Liang Hung, Fan-Hua Nan
FISH & SHELLFISH IMMUNOLOGY
(2012)
Article
Agriculture, Multidisciplinary
Yao-Wei Tsao, Yen-Chou Kuan, Jia-Lin Wang, Fuu Sheu
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2013)
Article
Agriculture, Multidisciplinary
Chih-Liang Hung, An-Ju Chang, Xhao-Kai Kuo, Fuu Sheu
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2014)
Article
Agriculture, Multidisciplinary
Ya-Ting Lu, Yen-Chou Kuan, Hui-Hsin Chang, Fuu Sheu
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2014)
Article
Multidisciplinary Sciences
Yen-Chou Kuan, Ying-Jou Wu, Chih-Liang Hung, Fuu Sheu
Article
Multidisciplinary Sciences
Todd Bradley, Masayuki Kuraoka, Chen-Hao Yeh, Ming Tian, Huan Chen, Derek W. Cain, Xuejun Chen, Cheng Cheng, Ali H. Ellebedy, Robert Parks, Maggie Barr, Laura L. Sutherland, Richard M. Scearce, Cindy M. Bowman, Hilary Bouton-Verville, Sampa Santra, Kevin Wiehe, Mark G. Lewis, Ane Ogbe, Persephone Borrow, David Montefiori, Mattia Bonsignori, M. Anthony Moody, Laurent Verkoczy, Kevin O. Saunders, Rafi Ahmed, John R. Mascola, Garnett Kelsoe, Frederick W. Alt, Barton F. Haynes
NATURE COMMUNICATIONS
(2020)
Article
Immunology
Chen-Hao Yeh, Joel Finney, Takaharu Okada, Tomohiro Kurosaki, Garnett Kelsoe
Summary: The study found that GC-resident and nonresident Tfh cells have distinct developmental requirements and activities, implying distinct functions.
Article
Immunology
Masayuki Kuraoka, Chen-Hao Yeh, Goran Bajic, Ryutaro Kotaki, Shengli Song, Ian Windsor, Stephen C. Harrison, Garnett Kelsoe
Summary: Immunization or microbial infection can establish long-term B cell memory both systemically and locally. Local B cell memory contributes to early local plasmacytic responses and recall germinal center (GC) reactions. The efficacy of recall GCs depends on the locality of immunization, and local boosts are more efficient at recruiting progeny of primary GC B cells. Additionally, local boosts lead to elevated levels of immunoglobulin mutation and higher avidity B cell antigen receptors (BCRs) in recall GCs. The importance of locality in humoral immunity and its implications for vaccination strategies are highlighted.
SCIENCE IMMUNOLOGY
(2022)
Article
Immunology
Jun Cui, Cheng Chen, Xiao Zhou, Wenju Shan, Yuhong Jian, Panpan Li, Yang Sun, Wei Yi
Summary: Bone marrow mesenchymal stem cells (BMSCs) are a promising therapy for sepsis, but metabolic syndromes threaten their effectiveness. This study investigated the potential of small extracellular vesicles from high-fat diet BMSCs in sepsis-induced liver-heart axis injury.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Binbin Zhu, Angyang Cao, Chunqu Chen, Weijian Zhou, Wenjun Luo, Yu Gui, Qinwen Wang, Zhipeng Xu, Jianhua Wang
Summary: GM6001 alleviates postoperative cognitive deficits and neuroinflammation, preserves blood-brain barrier integrity, and rescues aquaporin-4 mislocalization. MMP-9 inhibition plays a dual role in cognitive protection through direct anti-neuroinflammatory effects and regulation of aquaporin-4 membrane distribution.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Anika Sood, Valencia Fernandes, Kumari Preeti, Shruti Rajan, Dharmendra Kumar Khatri, Shashi Bala Singh
Summary: S1PR2 inhibitor improves cognitive function and skews microglia toward anti-inflammatory phenotype in type 2 diabetic mice, promising to be a potential therapy for neuroinflammation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Haochun Guo, Ran Yu, Haijun Zhang, Wanpeng Wang
Summary: Radiation therapy is an effective treatment for thoracic malignancies, but it can cause radiation-induced lung injury (RILI), including radiation pneumonitis (RP) and radiation pulmonary fibrosis (RPF). The damage to normal lung cells during radiation treatment leads to a pulmonary inflammatory response, resulting in RP and RPF.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Guanghui Wang, Haotian Zheng, Yunzhi Xiang, Yadong Wang, Kai Wang, Xiaoyang Ren, Jiajun Du
Summary: This study identified a T-cell synthetic driver-associated prognostic model that accurately predicted prognosis and effectiveness of immunotherapy in LUAD patients. It also highlighted the role of LDHA in promoting tumor cell proliferation, invasion, and resistance to treatment, as well as its involvement in immune escape within the tumor microenvironment. These findings provide a promising new therapeutic strategy for LUAD.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Bowen Wei, Aihua Wang, Wei Liu, Qingyun Yue, Yihua Fan, Bin Xue, Siwei Wang
Summary: This study systematically analyzed the association between pSS and cuproptosis, established a predictive model based on 5 genes, explored the pathogenic mechanisms and novel therapeutic strategies for pSS, and identified EED, CBL, and NFU1 as potential targets for treatment.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Nusrit Iqbal Andrabi, Aminur R. Sarkar, Syed Assim Haq, Diljeet Kumar, Dilpreet Kour, Diksha Saroch, Sanket Kumar Shukla, Ajay Kumar, Asha Bhagat, Asif Ali, Gurleen Kour, Zabeer Ahmed
Summary: Koenimbine and its novel semi-synthetic derivative 1G demonstrate significant anti-inflammatory effects by downregulating the nuclear factor kappa-B (NF-kappa B) signaling pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Jing-Mei Lu, Xiang Xu, Fumie Aosai, Ming-Yue Zhang, Lian-Xun Piao
Summary: This study found that arctiin can improve allergic acute liver injury caused by T.g.HSP70 by inhibiting TLR4 signaling and reducing the production of inflammatory mediators.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Minxuan Xu, Fang Shi, Yongshen Gao, Shumei Han, Chensuo Huang, Qinsheng Hou, Xiaoweng Wen, Bengshi Wang, Zhenyu Zhu, Lei Zou, Mingxin Xiong, Wei Dong, Jun Tan
Summary: There is a growing body of research highlighting the involvement of metabolic imbalance and the inflammatory response in the advancement of colitis. This study recognizes arabinose as a significant protector of the intestinal mucosal barrier, reducing damage to the intestines. In addition, lower levels of arabinose in the bloodstream are associated with a higher severity of inflammatory bowel disease and colorectal cancer.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yueqing Han, Haoxin Song, Yanshan Li, Rongxin Li, Ling Chen, Bo Gao, Yijun Chen, Shuzhen Wang
Summary: The combination of tetracycline antibiotics, demeclocycline (D), chlortetracycline (C), and minocycline (M), showed therapeutic potential against liver fibrosis by inhibiting the activation of hepatic stellate cells and the MAPK signaling. This study suggests that tetracyclines may be repurposed for the treatment of liver fibrosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yu Li, Hailing Liu, Danwen Zhao, Danjie Zhang
Summary: Chronic stress can lead to lung injury, with the spleen playing a crucial role. This study found that the spleen contributes to chronic restraint stress-induced lung injury, and splenic CD11b+ cells may be an important factor in this process.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yingqian Mi, Mengyan Tang, Qiong Wu, Yinan Wang, Qihui Liu, Pei Zhu, Xiaoyang Xue, Yuntong Liu, Xinyu Chai, Yuyang Hou, Dongmei Yan
Summary: BCG therapy can induce macrophage polarization to the M1 type, and NMAAP1 plays a crucial role in this process by regulating glycolysis and HIF-1α expression. This promotes the antitumor effect of macrophages.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Xiaosheng Liu, Tingxia Lv, Xiuxia Li, Jing Xue, Ling Lin, Lianfeng Lu, Xiaodi Li, Yang Yang, Yuanni Wu, Qiang Wei, Wei Cao, Taisheng Li
Summary: LLDT-8 exhibits notable efficacy in alleviating immune activation in both an in vivo animal model and in vitro human cell experiments, suggesting its potential as a drug for managing systemic immune activation associated with SIV/HIV infection.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Honghong Yu, Qi Li, Huimin Zhu, Chang Liu, Weiwei Chen, Lingyun Sun
Summary: The activation of the inflammasome plays a critical role in the pathogenesis of systemic lupus erythematosus (SLE), and mesenchymal stem cells (MSC) have been shown to alleviate SLE by suppressing inflammasome activation. This study found that the NLRP3 inflammasome was activated in macrophages from SLE patients and mice, and its activation correlated with disease activity. After MSC transplantation, the severity of SLE was reduced, and NLRP3 inflammasome activation was inhibited. These findings suggest that MSC suppress inflammasome activation and provide a potential therapeutic target for SLE.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Wei Zhou, Dan Zeng, Shunan Liu, Yunxia Huang, Fenglin Lv, Weikang Zhou
Summary: This study found that inhibiting HDAC3 can protect the skin from atopic dermatitis by activating the Nrf2 transcription to upregulate Nrf2/HO-1 signaling pathway activity.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)