Article
Environmental Sciences
Omayma Missawi, Ikram Ben Jeddou, Massimo Venditti, Nesrine Zitouni, Mohamed Amin Zaouali, Hassen Ben Abdennebi, Imed Messaoudi, Russel J. Reiter, Sergio Minucci, Mohamed Banni
Summary: This study investigated the impact of melatonin on ischemia-reperfusion injury induced by environmental microplastics. The results showed that melatonin can alleviate liver damage caused by microplastics and reduce cellular dysfunction.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Pharmacology & Pharmacy
Seyfi Kartal, Ahmet Sen, Levent Tumkaya, Basar Erdivanli, Tolga Mercantepe, Adnan Yilmaz
Summary: The study evaluated the hepatic protective effects of dexmedetomidine in diabetic rats with lower extremity ischemia-reperfusion, showing improvement in biochemical markers and histopathological parameters in liver tissue, and a decrease in liver damage after ischemia-reperfusion.
CLINICAL AND EXPERIMENTAL HYPERTENSION
(2021)
Article
Medicine, Research & Experimental
Tong Li, Houshuai Zeng, Wenjing Xian, Hongxing Cai, Jianbo Zhang, Shiji Zhou, Yingxue Yang, Min Luo, Peng Zhu
Summary: This study found that Maresin1 (MaR1) can reduce liver macrophage pyroptosis by reducing mitochondrial damage, thereby alleviating liver ischemia-reperfusion (I/R) injury. MaR1 inhibits liver macrophage pyroptosis by protecting mitochondria. Finally, it was found that MaR1 exerts mitochondrial protective effects through activation of its nuclear receptor RORa and the PI3K/AKT signaling pathway.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Biotechnology & Applied Microbiology
Yanyun Wang, Yi Wang, Shuyu Li, Yuliang Cui, Xiping Liang, Juanjuan Shan, Wei Gu, Juhui Qiu, Yiliang Li, Guixue Wang
Summary: The developed monocyte membranes-coated rapamycin nanoparticles (McM/RNPs) have shown promise in alleviating ischemia/reperfusion injury by reducing inflammation and inhibiting cell proliferation. These nanoparticles demonstrated improved targeting and therapeutic effects in animal models, with good safety profiles observed in vivo studies.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Article
Polymer Science
Ke Yao, Xin Liang, Guiyang Zhang, Yan Rong, Qiuxiang Zhang, Qiaobo Liao, Hong Zhang, Kai Xi, Junming Wang
Summary: In this study, covalent organic framework (COF) nanoparticles were investigated for their potential use in the local treatment of glaucoma. The results showed that COF could protect retinal ganglion cells (RGCs) and serve as a carrier for delayed release of the medication rapamycin. The COF-Rapa formulation effectively reduced RGCs death, improved retinal function, and alleviated inflammation in an animal model of glaucoma retinopathy.
Article
Biochemistry & Molecular Biology
Arun Samidurai, Manu Saravanan, Ramzi Ockaili, Donatas Kraskauskas, Suet Ying Valerie Lau, Varun Kodali, Shakthi Ramasamy, Karthikeya Bhoopathi, Megha Nair, Sean K. K. Roh, Rakesh C. C. Kukreja, Anindita Das
Summary: Rapamycin treatment can effectively alleviate cardiac remodeling and inflammation in diabetic patients by inhibiting robust activation of mTOR signaling. This treatment can preserve left ventricular ejection fraction and reduce fibrosis, as well as inhibit the formation of NLRP3 inflammasomes and reduce apoptosis in cardiomyocytes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Yanyao Liu, Zilun Lei, Hao Chai, Quan Kang, Xiaoyan Qin
Summary: Salidroside alleviates hepatic ischemia-reperfusion injury by modulating the TLR-4/NF-κB/NLRP3 inflammatory pathway.
SCIENTIFIC REPORTS
(2022)
Article
Medicine, Research & Experimental
Abolfazl Badripour, Mohamad Behzadi, Amin Hassanipour, Pasha Reza Shams Azar, Alireza Rahbar, Zhaleh Abbaslou, Elnaz Ehghaghi, Ashkan Piranviseh, Mohammad Mahdi Khavandi, Seyed Mohsen Ahmadi-Tafti, Mohammad Ashouri, Zahra Ebrahim Soltani, Ahmadreza Dehpour
Summary: This study aimed to evaluate the effects of Albendazole pretreatment on mesenteric ischemia reperfusion (MIR) injury. The findings demonstrated that Albendazole could ameliorate the inflammatory response and enhance the ischemia threshold following MIR injury.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Gastroenterology & Hepatology
Zhuolun Song, Hui Han, Xiaodong Ge, Sukanta Das, Romain Desert, Dipti Athavale, Wei Chen, Sai Santosh Babu Komakula, Daniel Lantvit, Natalia Nieto
Summary: This study investigated the protective role of intracellular neutrophil-derived HMGB1 in early allograft dysfunction after liver transplantation. The results showed that the absence of Hmgb1 in recipient myeloid cells exacerbated graft injury. Therefore, intracellular HMGB1 plays an important role in protecting against early graft injury after liver transplantation.
Article
Chemistry, Multidisciplinary
Omar Abdulhameed Almazroo, Imam H. Shaik, Christopher B. Hughes, Abhinav Humar, Raman Venkataramanan
Summary: Treprostinil treatment reduces ischemia-reperfusion injury and alters the expression of drug transporters in the liver. This is of great significance for improving the outcomes of deceased donor liver transplantation.
PHARMACEUTICAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Jun Ling, Haijian Cai, Muya Lin, Shunli Qi, Jian Du, Lijian Chen
Summary: The findings suggest that overexpression of RTN1-C is associated with cerebral ischemia/reperfusion injury, and RTN1-C can modulate autophagy, playing a significant role in brain injury.
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
(2021)
Article
Nutrition & Dietetics
Fayez T. Hammad, Suhail Al-Salam, Rahaf Ahmad, Javed Yasin, Awwab F. Hammad, Jasmine Abdul Rasheed, Loay Lubbad
Summary: It has been found that nerolidol has a protective effect on renal ischemia-reperfusion injury, improving renal function and reducing tissue damage.
Article
Oncology
Zhiyong Guo, Jinghong Xu, Shanzhou Huang, Meixian Yin, Qiang Zhao, Weiqiang Ju, Dongping Wang, Ningxin Gao, Changjun Huang, Lu Yang, Maogen Chen, Zhiheng Zhang, Zebin Zhu, Linhe Wang, Caihui Zhu, Yixi Zhang, Yunhua Tang, Haitian Chen, Kunpeng Liu, Yuting Lu, Yi Ma, Anbin Hu, Yinghua Chen, Xiaofeng Zhu, Xiaoshun He
Summary: Ischemia-free liver transplantation can avoid graft ischemia-reperfusion injury and has the potential to improve transplant outcomes and organ utilization.
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Article
Medicine, Research & Experimental
Walaa H. El-Maadawy, Marwa Hassan, Mohamed H. Badawy, AbdulRahman AbuSeada, Ehab Hafiz
Summary: This study is the first to demonstrate the protective effect of probenecid (PBN) against renal ischemia/reperfusion injury (RI/RI). PBN inhibits the Panx1/P2X7R axis, reduces the activation of the NLRP3 inflammasome signaling pathway, and enhances the activity of regulatory T cells, leading to renal recovery.
Review
Immunology
Victor Lopez-Lopez, Fernando Perez-Sanz, Carlos de Torre-Minguela, Josefa Marco-Abenza, Ricardo Robles-Campos, Francisco Sanchez-Bueno, Jose A. Pons, Pablo Ramirez, Alberto Baroja-Mazo
Summary: Proteomics has been used in liver transplantation research to study outcomes such as ischemia-reperfusion injury (IRI) and rejection, showing a higher number of shared proteins between these two conditions. Metabolism was found to be the most enriched pathway in liver biopsy samples, IRI, and rejection, while cytokine-cytokine receptor interactions were predominant in tolerance studies.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Jun Cui, Cheng Chen, Xiao Zhou, Wenju Shan, Yuhong Jian, Panpan Li, Yang Sun, Wei Yi
Summary: Bone marrow mesenchymal stem cells (BMSCs) are a promising therapy for sepsis, but metabolic syndromes threaten their effectiveness. This study investigated the potential of small extracellular vesicles from high-fat diet BMSCs in sepsis-induced liver-heart axis injury.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Binbin Zhu, Angyang Cao, Chunqu Chen, Weijian Zhou, Wenjun Luo, Yu Gui, Qinwen Wang, Zhipeng Xu, Jianhua Wang
Summary: GM6001 alleviates postoperative cognitive deficits and neuroinflammation, preserves blood-brain barrier integrity, and rescues aquaporin-4 mislocalization. MMP-9 inhibition plays a dual role in cognitive protection through direct anti-neuroinflammatory effects and regulation of aquaporin-4 membrane distribution.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Anika Sood, Valencia Fernandes, Kumari Preeti, Shruti Rajan, Dharmendra Kumar Khatri, Shashi Bala Singh
Summary: S1PR2 inhibitor improves cognitive function and skews microglia toward anti-inflammatory phenotype in type 2 diabetic mice, promising to be a potential therapy for neuroinflammation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Haochun Guo, Ran Yu, Haijun Zhang, Wanpeng Wang
Summary: Radiation therapy is an effective treatment for thoracic malignancies, but it can cause radiation-induced lung injury (RILI), including radiation pneumonitis (RP) and radiation pulmonary fibrosis (RPF). The damage to normal lung cells during radiation treatment leads to a pulmonary inflammatory response, resulting in RP and RPF.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Guanghui Wang, Haotian Zheng, Yunzhi Xiang, Yadong Wang, Kai Wang, Xiaoyang Ren, Jiajun Du
Summary: This study identified a T-cell synthetic driver-associated prognostic model that accurately predicted prognosis and effectiveness of immunotherapy in LUAD patients. It also highlighted the role of LDHA in promoting tumor cell proliferation, invasion, and resistance to treatment, as well as its involvement in immune escape within the tumor microenvironment. These findings provide a promising new therapeutic strategy for LUAD.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Bowen Wei, Aihua Wang, Wei Liu, Qingyun Yue, Yihua Fan, Bin Xue, Siwei Wang
Summary: This study systematically analyzed the association between pSS and cuproptosis, established a predictive model based on 5 genes, explored the pathogenic mechanisms and novel therapeutic strategies for pSS, and identified EED, CBL, and NFU1 as potential targets for treatment.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Nusrit Iqbal Andrabi, Aminur R. Sarkar, Syed Assim Haq, Diljeet Kumar, Dilpreet Kour, Diksha Saroch, Sanket Kumar Shukla, Ajay Kumar, Asha Bhagat, Asif Ali, Gurleen Kour, Zabeer Ahmed
Summary: Koenimbine and its novel semi-synthetic derivative 1G demonstrate significant anti-inflammatory effects by downregulating the nuclear factor kappa-B (NF-kappa B) signaling pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Jing-Mei Lu, Xiang Xu, Fumie Aosai, Ming-Yue Zhang, Lian-Xun Piao
Summary: This study found that arctiin can improve allergic acute liver injury caused by T.g.HSP70 by inhibiting TLR4 signaling and reducing the production of inflammatory mediators.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Minxuan Xu, Fang Shi, Yongshen Gao, Shumei Han, Chensuo Huang, Qinsheng Hou, Xiaoweng Wen, Bengshi Wang, Zhenyu Zhu, Lei Zou, Mingxin Xiong, Wei Dong, Jun Tan
Summary: There is a growing body of research highlighting the involvement of metabolic imbalance and the inflammatory response in the advancement of colitis. This study recognizes arabinose as a significant protector of the intestinal mucosal barrier, reducing damage to the intestines. In addition, lower levels of arabinose in the bloodstream are associated with a higher severity of inflammatory bowel disease and colorectal cancer.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yueqing Han, Haoxin Song, Yanshan Li, Rongxin Li, Ling Chen, Bo Gao, Yijun Chen, Shuzhen Wang
Summary: The combination of tetracycline antibiotics, demeclocycline (D), chlortetracycline (C), and minocycline (M), showed therapeutic potential against liver fibrosis by inhibiting the activation of hepatic stellate cells and the MAPK signaling. This study suggests that tetracyclines may be repurposed for the treatment of liver fibrosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yu Li, Hailing Liu, Danwen Zhao, Danjie Zhang
Summary: Chronic stress can lead to lung injury, with the spleen playing a crucial role. This study found that the spleen contributes to chronic restraint stress-induced lung injury, and splenic CD11b+ cells may be an important factor in this process.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yingqian Mi, Mengyan Tang, Qiong Wu, Yinan Wang, Qihui Liu, Pei Zhu, Xiaoyang Xue, Yuntong Liu, Xinyu Chai, Yuyang Hou, Dongmei Yan
Summary: BCG therapy can induce macrophage polarization to the M1 type, and NMAAP1 plays a crucial role in this process by regulating glycolysis and HIF-1α expression. This promotes the antitumor effect of macrophages.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Xiaosheng Liu, Tingxia Lv, Xiuxia Li, Jing Xue, Ling Lin, Lianfeng Lu, Xiaodi Li, Yang Yang, Yuanni Wu, Qiang Wei, Wei Cao, Taisheng Li
Summary: LLDT-8 exhibits notable efficacy in alleviating immune activation in both an in vivo animal model and in vitro human cell experiments, suggesting its potential as a drug for managing systemic immune activation associated with SIV/HIV infection.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Honghong Yu, Qi Li, Huimin Zhu, Chang Liu, Weiwei Chen, Lingyun Sun
Summary: The activation of the inflammasome plays a critical role in the pathogenesis of systemic lupus erythematosus (SLE), and mesenchymal stem cells (MSC) have been shown to alleviate SLE by suppressing inflammasome activation. This study found that the NLRP3 inflammasome was activated in macrophages from SLE patients and mice, and its activation correlated with disease activity. After MSC transplantation, the severity of SLE was reduced, and NLRP3 inflammasome activation was inhibited. These findings suggest that MSC suppress inflammasome activation and provide a potential therapeutic target for SLE.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Wei Zhou, Dan Zeng, Shunan Liu, Yunxia Huang, Fenglin Lv, Weikang Zhou
Summary: This study found that inhibiting HDAC3 can protect the skin from atopic dermatitis by activating the Nrf2 transcription to upregulate Nrf2/HO-1 signaling pathway activity.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)