Article
Medicine, Research & Experimental
Paulo da Silva Watanabe, Andreza Manzato Cavichioli, Joana D'Arc de Lima Mendes, Rubina Aktar, Madusha Peiris, L. Ashley Blackshaw, Eduardo Jose de Almeida Araujo
Summary: This study evaluated the anatomical and functional changes in the colon during the development of acute and chronic DSS-induced UC in mice. The results showed that UC caused thickening of the colonic wall, fibrosis, and reduction in tuft cells, leading to abnormal colonic motility. Further studies may focus on stimulating tuft cell hyperplasia to reduce damage caused by UC.
Article
Immunology
Jian Cui, Yan Li, Chenyang Jiao, Jianhua Gao, Yingxue He, Beibei Nie, Lingdong Kong, Wenjie Guo, Qiang Xu
Summary: Magnesium isoglycyrrhizinate shows potential in treating inflammatory bowel disease by alleviating colitis, inhibiting inflammation response, reducing ROS level, and preventing fibrosis in the colon after treatment with DSS.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Agriculture, Multidisciplinary
Weisong Wu, Limei Liu, Yingwei Zhu, Jingbin Ni, Jian Lu, Xiaoli Wang, Li Ma, Yanjun Jiang
Summary: In patients with inflammatory bowel diseases (IBDs), the immune system is disrupted and the intestinal barrier function is compromised. Six zinc-flavonoid particles were produced and tested for their cytocompatibility and ability to scavenge H2O2, free radicals, and LPS-induced ROS. The zinc-rutin particles (W-ZnRT) showed promising results, exhibiting high cell viability, efficient scavenging abilities, and the ability to restore normal levels of intracellular ROS. In addition, W-ZnRT was found to be more effective than rutin alone in treating chronic colitis in mice, improving intestinal permeability, reducing proinflammatory factors, and maintaining intestinal barrier function. Overall, these findings suggest that W-ZnRT is a safe and efficient therapeutic strategy for IBD.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Pengbo Yao, Taiqi Chen, Peng Jiang, Li Li, Wenjing Du
Summary: This study reveals that macrophage polarization plays a crucial role in determining the production of pro- or anti-inflammatory cytokines during bacterial and virus infections. It was found that lipopolysaccharide-induced pro-inflammatory macrophage polarization enhances the interaction between TRIM21 and SIRT5, leading to SIRT5 degradation and enhanced interleukin-1 beta production.
Article
Biochemistry & Molecular Biology
Jae-Sung Kim, Hyo Keun Kim, Minsoo Kim, Sein Jang, Euni Cho, Seok-Jun Mun, Joongho Lee, Dawon Hong, Seokhyun Yoon, Chul-Su Yang
Summary: This study reveals the important role of extracellular NAMPT in ulcerative colitis, as it can modulate the activation of inflammatory macrophages through binding with CYBB and TLR4. The researchers also developed a colon-targeted multifunctional NAMPT peptide that effectively reduces the severity of colitis by targeting the colon and inhibiting the interaction with CYBB or TLR4.
Article
Multidisciplinary Sciences
Jinhuang Shen, Xinhua Ma, Yubin He, Yanjun Wang, Tianhua Zhong, Yonghong Zhang
Summary: This study found that Melianodiol (MN) can activate the Nrf-2 signaling pathway and inhibit the JAK/STAT, iNOS/eNOS, and NF-kappa B signaling cascades, enhance intestinal barrier function, and effectively reduce the LPS-mediated inflammatory response in mouse macrophages and DSS-induced intestinal injury in UC.
Article
Biochemistry & Molecular Biology
Suisui Jiang, Huina Xu, Chunhui Zhao, Feng Zhong, Duo Li
Summary: Oyster polysaccharides (OPS) have strong anti-inflammatory effects and can regulate the gut microbiome. The study found that OPS can effectively alleviate colitis symptoms and restore histopathological damage. In addition, OPS inhibits pro-inflammatory cytokines and promotes the expression of tight junction proteins, while preventing bacterial endotoxin production. These results suggest that OPS may be a potential therapeutic candidate for the treatment of colitis.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Zhimin Ye, Ximiao Yang, Boxiong Deng, Zhenlin Liao, Xiang Fang, Jie Wang
Summary: This study investigated the preventative effects and underlying mechanism of water kefir microbiota on inflammatory bowel disease (IBD). The results showed that water kefir microbiota effectively improved disease severity in a colitis mouse model induced by dextran sodium sulfate (DSS), including decreased body weight and colon length, increased spleen index and DAI score, and colonic tissue damage. Water kefir microbiota also restored the abnormal expression of tight junction proteins and pro-inflammatory and anti-inflammatory cytokines, and inactivated the TLR4-MyD88-NF-κB pathway induced by DSS. Additionally, water kefir microbiota improved the composition and metabolism of intestinal microbiota.
Article
Chemistry, Applied
Xuefeng Li, Huixia Lv, Fanli Shi, Jie Song, Zhenhai Zhang
Summary: This study demonstrates that high-substituted hydroxypropyl cellulose (HHPC) and low-substituted hydroxypropyl cellulose (LHPC) can alleviate pathological damage and inflammation in DSS-induced colitis mice. HHPC also suppresses the secretion of inflammatory mediators and restores balance of intestinal flora.
CARBOHYDRATE POLYMERS
(2022)
Article
Biochemistry & Molecular Biology
Yu-Jing Wang, Hong-Yan Wang, Qiang-Ming Li, Xue-Qiang Zha, Jian-Ping Luo
Summary: In this study, the intervention effect of Dendrobium fimbriatum Hook polysaccharide (cDFPW1) on ulcerative colitis (UC) was confirmed through experiments on mice. The results showed that cDFPW1 significantly alleviated UC symptoms and promoted the proliferation of intestinal epithelial cells. Furthermore, cDFPW1 directly improved intestinal organoid damage and increased the number of epithelial cells, promoting stem cell-mediated intestinal epithelial regeneration.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Huan Chen, Ying Li, Jinrui Wang, Tingting Zheng, Chenyang Wu, Mengyao Cui, Yifan Feng, Hanyi Ye, Zhengqi Dong, Yunjie Dang
Summary: The pathogenesis of ulcerative colitis (UC) is closely related to inflammation, oxidative stress, and gut microbiota imbalance. This study explored the antioxidant activity and underlying mechanisms of various plant polyphenols, such as gallic acid, proanthocyanidin, ellagic acid, and tannic acid. The results showed that polyphenols with more phenolic hydroxyl groups exhibited stronger antioxidant activity. Moreover, these polyphenols effectively ameliorated UC symptoms and pathological progression in mice by reducing inflammatory cytokine levels, repairing the intestinal barrier, and regulating the intestinal microbiota.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Abigail R. Cannon, Esther H. Shim, Paulius Kuprys, Mashkoor A. Choudhry
Summary: Ulcerative colitis (UC) is a disease characterized by cycles of active flare and remission. Alcohol has been found to increase the severity of UC pathology. This study investigated the effects of alcohol on IL-22 expression and whether recombinant IL-22 or probiotic treatment could alleviate UC symptoms. The results showed that treatment with rIL-22 and Lactobacillus delbrueckii can attenuate UC exacerbation and increase IL-22 levels.
JOURNAL OF LEUKOCYTE BIOLOGY
(2022)
Article
Microbiology
Siwen Qu, Lina Fan, Yadong Qi, Chaochao Xu, Yingying Hu, Shujie Chen, Wei Liu, Weili Liu, Jianmin Si
Summary: Akkermansia muciniphila has been shown to play a crucial role in the progression of colitis, with its protective effects in acute colitis depending on NLRP3 activation. This study enriches the understanding of the mechanisms underlying A. muciniphila's effects and offers a new prospect for probiotic-based treatments of colitis. The interaction between gut microbiota and host immune response plays a significant role in intestinal inflammatory diseases.
MICROBIOLOGY SPECTRUM
(2021)
Article
Immunology
Qiulin Deng, Yichen Yao, Jing Yang, Ramina Khoshaba, Yi Shen, Xin Wang, Deliang Cao
Summary: AKR1B8 deficiency in IECs leads to severe acute colitis induced by low-dose DSS through activation of the innate immunity, resulting in compromised IEC barrier function, increased bacterial invasion and excessive immune cell infiltration.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Qi Yin, Xuelei Pi, Yuanyuan Jiang, Guiping Ren, Zhihang Liu, Han Liu, Mengxia Wang, Wenying Sun, Siyu Li, Zhenqiu Gao, Deshan Li, Jiechao Yin
Summary: The study found that FL-BsAb1/17 was more effective in treating ulcerative colitis than etanercept, indicating its potential as a new dual-target candidate for colitis treatment.
Article
Medicine, Research & Experimental
Karin Nelander, Maria Lagerstrom-Fermer, Carl Amilon, Erik Michaelsson, Maria Heijer, Magnus Kjaer, Muir Russell, David Han, Eva-Lotte Lindstedt, Carl Whatling, Li-Ming Gan, Hans Ericsson
Summary: The study demonstrated the safety and tolerability of AZD4831 in healthy subjects, with rapid absorption and steady-state achievement. A dose/concentration-effect relationship was established with over 50% MPO inhibition in plasma at low nanomolar concentrations, supporting further clinical development in patients with heart failure with preserved ejection fraction.
CTS-CLINICAL AND TRANSLATIONAL SCIENCE
(2021)
Article
Cardiac & Cardiovascular Systems
Chrishan J. A. Ramachandra, Myu Mai Ja Kp, Jasper Chua, Sauri Hernandez-Resendiz, Elisa A. Liehn, Ralph Knoll, Li-Ming Gan, Erik Michaelsson, Malin K. B. Jonsson, Katarina Ryden-Markinhuhta, Ratan Bhat, Regina Fritsche-Danielson, Ying-Hsi Lin, Sakthivel Sadayappan, Hak Chiaw Tang, Philip Wong, Winston Shim, Derek J. Hausenloy
Summary: This study demonstrates that MPO inhibition can alleviate the relaxation defect in hypertrophic iPSC-CMs through MYBPC3 phosphorylation, highlighting cardiomyocyte MPO as a novel therapeutic target for improving myocardial relaxation associated with HCM.
CARDIOVASCULAR RESEARCH
(2022)
Article
Cell Biology
Oleksandr Nychyk, Wiley Barton, Agata M. Rudolf, Serena Boscaini, Aaron Walsh, Thomaz F. S. Bastiaanssen, Linda Giblin, Paul Cormican, Liang Chen, Yolanda Piotrowicz, Davina Derous, Aine Fanning, Xiaofei Yin, Jim Grant, Silvia Melgar, Lorraine Brennan, Sharon E. Mitchell, John F. Cryan, Jun Wang, Paul D. Cotter, John R. Speakman, Kanishka N. Nilaweera
Summary: Dietary fat is the main driver of body weight gain and tissue weight, but the quantity and quality of protein have significant impacts, especially on the microbiota. High casein intake accentuated the negative metabolic effects of fat intake, while high whey intake reduced these effects.
Article
Biochemistry & Molecular Biology
Monica Aguilera, Valerio Rossini, Ana Hickey, Donjete Simnica, Fiona Grady, Valeria D. Felice, Amy Moloney, Lauren Pawley, Aine Fanning, Lorraine McCarthy, Siobhan M. O'Mahony, John F. Cryan, Ken Nally, Fergus Shanahan, Silvia Melgar
Summary: The inflammasome pathway plays an important role in visceral pain and neuroimmune responses, particularly in inflammatory gastrointestinal conditions with pain and changes in microbiota composition. This study highlights the significance of interactions between the gut microbiota, immune system, and nervous system for maintaining homeostasis in the gut.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Jerzy A. Woznicki, Nisha Saini, Peter Flood, Subhasree Rajaram, Ciaran M. Lee, Panagiota Stamou, Agnieszka Skowyra, Milan Bustamante-Garrido, Karine Regazzoni, Nyree Crawford, Simon S. McDade, Daniel B. Longley, Pedro Aza-Blanc, Fergus Shanahan, Syed A. Zulquernain, Jane McCarthy, Silvia Melgar, Bradford L. McRae, Ken Nally
Summary: Rewiring of host cytokine networks is a key feature of inflammatory bowel diseases like Crohn's disease. IFN-gamma and TNF-alpha can synergistically induce the death of intestinal epithelial cells, with JAK1/2 identified as the principal drivers of this process. This non-canonical cell death pathway may play a role in immunopathology in various autoinflammatory diseases.
CELL DEATH & DISEASE
(2021)
Article
Microbiology
Ana Hickey, Panagiota Stamou, Sreeram Udayan, Ana Ramon-Vazquez, Maria Esteban-Torres, Francesca Bottacini, Jerzy Adam Woznicki, Owen Hughes, Silvia Melgar, Marco Ventura, Douwe Van Sinderen, Valerio Rossini, Ken Nally
Summary: The study found that EPS production in human B. breve strains varies and the immune responses in human THP-1 monocytes are strain-specific rather than EPS status-specific.EPS proficient B. breve strains inhibit DC maturation and specific CD4(+) T cell activation responses, suggesting a new immunomodulatory role for B. breve EPS in host-microbe mutualism.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Immunology
Gonzalo Saiz-Gonzalo, Naomi Hanrahan, Valerio Rossini, Raminder Singh, Mary Ahern, Maebh Kelleher, Shane Hill, Ruairi O'Sullivan, Aine Fanning, Patrick T. T. Walsh, Seamus Hussey, Fergus Shanahan, Ken Nally, Caitriona M. M. O'Driscoll, Silvia Melgar
Summary: The study reveals a correlation between CEACAMs and the pathogenesis of IBD, with different IBD-associated triggers impacting the expression of CEACAMs.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Food Science & Technology
Vanessa Las Heras, Silvia Melgar, John MacSharry, Cormac G. M. Gahan
Summary: Diet plays a significant role in influencing host immune function and the gastrointestinal microbiota, particularly in the context of obesity, metabolic disease, inflammatory bowel disease, and infection.
ANNUAL REVIEW OF FOOD SCIENCE AND TECHNOLOGY
(2022)
Article
Gastroenterology & Hepatology
Sreeram Udayan, Panagiota Stamou, Fiona Crispie, Ana Hickey, Alexandria N. Floyd, Chyi-Song Hsieh, Paul D. Cotter, Orla O'Sullivan, Silvia Melgar, Paul W. O'Toole, Rodney D. Newberry, Valerio Rossini, Ken Nally
Summary: The study found that certain gut bacteria can disseminate to systemic tissues, and the relative abundance of Lactobacillus johnsonii in intestinal tissues is increased in mice with Myd88-dependent innate immune sensor pathway deficiency. L. johnsonii was frequently detected in multiple systemic tissues, indicating its potential role as a murine immunomodulatory endosymbiont.
Review
Biochemistry & Molecular Biology
Maria A. Nunez-Sanchez, Silvia Melgar, Keith O'Donoghue, Maria A. Martinez-Sanchez, Virgina E. Fernandez-Ruiz, Mercedes Ferrer-Gomez, Antonio J. Ruiz-Alcaraz, Bruno Ramos-Molina
Summary: Crohn's disease (CD) is a complex and disabling disorder with unknown etiology. The gut microbiota plays a crucial role in CD development, and dietary strategies may impact the composition and functionality of the gut microbiota. This review provides an overview of host-microbe interactions in CD pathogenesis and severity, and discusses the latest information on modulating gut microbiota through nutritional strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Gastroenterology & Hepatology
Peter Flood, Aine Fanning, Jerzy A. Woznicki, Tadhg Crowley, Andrea Christopher, Alessandra Vaccaro, Aileen Houston, Sheila McSweeney, Sarah Ross, Aileen Hogan, Elizabeth Brint, Agnieszka Skowyra, Milan Bustamante, Monica Ambrose, Gerard Moloney, John MacSharry, Marie-Louise Hammarstrom, Margot Hurley, Christine Fitzgibbons, Eamonn M. M. Quigley, Fergus Shanahan, Syed A. Zulquernain, Jane McCarthy, G. Steven Dodson, Karim Dabbagh, Bradford L. McRae, Silvia Melgar, Ken Nally
Summary: The DNA sensor pathways play a crucial role in the pathogenesis of ulcerative colitis (UC), and are associated with the overactivation of inflammasome and type I interferon (IFN) signaling pathways. Furthermore, the study discovered that the combination of type I IFN (IFN-beta) and TNF-alpha can induce JAK-dependent inflammatory cell death in colonic organoids, independent of the inflammasome.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2022)
Article
Oncology
J. M. Keane, C. J. Walsh, P. Cronin, K. Baker, S. Melgar, P. D. Cotter, S. A. Joyce, C. G. M. Gahan, A. Houston, N. P. Hyland
Summary: Distinct changes in the microbiota and host occur during AOM-induced tumorigenesis, with the inflammatory response becoming apparent at weeks 12 and 24, and aberrant crypt foci and adenomas first detectable at weeks 24 and 48, respectively.
BRITISH JOURNAL OF CANCER
(2023)
Article
Biochemistry & Molecular Biology
Caitlin O'Mahony, Adam Clooney, Siobhan F. Clarke, Monica Aguilera, Aisling Gavin, Donjete Simnica, Mary Ahern, Aine Fanning, Maurice Stanley, Raul Cabrera Rubio, Elaine Patterson, Tatiana Marques, Rebecca Wall, Aileen Houston, Amr Mahmoud, Michael W. Bennett, Catherine Stanton, Marcus J. Claesson, Paul D. Cotter, Fergus Shanahan, Susan A. Joyce, Silvia Melgar
Summary: Environmental factors, such as westernised diets and alterations to the gut microbiota, are considered risk factors for inflammatory bowel diseases (IBD). This study found that feeding mice a high-fat diet protected them from developing colitis and colitis-associated cancer (CAC) by modulating gut microbiota and bile acid metabolism, which then influenced vitamin D targeting pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Gastroenterology & Hepatology
Maria A. Nunez-Sanchez, Florence M. Herisson, Jonathan M. Keane, Natalia Garcia-Gonzalez, Valerio Rossini, Jorge Pinhiero, Jack Daly, Milan Bustamante-Garrido, Cara M. Hueston, Shriram Patel, Nuria Canela, Pol Herrero, Marcus J. Claesson, Silvia Melgar, Ken Nally, Noel M. Caplice, Cormac G. M. Gahan
Summary: Research has found that the activity of microbial bile salt hydrolase (BSH) potentially influences bacterial colonization and promotes infant gut development. This study is of great significance for understanding the mechanisms by which early microbial colonizers affect gut development.
Article
Gastroenterology & Hepatology
Raminder Singh, Valerio Rossini, Stephen R. Stockdale, Gonzalo Saiz-Gonzalo, Naomi Hanrahan, Tanya D' Souza, Adam Clooney, Lorraine A. Draper, Colin Hill, Ken Nally, Fergus Shanahan, Stefan Andersson-Engels, Silvia Melgar
Summary: Conflicting evidence exists regarding the association between NSAID consumption and worsening of IBD symptoms. The prevalence of pathobionts, such as AIEC, may explain this inconsistency. In IL10(-/-) mice, we found that NSAID aggravated colitis in AIEC-colonized animals and activated the NLRP3 inflammasome and Caspase-8. Inhibition of NLRP3 or Caspase-8 activity improved colitis and increased abundance of beneficial bacteria.
Article
Immunology
Jun Cui, Cheng Chen, Xiao Zhou, Wenju Shan, Yuhong Jian, Panpan Li, Yang Sun, Wei Yi
Summary: Bone marrow mesenchymal stem cells (BMSCs) are a promising therapy for sepsis, but metabolic syndromes threaten their effectiveness. This study investigated the potential of small extracellular vesicles from high-fat diet BMSCs in sepsis-induced liver-heart axis injury.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Binbin Zhu, Angyang Cao, Chunqu Chen, Weijian Zhou, Wenjun Luo, Yu Gui, Qinwen Wang, Zhipeng Xu, Jianhua Wang
Summary: GM6001 alleviates postoperative cognitive deficits and neuroinflammation, preserves blood-brain barrier integrity, and rescues aquaporin-4 mislocalization. MMP-9 inhibition plays a dual role in cognitive protection through direct anti-neuroinflammatory effects and regulation of aquaporin-4 membrane distribution.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Anika Sood, Valencia Fernandes, Kumari Preeti, Shruti Rajan, Dharmendra Kumar Khatri, Shashi Bala Singh
Summary: S1PR2 inhibitor improves cognitive function and skews microglia toward anti-inflammatory phenotype in type 2 diabetic mice, promising to be a potential therapy for neuroinflammation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Haochun Guo, Ran Yu, Haijun Zhang, Wanpeng Wang
Summary: Radiation therapy is an effective treatment for thoracic malignancies, but it can cause radiation-induced lung injury (RILI), including radiation pneumonitis (RP) and radiation pulmonary fibrosis (RPF). The damage to normal lung cells during radiation treatment leads to a pulmonary inflammatory response, resulting in RP and RPF.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Guanghui Wang, Haotian Zheng, Yunzhi Xiang, Yadong Wang, Kai Wang, Xiaoyang Ren, Jiajun Du
Summary: This study identified a T-cell synthetic driver-associated prognostic model that accurately predicted prognosis and effectiveness of immunotherapy in LUAD patients. It also highlighted the role of LDHA in promoting tumor cell proliferation, invasion, and resistance to treatment, as well as its involvement in immune escape within the tumor microenvironment. These findings provide a promising new therapeutic strategy for LUAD.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Bowen Wei, Aihua Wang, Wei Liu, Qingyun Yue, Yihua Fan, Bin Xue, Siwei Wang
Summary: This study systematically analyzed the association between pSS and cuproptosis, established a predictive model based on 5 genes, explored the pathogenic mechanisms and novel therapeutic strategies for pSS, and identified EED, CBL, and NFU1 as potential targets for treatment.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Nusrit Iqbal Andrabi, Aminur R. Sarkar, Syed Assim Haq, Diljeet Kumar, Dilpreet Kour, Diksha Saroch, Sanket Kumar Shukla, Ajay Kumar, Asha Bhagat, Asif Ali, Gurleen Kour, Zabeer Ahmed
Summary: Koenimbine and its novel semi-synthetic derivative 1G demonstrate significant anti-inflammatory effects by downregulating the nuclear factor kappa-B (NF-kappa B) signaling pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Jing-Mei Lu, Xiang Xu, Fumie Aosai, Ming-Yue Zhang, Lian-Xun Piao
Summary: This study found that arctiin can improve allergic acute liver injury caused by T.g.HSP70 by inhibiting TLR4 signaling and reducing the production of inflammatory mediators.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Minxuan Xu, Fang Shi, Yongshen Gao, Shumei Han, Chensuo Huang, Qinsheng Hou, Xiaoweng Wen, Bengshi Wang, Zhenyu Zhu, Lei Zou, Mingxin Xiong, Wei Dong, Jun Tan
Summary: There is a growing body of research highlighting the involvement of metabolic imbalance and the inflammatory response in the advancement of colitis. This study recognizes arabinose as a significant protector of the intestinal mucosal barrier, reducing damage to the intestines. In addition, lower levels of arabinose in the bloodstream are associated with a higher severity of inflammatory bowel disease and colorectal cancer.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yueqing Han, Haoxin Song, Yanshan Li, Rongxin Li, Ling Chen, Bo Gao, Yijun Chen, Shuzhen Wang
Summary: The combination of tetracycline antibiotics, demeclocycline (D), chlortetracycline (C), and minocycline (M), showed therapeutic potential against liver fibrosis by inhibiting the activation of hepatic stellate cells and the MAPK signaling. This study suggests that tetracyclines may be repurposed for the treatment of liver fibrosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yu Li, Hailing Liu, Danwen Zhao, Danjie Zhang
Summary: Chronic stress can lead to lung injury, with the spleen playing a crucial role. This study found that the spleen contributes to chronic restraint stress-induced lung injury, and splenic CD11b+ cells may be an important factor in this process.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yingqian Mi, Mengyan Tang, Qiong Wu, Yinan Wang, Qihui Liu, Pei Zhu, Xiaoyang Xue, Yuntong Liu, Xinyu Chai, Yuyang Hou, Dongmei Yan
Summary: BCG therapy can induce macrophage polarization to the M1 type, and NMAAP1 plays a crucial role in this process by regulating glycolysis and HIF-1α expression. This promotes the antitumor effect of macrophages.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Xiaosheng Liu, Tingxia Lv, Xiuxia Li, Jing Xue, Ling Lin, Lianfeng Lu, Xiaodi Li, Yang Yang, Yuanni Wu, Qiang Wei, Wei Cao, Taisheng Li
Summary: LLDT-8 exhibits notable efficacy in alleviating immune activation in both an in vivo animal model and in vitro human cell experiments, suggesting its potential as a drug for managing systemic immune activation associated with SIV/HIV infection.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Honghong Yu, Qi Li, Huimin Zhu, Chang Liu, Weiwei Chen, Lingyun Sun
Summary: The activation of the inflammasome plays a critical role in the pathogenesis of systemic lupus erythematosus (SLE), and mesenchymal stem cells (MSC) have been shown to alleviate SLE by suppressing inflammasome activation. This study found that the NLRP3 inflammasome was activated in macrophages from SLE patients and mice, and its activation correlated with disease activity. After MSC transplantation, the severity of SLE was reduced, and NLRP3 inflammasome activation was inhibited. These findings suggest that MSC suppress inflammasome activation and provide a potential therapeutic target for SLE.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Wei Zhou, Dan Zeng, Shunan Liu, Yunxia Huang, Fenglin Lv, Weikang Zhou
Summary: This study found that inhibiting HDAC3 can protect the skin from atopic dermatitis by activating the Nrf2 transcription to upregulate Nrf2/HO-1 signaling pathway activity.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
