Review
Cell Biology
Inbal Dagan, Raz Palty
Summary: Calcium signaling in cells plays a crucial role in regulating cell survival, proliferation, and death. Store-operated Ca2+ entry through CRAC channels is a major pathway for Ca2+ influx in non-excitable cells, regulated by a negative feedback mechanism called slow Ca2+ dependent inactivation (SCDI).
Article
Multidisciplinary Sciences
Ji-Hee Kim, Kyu-Hee Hwang, Bao T. N. Dang, Minseob Eom, In Deok Kong, Yousang Gwack, Seyoung Yu, Heon Yung Gee, Lutz Birnbaumer, Kyu-Sang Park, Seung-Kuy Cha
Summary: Insulin can affect Ora1 function in podocytes, leading to impaired kidney filter integrity and proteinuria via the Ca2+-calcineurin pathway. Tight balance of insulin action targeting podocyte Ora1 is critical for maintaining filter integrity and could provide new therapeutic strategies for proteinuric diseases.
NATURE COMMUNICATIONS
(2021)
Review
Cell Biology
Ting Lu, Yihua Zhang, Yong Su, Dayan Zhou, Qiang Xu
Summary: Store-operated channels (SOCs) are highly selective Ca2+ channels that mediate Ca2+ influx in various cells. These channels are activated by Ca2+ depletion of the endoplasmic reticulum and sarcoplasmic reticulum, independently of inositol 1,4,5-trisphosphate (InsP3). SOC plays critical roles in endothelial dysfunction and vascular smooth muscle proliferation, contributing to the progression of cardiovascular disease.
CELL COMMUNICATION AND SIGNALING
(2022)
Review
Biochemistry & Molecular Biology
Ningxia Zhang, Hongming Pan, Xiaojing Liang, Jiansheng Xie, Weidong Han
Summary: Store-operated Ca2+ entry (SOCE) is a major calcium signaling pathway that regulates various biological processes. TMEM family proteins, including STIM and ORAI, play essential roles in SOCE. TMEM proteins are a large family of transmembrane proteins that span biological membranes. However, the functional knowledge about TMEM proteins is still limited.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Review
Physiology
Declan Manning, Caroline Dart, Richard L. Evans
Summary: The skin is a complex organ with various functions such as protection, temperature regulation, sensation, immune surveillance, and biochemical functions. Dysfunction in store-operated channels is linked to skin pathologies, and these channels play vital roles in the normal physiology and function of the skin.
FRONTIERS IN PHYSIOLOGY
(2022)
Review
Neurosciences
Pragnya Chakraborty, Gaiti Hasan
Summary: Key components of endoplasmic reticulum (ER) Ca2+ release and store-operated Ca2+ entry (SOCE) are expressed in all metazoan cells. This review presents evidence on how these two mechanisms impact neuronal physiology and their interaction with ion channels in neurons. The careful regulation of neural SOCE is essential due to the detrimental effects of Ca2+ imbalance on neurons. The study also discusses different mechanisms of SOCE regulation in Drosophila and mammalian neurons, and their significance in human neurodegenerative diseases.
JOURNAL OF PHYSIOLOGY-LONDON
(2023)
Review
Cell Biology
Elena Lilliu, Stephane Koenig, Xaver Koenig, Maud Frieden
Summary: This study focuses on the peculiar aspects of skeletal muscle SOCE, differentiating it from its counterpart in non-excitable cells. It explores issues such as SOCE localization, protein movement, diversity of STIM isoforms, and the activation of phasic SOCE during EC coupling. The complexity of SOCE activation and regulation in skeletal muscle is highlighted, with an emphasis on the most recent findings.
Article
Pharmacology & Pharmacy
Xiaoman Yuan, Bin Tang, Yilan Chen, Lijuan Zhou, Jingwen Deng, Lin Han, Yonggong Zhai, Yandong Zhou, Donald L. Gill, Chuanjian Lu, Youjun Wang
Summary: Celastrol, a natural compound, is identified as a novel SOCE inhibitor. It ameliorates skin lesions and reduces PASI scores in psoriasis-like mice by inhibiting Ca2+ entry through its actions on STIM1 and Orai1. These findings suggest that the SOCE pathway may serve as a new druggable target for treating psoriasis.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Multidisciplinary Sciences
Hiroko Nemoto, Masanari Umemura, Fumina Suzuki, Akane Nagasako, Kagemichi Nagao, Yuko Hidaka, Rina Nakakaji, Keiji Uchida, Shinichi Suzuki, Munetaka Masuda, Yoshihiro Ishikawa
Summary: This study investigates the role of ORAI1/SOCE pathway in doxorubicin (DOX)-induced heart failure. The results demonstrate that DOX increases p53 protein expression level in human cardiac fibroblasts (HCFs), leading to apoptosis and cell cycle arrest in fibroblasts. DOX also increases production of reactive oxygen species (ROS) and the expression level of ORAI1 in cardiac fibroblasts. Inhibiting ORAI1/SOCE or knocking down ORAI1 gene attenuates DOX-induced cardiotoxicity. In vivo experiments in mice show that ORAI1/SOCE inhibitor also attenuates DOX-induced apoptosis. Therefore, ORAI1 may serve as a new target for preventing DOX-induced heart failure.
Article
Biochemistry & Molecular Biology
Pao-Huan Chen, Cheng-Chih Chung, Yuan-Feng Lin, Yu-Hsun Kao, Yi-Jen Chen
Summary: The study showed that therapeutic trough levels of lithium can reduce the migration and collagen synthesis abilities of human cardiac fibroblasts by inhibiting SOCE and Orai1 expression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Clinical Neurology
Tania Rizo, Lisa Gebhardt, Julia Riedlberger, Esther Eberhardt, Lars Fester, Dalia Alansary, Jurgen Winkler, Soeren Turan, Philipp Arnold, Barbara A. Niemeyer, Michael J. M. Fischer, Beate Winner
Summary: The study demonstrates that pathogenic variants in the SPAST gene lead to dysregulation of spastin, affecting the dynamics of the endoplasmic reticulum and resulting in aberrant calcium regulation.
Article
Biochemistry & Molecular Biology
Konstantin Gusev, Alexey Shalygin, Dmitrii Kolesnikov, Leonid Shuyskiy, Sofia Makeenok, Lyubov Glushankova, Konstantin Sivak, Kirill Yakovlev, Yana Orshanskaya, Guanghui Wang, Andrey Bakhtyukov, Kira Derkach, Alexander Shpakov, Elena Kaznacheyeva
Summary: Research shows that TRPC6 channels play a crucial role in podocyte function and their dysregulation is associated with kidney diseases. Through single channel patch clamp technique, it is found that TRPC6 channels in human podocytes and rat glomerular podocytes are sensitive to calcium store depletion. In a rat model of DM2, a reduction in store-operated calcium entry was observed in glomerular podocytes, along with a reorganization of calcium influx mediated by TRPC6 channels and ORAI.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cell Biology
Isaac Jardin, Jose J. Lopez, Jose Sanchez-Collado, Luis J. Gomez, Gines M. Salido, Juan A. Rosado
Summary: Cancer stem cells exhibit stemness features and their behavior is influenced by Ca2+ homeostasis and store-operated Ca2+ entry. Understanding the key components of store-operated Ca2+ entry is important for the understanding of cancer stem cell biology and tumorigenesis.
Article
Pharmacology & Pharmacy
Fenglian Zhang, Hanxing Wan, Fenglan Chu, Cheng Lu, Jun Chen, Hui Dong
Summary: This study found that glucose absorption through Na+-glucose co-transporter 1 in mouse upper jejunal epithelium is more efficient in the presence of extracellular Ca2+. Regulatory mechanisms involving Ca(v)1.3 channels, ER Ca2+ release, SOCE, and NCX1 were critical in modulating intestinal glucose uptake via Ca2+ signaling. Targeting these mechanisms in IEC may help regulate blood glucose and sodium levels in metabolic diseases.
BRITISH JOURNAL OF PHARMACOLOGY
(2021)
Review
Neurosciences
Anant B. Parekh
Summary: The house dust mite is a major source of airborne allergens worldwide, and exposure to these allergens can lead to the development of asthma. Mite-derived allergens activate various lung cell types and induce chronic inflammation. This article focuses on the role of CRAC channels in the recognition and signaling pathways of mite-derived allergens, and discusses the potential of targeting CRAC channels as a therapy for mite-induced asthma.
JOURNAL OF PHYSIOLOGY-LONDON
(2023)
Article
Biochemistry & Molecular Biology
Yasuhiro Yonetoku, Hirokazu Kubota, Yoji Miyazaki, Yoshinori Okamoto, Masashi Funatsu, Noriko Yoshimura-Ishikawa, Jun Ishikawa, Taiji Yoshino, Makoto Takeuchi, Mitsuaki Ohta
BIOORGANIC & MEDICINAL CHEMISTRY
(2008)
Article
Pharmacology & Pharmacy
Keiko Ohga, Sadao Kuromitsu, Ryuichi Takezawa, Mako Numazaki, Jun Ishikawa, Shinya Nagashima, Yasuaki Shimizu
EUROPEAN JOURNAL OF PHARMACOLOGY
(2008)
Article
Pharmacology & Pharmacy
Keiko Ohga, Ryuichi Takezawa, Taiji Yoshino, Toshimitsu Yamada, Yasuaki Shimizu, Jun Ishikawa
PULMONARY PHARMACOLOGY & THERAPEUTICS
(2008)
Article
Pharmacology & Pharmacy
Taiji Yoshino, Jun Ishikawa, Keiko Ohga, Tatsuaki Morokata, Ryuichi Takezawa, Hiroki Morio, Youhei Okada, Kazuo Honda, Toshimitsu Yamada
EUROPEAN JOURNAL OF PHARMACOLOGY
(2007)
Article
Biochemistry & Molecular Biology
Yasuhiro Yonetoku, Hirokazu Kubota, Yoshinori Okamoto, Jun Ishikawa, Makoto Takeuchi, Mitsuaki Ohta, Shin-ichi Tsukamoto
BIOORGANIC & MEDICINAL CHEMISTRY
(2006)
Article
Biochemistry & Molecular Biology
Y Yonetoku, H Kubota, Y Okamoto, A Toyoshima, M Funatsu, J Ishikawa, M Takeuchi, M Ohta, S Tsukamoto
BIOORGANIC & MEDICINAL CHEMISTRY
(2006)
Article
Pharmacology & Pharmacy
R Takezawa, H Cheng, A Beck, J Ishikawa, P Launay, H Kubota, JP Kinet, A Fleig, T Yamada, R Penner
MOLECULAR PHARMACOLOGY
(2006)
Article
Immunology
T Morokata, K Suzuki, K Ida, H Tsuchiyama, J Ishikawa, T Yamada
INTERNATIONAL IMMUNOPHARMACOLOGY
(2004)
Article
Immunology
J Ishikawa, K Ohga, T Yoshino, R Takezawa, A Ichikawa, H Kubota, T Yamada
JOURNAL OF IMMUNOLOGY
(2003)
Article
Pharmacology & Pharmacy
M Aoki, M Kobayashi, J Ishikawa, Y Saita, Y Terai, K Takayama, K Miyata, T Yamada
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
(2000)
Article
Immunology
T Morokata, J Ishikawa, T Yamada
IMMUNOLOGY LETTERS
(2000)
Article
Pharmacology & Pharmacy
J Ishikawa, Y Okada, IN Bird, B Jasani, JH Spragg, T Yamada
JAPANESE JOURNAL OF PHARMACOLOGY
(2002)
Article
Immunology
Jun Cui, Cheng Chen, Xiao Zhou, Wenju Shan, Yuhong Jian, Panpan Li, Yang Sun, Wei Yi
Summary: Bone marrow mesenchymal stem cells (BMSCs) are a promising therapy for sepsis, but metabolic syndromes threaten their effectiveness. This study investigated the potential of small extracellular vesicles from high-fat diet BMSCs in sepsis-induced liver-heart axis injury.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Binbin Zhu, Angyang Cao, Chunqu Chen, Weijian Zhou, Wenjun Luo, Yu Gui, Qinwen Wang, Zhipeng Xu, Jianhua Wang
Summary: GM6001 alleviates postoperative cognitive deficits and neuroinflammation, preserves blood-brain barrier integrity, and rescues aquaporin-4 mislocalization. MMP-9 inhibition plays a dual role in cognitive protection through direct anti-neuroinflammatory effects and regulation of aquaporin-4 membrane distribution.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Anika Sood, Valencia Fernandes, Kumari Preeti, Shruti Rajan, Dharmendra Kumar Khatri, Shashi Bala Singh
Summary: S1PR2 inhibitor improves cognitive function and skews microglia toward anti-inflammatory phenotype in type 2 diabetic mice, promising to be a potential therapy for neuroinflammation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Haochun Guo, Ran Yu, Haijun Zhang, Wanpeng Wang
Summary: Radiation therapy is an effective treatment for thoracic malignancies, but it can cause radiation-induced lung injury (RILI), including radiation pneumonitis (RP) and radiation pulmonary fibrosis (RPF). The damage to normal lung cells during radiation treatment leads to a pulmonary inflammatory response, resulting in RP and RPF.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Guanghui Wang, Haotian Zheng, Yunzhi Xiang, Yadong Wang, Kai Wang, Xiaoyang Ren, Jiajun Du
Summary: This study identified a T-cell synthetic driver-associated prognostic model that accurately predicted prognosis and effectiveness of immunotherapy in LUAD patients. It also highlighted the role of LDHA in promoting tumor cell proliferation, invasion, and resistance to treatment, as well as its involvement in immune escape within the tumor microenvironment. These findings provide a promising new therapeutic strategy for LUAD.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Bowen Wei, Aihua Wang, Wei Liu, Qingyun Yue, Yihua Fan, Bin Xue, Siwei Wang
Summary: This study systematically analyzed the association between pSS and cuproptosis, established a predictive model based on 5 genes, explored the pathogenic mechanisms and novel therapeutic strategies for pSS, and identified EED, CBL, and NFU1 as potential targets for treatment.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Nusrit Iqbal Andrabi, Aminur R. Sarkar, Syed Assim Haq, Diljeet Kumar, Dilpreet Kour, Diksha Saroch, Sanket Kumar Shukla, Ajay Kumar, Asha Bhagat, Asif Ali, Gurleen Kour, Zabeer Ahmed
Summary: Koenimbine and its novel semi-synthetic derivative 1G demonstrate significant anti-inflammatory effects by downregulating the nuclear factor kappa-B (NF-kappa B) signaling pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Jing-Mei Lu, Xiang Xu, Fumie Aosai, Ming-Yue Zhang, Lian-Xun Piao
Summary: This study found that arctiin can improve allergic acute liver injury caused by T.g.HSP70 by inhibiting TLR4 signaling and reducing the production of inflammatory mediators.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Minxuan Xu, Fang Shi, Yongshen Gao, Shumei Han, Chensuo Huang, Qinsheng Hou, Xiaoweng Wen, Bengshi Wang, Zhenyu Zhu, Lei Zou, Mingxin Xiong, Wei Dong, Jun Tan
Summary: There is a growing body of research highlighting the involvement of metabolic imbalance and the inflammatory response in the advancement of colitis. This study recognizes arabinose as a significant protector of the intestinal mucosal barrier, reducing damage to the intestines. In addition, lower levels of arabinose in the bloodstream are associated with a higher severity of inflammatory bowel disease and colorectal cancer.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yueqing Han, Haoxin Song, Yanshan Li, Rongxin Li, Ling Chen, Bo Gao, Yijun Chen, Shuzhen Wang
Summary: The combination of tetracycline antibiotics, demeclocycline (D), chlortetracycline (C), and minocycline (M), showed therapeutic potential against liver fibrosis by inhibiting the activation of hepatic stellate cells and the MAPK signaling. This study suggests that tetracyclines may be repurposed for the treatment of liver fibrosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yu Li, Hailing Liu, Danwen Zhao, Danjie Zhang
Summary: Chronic stress can lead to lung injury, with the spleen playing a crucial role. This study found that the spleen contributes to chronic restraint stress-induced lung injury, and splenic CD11b+ cells may be an important factor in this process.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yingqian Mi, Mengyan Tang, Qiong Wu, Yinan Wang, Qihui Liu, Pei Zhu, Xiaoyang Xue, Yuntong Liu, Xinyu Chai, Yuyang Hou, Dongmei Yan
Summary: BCG therapy can induce macrophage polarization to the M1 type, and NMAAP1 plays a crucial role in this process by regulating glycolysis and HIF-1α expression. This promotes the antitumor effect of macrophages.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Xiaosheng Liu, Tingxia Lv, Xiuxia Li, Jing Xue, Ling Lin, Lianfeng Lu, Xiaodi Li, Yang Yang, Yuanni Wu, Qiang Wei, Wei Cao, Taisheng Li
Summary: LLDT-8 exhibits notable efficacy in alleviating immune activation in both an in vivo animal model and in vitro human cell experiments, suggesting its potential as a drug for managing systemic immune activation associated with SIV/HIV infection.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Honghong Yu, Qi Li, Huimin Zhu, Chang Liu, Weiwei Chen, Lingyun Sun
Summary: The activation of the inflammasome plays a critical role in the pathogenesis of systemic lupus erythematosus (SLE), and mesenchymal stem cells (MSC) have been shown to alleviate SLE by suppressing inflammasome activation. This study found that the NLRP3 inflammasome was activated in macrophages from SLE patients and mice, and its activation correlated with disease activity. After MSC transplantation, the severity of SLE was reduced, and NLRP3 inflammasome activation was inhibited. These findings suggest that MSC suppress inflammasome activation and provide a potential therapeutic target for SLE.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Wei Zhou, Dan Zeng, Shunan Liu, Yunxia Huang, Fenglin Lv, Weikang Zhou
Summary: This study found that inhibiting HDAC3 can protect the skin from atopic dermatitis by activating the Nrf2 transcription to upregulate Nrf2/HO-1 signaling pathway activity.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)