Article
Immunology
Javier Marin-Prida, Nancy Pavon-Fuentes, Nielsen Lagumersindez-Denis, Hanlet Camacho-Rodriguez, Ana Margarita Garcia-Soca, Rocio De La Caridad Sarduy-Chavez, Erica Leandro Marciano Vieira, Juliana Carvalho-Tavares, Viviana Falcon-Cama, Julio Raul Fernandez-Masso, Ignacio Hernandez-Gonzalez, Gillian Martinez-Donato, Gerardo Guillen-Nieto, Eduardo Penton-Arias, Mauro Martins Teixeira, Giselle Penton-Rol
Summary: In this study, the potential benefits and mechanisms of action of Phycocyanobilin (PCB) in combating chronic experimental autoimmune encephalomyelitis (EAE), a nonclinical model of multiple sclerosis (MS), were evaluated. The study found that PCB can improve neurological symptoms, reduce inflammatory cytokine levels, and regulate relevant genes at the genetic level. In addition, PCB can reduce demyelination, decrease neuronal damage, and promote the generation of oligodendrocyte precursor cells. The combination of PCB with Interferon-beta (IFN-beta) showed better therapeutic effects.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, Research & Experimental
Alba Sanchez-Fernandez, Stephanie Zandee, Jesus Amo-Aparicio, Marc Charabati, Alexandre Prat, Cecilia Garlanda, Elan Z. Eisenmesser, Charles A. Dinarello, Ruben Lopez-Vales
Summary: This study demonstrates that IL-37 reduces inflammation and protects against neurological deficits and myelin loss in EAE mice by acting via IL1-R5/IL1-R8. Administration of recombinant human IL-37 exerts therapeutic actions in EAE mice, but IL-37 transcripts are not up-regulated in peripheral blood mononuclear cells and brain lesions of MS patients.
Article
Medicine, Research & Experimental
Arezoo Hosseini, Tohid Gharibi, Adel Mohammadzadeh, Abbas Ebrahimi-Kalan, Farhad Jadidi-niaragh, Zohreh Babaloo, Dariush Shanehbandi, Elham Baghbani, Behzad Baradaran
Summary: Ruxolitinib ameliorated the severity of EAE by modulating the balance between Th17 cells and Tregs, reducing inflammatory markers levels and increasing levels of anti-inflammatory cytokines.
Article
Immunology
Barbara Rossi, Silvia Dusi, Gabriele Angelini, Alessandro Bani, Nicola Lopez, Vittorina Della Bianca, Enrica Caterina Pietronigro, Elena Zenaro, Carlotta Zocco, Gabriela Constantin
Summary: Study found that leptomeningeal vessels in the subarachnoid space serve as a central route for T cells to enter the CNS during EAE. Alpha 4 beta 7 integrin plays a key role in Th17 cell migration, and blocking it can attenuate the clinical severity of the disease and reduce neuroinflammation.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Clinical Neurology
Vittoria Borgonetti, Maria Domenica Sanna, Laura Lucarini, Nicoletta Galeotti
Summary: This study revealed that targeting HuR in experimental autoimmune encephalomyelitis (EAE) mice could reduce inflammation, restore blood-brain barrier permeability, promote a shift in microglia phenotype from proinflammatory to anti-inflammatory and regenerative, and improve EAE-related motor dysfunction, pain hypersensitivity, and body weight loss. Targeting HuR might be a promising approach to control neurological disturbances in multiple sclerosis patients.
Review
Neurosciences
Sofia Pereira das Neves, Joao Carlos Sousa, Nuno Sousa, Joao Jose Cerqueira, Fernanda Marques
Summary: Multiple sclerosis is a chronic inflammatory disease of the central nervous system that affects about 2.5 million people worldwide. There is currently no cure for MS and the available treatments only slow the initial phases of the disease. Disease progression and disability in MS are better correlated with the maintenance of a persistent low-grade inflammation inside the CNS, driven by local glial cells like astrocytes.
Article
Biochemistry & Molecular Biology
Nozomi Sachi, Naganori Kamiyama, Benjawan Saechue, Sotaro Ozaka, Astri Dewayani, Shimpei Ariki, Thanyakorn Chalalai, Yasuhiro Soga, Chiaki Fukuda, Yomei Kagoshima, Supanuch Ekronarongchai, Takashi Kobayashi
Summary: Multiple sclerosis is an autoimmune disease characterized by immune attack on the nerve myelin sheath. The balance between pathogenic Th17 cells and regulatory Treg cells, expressing chemokine receptor CCR6, is crucial in determining disease activity. The role of CCL20, the ligand of CCR6, in attracting immune cells to the central nervous system (CNS) in multiple sclerosis has not been fully understood. This study generated CCL20-knockout and CCR6-knockout mice using CRISPR/Cas9 system and found that the migratory function mediated by CCL20/CCR6 may not be necessary for the onset of experimental autoimmune encephalomyelitis (EAE).
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Review
Neurosciences
Taekyun Shin, Meejung Ahn, Jeongtae Kim, Kyungsook Jung, Changjong Moon, Moon-Doo Kim
Summary: Visual disabilities are important symptoms in central nervous system autoimmune diseases such as multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE). Past studies have focused on neuro-inflammatory changes in the white matter of the brain, but lesions have been found in the visual pathway and retina/optic nerves. While retina and optic nerves are immunologically privileged sites, inflammation can occur via other routes.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Chiara Camponeschi, Maria De Carluccio, Susanna Amadio, Maria Elisabetta Clementi, Beatrice Sampaolese, Cinzia Volonte, Maria Tredicine, Vincenzo Romano Spica, Rosa Di Liddo, Francesco Ria, Fabrizio Michetti, Gabriele Di Sante
Summary: The study demonstrated a direct correlation between S100B and inflammatory processes, and investigated the effect of AA on a mouse model of multiple sclerosis by inhibiting astrocytic S100B synthesis. The results showed that the AA-treated group had milder symptoms in the early phase of the disease and reduced various pathological features.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Clinical Neurology
Marina Boziki, Paschalis Theotokis, Evangelia Kesidou, Eleni Karafoulidou, Chrystalla Konstantinou, Iliana Michailidou, Yasemin Bahar, Ayse Altintas, Nikolaos Grigoriadis
Summary: Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS) with a neurodegenerative component. Age plays a role in the disease phenotype and progression, as well as the transition from relapsing-remitting MS (RRMS) to secondary progressive disease. Sex also influences disease phenotype and immune system in both humans and animal models. This review focuses on the effects of sex and aging on MS phenotype, immune system, and CNS, using experimental autoimmune encephalomyelitis (EAE) models.
FRONTIERS IN NEUROLOGY
(2023)
Article
Biochemistry & Molecular Biology
Dafni Birmpili, Imane Charmarke Askar, Lucas Dinh Pham-Van, Thomas Kuntzel, Caroline Spenle, Aurelien Riou, Dominique Bagnard
Summary: In this study, a molecular RNA signature for each phase of multiple sclerosis (MS) was established using the EAE-PLP animal model. By comparing variances of expression of known biomarkers, the study provides insights into the disease features. The research is important for understanding the pathophysiological processes and finding clinically relevant biomarkers of MS.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Goran Stegnjaic, Milica Lazarevic, Dimitrios A. Diamantis, Neda Djedovic, Bojan Jevtic, Suzana Stanisavljevic, Mirjana Dimitrijevic, Miljana Momcilovic, Andreas G. Tzakos, Dorde Miljkovic
Summary: This study evaluated the immunomodulatory properties of a phenethyl ester derivative of rosmarinic acid (PERA) in an animal model of central nervous system autoimmunity. PERA was found to have anti-encephalitogenic effects by shortening disease duration and reducing clinical scores, as well as inhibiting the production of encephalitogenic cytokines and nitric oxide. The study suggests that PERA could be a potential therapy for multiple sclerosis.
IMMUNOLOGY LETTERS
(2022)
Article
Chemistry, Medicinal
Gareth Pryce, Sofia Sisay, Gavin Giovannoni, David L. Selwood, David Baker
Summary: The study found that BK channel openers have neuroprotective effects and can inhibit nerve loss and disability caused by autoimmune diseases. This could make them potential stand-alone neuroprotective agents or add-ons to treat multiple sclerosis.
Review
Cell Biology
Maria Concetta Geloso, Nadia D'Ambrosi
Summary: Microglia can rapidly respond to environmental changes and play a role in shaping neuronal wiring. They regulate the elimination of weaker synapses, actively participating in modulating neuronal function. Synaptic dysfunction may be an early and independent event in the neurodegenerative process associated with diseases like multiple sclerosis.
Review
Immunology
Donghui Shen, Kang Liu, Hongyan Wang, Haifeng Wang
Summary: Autophagy plays a significant role in both protective and detrimental effects in multiple sclerosis (MS). Targeting autophagy may be a potential therapeutic approach, but further studies are needed to determine its mechanisms.
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
(2022)
Article
Infectious Diseases
Angelica da Conceicao Oliveira Coelho Fabri, Ana Paula Mendes Carvalho, Sergio Araujo, Luiz Ricardo Goulart, Ana Marcia Menezes de Mattos, Henrique Couto Teixeira, Isabela Maria Bernardes Goulart, Malcolm S. Duthie, Rodrigo Correa-Oliveira, Francisco Carlos Felix Lana
BMC INFECTIOUS DISEASES
(2015)
Article
Infectious Diseases
Alexandre Silva Chaves, Michele Fernandes Rodrigues, Ana Marcia Menezes Mattos, Henrique Couto Teixeira
BRAZILIAN JOURNAL OF INFECTIOUS DISEASES
(2015)
Article
Rheumatology
Herval de Lacerda Bonfante, Caroline de Souza Almeida, Clarice Abramo, Sabrine Teixeira Ferraz Grunewald, Roger Abramino Levy, Henrique Couto Teixeira
INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES
(2017)
Article
Surgery
Sabrine Teixeira Ferraz Grunewald, Alice Belleigoli Rezende, Barbara Bruna Muniz Figueiredo, Ana Carolina de Paula Mendonca, Caroline de Souza Almeida, Erick Esteves de Oliveira, Flavia de Paoli, Henrique Couto Teixeira
JOURNAL OF INVESTIGATIVE SURGERY
(2017)
Article
Immunology
Ana Marcia Menezes Mattos, Alexandre Silva Chaves, Kees L. M. C. Franken, Barbara Bruna Muniz Figueiredo, Ana Paula Ferreira, Tom H. M. Ottenhoff, Henrique Couto Teixeira
Article
Public, Environmental & Occupational Health
A. M. F. Matos, A. C. O. Coelho, L. P. T. Araujo, M. J. M. Alves, O. S. Baquero, M. S. Duthie, H. C. Teixeira
EPIDEMIOLOGY AND INFECTION
(2018)
Article
Parasitology
Pedro Henrique Ferreira Marcal, Lucia Alves de Oliveira Fraga, Ana Marcia Menezes de Mattos, Laura Menegati, Angelica da Conceicao Oliveira Coelho, Roberta Olmo Pinheiro, Euzenir Nunes Sarno, Malcolm S. Duthie, Henrique Couto Teixeira
MEMORIAS DO INSTITUTO OSWALDO CRUZ
(2018)
Article
Biochemistry & Molecular Biology
R. Domingues, S. Wohlres-Viana, D. R. L. Reis, H. C. Teixeira, A. P. Ferreira, S. E. F. Guimaraes, M. C. A. Prata, J. Furlong, R. S. Verneque, M. A. Machado
GENETICS AND MOLECULAR RESEARCH
(2014)
Article
Multidisciplinary Sciences
Patricia P. Corsetti, Leonardo A. de Almeida, Natalia B. Carvalho, Vasco Azevedo, Teane M. A. Silva, Henrique C. Teixeira, Ana C. Faria, Sergio C. Oliveira
Article
Multidisciplinary Sciences
Caio Cesar de Souza Alves, Adam Collison, Luke Hatchwell, Maximilian Plank, Matthew Morten, Paul S. Foster, Sebastian L. Johnston, Cristiane Franca da Costa, Mauro Vieira de Almeida, Henrique Couto Teixeira, Ana Paula Ferreira, Joerg Mattes
Article
Medicine, General & Internal
Kyssia Karen de Paiva e Silva, Erick Esteves de Oliveira, Carolina Martins Moreira Elias, Ingrid Estevam Pereira, Roberta Olmo Pinheiro, Euzenir Nunes Sarno, Malcolm Scott Duthie, Henrique Couto Teixeira
Summary: This study found that multibacillary leprosy patients had elevated serum IgA responses, while paucibacillary patients showed increased IgA reactivity mainly to NDO-HSA. Household contacts also exhibited higher IgA responses to NDO-HSA, suggesting that measuring serum IgA against NDO-HSA could be a useful tool for diagnosis and classification of leprosy.
FRONTIERS IN MEDICINE
(2021)
Article
Microbiology
Ingrid E. Pereira, Kyssia P. Silva, Laura M. Menegati, Aimara C. Pinheiro, Elaine A. O. Assuncao, Maria De Lourdes P. Araujo, Elfadil Abass, Malcolm S. Duthie, Ulrich Steinhoff, Henrique C. Teixeira
EUROPEAN JOURNAL OF MICROBIOLOGY AND IMMUNOLOGY
(2020)
Article
Biochemistry & Molecular Biology
A. C. C. Gouveia, F. G. Braga, M. Mota, F. M. C. Silva, A. S. S. Brugiolo, E. E. Oliveira, M. C. Ayupe, H. C. Teixeira, A. P. Ferreira
Article
Immunology
F. M. C. Silva, E. E. Oliveira, A. C. C. Gouveia, A. S. S. Brugiolo, C. C. Alves, J. O. A. Correa, J. Gameiro, J. Mattes, H. C. Teixeira, A. P. Ferreira
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
(2017)
Article
Parasitology
Lily P. Martinez Abad, Caroline S. Almeida, Ana Marcia M. Mattos, Ana Carolina P. Mendonca, Marcio J. M. Alves, Aimara C. Pinheiro, Renato Porrozzi, Elfadil Abass, Ulrich Steinhoff, Henrique C. Teixeira
Article
Immunology
Jun Cui, Cheng Chen, Xiao Zhou, Wenju Shan, Yuhong Jian, Panpan Li, Yang Sun, Wei Yi
Summary: Bone marrow mesenchymal stem cells (BMSCs) are a promising therapy for sepsis, but metabolic syndromes threaten their effectiveness. This study investigated the potential of small extracellular vesicles from high-fat diet BMSCs in sepsis-induced liver-heart axis injury.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Binbin Zhu, Angyang Cao, Chunqu Chen, Weijian Zhou, Wenjun Luo, Yu Gui, Qinwen Wang, Zhipeng Xu, Jianhua Wang
Summary: GM6001 alleviates postoperative cognitive deficits and neuroinflammation, preserves blood-brain barrier integrity, and rescues aquaporin-4 mislocalization. MMP-9 inhibition plays a dual role in cognitive protection through direct anti-neuroinflammatory effects and regulation of aquaporin-4 membrane distribution.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Anika Sood, Valencia Fernandes, Kumari Preeti, Shruti Rajan, Dharmendra Kumar Khatri, Shashi Bala Singh
Summary: S1PR2 inhibitor improves cognitive function and skews microglia toward anti-inflammatory phenotype in type 2 diabetic mice, promising to be a potential therapy for neuroinflammation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Haochun Guo, Ran Yu, Haijun Zhang, Wanpeng Wang
Summary: Radiation therapy is an effective treatment for thoracic malignancies, but it can cause radiation-induced lung injury (RILI), including radiation pneumonitis (RP) and radiation pulmonary fibrosis (RPF). The damage to normal lung cells during radiation treatment leads to a pulmonary inflammatory response, resulting in RP and RPF.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Guanghui Wang, Haotian Zheng, Yunzhi Xiang, Yadong Wang, Kai Wang, Xiaoyang Ren, Jiajun Du
Summary: This study identified a T-cell synthetic driver-associated prognostic model that accurately predicted prognosis and effectiveness of immunotherapy in LUAD patients. It also highlighted the role of LDHA in promoting tumor cell proliferation, invasion, and resistance to treatment, as well as its involvement in immune escape within the tumor microenvironment. These findings provide a promising new therapeutic strategy for LUAD.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Bowen Wei, Aihua Wang, Wei Liu, Qingyun Yue, Yihua Fan, Bin Xue, Siwei Wang
Summary: This study systematically analyzed the association between pSS and cuproptosis, established a predictive model based on 5 genes, explored the pathogenic mechanisms and novel therapeutic strategies for pSS, and identified EED, CBL, and NFU1 as potential targets for treatment.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Nusrit Iqbal Andrabi, Aminur R. Sarkar, Syed Assim Haq, Diljeet Kumar, Dilpreet Kour, Diksha Saroch, Sanket Kumar Shukla, Ajay Kumar, Asha Bhagat, Asif Ali, Gurleen Kour, Zabeer Ahmed
Summary: Koenimbine and its novel semi-synthetic derivative 1G demonstrate significant anti-inflammatory effects by downregulating the nuclear factor kappa-B (NF-kappa B) signaling pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Jing-Mei Lu, Xiang Xu, Fumie Aosai, Ming-Yue Zhang, Lian-Xun Piao
Summary: This study found that arctiin can improve allergic acute liver injury caused by T.g.HSP70 by inhibiting TLR4 signaling and reducing the production of inflammatory mediators.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Minxuan Xu, Fang Shi, Yongshen Gao, Shumei Han, Chensuo Huang, Qinsheng Hou, Xiaoweng Wen, Bengshi Wang, Zhenyu Zhu, Lei Zou, Mingxin Xiong, Wei Dong, Jun Tan
Summary: There is a growing body of research highlighting the involvement of metabolic imbalance and the inflammatory response in the advancement of colitis. This study recognizes arabinose as a significant protector of the intestinal mucosal barrier, reducing damage to the intestines. In addition, lower levels of arabinose in the bloodstream are associated with a higher severity of inflammatory bowel disease and colorectal cancer.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yueqing Han, Haoxin Song, Yanshan Li, Rongxin Li, Ling Chen, Bo Gao, Yijun Chen, Shuzhen Wang
Summary: The combination of tetracycline antibiotics, demeclocycline (D), chlortetracycline (C), and minocycline (M), showed therapeutic potential against liver fibrosis by inhibiting the activation of hepatic stellate cells and the MAPK signaling. This study suggests that tetracyclines may be repurposed for the treatment of liver fibrosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yu Li, Hailing Liu, Danwen Zhao, Danjie Zhang
Summary: Chronic stress can lead to lung injury, with the spleen playing a crucial role. This study found that the spleen contributes to chronic restraint stress-induced lung injury, and splenic CD11b+ cells may be an important factor in this process.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yingqian Mi, Mengyan Tang, Qiong Wu, Yinan Wang, Qihui Liu, Pei Zhu, Xiaoyang Xue, Yuntong Liu, Xinyu Chai, Yuyang Hou, Dongmei Yan
Summary: BCG therapy can induce macrophage polarization to the M1 type, and NMAAP1 plays a crucial role in this process by regulating glycolysis and HIF-1α expression. This promotes the antitumor effect of macrophages.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Xiaosheng Liu, Tingxia Lv, Xiuxia Li, Jing Xue, Ling Lin, Lianfeng Lu, Xiaodi Li, Yang Yang, Yuanni Wu, Qiang Wei, Wei Cao, Taisheng Li
Summary: LLDT-8 exhibits notable efficacy in alleviating immune activation in both an in vivo animal model and in vitro human cell experiments, suggesting its potential as a drug for managing systemic immune activation associated with SIV/HIV infection.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Honghong Yu, Qi Li, Huimin Zhu, Chang Liu, Weiwei Chen, Lingyun Sun
Summary: The activation of the inflammasome plays a critical role in the pathogenesis of systemic lupus erythematosus (SLE), and mesenchymal stem cells (MSC) have been shown to alleviate SLE by suppressing inflammasome activation. This study found that the NLRP3 inflammasome was activated in macrophages from SLE patients and mice, and its activation correlated with disease activity. After MSC transplantation, the severity of SLE was reduced, and NLRP3 inflammasome activation was inhibited. These findings suggest that MSC suppress inflammasome activation and provide a potential therapeutic target for SLE.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Wei Zhou, Dan Zeng, Shunan Liu, Yunxia Huang, Fenglin Lv, Weikang Zhou
Summary: This study found that inhibiting HDAC3 can protect the skin from atopic dermatitis by activating the Nrf2 transcription to upregulate Nrf2/HO-1 signaling pathway activity.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
