Review
Medicine, General & Internal
Wen-Ming Wang, Feng Li, Hong-Zhong Jin
Summary: Psoriasis is a chronic inflammatory disease where TLRs, IRFs, and type I IFNs play important roles in its pathogenesis. These factors interact with each other, regulating the development of psoriasis.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Anette Christ, Pieter G. Goossens, Erwin Wijnands, Han Jin, Bart Legein, Tammy Oth, Aaron Isaacs, Monika Stoll, Joris Vanderlocht, Esther Lutgens, Mat J. A. P. Daemen, Martin Zenke, Erik A. L. Biessen
Summary: Hyperlipidemia significantly affects the activation and immune response of pDCs, particularly in response to pathogen-derived signals.
Article
Biochemistry & Molecular Biology
Zhen Gan, Jun Cheng, Jing Hou, Liqun Xia, Yishan Lu, Pin Nie
Summary: The study identified a homologous IRF1 gene named Xt-IRF1 in amphibians, which has similar genomic structure and flanking genes, and shows inducible expression under various stimulations.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Endocrinology & Metabolism
Ting Yao, Hongmei Yan, Xiaopeng Zhu, Qiongyue Zhang, Xingyu Kong, Shanshan Guo, Yonghao Feng, Hui Wang, Yinghui Hua, Jing Zhang, Steven D. Mittelman, Peter Tontonoz, Zhenqi Zhou, Tiemin Liu, Xingxing Kong
Summary: The study reveals that increased levels of interferon regulatory factor 4 (IRF4) in skeletal muscle are associated with obesity. Mice with specific IRF4 loss in skeletal muscle showed protection against the metabolic effects of high-fat diet. IRF4 regulates skeletal muscle metabolism through the upregulation of mitochondrial branched-chain aminotransferase (BCATm) expression.
Article
Biochemistry & Molecular Biology
Katarzyna Kurianowicz, Maria Klatka, Agnieszka Polak, Anna Hymos, Dominika Bebnowska, Martyna Podgajna, Rafal Hrynkiewicz, Olga Sierawska, Paulina Niedzwiedzka-Rystwej
Summary: This study found significant differences in the expression levels of TLR2, TLR4, and TLR9 in early stage and chronically treated DM1 patients compared to healthy controls. Additionally, differences were observed in the numbers of CD19+ B cells, CD3+ CD4+, CD3+ CD8+ T cells and NK cells among newly diagnosed DM1 individuals, chronic patients, and healthy controls. Higher levels of IL-10 were also found in newly diagnosed DM1 patients, consistent with existing literature reports.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Grzegorz Chodaczek, Philippe P. Pagni, Gustaf Christoffersson, Sowbarnika S. Ratliff, Monika Toporkiewicz, Agnieszka S. Wegrzyn, Matthias von Herrath
Summary: In this study, Treg dynamics were modulated using Toll-like receptor agonists, revealing that Tregs show enhanced migration towards TLR2 signals. This finding may have implications for clinical Treg induction protocols.
JOURNAL OF AUTOIMMUNITY
(2021)
Article
Biochemistry & Molecular Biology
Lei Zhang, Guangshuai Liu, Tian Xia, Xiufeng Yang, Guolei Sun, Chao Zhao, Chunzhu Xu, Honghai Zhang
Summary: The study analyzed TLR genes from the genomes and transcriptomes of 102 amphibian species to understand their evolutionary patterns. Results showed that TLR genes can be divided into seven subfamilies, with TLR4 subfamily found only in Anura. Purification selection played a leading role in amphibian TLR evolution, and different domains had different evolution rates. Positive selection patterns and single-nucleotide polymorphisms were observed in TLR genes.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Review
Immunology
Mridu Acharya, Shaun W. Jackson
Summary: This article introduces the evolutionary mechanisms that control the abnormal activation of endosomal Toll-like receptors, emphasizing the crucial role of B cells in the pathogenesis of systemic lupus erythematosus and how modulation of B cell endolysosomal flux tunes NA-sensing TLR activation signals.
IMMUNOLOGICAL REVIEWS
(2022)
Article
Food Science & Technology
Misa Nakasuji-Togi, Sumihito Togi, Keita Saeki, Yasuhiko Kojima, Keiko Ozato
Summary: The study found that the internatural (INT) mixture can induce type I interferons (IFNs) in murine bone marrow-derived macrophages (BMDMs) to enhance the body's immunity. This induction is mediated by the Toll-like receptor 4 (TLR4) pathway. The supernatants from INT-treated cells also displayed antiviral activity.
FOOD & NUTRITION RESEARCH
(2022)
Review
Chemistry, Multidisciplinary
Xin Zhi, Peipei Yang, Yunxue Xu, Zhifei Dai, Xiuli Yue, Linxue Qian
Summary: This review discusses the functions of Toll-like receptors (TLRs) in the tumor microenvironment and the pathways that activate immune responses. It also summarizes recent developments in nanotechnology for immunomodulation with TLR agonists. Nanotechnology can improve the efficacy of TLR agonist-based immunotherapy and address its limitations.
Review
Biochemistry & Molecular Biology
Yuan-Tung Chu, Min-Tser Liao, Kuo-Wang Tsai, Kuo-Cheng Lu, Wan-Chung Hu
Summary: A comprehensive framework has been established to understand immunological pathways, and specific associations between immune responses and immune receptors have been identified. These findings contribute to the identification of biomarkers for immune cells and provide insights into host immunological pathways.
Article
Microbiology
Jun Kang, Mengqian Huang, Jinyu Li, Keke Zhang, Cheng Zhu, Sihua Liu, Zhenwei Zhou, Tao Wang, Zhiyun Wang
Summary: EV-D68 is a globally emerging pathogen causing severe respiratory illnesses mainly in children. The structural protein VP3 of EV-D68 interacts with IRF7 and inhibits its phosphorylation and nuclear translocation, resulting in the repression of IFN production. VP3 also inhibits the ubiquitination of IRF7 induced by TRAF6 through competitive interaction. The control of IRF7 by VP3 may contribute to the subversion of host innate immune responses by EV-D68.
MICROBIOLOGY SPECTRUM
(2023)
Article
Oncology
Yihe Yan, Leting Zheng, Qiang Du, Xiao Cui, Kun Dong, Yarong Guo, David A. Geller
Summary: CHK1 is overexpressed in human HCC tumors compared to non-cancerous liver, and high CHK1 predicts worse prognosis. IFN-gamma suppresses CHK1 in HCC cells through IRF-1, leading to apoptosis. Upregulated IRF-1 induces miR-195 to suppress CHK1 and promote cellular apoptosis in HCC.
BRITISH JOURNAL OF CANCER
(2021)
Article
Immunology
Guadalupe Rivera-Torruco, Carolina A. Martinez-Mendiola, Tania Angeles-Floriano, Gustavo Alberto Jaimes-Ortega, Jose Luis Maravillas-Montero, Rodolfo Garcia-Contreras, Yolanda Gonzalez, Esmeralda Juarez, Porfirio Nava, Vianney Ortiz-Navarrete, Oscar Medina-Contreras, Paula Licona-Limon, Ricardo Valle-Rios
Summary: The process of blood cell generation and the role of lung as a significant source of hematopoietic progenitors have been investigated. A study identified ISM1 as a novel biomarker associated with progenitor-like cells in the lung. ISM1(+) cells were shown to be enriched in short-term hematopoietic stem cells and were affected in a mouse model of bacterial infection. These findings suggest a potential link between ISM1-producing cells and dangerous inflammatory responses.
JOURNAL OF IMMUNOLOGY RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Xiaoqin Tang, Qian Xu, Shuo Yang, Xinwu Huang, Long Wang, Feihong Huang, Jiesi Luo, Xiaogang Zhou, Anguo Wu, Qibing Mei, Chunling Zhao, Jianming Wu
Summary: Platelets, as the second most abundant blood component, play a crucial role in various physiological and pathological functions. In addition to its traditional role in hemostasis and thrombosis, platelets also have an indispensable role in inflammatory diseases. Thrombocytopenia, a common hematologic problem, is closely related to the fatality of many diseases, highlighting the significance of its prevention and treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Young San Ko, Sung Jin Cho, Jinju Park, Younghoon Kim, Yong Joon Choi, Jung-Soo Pyo, Bo Gun Jang, Jong-Wan Park, Woo Ho Kim, Byung Lan Lee
BRITISH JOURNAL OF CANCER
(2015)
Article
Oncology
Dong Hoon Shin, Yong-Joon Choi, Peng Jin, Haejin Yoon, Yang-Sook Chun, Hyun-Woo Shin, Ja-Eun Kim, Jong-Wan Park
Article
Oncology
Yong-Joon Choi, Hyun-Woo Shin, Yang-Sook Chun, Alain Simplice Leutou, Byeng Wha Son, Jong-Wan Park
Article
Biochemistry & Molecular Biology
Ji-Hong Lim, Yoon-Mi Lee, Gibok Lee, Yong-Joon Choi, Beong-Ou Lim, Young Jun Kim, Dong-Kug Choi, Jong-Wan Park
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2014)
Article
Medicine, Research & Experimental
Yong-Joon Choi, Nam Ho Kim, Man Sup Lim, Hee Jae Lee, Sung Soo Kim, Wanjoo Chun
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2014)
Article
Biochemistry & Molecular Biology
Hyo Jin Lim, Guang-zhi Dong, Hwa Jin Lee, Jae-Ha Ryu
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
(2015)
Article
Engineering, Electrical & Electronic
Jisung Jang, Sangkwon Han, Su Eun Chung, Yong Joon Choi, Sunghoon Kwon
MICROELECTRONIC ENGINEERING
(2014)
Article
Multidisciplinary Sciences
Yong-Joon Choi, Iljin Kim, Jae Eun Lee, Jong-Wan Park
SCIENTIFIC REPORTS
(2019)
Article
Chemistry, Multidisciplinary
Hyun-Hee Kim, Sung-Jin Kim, Sung-Min Yoon, Yong-Joon Choi, Min-Cheol Lee
Summary: Two techniques, flying touch and velocity synchronization, are proposed to reduce scratch formation in the finishing mill of the hot rolling process. Simulations and experiments show that these methods can effectively reduce frictional and impact forces that cause scratch formation on steel plates in the hot rolling process.
APPLIED SCIENCES-BASEL
(2021)
Article
Endocrinology & Metabolism
Byung Wan Lee, Kyu Jeung Ahn, Ho Chan Cho, Eun Young Lee, KyungWan Min, Amine Dahaoui, Jin Sook Jeong, Hyo Jin Lim, Hak Chul Jang
Summary: This study investigated the safety and effectiveness of insulin degludec (IDeg) in a population of Korean patients with diabetes undergoing insulin therapy. The results showed that IDeg treatment significantly improved glycemic parameters with a low incidence of adverse events in Korean patients.
Article
Critical Care Medicine
Dong Joon Kim, Yong Joon Choi, Young Sun Yoo
ACUTE AND CRITICAL CARE
(2019)
Proceedings Paper
Automation & Control Systems
Ilhwan Noh, Changki Jeong, Yong-Joon Choi, Namwoong Kong
2017 IEEE CONFERENCE ON CONTROL TECHNOLOGY AND APPLICATIONS (CCTA 2017)
(2017)
Meeting Abstract
Biochemistry & Molecular Biology
Yong-Joon Choi, Jong-Wan Park
Proceedings Paper
Automation & Control Systems
Jonghyun Lee, Yong Joon Choi
2014 IEEE EMERGING TECHNOLOGY AND FACTORY AUTOMATION (ETFA)
(2014)
Proceedings Paper
Computer Science, Artificial Intelligence
Hyun-Hee Kim, Sung-Jin Kim, Yong-Joon Choi, Min-Cheol Lee
INTELLIGENT ROBOTICS AND APPLICATIONS, ICIRA 2014, PT II
(2014)
Article
Immunology
Jun Cui, Cheng Chen, Xiao Zhou, Wenju Shan, Yuhong Jian, Panpan Li, Yang Sun, Wei Yi
Summary: Bone marrow mesenchymal stem cells (BMSCs) are a promising therapy for sepsis, but metabolic syndromes threaten their effectiveness. This study investigated the potential of small extracellular vesicles from high-fat diet BMSCs in sepsis-induced liver-heart axis injury.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Binbin Zhu, Angyang Cao, Chunqu Chen, Weijian Zhou, Wenjun Luo, Yu Gui, Qinwen Wang, Zhipeng Xu, Jianhua Wang
Summary: GM6001 alleviates postoperative cognitive deficits and neuroinflammation, preserves blood-brain barrier integrity, and rescues aquaporin-4 mislocalization. MMP-9 inhibition plays a dual role in cognitive protection through direct anti-neuroinflammatory effects and regulation of aquaporin-4 membrane distribution.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Anika Sood, Valencia Fernandes, Kumari Preeti, Shruti Rajan, Dharmendra Kumar Khatri, Shashi Bala Singh
Summary: S1PR2 inhibitor improves cognitive function and skews microglia toward anti-inflammatory phenotype in type 2 diabetic mice, promising to be a potential therapy for neuroinflammation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Haochun Guo, Ran Yu, Haijun Zhang, Wanpeng Wang
Summary: Radiation therapy is an effective treatment for thoracic malignancies, but it can cause radiation-induced lung injury (RILI), including radiation pneumonitis (RP) and radiation pulmonary fibrosis (RPF). The damage to normal lung cells during radiation treatment leads to a pulmonary inflammatory response, resulting in RP and RPF.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Guanghui Wang, Haotian Zheng, Yunzhi Xiang, Yadong Wang, Kai Wang, Xiaoyang Ren, Jiajun Du
Summary: This study identified a T-cell synthetic driver-associated prognostic model that accurately predicted prognosis and effectiveness of immunotherapy in LUAD patients. It also highlighted the role of LDHA in promoting tumor cell proliferation, invasion, and resistance to treatment, as well as its involvement in immune escape within the tumor microenvironment. These findings provide a promising new therapeutic strategy for LUAD.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Bowen Wei, Aihua Wang, Wei Liu, Qingyun Yue, Yihua Fan, Bin Xue, Siwei Wang
Summary: This study systematically analyzed the association between pSS and cuproptosis, established a predictive model based on 5 genes, explored the pathogenic mechanisms and novel therapeutic strategies for pSS, and identified EED, CBL, and NFU1 as potential targets for treatment.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Nusrit Iqbal Andrabi, Aminur R. Sarkar, Syed Assim Haq, Diljeet Kumar, Dilpreet Kour, Diksha Saroch, Sanket Kumar Shukla, Ajay Kumar, Asha Bhagat, Asif Ali, Gurleen Kour, Zabeer Ahmed
Summary: Koenimbine and its novel semi-synthetic derivative 1G demonstrate significant anti-inflammatory effects by downregulating the nuclear factor kappa-B (NF-kappa B) signaling pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Jing-Mei Lu, Xiang Xu, Fumie Aosai, Ming-Yue Zhang, Lian-Xun Piao
Summary: This study found that arctiin can improve allergic acute liver injury caused by T.g.HSP70 by inhibiting TLR4 signaling and reducing the production of inflammatory mediators.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Minxuan Xu, Fang Shi, Yongshen Gao, Shumei Han, Chensuo Huang, Qinsheng Hou, Xiaoweng Wen, Bengshi Wang, Zhenyu Zhu, Lei Zou, Mingxin Xiong, Wei Dong, Jun Tan
Summary: There is a growing body of research highlighting the involvement of metabolic imbalance and the inflammatory response in the advancement of colitis. This study recognizes arabinose as a significant protector of the intestinal mucosal barrier, reducing damage to the intestines. In addition, lower levels of arabinose in the bloodstream are associated with a higher severity of inflammatory bowel disease and colorectal cancer.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yueqing Han, Haoxin Song, Yanshan Li, Rongxin Li, Ling Chen, Bo Gao, Yijun Chen, Shuzhen Wang
Summary: The combination of tetracycline antibiotics, demeclocycline (D), chlortetracycline (C), and minocycline (M), showed therapeutic potential against liver fibrosis by inhibiting the activation of hepatic stellate cells and the MAPK signaling. This study suggests that tetracyclines may be repurposed for the treatment of liver fibrosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yu Li, Hailing Liu, Danwen Zhao, Danjie Zhang
Summary: Chronic stress can lead to lung injury, with the spleen playing a crucial role. This study found that the spleen contributes to chronic restraint stress-induced lung injury, and splenic CD11b+ cells may be an important factor in this process.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yingqian Mi, Mengyan Tang, Qiong Wu, Yinan Wang, Qihui Liu, Pei Zhu, Xiaoyang Xue, Yuntong Liu, Xinyu Chai, Yuyang Hou, Dongmei Yan
Summary: BCG therapy can induce macrophage polarization to the M1 type, and NMAAP1 plays a crucial role in this process by regulating glycolysis and HIF-1α expression. This promotes the antitumor effect of macrophages.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Xiaosheng Liu, Tingxia Lv, Xiuxia Li, Jing Xue, Ling Lin, Lianfeng Lu, Xiaodi Li, Yang Yang, Yuanni Wu, Qiang Wei, Wei Cao, Taisheng Li
Summary: LLDT-8 exhibits notable efficacy in alleviating immune activation in both an in vivo animal model and in vitro human cell experiments, suggesting its potential as a drug for managing systemic immune activation associated with SIV/HIV infection.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Honghong Yu, Qi Li, Huimin Zhu, Chang Liu, Weiwei Chen, Lingyun Sun
Summary: The activation of the inflammasome plays a critical role in the pathogenesis of systemic lupus erythematosus (SLE), and mesenchymal stem cells (MSC) have been shown to alleviate SLE by suppressing inflammasome activation. This study found that the NLRP3 inflammasome was activated in macrophages from SLE patients and mice, and its activation correlated with disease activity. After MSC transplantation, the severity of SLE was reduced, and NLRP3 inflammasome activation was inhibited. These findings suggest that MSC suppress inflammasome activation and provide a potential therapeutic target for SLE.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Wei Zhou, Dan Zeng, Shunan Liu, Yunxia Huang, Fenglin Lv, Weikang Zhou
Summary: This study found that inhibiting HDAC3 can protect the skin from atopic dermatitis by activating the Nrf2 transcription to upregulate Nrf2/HO-1 signaling pathway activity.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)