Article
Immunology
William A. Werbel, Diane M. Brown, Oyinkansola T. Kusemiju, Brianna L. Doby, Shanti M. Seaman, Andrew D. Redd, Yolanda Eby, Reinaldo E. Fernandez, Niraj M. Desai, Jernelle Miller, Gilad A. Bismut, Charles S. Kirby, Haley A. Schmidt, William A. Clarke, Michael Seisa, Christos J. Petropoulos, Thomas C. Quinn, Sander S. Florman, Shirish Huprikar, Meenakshi M. Rana, Rachel J. Friedman-Moraco, Aneesh K. Mehta, Peter G. Stock, Jennifer C. Price, Valentina Stosor, Shikha G. Mehta, Alexander J. Gilbert, Nahel Elias, Michele Morris, Sapna A. Mehta, Catherine B. Small, Ghady Haidar, Maricar Malinis, Jennifer S. Husson, Marcus R. Pereira, Gaurav Gupta, Jonathan Hand, Varvara A. Kirchner, Avinash Agarwal, Saima Aslam, Emily A. Blumberg, Cameron R. Wolfe, Kevin Myer, R. Patrick Wood, Nikole Neidlinger, Sara Strell, Marion Shuck, Harry Wilkins, Matthew Wadsworth, Jennifer D. Motter, Jonah Odim, Dorry L. Segev, Christine M. Durand, Aaron A. R. Tobian
Summary: This study investigates the clinical, immunologic, and virologic characteristics of HIV-positive organ donors. The findings suggest that the use of HIV-positive donor organs is increasing but the prevalence of HIV drug resistance is relatively low, especially for integrase strand transfer inhibitors.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Surgery
A. K. Israni, D. Zaun, J. D. Rosendale, C. Schaffhausen, W. McKinney, J. J. Snyder
Summary: In 2019, there was an increase in both the number of deceased organ donors and organ transplants, which may be linked to the rising death rates of young people due to the opioid epidemic. The data indicates an opportunity to increase transplant numbers by reducing organ discards.
AMERICAN JOURNAL OF TRANSPLANTATION
(2021)
Article
Surgery
Matthew J. Bock, Gabrielle R. Vaughn, Peter Chau, Jennifer A. Berumen, John J. Nigro, Elizabeth G. Ingulli
Summary: The study suggests that COVID-19 infection in deceased solid organ transplant donors does not affect recipient survival. However, there is a lack of information regarding the selection of COVID-19-positive donors.
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Article
Medicine, General & Internal
Mengmeng Ji, Amanda J. Vinson, Su-Hsin Chang, Massini Merzkani, Krista L. Lentine, Yasar Caliskan, Kristin Progar, Nicole Nesselhauf, Casey Dubrawka, Tarek Alhamad
Summary: This study evaluated kidney use and transplant outcomes from deceased donors with active or resolved COVID-19, showing a decreasing likelihood of nonuse over time and no worse outcomes within 2 years post-transplant.
Article
Surgery
Kathleen Yu, Syed A. Husain, Kristen King, Jacob S. Stevens, Chirag R. Parikh, Sumit Mohan
Summary: Acute kidney injury (AKI) severity is a strong risk factor for kidney nonprocurement in deceased organ donors. Efforts to address the organ shortage should focus on encouraging the procurement and utilization of kidneys from deceased donors with severe AKI, given the large prevalence of donor AKI and successful transplant outcomes with these kidneys.
CLINICAL TRANSPLANTATION
(2022)
Article
Multidisciplinary Sciences
Ryan Nazemian, Maroun Matta, Amer Aldamouk, Lin Zhu, Mohamed Awad, Megan Pophal, Nicole R. Palmer, Tonya Armes, Alfred Hausladen, Jonathan S. Stamler, James D. Reynolds
Summary: Based on clinical findings, SNO-Hb levels are significantly decreased after brain death, which negatively impacts StO(2) and reduces the number of organs available for transplantation from DNC human donors. The inclusion of exogenous S-nitrosylating agents can increase organ yields and quality for transplantation.
SCIENTIFIC REPORTS
(2022)
Editorial Material
Immunology
Judith A. Anesi, Ebbing Lautenbach, Jennifer Han, Dong Heun Lee, Heather Clauss, Antonette Climaco, Richard Hasz, Warren B. Bilker, Esther Molnar, Darcy Alimenti, Sharon West, Pam Tolomeo, Emily A. Blumberg
Summary: The study found that a high percentage of deceased organ donors received antibiotics during their terminal hospitalization, with some potentially receiving redundant antibiotics, indicating a need for better stewardship in antibiotic use in this population.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Surgery
Takayuki Yamamoto, Srilakshmi Atthota, Divyansh Agarwal, Kerry Crisalli, Malcolm Macconmara, Tsukasa Nakamura, Richard Teo, Leigh Anne Dageforde, Shoko Kimura, Nahel Elias, Heidi Yeh, Adel Bozorgzadeh, Tatsuo Kawai, James F. Markmann
Summary: This study compares the outcomes of liver allografts preserved using portable normothermic machine perfusion (NMP) and ischemic cold storage (ICS) in liver transplantation procedures. It concludes that NMP can significantly reduce the incidence of early allograft dysfunction, reperfusion syndrome, and ischemic cholangiopathy after donation after circulatory death (DCD) liver transplantation.
Article
Immunology
Balthasar A. Heesters, Kyah van Megesen, Ilhan Tomris, Robert P. de Vries, Giuliana Magri, Hergen Spits
Summary: FDCs play a crucial role in germinal centers by interacting with B cells and maintaining antigen gradients, while their transcriptome is still incompletely defined and some functions are substituted by MRCs and other cells. FDCs also express various genes related to T cell regulation, indicating an intimate connection with T cells.
JOURNAL OF EXPERIMENTAL MEDICINE
(2021)
Article
Surgery
Wen Wang, Michael A. Rees, Alan B. Leichtman, Peter X. -K. Song, Mathieu Bray, Valarie B. Ashby, Tempie Shearon, Andrew Whiteman, John D. Kalbfleisch
Summary: This study simulates a revised kidney allocation system and estimates the potential increase in number of transplants by including deceased donor kidneys as chain-initiating kidneys in a kidney paired donation pool. The simulations show that this approach can significantly increase the number of transplants and reduce the waiting times for KPDP candidates.
AMERICAN JOURNAL OF TRANSPLANTATION
(2021)
Article
Surgery
George H. B. Greenhall, Brian A. Rous, Matthew L. Robb, Chloe Brown, Gillian Hardman, Rachel M. Hilton, James M. Neuberger, John H. Dark, Rachel J. Johnson, John L. R. Forsythe, Laurie A. Tomlinson, Chris J. Callaghan, Christopher J. E. Watson
Summary: This cohort study suggests that the risk of cancer transmission in transplants from deceased donors with primary brain tumors is lower than previously thought, and long-term transplant outcomes are favorable, providing a possibility for safely expanding organ usage.
Article
Clinical Neurology
Yona Vaisbuch, Davood K. Hosseini, Andreas Wagner, Bernhard Hirt, Marcus Mueller, Ravikumar Ponnusamy, Stefan Heller, Alan G. Cheng, Hubert Lowenheim, Ksenia A. Aaron
Summary: The objective of this study was to develop a surgical approach for rapid and minimally traumatic recovery of inner ear tissue from human organ and tissue donors to provide fresh tissue for inner ear research. The results showed that the modified technique of trans-canal/trans-otic approach enabled timely extraction of vestibular and auditory end organs. Organ and tissue donors are a promising but underutilized resource for inner ear research.
OTOLOGY & NEUROTOLOGY
(2022)
Article
Transplantation
George H. B. Greenhall, Matthew Robb, Rachel J. Johnson, Maria Ibrahim, Rachel Hilton, Laurie A. Tomlinson, Chris J. Callaghan, Christopher J. E. Watson
Summary: This study examined the relationship between deceased donor albuminuria and kidney utilization, survival, and function. The findings suggest that kidneys from donors with albuminuria are less likely to be accepted for transplantation, but there is no evidence of an association between albuminuria and graft survival or function.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2022)
Article
Oncology
Prisca Bustamante Alvarez, Alexander Laskaris, Alicia A. Goyeneche, Yunxi Chen, Carlos M. Telleria, Julia Burnier
Summary: This study demonstrates that MF impedes the proliferation of UM cells in a concentration-dependent manner, with lower concentrations resulting in cell growth arrest and higher concentrations leading to cell death. MF, with a good safety profile, could be a reliable adjuvant of a repurposing therapy against UM.
CANCER CELL INTERNATIONAL
(2021)
Article
Surgery
Elizabeth M. Sonnenberg, Jesse Y. Hsu, Jordana B. Cohen, Vishnu S. Potluri, Zhi Geng, Matthew H. Levine, Peter L. Abt, Peter P. Reese
Summary: This study found that kidney transplants from deceased donors with persistent acute kidney injury (AKI) did not have clinically meaningful differences in graft survival and function compared to transplants from donors without kidney injury.