期刊
INTERNATIONAL IMMUNOLOGY
卷 21, 期 5, 页码 599-606出版社
OXFORD UNIV PRESS
DOI: 10.1093/intimm/dxp029
关键词
CD8 lymphocytes; dendritic cells; IL-15 receptor alpha; membrane-bound IL-15; NK cells
类别
资金
- Associazione Italiana per la Ricerca sul Cancro
- Ministero Italiano della Salute-Programma Straordinario Ricerca Oncologica
- Fondazione Banco di Sicilia
- Regione Sicilia Ricerca Sanitaria Regionale
- Fondazione Italiana per la Ricerca sul Cancro
NK cell recognition of cells that do not express or express low amounts of MHC class I molecules results not only in direct killing of target cells but also in the generation of specific T cell responses consequent to the induction of dendritic cell (DC) activation. While IL-12 production by NK cell-activated DCs is generally thought to play a critical role, a similar DC-mediated NK cell help has been reported also in IL-12-knockout mice. Here, we show that human NK cells can induce on DC surface membrane, via IFN-gamma secretion, the expression of high levels of IL-15. Remarkably, we show that DC expression of this membrane-bound form of IL-15, which is only partially associated with IL-15R molecules, is essential to promote specific CD8(+) T lymphocyte response in the absence of DC-derived IL-12.
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