期刊
INTERNATIONAL IMMUNOLOGY
卷 21, 期 5, 页码 587-598出版社
OXFORD UNIV PRESS
DOI: 10.1093/intimm/dxp028
关键词
cell activation; co-stimulation; CD95L; FasFc; signal transduction
类别
资金
- Deutsche Forschungsgemeinschaft [SFB 415, A9]
- Hensel foundation
- Medical Faculty, Christian-Albrechts-University, Kiel
Activation of resting T cells in vitro is triggered by combined TCR and CD28 engagement and can be modulated by simultaneous ligation of various other surface receptors. Although the Fas ligand (FasL) is best known for its capacity to initiate cell death in Fas-bearing cells, it has recently been implicated in the regulation of T cell activation. Thus, a cross-talk between the TCR and FasL is likely, but far from being biochemically elucidated. We now report that FasL engagement by immobilized but not soluble FasFc fusion protein and anti-FasL polyclonal antibody blocks the activation of human peripheral T cells even in the presence of CD28 co-stimulation. The data presented here stress the importance of the Fas/FasL system for signal initiation via the TCR-CD3 complex and provide further arguments for a retrograde signaling capacity of FasL or a crucial role of Fas as a co-stimulatory molecule.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据