期刊
INTERNATIONAL IMMUNOLOGY
卷 21, 期 11, 页码 1205-1211出版社
OXFORD UNIV PRESS
DOI: 10.1093/intimm/dxp096
关键词
antigen presentation; Atg16L1; central tolerance; IRGM; macroautophagy; NOD2; Paneth cells; T cells; Toll-like receptors
类别
资金
- National Cancer Institute [R01CA108609, R01CA101741]
- Foundation for the National Institutes of Health
- German Research Foundation (Deutsche Forschungsgemeinschaft)
Mutations in genes involved in macroautophagy have been found to be associated with Morbus Crohn, also called Crohn's disease (CD), an inflammatory bowel disease. Taking this disease as an example for pathogenesis due to altered macroautophagy, we discuss here how macroautophagy supports innate and adaptive immunity. This support ranges from maintenance of components of the immune system, antigen processing for presentation to the immune system, to education of the immune system in order to distinguish self from dangerous non-self. A better understanding of these mechanisms should allow us not only to develop therapeutical strategies for CD but also to utilize macroautophagy for enhanced immunity against pathogens and tumors.
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