Article
Biochemistry & Molecular Biology
Maria Cristina Curia, Pamela Pignatelli, Domenica Lucia D'Antonio, Damiano D'Ardes, Elena Olmastroni, Luca Scorpiglione, Francesco Cipollone, Alberico Luigi Catapano, Adriano Piattelli, Marco Bucci, Paolo Magni
Summary: This study found a higher abundance of Pg in the oral cavity of high-risk patients previously diagnosed with ASCVD, with or without FH. The abundance of Fn was similar between groups. Patients with HeFH and ASCVD had even higher Pg abundance compared to non-HeFH patients and healthy subjects. However, there was no difference in Pg and Fn abundance in HeFH subjects in primary prevention compared to healthy subjects.
Article
Medicine, General & Internal
In Sun Ryou, Ju Young Kim, Hwa Yeon Park, Sohee Oh, Sehun Kim, Hwa Jung Kim
Summary: The study found that the risk of MACE incidence decreased in statin users, but increased for low-risk statin users, with no significant relationship identified for intermediate and borderline risk groups. The risk of MACE incidence decreased only in the high CVD risk group among statin users.
FRONTIERS IN MEDICINE
(2022)
Article
Peripheral Vascular Disease
In-Chang Hwang, Chee Hae Kim, Jae-Young Kim, Hong-Mi Choi, Yeonyee E. Yoon, Goo-Yeong Cho
Summary: The incremental 10-year risk of atherosclerotic cardiovascular disease (ASCVD) is associated with the risk of future ASCVD events, indicating the success or failure in controlling major cardiovascular risk factors. Effective control of risk factors leads to lower ASCVD event rates, whereas failure to control these risk factors results in higher ASCVD event rates.
Article
Cardiac & Cardiovascular Systems
Anurag Mehta, Nestor Vasquez, Colby R. Ayers, Jaideep Patel, Ananya Hooda, Amit Khera, Roger S. Blumenthal, Michael D. Shapiro, Carlos J. Rodriguez, Michael Y. Tsai, Laurence S. Sperling, Salim S. Virani, Michael J. Blaha, Parag H. Joshi
Summary: Elevated lipoprotein(a) and coronary artery calcium are independently associated with ASCVD risk, and may be concurrently useful in guiding primary prevention therapy decisions, as demonstrated in the MESA and DHS cohorts.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Article
Medicine, Research & Experimental
Jiayi Yi, Lili Wang, Xinli Guo, Xiangpeng Ren
Summary: This study analyzed data from seven community-based prospective cohort studies to investigate the influence of historical cardiovascular risk status on future risk of atherosclerotic cardiovascular disease (ASCVD). The results showed that individuals with different historical cardiovascular disease (CVD) risks but the same current CVD risk status exhibited varying risks of future ASCVD incidents. Therefore, incorporating historical risk status into cardiovascular risk stratification can enable more accurate risk evaluation and inform decision-making regarding preventive interventions.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Katrina K. Poppe, Sue Wells, Rod Jackson, Robert N. Doughty, Andrew J. Kerr
Summary: This study developed a CVD risk score for individuals with ASCVD to complement existing scores for primary prevention. The median CVD risk for those with ASCVD is eight times higher than those without, but there is overlap and the widest distribution of CVD risk is among individuals with ASCVD.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Anthony Matta, Jean Pierre Rabes, Dorota Taraszkiewicz, Didier Carrie, Jerome Roncalli, Jean Ferrieres
Summary: This study evaluated the predictive effect of a causative genetic variant on cardiovascular events in HFH patients undergoing treatment and found that the presence of the variant did not independently predict the occurrence of cardiovascular diseases in HFH patients, while low-density lipoprotein cholesterol level played a decisive role.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Review
Cardiac & Cardiovascular Systems
Rishi Rikhi, Michael D. Shapiro
Summary: This report examines the application of pooled cohort equations in primary prevention and cardiovascular health assessment. It suggests the use of statin therapy based on risk assessments and highlights the importance of cardiovascular health assessment for all individuals.
JOURNAL OF CARDIOPULMONARY REHABILITATION AND PREVENTION
(2022)
Article
Medicine, General & Internal
Reed Mszar, Gayley B. Webb, Vivek T. Kulkarni, Zahid Ahmad, Daniel Soffer
Summary: Genetic lipid disorders, including common dyslipidemias such as familial hypercholesterolemia and familial combined hyperlipidemia, affect millions of individuals and often go undiagnosed in the general population. Clinicians should consider the potential of inherited lipid disorders or syndromes when severe derangements in lipid parameters are observed.
MEDICAL CLINICS OF NORTH AMERICA
(2022)
Review
Peripheral Vascular Disease
Aneesha Thobani, Lauren Hassen, Laxmi S. Mehta, Anandita Agarwala
Summary: This review discusses strategies for managing dyslipidemia in pregnant women with ASCVD, emphasizing the importance of screening, identifying, counseling, and treating women of childbearing age to mitigate the risks of complications and mortality. Treating hypercholesterolemia during pregnancy is crucial, presenting an opportune time for cross-collaboration of subspecialties in cardiology, obstetrics, and gynecology.
CURRENT ATHEROSCLEROSIS REPORTS
(2021)
Article
Cardiac & Cardiovascular Systems
Saket Girotra, Amanda Stebbins, Lisa Wruck, Guillaume Marquis-Gravel, Kamal Gupta, Peter Farrehi, Catherine P. Benziger, Mark B. Effron, Jeffrey Whittle, Daniel Munoz, Sunil Kripalani, David Anderson, Sandeep K. Jain, Tamar S. Polonsky, Faraz S. Ahmad, Matthew T. Roe, Russell L. Rothman, Robert A. Harrington, Adrian F. Hernandez, W. Schuyler Jones
Summary: This study found that baseline use of P2Y12 inhibitors did not modify the relative effectiveness and safety of high- versus low-dose aspirin.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Medicine, General & Internal
Andrea Aparicio, Francisco Villazon, Lorena Suarez-Gutierrez, Juan Gomez, Ceferino Martinez-Faedo, Edelmiro Mendez-Torre, Pablo Avanzas, Rut alvarez-Velasco, Elias Cuesta-Llavona, Claudia Garcia-Lago, David Neuhalfen, Eliecer Coto, Rebeca Lorca
Summary: Familial hypercholesterolemia (FH) is a common genetic disorder associated with premature atherosclerotic cardiovascular (CV) disease (ASCVD). However, it is often not diagnosed correctly. Initiating lipid-lowering therapy (LLT) early in life can significantly reduce ASCVD risk in FH patients. Genetic testing can be useful in identifying FH.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Chemistry, Medicinal
Chrysoula Boutari, Christos V. V. Rizos, Michalis Doumas, George Liamis, Ioannis Skoumas, Loukianos Rallidis, Anastasia Garoufi, Genovefa Kolovou, Konstantinos Tziomalos, Emmanouil Skalidis, Vasileios Kotsis, George Sfikas, Vaia Lambadiari, Panagiotis Anagnostis, Eleni Bilianou, Georgia Anastasiou, Iosif Koutagiar, Estela Kiouri, Achilleas Attilakos, Vana Kolovou, Evangelos Zacharis, Christina Antza, Evangelos Liberopoulos
Summary: Familial hypercholesterolemia (FH) and type 2 diabetes mellitus (T2DM) are both associated with a high risk of atherosclerotic cardiovascular disease (ASCVD). A study found that FH patients with T2DM had a higher prevalence of ASCVD, coronary artery disease (CAD), and stroke compared to those without T2DM. T2DM was significantly associated with prevalent ASCVD even after adjusting for various factors. FH patients with T2DM were also more likely to undergo coronary revascularization procedures. These findings highlight the importance of risk stratification and treatment intensity in FH patients.
Review
Peripheral Vascular Disease
Takashi Hisamatsu, Minako Kinuta
Summary: Coronary artery calcium (CAC) detected by computed tomography scanning is a reliable indicator of subclinical atherosclerosis and has important implications for ASCVD risk assessment and primary prevention. However, more research is needed to validate its use and clinical efficacy in non-Western populations, including Japan.
JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS
(2023)
Article
Cardiac & Cardiovascular Systems
Emily Aldridge, Maleesa Pathirana, Melanie Wittwer, Susan Sierp, Shalem Y. Leemaqz, Claire T. Roberts, Gustaaf A. Dekker, Margaret A. Arstall
Summary: The study investigates the prevalence of metabolic syndrome in women who experienced complications in pregnancy and found that a significant number of women already show signs of metabolic syndrome or multiple risk factors within 7 months postpartum.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)