Article
Nutrition & Dietetics
Luigi Castaldo, Marianna Toriello, Raffaele Sessa, Luana Izzo, Sonia Lombardi, Alfonso Narvaez, Alberto Ritieni, Michela Grosso
Summary: The study showed that digested coffee has higher polyphenol content and antioxidant activity, reducing intracellular reactive oxygen species and interleukin-6 levels while causing fewer cytotoxic effects. These findings suggest that coffee may have antioxidant and anti-inflammatory properties, with the digestion process releasing compounds with higher bioactivity.
Review
Physiology
Juliana Carvalho Santos, Marcelo Lima Ribeiro, Alessandra Gambero
Summary: COVID-19, declared as a pandemic in March 2020 by the World Health Organization, is characterized by cytokine storm, ARDS, and systemic inflammation-related pathology, leading to over 1.5 million deaths worldwide. Advanced age and obesity in COVID-19 patients are associated with enhanced inflammatory status, making them a high-risk group for rapid clinical deterioration. Understanding SARS-CoV-2 infection in high-risk populations with inflammatory disorders is crucial for developing therapies to combat severe COVID-19.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Immunology
Yufeng Zhai, Lihua Ao, Qingzhou Yao, Erlinda The, David A. Fullerton, Xianzhong Meng
Summary: This study confirmed that elevated expression of myocardial TLR2 contributes to the mechanism by which aging exacerbates the inflammatory responses, adverse remodeling, and cardiac dysfunction following myocardial I/R in aging.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Cell Biology
Akihiko Kubota, Nikolaos G. Frangogiannis
Summary: Following myocardial infarction, macrophages play important roles in both injurious and reparative responses. They regulate the inflammatory response through phagocytosis and secretion of mediators, and contribute to the repair of the infarcted heart. However, the relationship between transcriptomic profiles and functional properties of macrophages in infarcted hearts is still unclear.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Jamie Francisco, Dominic P. Del Re
Summary: Acute myocardial infarction (MI) is a condition that causes cardiac damage and cell loss. Restoring coronary flow is the standard treatment for MI, but reperfusion triggers inflammation and worsens heart injury. The immune response plays a crucial role in the pathogenesis and resolution of ischemia/reperfusion (I/R) injury, but our understanding is still incomplete.
Article
Chemistry, Multidisciplinary
Qiming Pang, Cui Wang, Bangtao Li, Suli Zhang, Jiaoyang Li, Shuo Gu, Xueyu Shi
Summary: This study evaluated the effects of resveratrol loaded in copolymer nanoparticles on cerebral ischemia/reperfusion (I/R) injury in rats. The results showed that RES.CP.NPs could have neuroprotective effects through their antioxidant and anti-inflammatory activities, leading to improved neurological disability scores and decreased oxidative stress levels.
ARABIAN JOURNAL OF CHEMISTRY
(2024)
Article
Medicine, Research & Experimental
Kunsheng Li, Pengyu Zhou, Jie Li, Yongqing Cheng, Shiliang Li, Yumeng Wang, Weipeng Jiang, Yang Bai, Hailong Cao, Dongjin Wang
Summary: The expression and function of P2Y14 receptor in neutrophils after myocardial infarction/reperfusion (MIR) injury were investigated. The results showed that P2Y14 receptor is involved in the regulation of inflammation in the infarct area after MIR, and it establishes a novel signaling pathway concerning the interplay between cardiomyocytes and neutrophils in the heart tissue.
Article
Pharmacology & Pharmacy
Sureshbabu Mangali, Audesh Bhat, Deepika Dasari, Dharmarajan Sriram, Arti Dhar
Summary: Protein kinase R (PKR) inhibition attenuated myocardial dysfunction, cardiac fibrosis, oxidative/nitrosative stress, inflammation, cell death, and interrelated signalling pathways in a myocardial ischemia model. Inhibition of PKR improved ischemia-mediated inflammation, apoptosis, cardiac hypertrophy, and fibrosis, suggesting it as a potential intervention therapy for myocardial ischemia.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Jan Philipp Schuette, Mailin-Christin Manke, Katherina Hemmen, Patrick Muenzer, Barbara F. Schoerg, Gustavo Campos Ramos, Michaela Pogoda, Valerie Dicenta, Sabrina H. L. Hoffmann, Juergen Pinnecker, Ferdinand Kollotzek, Monika Zdanyte, Karin A. L. Mueller, Yogesh Singh, Andreas F. Mack, Bernd Pichler, Florian Lang, Bernhard Nieswandt, Meinrad Gawaz, Katrin G. Heinze, Nicolas Casadei, Oliver Borst
Summary: Platelet-derived miRNAs play a critical role in myocardial inflammation and structural remodeling in response to myocardial ischemia/reperfusion (I/R). In a mouse model with a Dicer gene deletion, disrupted miRNA processing machinery in platelets led to increased myocardial inflammation, impaired angiogenesis, accelerated cardiac fibrosis, and larger infarct size. These findings highlight the importance of platelet-derived miRNA in regulating cellular processes following myocardial I/R.
CIRCULATION RESEARCH
(2023)
Article
Plant Sciences
Wei Lei, Xiao Li, Lin Li, Ming Huang, Yu Cao, Xingyi Sun, Min Jiang, Boli Zhang, Han Zhang
Summary: The study aimed to explore the biological mechanism of constituents in CDDP synergistically improving post ischemic myocardial inflammation. The results demonstrated that CDDP effectively ameliorated post ischemic myocardial inflammation through simultaneously modulating MAPK, PI3K/AKT and PPAR pathways in a multi-components synergetic manner.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Yajing He, Zhigao Sun, JunYing Bai, Yu Zhang, Yu Qian, Xin Zhao, Shanshan Chen
Summary: Citrus peel polyphenols have significant anti-inflammatory effects and can alleviate symptoms of ulcerative colitis. This research aimed to investigate the anti-inflammatory effect and mechanisms of citrus peel polyphenols. The extracts containing flavanones, flavonoids, and phenolic acids were administered to mice with acute colitis, resulting in a significant improvement in the severity of colitis symptoms. Citrus peel polyphenols reduced the activity of myeloperoxidase, suppressed the secretion of pro-inflammatory cytokines, and blocked the activation of the nuclear factor-kappa B pathway.
Review
Medicine, General & Internal
Tissa Wijeratne, Carmela Sales
Summary: The study analyzed the inflammatory basis of post-stroke depression, which results in cell death, persistent neuro-inflammation, and disrupted neuronal networks in mood-related brain regions. Furthermore, the anatomical structures related to post-stroke depression may involve complex circuitries in cortical and subcortical regions.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Multidisciplinary Sciences
Zi-jie Zhang, Zhi-xiang Sun, Hai-jian Liu
Summary: The treatment of myocardial ischemia-reperfusion (IR) injury is a clinical challenge. Dexmedetomidine (DEX) has been found to protect the myocardium, but its regulatory mechanism is unclear. This study discovered that a series of cytokines and chemokines, as well as Eukaryotic translation elongation factor 1 alpha 2 (EEF1A2), were induced by IR and reduced by DEX pretreatment. PRDX1 interacted with EEF1A2 and played a significant role in the regulation of cytokine and chemokine gene expression.
Article
Immunology
Haijian Zhang, Yifei Liu, Xiaoqing Cao, Wenmiao Wang, Xiaohong Cui, Xuechao Yang, Yan Wang, Jiahai Shi
Summary: The study revealed that Nrf2, in collaboration with Programmed Cell Death 4, promotes the transcription initiation of Ccl3 in myocardial tissues under IR6h conditions, leading to the activation of Ccr1-positive macrophages and the release of pro-inflammatory factors IL-1β and IL-6, highlighting the damaging effect of Nrf2 in early myocardial ischemia-reperfusion.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Qihong Wu, Rong Xu, Kun Zhang, Ran Sun, Mengxi Yang, Kuan Li, Hanrui Liu, Yiyuan Xue, Huayan Xu, Yingkun Guo
Summary: This study comprehensively characterized the physiopathologic changes of myocardial injury after ischemia-reperfusion. It found that the early stage of reperfusion injury is mainly characterized by edema rather than inflammation, and suggested that edema may be a crucial factor contributing to myocardial injury.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Sport Sciences
E. Miyamoto-Mikami, H. Zempo, N. Fuku, N. Kikuchi, M. Miyachi, H. Murakami
SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS
(2018)
Article
Sport Sciences
Thomas P. Yvert, Hirofumi Zempo, Leysan J. Gabdrakhmanova, Naoki Kikuchi, Eri Miyamoto-Mikami, Haruka Murakami, Hisashi Naito, Pawel Cieszczyk, Katarzyna Leznicka, Elena S. Kostryukova, Dmitry G. Alexeev, Emiliya S. Egorova, Agnieszka Maciejewska-Skrendo, Andrey K. Larin, Edward V. Generozov, Nickolay A. Kulemin, Elena A. Ospanova, Alexander V. Pavlenko, Marek Sawczuk, Piotr Zmijewski, Ewelina Lulinska-Kuklik, Vadim M. Govorun, Motohiko Miyachi, Ildus I. Ahmetov, Noriyuki Fuku
Article
Sport Sciences
Hiroshi Kumagai, Eri Miyamoto-Mikami, Kosuke Hirata, Naoki Kikuchi, Nobuhiro Kamiya, Seigo Hoshikawa, Hirofumi Zempo, Hisashi Naito, Naokazu Miyamoto, Noriyuki Fuku
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
(2019)
Article
Genetics & Heredity
Eri Miyamoto-Mikami, Naokazu Miyamoto, Hiroshi Kumagai, Kosuke Hirata, Naoki Kikuchi, Hirofumi Zempo, Noriko Kimura, Nobuhiro Kamiya, Hiroaki Kanehisa, Hisashi Naito, Noriyuki Fuku
BMC MEDICAL GENETICS
(2019)
Article
Physiology
Ekaterina A. Semenova, Eri Miyamoto-Mikami, Egor B. Akimov, Fatima Al-Khelaifi, Haruka Murakami, Hirofumi Zempo, Elena S. Kostryukova, Nikolay A. Kulemin, Andrey K. Larin, Oleg V. Borisov, Motohiko Miyachi, Daniil V. Popov, Eugenia A. Boulygina, Mizuki Takaragawa, Hiroshi Kumagai, Hisashi Naito, Vladimir P. Pushkarev, Dmitry A. Dyatlov, Eugene V. Lekontsev, Yuliya E. Pushkareva, Liliya B. Andryushchenko, Mohamed A. Elrayess, Edward V. Generozov, Noriyuki Fuku, Ildus I. Ahmetov
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY
(2020)
Article
Genetics & Heredity
Fatima Al-Khelaifi, Noha A. Yousri, Ilhame Diboun, Ekaterina A. Semenova, Elena S. Kostryukova, Nikolay A. Kulemin, Oleg V. Borisov, Liliya B. Andryushchenko, Andrey K. Larin, Edward V. Generozov, Eri Miyamoto-Mikami, Haruka Murakami, Hirofumi Zempo, Motohiko Miyachi, Mizuki Takaragawa, Hiroshi Kumagai, Hisashi Naito, Noriyuki Fuku, David Abraham, Aroon Hingorani, Francesco Donati, Francesco Botre, Costas Georgakopoulos, Karsten Suhre, Ildus I. Ahmetov, Omar Albagha, Mohamed A. Elrayess
FRONTIERS IN GENETICS
(2020)
Article
Sport Sciences
Hiroshi Kumagai, Eri Miyamoto-Mikami, Naoki Kikuchi, Nobuhiro Kamiya, Hirofumi Zempo, Noriyuki Fuku
Summary: This study found that the CYP19A1 gene rs936306 C/T polymorphism is associated with the risk of stress fractures in top-level Japanese athletes.
JOURNAL OF STRENGTH AND CONDITIONING RESEARCH
(2022)
Article
Endocrinology & Metabolism
Hiroshi Kumagai, Ana Raquel Coelho, Junxiang Wan, Hemal H. Mehta, Kelvin Yen, Amy Huang, Hirofumi Zempo, Noriyuki Fuku, Seiji Maeda, Paulo J. Oliveira, Pinchas Cohen, Su-Jeong Kim
Summary: MOTS-c, a mitochondrial-derived peptide, reduces high-fat-diet-induced muscle atrophy signaling by decreasing myostatin expression. The CK2-PTEN-mTORC2-AKT-FOXO1 pathways play key roles in MOTS-c action on myostatin expression.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2021)
Article
Physiology
Joao Paulo Limongi Franca Guilherme, Ekaterina A. Semenova, Hirofumi Zempo, Gabriel L. Martins, Antonio H. Lancha Junior, Eri Miyamoto-Mikami, Hiroshi Kumagai, Takuro Tobina, Keisuke Shiose, Ryo Kakigi, Takamasa Tsuzuki, Noriko Ichinoseki-Sekine, Hiroyuki Kobayashi, Hisashi Naito, Oleg Borisov, Elena S. Kostryukova, Nikolay A. Kulemin, Andrey K. Larin, Edward Generozov, Noriyuki Fuku, Ildus I. Ahmetov
Summary: The rs3213537 polymorphism in the CPNE5 gene is associated with sprinting ability and an increased proportion of fast-twitch muscle fibers. The homozygous G/G genotype is preferable for performance.
INTERNATIONAL JOURNAL OF SPORTS PHYSIOLOGY AND PERFORMANCE
(2021)
Article
Sport Sciences
Eri Miyamoto-mikami, Hiroshi Kumagai, Kumpei Tanisawa, Yuki Taga, Kosuke Hirata, Naoki Kikuchi, Nobuhiro Kamiya, Ryoko Kawakami, Taishi Midorikawa, Takuji Kawamura, Ryo Kakigi, Toshiharu Natsume, Hirofumi Zempo, Koya Suzuki, Yoshimitsu Kohmura, Kazunori Mizuno, Suguru Torii, Shizuo Sakamoto, Koichiro Oka, Mitsuru Higuchi, Hisashi Naito, Naokazu Miyamoto, Noriyuki Fuku
Summary: The study investigated the association between the COL1A1 rs1107946 variant and fatigue fracture/muscle injury in athletes, and found that C-allele carriers had a higher risk of fatigue fracture but a lower risk of muscle injury. In nonathletes, C-allele carriers showed lower BMD and muscle stiffness.
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
(2021)
Article
Biochemistry & Molecular Biology
Hiroshi Kumagai, Toshiharu Natsume, Su-Jeong Kim, Takuro Tobina, Eri Miyamoto-Mikami, Keisuke Shiose, Noriko Ichinoseki-Sekine, Ryo Kakigi, Takamasa Tsuzuki, Brendan Miller, Kelvin Yen, Haruka Murakami, Motohiko Miyachi, Hirofumi Zempo, Shohei Dobashi, Shuichi Machida, Hiroyuki Kobayashi, Hisashi Naito, Pinchas Cohen, Noriyuki Fuku
Summary: The heterogeneity of human skeletal muscle fiber is influenced by the diversity of slow- and fast-twitch fibers, which in turn affects physical performance. The East Asian-specific m.1382A>C polymorphism leading to the MOTS-c K14Q variant can influence activity type and performance through regulating skeletal muscle fiber composition.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2022)
Article
Genetics & Heredity
Mizuki Takaragawa, Takuro Tobina, Keisuke Shiose, Ryo Kakigi, Takamasa Tsuzuki, Noriko Ichinoseki-Sekine, Hiroshi Kumagai, Hirofumi Zempo, Eri Miyamoto-Mikami, Hiroyuki Kobayashi, Hisashi Naito, Noriyuki Fuku
Summary: Human muscle fiber composition is determined by genetic factors, and a study found a potential association between a genotype score based on specific polymorphisms related to iron status and muscle fiber composition, especially in women.
Article
Sport Sciences
Hiroshi Kumagai, Tomoko Kaneko, Yuko Shintake, Eri Miyamoto-Mikami, Hiroyuki Tomita, Makoto Fukuo, Wataru Kawai, Mutsumi Harada, Naoki Kikuchi, Nobuhiro Kamiya, Kosuke Hirata, Hirofumi Zempo, Seiji Maeda, Naokazu Miyamoto, Noriyuki Fuku
Summary: This study found that genetic polymorphisms related to muscular strength and flexibility play important roles in male artistic gymnastics, specifically influencing the performance of events that require muscular strength and flexibility. However, no such associations were observed in female gymnasts.
EUROPEAN JOURNAL OF SPORT SCIENCE
(2023)
Article
Cell Biology
Ekaterina A. A. Semenova, Hirofumi Zempo, Eri Miyamoto-Mikami, Hiroshi Kumagai, Andrey K. K. Larin, Rinat I. I. Sultanov, Konstantin A. A. Babalyan, Andrey V. V. Zhelankin, Takuro Tobina, Keisuke Shiose, Ryo Kakigi, Takamasa Tsuzuki, Noriko Ichinoseki-Sekine, Hiroyuki Kobayashi, Hisashi Naito, Jatin Burniston, Edward V. V. Generozov, Noriyuki Fuku, Ildus I. I. Ahmetov
Summary: Muscle fiber composition is associated with physical performance, and the CDKN1A rs236448 SNP may play a role in determining muscle fiber composition and affecting athletic performance.
Article
Cell Biology
Hirofumi Zempo, Su-Jeong Kim, Noriyuki Fuku, Yuichiro Nishida, Yasuki Higaki, Junxiang Wan, Kelvin Yen, Brendan Miller, Roberto Vicinanza, Eri Miyamoto-Mikami, Hiroshi Kumagai, Hisashi Naito, Jialin Xiao, Hemal H. Mehta, Changhan Lee, Megumi Hara, Yesha M. Patel, Veronica W. Setiawan, Timothy M. Moore, Andrea L. Hevener, Yoichi Sutoh, Atsushi Shimizu, Kaname Kojima, Kengo Kinoshita, Yasumichi Arai, Nobuyoshi Hirose, Seiji Maeda, Keitaro Tanaka, Pinchas Cohen
Summary: The m.1382A>C polymorphism is associated with susceptibility to T2D in men, possibly interacting with exercise, and contributing to the risk of T2D in sedentary males by reducing the activity of MOTS-c.
