Article
Clinical Neurology
Mark Zimmerman, Daniel Mackin
Summary: This study compared two methods, the Young Mania Rating Scale (YMRS) and DSM-5 Mixed Features Specifier Interview (DMSI), for assessing mixed features in depressed patients. The agreement between the two methods was found to be poor, and the algorithm used in YMRS had a significant impact on the prevalence of mixed features.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Clinical Neurology
Luis R. Patino, Maxwell J. Tallman, Hongbo Wen, Caleb M. Adler, Jeffrey A. Welge, Melissa P. DelBello
Summary: The objective of this study was to evaluate differences in sustained attention and associated neurofunctional profiles between bipolar disorder type I, attention-deficit/hyperactivity disorder, and healthy comparison youth. Adolescent participants underwent MRI while completing a modified Continuous Performance Task. BD participants displayed deficits in sustained attention and lower activation in brain regions associated with performance and neural integration. These differences were distinct to the BD group and not attributable to ADHD comorbidity.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Psychiatry
Larissa Gama-Chonlon, James M. Scanlan, Rebecca M. Allen
Summary: This retrospective study analyzed the medical records of 317 patients undergoing rTMS treatment and found that bipolar depressed (BD) patients had greater changes in PHQ-9 scores than unipolar depressed (UD) patients by treatment conclusion. There were no between-group differences in GAD-7 score changes. Unilateral treatment resulted in higher rates of remission and response for BD patients compared to UD patients.
PSYCHIATRY RESEARCH
(2022)
Review
Clinical Neurology
Beatriz Corte-Real, Rodrigo Saraiva, Catarina Rodrigues Cordeiro, Benicio N. Frey, Flavio Kapczinski, Taiane de Azevedo Cardoso
Summary: The study aimed to investigate whether atypical antipsychotics (AA) can induce mania in mood disorders. A systematic review and meta-analysis showed that AA-induced mania is rare and the use of AA is more effective in preventing the development of mania compared to placebo.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Clinical Neurology
Jess G. Fiedorowicz, Jane E. Persons, Shervin Assari, Michael J. Ostacher, Fernando S. Goes, John Nurnberger, William H. Coryell
Summary: Depressive symptoms are strongly linked to suicidal ideation and behavior, serving as important risk factors for suicide. However, manic symptoms show no clear association with suicide risk, and mixed symptoms do not convey a greater risk of suicidal ideation or behavior than depressive symptoms alone.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Psychiatry
F. Pacchioni, F. Casoni, A. Sarzetto, F. Attanasio, B. Barbini, M. Locatelli, C. Colombo, M. C. Cavallini, L. Fregna
Summary: Sleep plays a crucial role in the development and manifestation of mood disorders, but few studies have examined sleep architecture during manic episodes of Bipolar Disorder (BD) and changes in sleep parameters. This study investigated 21 BD patients in the manic phase and found that their sleep quantity and quality improved during hospitalization, accompanied by clinical improvement. The study also revealed an increase in REM sleep. These findings suggest that changes in sleep architecture can serve as sensitive markers for clinical variations during manic phases of Bipolar Disorder.
PSYCHIATRY RESEARCH
(2023)
Article
Environmental Sciences
Michele Carugno, Dario Palpella, Alessandro Ceresa, Angela Cecilia Pesatori, Massimiliano Buoli
Summary: The study found that short-term exposure to air pollution can lead to a decrease in symptoms in patients with manic episodes, especially in cases with mixed features. Additionally, short-term exposure to particulate matter PM10 also increases the likelihood of hospitalization for cases with mixed features.
ENVIRONMENTAL RESEARCH
(2021)
Article
Clinical Neurology
Jungwon Cha, Sidra Speaker, Bo Hu, Murat Altinay, Parashar Koirala, Harish Karne, Jeffrey Spielberg, Amy Kuceyeski, Elvisha Dhamala, Amit Anand
Summary: Using emotional inhibition tasks in fMRI, this study found that MDD- subjects exhibited lower activation in various brain regions compared to both BDD and MDD+ groups. The study also showed efficient discrimination between MDD- and BDD as well as MDD+ subjects, but less efficient discrimination between BDD and MDD+ groups.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Psychiatry
Alessandro Sarzetto, Maria Cristina Cavallini, Lorenzo Fregna, Federico Pacchioni, Francesco Attanasio, Barbara Barbini, Linda Franchini, Cristina Colombo
Summary: This study aims to evaluate the impact of chronotherapeutics on sleep architecture in bipolar depressive patients. The results show significant changes in sleep architecture, which are correlated with the reduction of depressive symptoms.
PSYCHIATRY RESEARCH
(2022)
Article
Psychiatry
Mirian A. F. Hayashi, Nicolas Salvetat, Christopher Cayzac, Francisco Jesus Checa-Robles, Benjamin Dubuc, Sandie Mereuze, Joao V. Nani, Franck Molina, Elisa Brietzke, Dinah Weissmann
Summary: This study identified a panel of RNA editing-based blood biomarkers that can accurately distinguish bipolar disorder (BD) patients from unipolar depression patients, highlighting the diagnostic value of RNA editing in BD. The study also discovered new combinations of biomarkers that can effectively differentiate BD patients from healthy controls and subgroups within BD.
PSYCHIATRY RESEARCH
(2023)
Letter
Clinical Neurology
Mustafa Akkus
Summary: This case suggests that lithium-induced tardive dyskinesia may be reversible in a dose-dependent manner.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Health Care Sciences & Services
Chih-Ken Chen, Lawrence Shih-Hsin Wu, Ming-Chyi Huang, Chian-Jue Kuo, Andrew Tai-Ann Cheng
Summary: This study investigates the effects of individual genomics and antidepressant medication on the risk of manic switch in bipolar I disorder. The results suggest that the rs10262219 variant on chromosome 7 and antidepressant treatment significantly increase the risk of manic switch after bipolar depression.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Psychiatry
Hua-Meng Shi, De-Guo Jiang
Summary: This study found that mood-incongruent psychosis during the first manic episode of bipolar disorder appears to predict an increased likelihood of persistent psychotic symptoms over the subsequent 24 months. This persistence of psychosis is associated with a worse overall course of illness.
ASIAN JOURNAL OF PSYCHIATRY
(2022)
Review
Clinical Neurology
Margherita Barbuti, Giulia Menculini, Norma Verdolini, Isabella Pacchiarotti, Georgios D. Kotzalidis, Alfonso Tortorella, Eduard Vieta, Giulio Perugi
Summary: The present systematic review aimed to summarize the evidence about treatment-emergent mood switches in patients with bipolar disorder (BD). Thirty-two original studies met the inclusion criteria, and the majority focused on manic switches with limited research on depressive switches. Treatment-emergent mania/hypomania ranged from 17.3% to 48.8% and was more frequent with antidepressant monotherapy compared to combination treatment with mood stabilizers. Depressive switches were detected in 5-16% of patients and were associated with antipsychotic use. Methodological heterogeneity and small sample sizes were limitations in the included studies.
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Rachel Shvartsur, Galila Agam, Sarit Uzzan, Abed N. Azab
Summary: Mounting evidence suggests that immune-system dysfunction and inflammation play a role in the pathophysiology and treatment of mood disorders. This study found that chronic combined treatment attenuated LPS-induced hypothermia and reduced cytokine levels, suggesting a potential approach for treating inflammation-related mental illness. The treatment also showed antidepressant-like effects.
Article
Medicine, General & Internal
Daisy Ng-Mak, Jiat-Ling Poon, Laurie Roberts, Leah Kleinman, Dennis A. Revicki, Krithika Rajagopalan
PATIENT PREFERENCE AND ADHERENCE
(2018)
Article
Medicine, General & Internal
Daisy Ng-Mak, Rachel Halpern, Krithika Rajagopalan, Antony Loebel
CURRENT MEDICAL RESEARCH AND OPINION
(2019)
Article
Medicine, General & Internal
Daisy Ng-Mak, Krithika Rajagopalan
CURRENT MEDICAL RESEARCH AND OPINION
(2019)
Article
Respiratory System
Edward M. Kerwin, James F. Donohue, Gary T. Ferguson, Vaidyanathan Ganapathy, Ayca Ozol-Godfrey, Krithika Rajagopalan
JOURNAL OF AEROSOL MEDICINE AND PULMONARY DRUG DELIVERY
(2019)
Article
Behavioral Sciences
Joyce A. Cramer, Krithika Rajagopalan, Kathryn Plante Anastassopoulos, David Blum
EPILEPSY & BEHAVIOR
(2019)
Article
Behavioral Sciences
Krithika Rajagopalan, Lulu K. Lee
EPILEPSY & BEHAVIOR
(2019)
Article
Medicine, Research & Experimental
Ismaeel Yunusa, Nazia Rashid, George N. Demos, Bhargavi S. Mahadik, Victor C. Abler, Krithika Rajagopalan
Summary: Compared with placebo, quetiapine showed no significant improvement in psychosis in dementia patients, while olanzapine and aripiprazole demonstrated non-significant small improvements. However, these off-label AAPs are associated with higher odds of mortality, CVAEs, and discontinuations due to AEs than placebo, indicating the need for newer pharmacological options for the treatment of DRP.
ADVANCES IN THERAPY
(2022)
Review
Geriatrics & Gerontology
Ismaeel Yunusa, Nazia Rashid, Roxanna Seyedin, Deepika Paratane, Krithika Rajagopalan
Summary: This study compared the efficacy, safety, and acceptability of several atypical antipsychotics (AAPs) in patients with Parkinson's Disease Psychosis (PDP) through a systematic review and network meta-analysis. The results showed that pimavanserin and clozapine significantly improved symptoms, while quetiapine might have an impact on cognition and should be avoided in PDP patients with reduced cognitive abilities.
JOURNAL OF GERIATRIC PSYCHIATRY AND NEUROLOGY
(2023)
Article
Economics
Krithika Rajagopalan, Nazia Rashid, Shikhar Kumar, Dilesh Doshi
Summary: This study analyzed PDP patients treated with PIM monotherapy and found that it led to nearly 12% and 7% reductions in all-cause hospitalizations and ER visits compared to other-AAPs.
JOURNAL OF MEDICAL ECONOMICS
(2023)
Article
Pharmacology & Pharmacy
Daniel R. Touchette, Deval Gor, Dolly Sharma, Rachel R. Chennault, Daisy S. Ng-Mak, Krithika Rajagopalan, Vicki Ellingrod
Summary: This study found that clinicians considered efficacy and safety equally important when choosing atypical antipsychotics. Formulary restrictions were perceived as impacting treatment choice and outcomes.
JOURNAL OF PHARMACY PRACTICE
(2021)
Article
Health Care Sciences & Services
Kathryn Fitch, Xiaoyun Pan, Jocelyn Lau, Tyler Engel, Krithika Rajagopalan
AMERICAN HEALTH AND DRUG BENEFITS
(2019)
Article
Health Policy & Services
Molly Finnerty, Elizabeth Austin, Qingxian Chen, Deborah Layman, Edith Kealey, Daisy Ng-Mak, Krithika Rajagopalan, Kimberly Hoagwood
COMMUNITY MENTAL HEALTH JOURNAL
(2019)
Article
Respiratory System
Gary T. Ferguson, Edward M. Kerwin, James F. Donohue, Vaidyanathan Ganapathy, Robert L. Tosiello, Vamsi K. Bollu, Krithika Rajagopalan
CHRONIC OBSTRUCTIVE PULMONARY DISEASES-JOURNAL OF THE COPD FOUNDATION
(2018)
Article
Health Care Sciences & Services
Krithika Rajagopalan, Sean D. Candrilli, Mayank Ajmera
CLINICOECONOMICS AND OUTCOMES RESEARCH
(2018)
Article
Health Policy & Services
Stanley N. Caroff, Shirley H. Leong, Daisy Ng-Mak, E. Cabrina Campbell, Rosalind M. Berkowitz, Krithika Rajagopalan, Chien-Chia Chuang, Antony Loebel
COMMUNITY MENTAL HEALTH JOURNAL
(2018)