Article
Biochemistry & Molecular Biology
Kavita Vats, Oleg Kruglov, Alicia Mizes, Svetlana N. Samovich, Andrew A. Amoscato, Vladimir A. Tyurin, Yulia Y. Tyurina, Valerian E. Kagan, Yuri L. Bunimovich
Summary: This research indicates that UVB-induced skin inflammation is primarily mediated by ferroptosis in epidermal keratinocytes, rather than apoptosis or pyroptosis. Inhibition of ferroptosis can prevent inflammation and has implications for the prevention and treatment of various skin diseases induced by UVB.
Article
Biochemistry & Molecular Biology
Ewan Eadie, Paul O'Mahoney, Louise Finlayson, Isla Rose Mary Barnard, Sally Helen Ibbotson, Kenneth Wood
Summary: This study compares the DNA damage caused by far-UVC and sunlight exposure in different climatic conditions, revealing that sunlight exposure poses greater risk for DNA damage compared to far-UVC. It should be noted that the photochemical reactions and consequences of high-energy far-UVC photons absorbed by the stratum corneum remain unknown.
PHOTOCHEMISTRY AND PHOTOBIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Tuba M. Ansary, Md. Razib Hossain, Koji Kamiya, Mayumi Komine, Mamitaro Ohtsuki
Summary: Skin is the largest and most complex organ in the human body, composed of different types of cells. Various environmental stressors, such as UVR, can accelerate skin aging by stimulating inflammatory molecules. UVR-induced skin aging is characterized by loss of elasticity, among other factors, and aged skin serves as a source of circulatory inflammatory molecules that further accelerate aging and contribute to aging-related diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Dermatology
Megan H. Trager, Larisa J. Geskin, Faramarz H. Samie, Liang Liu
Summary: The rates of melanoma and non-melanoma skin cancer in the United States have been increasing due to increased ultraviolet radiation exposure. However, skin cancer prevention remains challenging due to the lack of reliable risk assessment methods. There has been significant interest in developing biomarkers for UV exposure in order to improve early detection of skin malignancies.
EXPERIMENTAL DERMATOLOGY
(2022)
Review
Oncology
Christian Vogeley, Katharina M. Rolfes, Jean Krutmann, Thomas Haarmann-Stemmann
Summary: This article summarizes the role of AHR in skin carcinogenesis, focusing on its impact on defense mechanisms such as DNA repair, apoptosis, and anti-tumor immune responses, as well as the possible consequences of simultaneous exposure to different AHR-stimulating environmental factors on the development of cutaneous SCC.
FRONTIERS IN ONCOLOGY
(2022)
Review
Oncology
Jeremy A. Snell, Jana Jandova, Georg T. Wondrak
Summary: Extrinsic and intrinsic factors interact to determine skin health outcomes. Hypochlorous acid (HOCl) plays important roles as part of the skin exposome, functioning in immunity, disinfection, and anti-inflammatory processes. Recent studies have found that topical HOCl can prevent UV-induced skin cancer.
FRONTIERS IN ONCOLOGY
(2022)
Article
Chemistry, Physical
Yu Fu, Ruoyu Wan, Lei Yang, Lidan Xiong, Junfei Hu, Jie Tang, Hailun He, Zhipeng Gu, Li Li, Yiwen Li
Summary: This study utilized natural ultraviolet-blocking molecule caffeic acid phenethyl ester (CAPE) to prepare poly(CAPE) nanoparticles (NPs) and successfully applied them in the fabrication of bioinspired hydrogel sunscreens. Poly(CAPE) NPs showed better dispersion and stability in water compared to small molecular CAPE, with lower toxicity and skin permeability. The resulting composite hydrogel sunscreens exhibited excellent water resistance and safety upon contact with the skin, as well as providing effective UV protection and maintaining skin barrier functions.
Article
Medicine, Research & Experimental
Yuling L. Yang, Chu Zhou, Qi Chen, Shuzhan Z. Shen, Jiandan D. Li, Xiuli L. Wang, Peiru R. Wang
Summary: The lymphatic-centered immune microenvironment has adapted under continuous UVR via regulating YAP1/VEGFC and Piezo1. There are two turning points of lymphatic changes occurred during UV-induced cSCC formation. YAP1, Piezo1, LVs, and immune cells constantly changed with the skin state induced by UVR. According to these changes, the process of cSCC can be identified in advance and intervene timely.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Oncology
Mustafa Tugfan Bilkan, Zehra Cicek, Ayse Gulnihal Canseven Kursun, Mehmet Ozler, Meric Arda Esmekaya
Summary: This study investigates the chemotherapeutic potential of titanium dioxide nanoparticles on skin and breast cancer cells. The findings show that the viability of cells decreases and the percentage of apoptotic cells increases when titanium dioxide and UV-A radiation are applied together.
Article
Dermatology
F. Flament, D. G. Mercurio, B. Muller, J. Li, C. Tricaud, F. Bernerd, A. Roudot, D. Candau, T. Passeron
Summary: Under outdoor summer conditions, the SPF50/MCE sunscreen offers better protection against UVA1 radiation, resulting in reduced pigmentation and signs of aging.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Article
Multidisciplinary Sciences
Gareth Hazell, Marina Khazova, Paul O'Mahoney
Summary: Sunlight exposure in the UK has been shown to upregulate the cardio protectant nitric oxide (NO) in in vitro skin cell lines, with minimal impact on DNA damage and cell death. The release of NO is primarily driven by the whole UV-A spectrum, with higher efficiency observed at shorter wavelengths.
SCIENTIFIC REPORTS
(2023)
Article
Engineering, Chemical
Shang-Ming Huang, Chwen-Jen Shieh, Yu-Lin Wu, Yang-Zing Pan, Chi-Yang Yu
Summary: S. sinensis extracts show effective antioxidant properties and have the potential to protect skin fibroblasts from UVB-induced damage.
Review
Biochemistry & Molecular Biology
Blanca Ibanez, Ana Melero, Alegria Montoro, Nadia San Onofre, Jose M. Soriano
Summary: Propolis is a natural substance produced by bees that has antimicrobial, anti-inflammatory, and wound-healing properties. This manuscript reviews the radioprotective effect of propolis and includes studies on cell-based experiments, animal models, and human trials. The results suggest that propolis can protect against radiation, and its efficacy is attributed to its various bioactive compounds. The characterization and dosage forms of propolis varied among different studies, and the ethanolic extract of propolis showed a significant presence of lipophilic bioactive compounds.
Article
Biochemistry & Molecular Biology
Yocasta Martinez-Alvarado, Eduardo Amezcua-Galvez, Judith Davila-Rodriguez, Ana Sandoval-Rodriguez, Marina Galicia-Moreno, Monica Almeida-Lopez, Silvia Lucano-Landeros, Arturo Santos, Hugo Christian Monroy-Ramirez, Juan Armendariz-Borunda
Summary: Ultraviolet radiation (UV) is the main cause of skin photodamage, which leads to histological degenerative changes and non-melanoma skin cancer. Retinoids have been commonly used to treat photoaging, but their adverse effects are recognized. Pirfenidone (PFD) has shown anti-inflammatory, antifibrogenic, and antioxidant properties. In this study, topical PFD was found to effectively reduce photodamage and inflammation in a UVB-induced model, making it a promising treatment for cell photodamage in humans. Clinical trials are needed to further investigate its potential.
Article
Optics
Jose Luis Silva Acosta, Fernando Mendoza Santoyo, Jorge Mauricio Flores Moreno, Maria del Socorro Hernandez Montes, Manuel H. De la Torre Ibarra, Gloria R. Frausto, Silvino S. Munoz, Edgard Efren Lozada Hernandez
Summary: This study provides an in-depth analysis of the vibration patterns' response of mouse skin samples exposed to UV radiation, revealing an increase in tension as areal density decreases, a key indicator of skin aging effects.
OPTICS AND LASERS IN ENGINEERING
(2021)
Correction
Chemistry, Multidisciplinary
Bence Paul, Dominic J. Hare, David P. Bishop, Chad Paton, Van Tran Nguyen, Nerida Cole, Megan M. Niedzwiecki, Erica Andreozzi, Angela Vais, Jessica L. Billings, Lisa Bray, Ashley I. Bush, Gawain McColl, Blaine R. Roberts, Paul A. Adlard, David I. Finkelstein, John Hellstrom, Janet M. Hergt, Jon D. Woodhead, Philip A. Doble
Article
Chemistry, Multidisciplinary
Bence Paul, Dominic J. Hare, David P. Bishop, Chad Paton, Van Tran Nguyen, Nerida Cole, Megan M. Niedwiecki, Erica Andreozzi, Angela Vais, Jessica L. Billings, Lisa Bray, Ashley I. Bush, Gawain McColl, Blaine R. Roberts, Paul A. Adlard, David I. Finkelstein, John Hellstrom, Janet M. Hergt, Jon D. Woodhead, Philip A. Doble
Article
Engineering, Biomedical
Renxun Chen, Nerida Cole, Debarun Dutta, Naresh Kumar, Mark D. P. Willcox
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
(2017)
Article
Biochemical Research Methods
Maiken Ueland, Lucas Blanes, Regina V. Taudte, Barbara H. Stuart, Nerida Cole, Peter Willis, Claude Roux, Philip Doble
JOURNAL OF CHROMATOGRAPHY A
(2016)
Article
Medicine, Legal
Natasha Benson, Robson Oliveria Dos Santos, Kate Griffiths, Nerida Cole, Philip Doble, Claude Roux, Lucas Blanes
FORENSIC SCIENCE INTERNATIONAL
(2017)
Article
Chemistry, Analytical
David P. Bishop, Mandy Grossgarten, Doerthe Dietrich, Antje Vennemann, Nerida Cole, Michael Sperling, Martin Wiemann, Philip A. Doble, Uwe Karst
ANALYTICAL METHODS
(2018)
Review
Chemistry, Multidisciplinary
David P. Bishop, Nerida Cole, Tracy Zhang, Philip A. Doble, Dominic J. Hare
CHEMICAL SOCIETY REVIEWS
(2018)
Article
Medicine, General & Internal
Alanna Huynh, Rose Cairns, Jared A. Brown, Ann-Maree Lynch, Jeff Robinson, Carol Wylie, Nicholas A. Buckley, Andrew H. Dawson
MEDICAL JOURNAL OF AUSTRALIA
(2018)
Article
Engineering, Biomedical
Kitty K. K. Ho, Renxun Chen, Mark D. P. Willcox, Scott A. Rice, Nerida Cole, George Iskander, Naresh Kumar
Review
Ophthalmology
Susan Truong, Nerida Cole, Fiona Stapleton, Blanka Golebiowski
CLINICAL AND EXPERIMENTAL OPTOMETRY
(2014)
Article
Ophthalmology
Nerida Cole, Emma B. H. Hume, Shamila Khan, Linda Garthwaite, Tim C. R. Conibear, Mark D. P. Willcox
EXPERIMENTAL EYE RESEARCH
(2014)
Article
Microbiology
Bart A. Eijkelkamp, Jacqueline R. Morey, Stephanie L. Neville, Aimee Tan, Victoria G. Pederick, Nerida Cole, Prashina P. Singh, Cheryl-Lynn Y. Ong, Raquel Gonzalez de Vega, David Clases, Bliss A. Cunningham, Catherine E. Hughes, Iain Comerford, Erin B. Brazel, Jonathan J. Whittall, Charles D. Plumptre, Shaun R. McColl, James C. Paton, Alastair G. McEwan, Philip A. Doble, Christopher A. Mcdevitt
Article
Toxicology
Alanna Huynh, Rose Cairns, Jared A. Brown, Stephen Jan, Jeff Robinson, Ann-Maree Lynch, Carol Wylie, Nicholas A. Buckley, Andrew H. Dawson
CLINICAL TOXICOLOGY
(2020)
Article
Engineering, Biomedical
Yashaswini Vegi, Mirren Charnley, Stuart K. Earl, Carmine Onofrillo, Blanca del Rosal, Christopher J. H. Chong, Paul R. Stoddart, Nerida Cole, Peter F. Choong, Simon E. Moulton, Nicholas P. Reynolds
Summary: This study presents a method for cell detachment using gold nanorods that triggers the separation of mesenchymal stem cells through photothermal effects, resulting in cells with maintained multipotency, viability, and differentiation ability. Compared to enzymatic cell harvesting, this new method shows improved cellular characteristics, making it a promising approach for recovering stem cells from in vitro culture substrates.
ACTA BIOMATERIALIA
(2021)
Article
Chemistry, Analytical
Mika T. Westerhausen, Thomas E. Lockwood, Raquel Gonzalez de Vega, Anna Roehnelt, David P. Bishop, Nerida Cole, Philip A. Doble, David Clases