Review
Cardiac & Cardiovascular Systems
Agnieszka Kaplon-Cieslicka, Anzhela Soloveva, Yura Mareev, Irina Cabac-Pogorevici, Frederik Hendrik Verbrugge, Panagiotis Vardas
Summary: Hyponatraemia is common in heart failure patients, associated with increased mortality and morbidity. Recognizing hyponatraemia and its causes can guide treatment strategies.
Article
Gastroenterology & Hepatology
Blanca Lizaola-Mayo, Hugo E. Vargas
Summary: Hepatorenal syndrome (HRS), now called HRS-AKI, is a complex response to chronic vasodilatory changes in cirrhosis patients, which is exacerbated by inflammatory responses and has a poor prognosis. Discontinuation of triggering agents and elimination of other possible causes are crucial in the diagnosis of HRS-AKI. Volume expansion and vasoconstrictive drugs are the most effective medical treatments, while liver transplantation is considered the most effective therapy. Terlipressin has shown promising results in treating HRS-AKI and could improve patient survival and reduce the need for renal replacement therapy.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Yuke Sarastri, Juang Idaman Zebua, Puja Nastia Lubis, Fathi Zahra, Anggia Chairuddin Lubis
Summary: Heart failure remains a major cardiovascular problem in Indonesia. Hyponatraemia, a common electrolyte disorder in heart failure patients, is associated with increased risk of mortality and hospitalization.
Article
Gastroenterology & Hepatology
Xingshun Qi, Zhaohui Bai, Qiang Zhu, Gang Cheng, Yu Chen, Xiaowei Dang, Huiguo Ding, Juqiang Han, Lei Han, Yingli He, Fanpu Ji, Hongxu Jin, Bimin Li, Hongyu Li, Yiling Li, Zhiwei Li, Bang Liu, Fuquan Liu, Lei Liu, Su Lin, Dapeng Ma, Fanping Meng, Ruizhao Qi, Tianshu Ren, Lichun Shao, Shanhong Tang, Yufu Tang, Yue Teng, Chunhui Wang, Ran Wang, Yunhai Wu, Xiangbo Xu, Ling Yang, Jinqiu Yuan, Shanshan Yuan, Yida Yang, Qingchun Zhao, Wei Zhang, Yongping Yang, Xiaozhong Guo, Weifen Xie
Summary: This research developed evidence-based clinical practice guidance on the use of terlipressin for liver cirrhosis-related complications. It proposed 10 major guidance statements regarding the efficacy and safety of terlipressin in liver cirrhosis. Terlipressin was found to be beneficial for the management of acute variceal bleeding and hepatorenal syndrome, but further studies are needed to explore its potential effects in other complications.
THERAPEUTIC ADVANCES IN GASTROENTEROLOGY
(2022)
Article
Gastroenterology & Hepatology
Salvatore Piano, Carmine Gambino, Elia Vettore, Valeria Calvino, Marta Tonon, Patrizia Boccagni, Enrico Gringeri, Giacomo Germani, Patrizia Burra, Umberto Cillo, Paolo Angeli
Summary: The response to treatment with terlipressin and albumin in patients with AKI-HRS can reduce the need for renal replacement therapy after liver transplantation (LT) and decrease the risk of chronic kidney disease (CKD) at 1 year post-LT.
Article
Endocrinology & Metabolism
Sadrija Cukoski, Thomas Osterholt, Victor Suarez, Matthias Johannes Hackl, Franziska Grundmann, Volker Burst, Kathrin Moellenhoff
Summary: Achieving recommended targets of sodium correction is challenging due to high variability in responses to treatment. Factors such as baseline sodium levels and treatment strategies play a significant role in sodium evolution. Adjusting therapy according to aetiology and pretreatment sodium is crucial for successful treatment.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2023)
Review
Gastroenterology & Hepatology
Victor Dong, Mitra K. Nadim, Constantine J. Karvellas
Summary: AKI is a common complication following liver transplantation, with significant impact on patient outcomes. Special consideration is needed for immunosuppressive therapy to prevent nephrotoxicity. Optimizing various factors can help reduce the risk of AKI, and strategies are available to improve renal function in post-LT patients with AKI.
LIVER TRANSPLANTATION
(2021)
Article
Pharmacology & Pharmacy
Andrew R. Scheinberg, Paul Martin, Joshua A. Turkeltaub
Summary: Terlipressin, a synthetic vasopressin analog, has been approved by the FDA for the treatment of hepatorenal syndrome. It stimulates vasopressin receptors, resulting in vasoconstriction and improved renal perfusion. This review discusses its approved use, safety, tolerability, and potential applications in chronic liver disease.
EXPERT OPINION ON PHARMACOTHERAPY
(2023)
Article
Medicine, Research & Experimental
Jun Weng, Xu Han, Fanhong Zeng, Yue Zhang, Lei Feng, Lei Cai, Kangyan Liang, Shusong Liu, Shao Li, Gongbo Fu, Min Zeng, Yi Gao
Summary: The study utilized a fiber scaffold bioreactor for high-density, 3D culture of porcine hepatocytes to construct a bioartificial liver and evaluated its protective effects in an ALF porcine model. The bioartificial liver treatment enhanced liver regeneration, alleviated systemic inflammatory response, and reduced extrahepatic organ injury, leading to prolonged survival in the ALF model.
Article
Geriatrics & Gerontology
Kwanghee Jun, Yujin Kim, Young-Mi Ah, Ju-Yeun Lee
Summary: The proportion of older patients prescribed hyponatraemia-inducing medications (HIMs) after treatment for symptomatic or severe hyponatraemia has decreased, but there are still potential risks. Particularly, the use of multiple HIMs in combination with thiazide diuretics may increase the risk of recurrence of severe hyponatraemia in geriatric patients.
Article
Gastroenterology & Hepatology
Alexandra Shingina, Nizar Mukhtar, Jamile Wakim-Fleming, Saleh Alqahtani, Robert J. Wong, Berkeley N. Limketkai, Anne M. Larson, Lafaine Grant
Summary: Acute liver failure (ALF) is a rare, potentially reversible condition that causes severe liver damage and rapid clinical deterioration in patients without preexisting liver disease. Due to limited studies, guidelines provided by the American College of Gastroenterology serve as the official practice recommendations for the identification, treatment, and management of ALF. The guidelines were developed through a process of reviewing scientific evidence and using expert opinions when robust evidence was lacking. Individualized care should be applied in specific clinical scenarios due to the varied clinical presentations of ALF.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Geriatrics & Gerontology
Kwanghee Jun, Young-Mi Ah, Jaekyu Shin, Ju-Yeun Lee
Summary: A case-control study was conducted to evaluate the risk of severe hyponatraemia associated with newly started and concurrently used medications in older people.
Article
Gastroenterology & Hepatology
Florence Wong, Stephen Chris Pappas, K. Rajender Reddy, Hugo Vargas, Michael P. Curry, Arun Sanyal, Khurram Jamil
Summary: The use of terlipressin in patients with HRS1 and ACLF may increase the incidence of RF, especially in patients with grade 3 ACLF. Patients with hypoxemia are at an increased risk of RF and mortality.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Surgery
Liang Zhang, Ming Tian, Li-Ying Sun, Zhi-Jun Zhu
Summary: This study aimed to evaluate the effectiveness of prophylactic use of terlipressin in reducing the occurrence of severe postreperfusion syndrome (PRS) in deceased donor liver transplantation. The results showed that the terlipressin group had stable mean arterial pressure and heart rate at 30 minutes after surgery, and a lower incidence of severe PRS compared to the control group (9.4% vs 53.1%). However, the use of terlipressin resulted in an increased pulmonary capillary wedge pressure. Patients in the terlipressin group also experienced a decrease in right portal vein flow velocity, longer mechanical ventilation time, lower initial poor graft function rate, and lower peak alanine transaminase levels after transplantation.
INTERNATIONAL JOURNAL OF SURGERY
(2023)
Review
Gastroenterology & Hepatology
Sunbin Ling, Guangjiang Jiang, Qingyang Que, Shengjun Xu, Junli Chen, Xiao Xu
Summary: Liver transplantation in China has seen rapid development, with China performing the second-highest number of liver transplants globally each year. Despite the challenges, the quality of liver transplantation continues to improve, and there are promising prospects for its future development in China.
LIVER INTERNATIONAL
(2022)
Article
Surgery
Katelynn Madill-Thomsen, Marwan Abouljoud, Chandra Bhati, Michal Ciszek, Magdalena Durlik, Sandy Feng, Bartosz Foroncewicz, Iman Francis, Michal Grat, Krzysztof Jurczyk, Goran Klintmalm, Maciej Krasnodebski, Geoff McCaughan, Rosa Miquel, Aldo Montano-Loza, Dilip Moonka, Krzysztof Mucha, Marek Myslak, Leszek Paczek, Agnieszka Perkowska-Ptasinska, Grzegorz Piecha, Trevor Reichman, Alberto Sanchez-Fueyo, Olga Tronina, Marta Wawrzynowicz-Syczewska, Andrzej Wiecek, Krzysztof Zieniewicz, Philip F. Halloran
AMERICAN JOURNAL OF TRANSPLANTATION
(2020)
Article
Microbiology
Ana Maria Valencia-Hernandez, Wei Yi Ng, Nazanin Ghazanfari, Sonia Ghilas, Maria N. de Menezes, Lauren E. Holz, Cheng Huang, Kieran English, Myo Naung, Peck Szee Tan, Kirsteen M. Tullett, Thiago M. Steiner, Matthias H. Enders, Lynette Beattie, Yu Cheng Chua, Claerwen M. Jones, Anton Cozijnsen, Vanessa Mollard, Yeping Cai, David G. Bowen, Anthony W. Purcell, Nicole L. La Gruta, Jose A. Villadangos, Tania de Koning-Ward, Alyssa E. Barry, Winfried Barchet, Ian A. Cockburn, Geoffrey McFadden, Stephanie Gras, Mireille H. Lahoud, Patrick Bertolino, Ralf B. Schittenhelm, Irina Caminschi, William R. Heath, Daniel Fernandez-Ruiz
CELL HOST & MICROBE
(2020)
Editorial Material
Nutrition & Dietetics
Helen Vidot, Katharine Kline, Robert Cheng, Liam Finegan, Amelia Lin, Elise Kempler, Simone I. Strasser, David Geoffrey Bowen, Geoffrey William McCaughan, Sharon Carey, Margaret Allman-Farinelli, Nicholas Adam Shackel
Letter
Gastroenterology & Hepatology
Ken Liu, Keval Pandya, Claire West, Susan Virtue, Geoffrey W. McCaughan
LIVER TRANSPLANTATION
(2021)
Letter
Gastroenterology & Hepatology
Ken Liu, David Yeo, Michael Crawford, Simone I. Strasser, Geoffrey W. McCaughan
LIVER TRANSPLANTATION
(2021)
Letter
Pathology
Georgia McCaughan, Susan Jarvis, Joanne Joseph
Letter
Pathology
Nwe Ni Than, Simone Chin, James G. Kench, Geoff McCaughan, Avik Majumdar
Review
Immunology
Ngee-Soon Lau, Andrew Jacques, Geoffrey McCaughan, Michael Crawford, Ken Liu, Carlo Pulitano
Summary: This review assesses technical advancements in split liver transplantation, such as in-situ splitting, machine perfusion, and arterial reconstruction. The use of in-situ splitting reduces cold ischemia time, while machine perfusion shows potential for improving graft quality. Additionally, the use of interposition grafts during split liver transplantation must be carefully considered due to increased risk of hepatic artery thrombosis.
TRANSPLANTATION REVIEWS
(2021)
Article
Medicine, General & Internal
Emily Nash, Abdul-Hamid Sabih, John Chetwood, Georgette Wood, Keval Pandya, Terry Yip, Avik Majumdar, Geoffrey W. McCaughan, Simone Strasser, Ken Liu
Summary: The study compared characteristics and outcomes of drug-induced liver injury (DILI) caused by paracetamol and non-paracetamol medications, particularly herbal and dietary supplements, in a single center over a period of 2009-2020. It found that patients with paracetamol-related DILI had higher 90-day transplant-free survival rates compared to those with non-paracetamol DILI, especially cases involving herbal and dietary supplements. The proportion of DILI cases linked to herbal and dietary supplements has been increasing since 2009.
MEDICAL JOURNAL OF AUSTRALIA
(2021)
Article
Transplantation
Ngee-Soon Lau, Ken Liu, Abdullah Almoflihi, Josephine Xu, Geoffrey McCaughan, Michael Crawford, Carlo Pulitano
Summary: The study found that liberal use of interposition grafts for arterial reconstruction in split liver transplantation is safe and does not result in increased complications.
TRANSPLANTATION DIRECT
(2021)
Article
Gastroenterology & Hepatology
Jess Howell, Avik Majumdar, Michael A. Fink, Mandy Byrne, Geoff McCaughan, Simone Strasser, Michael Crawford, Peter Hodgkinson, Katherine A. Stuart, Caroline Tallis, John Chen, Alan Wigg, Robert Jones, Bryon Jaques, Gary Jeffrey, Leon Adams, Michael C. Wallace, Stephen Munn, Ed Gane, Alex J. Thompson, Paul Gow
Summary: Since the introduction of universal access to DAAs in 2016 in Australia and New Zealand, the number and proportion of liver transplantations performed for HCV-related liver cirrhosis and HCC have decreased. This was also associated with a 31% reduction in death after liver transplantation.
LIVER TRANSPLANTATION
(2022)
Letter
Medicine, General & Internal
Mark Bonnichsen, Ted Stoklosa, David Bowen, Avik Majumdar
INTERNAL MEDICINE JOURNAL
(2022)
Article
Education & Educational Research
Joanne Hart, Jonathan Hakim, Rajneesh Kaur, Richmond Jeremy, Genevieve Coorey, Eszter Kalman, Rebekah Jenkin, David Bowen
Summary: This study investigated the barriers to and enablers of successful medical student research projects. Research supervisors reported that students needed both generic skills and research-based skills to successfully complete the project. Protected research time and academic support were identified as factors that would improve the research project program.
BMC MEDICAL EDUCATION
(2022)
Letter
Pathology
R. E. McCarthy, D. G. Bowen, S. I. Strasser, C. McKenzie