Article
Clinical Neurology
Takuma Minami, Takeshi Matsumoto, Yasuharu Tabara, David Gozal, Dale Smith, Kimihiko Murase, Kiminobu Tanizawa, Naomi Takahashi, Yoshinari Nakatsuka, Satoshi Hamada, Tomohiro Handa, Hirofumi Takeyama, Toru Oga, Isuzu Nakamoto, Tomoko Wakamura, Naoko Komenami, Kazuya Setoh, Takanobu Tsutsumi, Takahisa Kawaguchi, Yoichiro Kamatani, Yoshimitsu Takahashi, Satoshi Morita, Takeo Nakayama, Toyohiro Hirai, Fumihiko Matsuda, Kazuo Chin
Summary: The study showed a significant association between moderate-to-severe sleep-disordered breathing and diabetes risk in females with a family history of diabetes, but the association was weaker in males. Further research is needed to determine whether treating sleep-disordered breathing can prevent the onset of diabetes in females with a family history of the disease.
JOURNAL OF CLINICAL SLEEP MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Kazuhiro Yamazaki, Kenji Minakata, Takeichiro Nakane, Hideyuki Kinoshita, Kiminobu Tanizawa, Shinji Sumiyoshi, Hiroki Sato, Kenji Minatoya, Ryuzo Sakata
Summary: A 32-year-old male patient was initially diagnosed with fibrosing mediastinitis, but later found to have constrictive pericarditis. After surgical resection, angiosarcoma was discovered. Despite the diagnosis, the patient is still alive seven years later. This is a rare case of atypical primary angiosarcoma causing pericarditis and pulmonary dysfunction.
GENERAL THORACIC AND CARDIOVASCULAR SURGERY
(2021)
Article
Surgery
Haruhiko Shiiya, Jun Nakajima, Hiroshi Date, Toyofumi Fengshi Chen-Yoshikawa, Kiminobu Tanizawa, Tomohiro Handa, Takahiro Oto, Shinji Otani, Toshio Shiotani, Yoshinori Okada, Yasushi Matsuda, Takeshi Shiraishi, Toshihiko Moroga, Masato Minami, Soichiro Funaki, Masayuki Chida, Ichiro Yoshino, Go Hatachi, Yukari Uemura, Masaaki Sato
Summary: Despite extrapulmonary problems such as a flat chest, low BMI, and associated restrictive impairment persisting in patients with IPPFE, patient survival after LT for IPPFE or IPF was equivalent.
Article
Multidisciplinary Sciences
Saori Sakaue, Etsuro Yamaguchi, Yoshikazu Inoue, Meiko Takahashi, Jun Hirata, Ken Suzuki, Satoru Ito, Toru Arai, Masaki Hirose, Yoshinori Tanino, Takefumi Nikaido, Toshio Ichiwata, Shinya Ohkouchi, Taizou Hirano, Toshinori Takada, Satoru Miyawaki, Shogo Dofuku, Yuichi Maeda, Takuro Nii, Toshihiro Kishikawa, Kotaro Ogawa, Tatsuo Masuda, Kenichi Yamamoto, Kyuto Sonehara, Ryushi Tazawa, Konosuke Morimoto, Masahiro Takaki, Satoshi Konno, Masaru Suzuki, Keisuke Tomii, Atsushi Nakagawa, Tomohiro Handa, Kiminobu Tanizawa, Haruyuki Ishii, Manabu Ishida, Toshiyuki Kato, Naoya Takeda, Koshi Yokomura, Takashi Matsui, Masaki Watanabe, Hiromasa Inoue, Kazuyoshi Imaizumi, Yasuhiro Goto, Hiroshi Kida, Tomoyuki Fujisawa, Takafumi Suda, Takashi Yamada, Yasuomi Satake, Hidenori Ibata, Nobuyuki Hizawa, Hideki Mochizuki, Atsushi Kumanogoh, Fumihiko Matsuda, Koh Nakata, Tomomitsu Hirota, Mayumi Tamari, Yukinori Okada
Summary: Autoimmune pulmonary alveolar proteinosis (aPAP) is a complex lung disease caused by abnormal surfactant homeostasis. In a genome-wide association study in a Japanese cohort, variants in the MHC were found and suggested a predisposition to abnormal antibody production.
NATURE COMMUNICATIONS
(2021)
Article
Medicine, General & Internal
Feng Xu, Naoya Tanabe, Dragos M. Vasilescu, John E. McDonough, Harvey O. Coxson, Kohei Ikezoe, Daisuke Kinose, Kevin W. Ng, Stijn E. Verleden, Wim A. Wuyts, Bart M. Vanaudenaerde, Johny Verschakelen, Joel D. Cooper, Marc E. Lenburg, Katrina B. Morshead, Alexander R. Abbas, Joseph R. Arron, Avrum Spira, Tillie-Louise Hackett, Thomas Colby, Christopher J. Ryerson, Raymond T. Ng, James C. Hogg
Summary: The study focuses on the molecular and cellular mechanisms associated with the transition of idiopathic pulmonary fibrosis (IPF) from normal lung anatomy to minimal and established fibrosis, revealing gene expression changes related to this transition. These gene expression patterns indicate activation of immune responses, increased infiltration of inflammatory immune cells, and participation of various pathways in the development of IPF.
Article
Critical Care Medicine
Kohei Ikezoe, Tillie-Louise Hackett, Samuel Peterson, Dante Prins, Cameron J. Hague, Darra Murphy, Stacey LeDoux, Fanny Chu, Feng Xu, Joel D. Cooper, Naoya Tanabe, Christopher J. Ryerson, Peter D. Pare, Harvey O. Coxson, Thomas Colby, James C. Hogg, Dragos M. Vasilescu
Summary: The study conducted three-dimensional assessment of IPF lung microstructure using stereology and multiresolution computed tomography (CT) imaging, revealing significant changes in lung tissue of IPF patients, particularly in small airways which may have important implications for IPF outcomes.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2021)
Article
Cell Biology
Naoya Ikegami, Naoki Nakajima, Akihiko Yoshizawa, Tomohiro Handa, Toyofumi Chen-Yoshikawa, Takeshi Kubo, Kiminobu Tanizawa, Akihiro Ohsumi, Yoshito Yamada, Masatsugu Hamaji, Daisuke Nakajima, Yojiro Yutaka, Satona Tanaka, Kizuku Watanabe, Yoshinari Nakatsuka, Yuko Murase, Tomoko Nakanishi, Takafumi Niwamoto, Kazuo Chin, Hiroshi Date, Toyohiro Hirai
Summary: This study evaluated the pathological findings associated with radiological PPFE-like lesions and the clinical and morphological features of patients with pathological PPFE. The results showed that pathological PPFE was related to previous pneumothorax, volume loss in the upper lobes, and a flattened chest. Patients with idiopathic disease and those with secondary disease with pathological PPFE had similar clinical, radiological, and pathological findings. However, fibroblastic foci were more common in idiopathic cases and alveolar septal thickening with elastosis or fibrosis were more common in secondary cases. The post-transplantation survival of patients with pathological PPFE was similar to those with idiopathic pulmonary fibrosis (IPF).
Article
Clinical Neurology
Naomi Takahashi, Takeshi Matsumoto, Yoshinari Nakatsuka, Kimihiko Murase, Yasuharu Tabara, Hirofumi Takeyama, Takuma Minami, Satoshi Hamada, Osamu Kanai, Kiminobu Tanizawa, Isuzu Nakamoto, Takahisa Kawaguchi, Kazuya Setoh, Takanobu Tsutsumi, Yoshimitsu Takahashi, Tomohiro Handa, Tomoko Wakamura, Naoko Komenami, Satoshi Morita, Toyohiro Hirai, Fumihiko Matsuda, Takeo Nakayama, Kazuo Chin
Summary: A study found that subjective sleep duration (SSD) is generally longer than objective sleep duration (OSD), but the difference between them may vary based on OSD. The difference between SSD and OSD is associated with sleep-disordered breathing (SDB) and nonrestorative sleep.
JOURNAL OF CLINICAL SLEEP MEDICINE
(2022)
Letter
Critical Care Medicine
Dragos M. Vasilescu, Kohei Ikezoe, Christopher J. Ryerson, James C. Hogg, Tillie-Louise Hackett
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Article
Respiratory System
Kiminobu Tanizawa, Tomohiro Handa, Sonoko Nagai, Kohei Ikezoe, Takeshi Kubo, Takafumi Yokomatsu, Seigen Ueda, Yasutaka Fushimi, Shumpei Ogino, Kizuku Watanabe, Yoshinari Nakatsuka, Toyohiro Hirai, Takateru Izumi
Summary: The study aimed to evaluate the epidemiology and clinical relevance of lung function decline in sarcoidosis, finding that a certain proportion of patients experienced a decline in lung function within 24 months, which did not necessarily lead to further decline in lung function.
RESPIRATORY INVESTIGATION
(2022)
Article
Respiratory System
Kiminobu Tanizawa, Tomohiro Handa, Sonoko Nagai, Takafumi Yokomatsu, Seigen Ueda, Kohei Ikezoe, Shumpei Ogino, Toyohiro Hirai, Takateru Izumi
Summary: This study investigated the association between basal interventricular septum thinning and longterm cardiac function in patients with sarcoidosis. The results showed that basal IVS thinning predicted a delayed onset of left ventricular dysfunction, even when the LV function was preserved at the time of detection.
RESPIRATORY INVESTIGATION
(2022)
Article
Cardiac & Cardiovascular Systems
Shunichi Nagata, Akihiro Ohsumi, Tomohiro Handa, Yoshito Yamada, Satona Tanaka, Yojiro Yutaka, Daisuke Nakajima, Kiminobu Tanizawa, Toyohiro Hirai, Hiroshi Date
Summary: By analyzing registered lung transplant patients, the study found that a decline of more than 10% in lung function within 6 months and a 6-minute walking distance of less than 250m were associated with a worse prognosis (death or living-donor lobar LT). The ISHLT criteria could appropriately identify ILD patients with potentially poor prognosis.
GENERAL THORACIC AND CARDIOVASCULAR SURGERY
(2023)
Article
Respiratory System
Satoshi Hamada, Tomohiro Handa, Naoya Tanabe, Susumu Sato, Kiminobu Tanizawa, Atsuyasu Sato, Satoshi Morita, Kazuo Chin, Toyohiro Hirai
Summary: This study evaluated the performance of TeleOx(R), a remote monitoring device, in ILD and COPD patients and found that its performance varied depending on the device's position, oxygen flow rates, and patients' diseases.
SARCOIDOSIS VASCULITIS AND DIFFUSE LUNG DISEASES
(2022)
Article
Respiratory System
Kimihiko Murase, Takeshi Matsumoto, Yasuharu Tabara, Adrienne Ohler, David Gozal, Takuma Minami, Osamu Kanai, Hirofumi Takeyama, Naomi Takahashi, Satoshi Hamada, Kiminobu Tanizawa, Tomoko Wakamura, Naoko Komenami, Kazuya Setoh, Takahisa Kawaguchi, Takanobu Tsutsumi, Satoshi Morita, Yoshimitsu Takahashi, Takeo Nakayama, Motoko Yanagita, Toyohiro Hirai, Fumihiko Matsuda, Kazuo Chin
Summary: Sleep-disordered breathing and office blood pressure are independently and synergistically associated with urinary albumin excretion, which is a risk factor for chronic kidney disease and cardiovascular events.
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2022)
Article
Respiratory System
Tomohiro Handa, Kiminobu Tanizawa, Tsuyoshi Oguma, Ryuji Uozumi, Kizuku Watanabe, Naoya Tanabe, Takafumi Niwamoto, Hiroshi Shima, Ryobu Mori, Tomomi W. Nobashi, Ryo Sakamoto, Takeshi Kubo, Atsuko Kurosaki, Kazuma Kishi, Yuji Nakamoto, Toyohiro Hirai
Summary: In this study, an artificial intelligence-based image analysis software was developed to quantify parenchymal lesions and airway volumes in patients with idiopathic pulmonary fibrosis (IPF). The results showed that bronchial and normal lung volumes on chest high-resolution CT imaging may provide additional prognostic information on the gender-age-lung physiology stage of IPF.
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2022)
