期刊
INTERNAL MEDICINE
卷 51, 期 10, 页码 1245-1247出版社
JAPAN SOC INTERNAL MEDICINE
DOI: 10.2169/internalmedicine.51.6810
关键词
progressive multifocal leukoencephalopathy; systemic lupus erythematosus; mefloquine
We describe a case of a 67-year-old man with systemic lupus erythematosus who presented with progressive left hemiplegia. Although the cerebral spinal fluid (CSF) polymerase chain reaction (PCR) for the JC virus was negative, a brain biopsy confirmed the diagnosis of progressive multifocal leukoencephalopathy (PML). The tapering of prednisone and the use of cidofovir could not arrest the disease progression. Administration of mefloquine stopped the extension of the lesion, and resulted in obvious clinical improvement. The CSF nested PCR for the JC virus also became negative. This widely used drug should be tried for the treatment of non-HIV PML.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据