期刊
INTERNAL MEDICINE
卷 51, 期 2, 页码 205-209出版社
JAPAN SOC INTERNAL MEDICINE
DOI: 10.2169/internalmedicine.51.6253
关键词
progressive multifocal leukoencephalopathy (PML); human immunodeficiency virus infection (HIV); highly active anti-retroviral therapy (HAART); mefloquine; proton magnetic resonance spectroscopy (H-1-MRS); apparent diffusion coefficient (ADC)
资金
- Grants-in-Aid for Scientific Research [23790993] Funding Source: KAKEN
We report a case of a patient with highly active anti-retroviral therapy-resistant human immunodeficiency virus (HIV)-associated progressive multifocal leukoencephalopathy (PML). The patient showed an improvement in imaging findings and clinical symptoms after mefloquine was introduced as an additional treatment. Serial assessment of white matter lesions was conducted by proton magnetic resonance spectroscopy (H-1-MRS) and diffusion-weighted imaging (DWI). As the clinical symptoms improved, the N-acetylaspartate/creatine ratio increased, the choline/creatine ratio decreased, and the elevated ADC value decreased. These concomitant changes suggested that H-1-MRS and DWI were useful for the assessment of the therapeutic effect on PML.
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