Article
Nutrition & Dietetics
Aviv Kfir, Yair Lahav, Yftach Gepner
Summary: The current prediction equations for resting metabolic rate (RMR) have limitations due to small sample size and individual variance. This study evaluated the accuracy of five common RMR equations and developed a new prediction equation that includes body composition. The results showed that all the prediction equations underestimated RMR, and the proposed model, which includes sex, age, fat mass (FM), and free-fat mass (FFM), successfully predicted 73.5% of the explained variation of RMR with a bias of 0.7%.
Review
Clinical Neurology
Ozeas Lins-Filho, Jose Lucas Porto Aguiar, Jose Ricardo Vieira de Almeida, Antonio Henrique Soares, Raphael Ritti-Dias, Maria Julia da Silva, Rodrigo Pinto Pedrosa
Summary: Exercise training significantly reduced body mass index, body fat percentage, neck circumference, total body weight, and AHI in patients with OSA. However, the improvement in AHI may not solely be attributed to changes in adiposity. The study suggests that exercise can improve body composition in OSA patients, but the clinical significance of this improvement may be limited.
Article
Nutrition & Dietetics
Dimitra Siopi, Paschalis Steiropoulos
Summary: Energy expenditure and physical activity levels are disturbed in obese patients with Obstructive Sleep Apnea (OSA). This study explores the effects of Continuous Positive Airway Pressure treatment (CPAP) on these disruptions. The results show that CPAP treatment significantly decreases basal metabolic rate (BMR) but does not lead to a significant increase in physical activity levels.
Article
Medicine, Research & Experimental
Lucia Pinilla, Ivan D. Benitez, Fernando Santamaria-Martos, Adriano Targa, Anna Moncusi-Moix, Mireia Dalmases, Olga Minguez, Maria Aguila, Mariona Jove, Joaquim Sol, Reinald Pamplona, Ferran Barbe, Manuel Sanchez-de-la-Torre
Summary: The study investigated the plasma metabolome and lipidome of patients with suspected OSA to identify potential biomarkers for diagnosis and understand the underlying mechanisms of the disease. Results showed a plasma profile comprising 33 metabolites in OSA patients, with a specific 4-metabolite signature providing high accuracy for OSA detection. CPAP treatment led to changes in 5 plasma metabolites affected by OSA, indicating a potential for personalized OSA management using blood-based biomarkers and suggesting adaptive mechanisms in response to OSA-induced hypoxia.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Endocrinology & Metabolism
Juan Wang, Haobo Xu, Jiansong Yuan, Chao Guo, Fenghuan Hu, Weixian Yang, Lei Song, Xiaoliang Luo, Rong Liu, Jingang Cui, Shengwen Liu, Yushi Chun, Shubin Qiao
Summary: The study revealed an independent association between obstructive sleep apnea (OSA) and metabolic dysfunction in patients with hypertrophic cardiomyopathy (HCM), including obesity, elevated blood pressure, and high triglycerides. Further clinical trials are needed to determine if treating OSA can improve metabolic abnormalities and long-term outcomes in HCM patients.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Clinical Neurology
Tingting Ji, Xiaodan Li, Jun Chen, Xuemin Ren, Lin Mei, Yue Qiu, Jie Zhang, Shengcai Wang, Zhifei Xu, Hongbin Li, Zheng Li, Yun Peng, Yue Liu, Xin Ni, Jun Tai, Jiangang Liu
Summary: Children with obstructive sleep apnea (OSA) exhibit abnormal neural activities in specific brain regions and impaired cognitive functions, with the former possibly being the neural mechanism of the latter.
Article
Biology
Leeba Rezaie, Soroush Maazinezhad, Donald J. Fogelberg, Habibolah Khazaie, Dena Sadeghi-Bahmani, Serge Brand
Summary: Individuals with obstructive sleep apnea (OSA) are at a higher risk for somatic and sleep-related complaints. By combining demographic, anthropometric, subjective, and objective sleep- and breathing-related data, it was found that higher AHI scores were associated with higher BMI, daytime sleepiness, respiratory disturbance index, and snoring. Additionally, shorter sleep duration, more N2 sleep, and a higher RDI were predictive of AHI scores. This integrated approach provides a more effective way to identify individuals at higher risk for OSA.
Article
Clinical Neurology
Nana Feng, Jundong Yang, Huajun Xu, Chujun Zhang, Fan Wang, Xiaolin Wu, Meizhen Gu
Summary: This study evaluated the associations between sleep architecture and metabolic parameters in 2,308 patients with suspected OSA, finding weak correlations between sleep quality and metabolic parameters such as weight, blood sugar, and cholesterol. The clinical impact of sleep structure on metabolism appears to be negligible, highlighting the need for further prospective studies to confirm these findings.
FRONTIERS IN NEUROLOGY
(2021)
Review
Endocrinology & Metabolism
Sara Q. C. Giampa, Geraldo Lorenzi-Filho, Luciano F. Drager
Summary: Metabolic syndrome (MS) is associated with increased cardiovascular risk, and there is evidence suggesting that obstructive sleep apnea (OSA) is associated with MS and its components. The biological plausibility of this association is supported by the intermittent hypoxia seen in OSA, which leads to various physiological effects related to MS. However, the clinical evidence is mainly based on cross-sectional data, and confounders such as obesity and medication use pose challenges in determining the independent contribution of OSA to MS. This review discusses the evidence on how OSA/intermittent hypoxia may affect MS parameters independently of adiposity and highlights the need for further high-quality interventional studies.
Article
Public, Environmental & Occupational Health
Li-Ang Lee, Hai-Hua Chuang, Hui-Shan Hsieh, Chao-Yung Wang, Li-Pang Chuang, Hsueh-Yu Li, Tuan-Jen Fang, Yu-Shu Huang, Guo-She Lee, Albert C. Yang, Terry B. J. Kuo, Cheryl C. H. Yang
Summary: This retrospective case series investigated the effects of adenotonsillectomy on heart rate variability (HRV) indices in children with obstructive sleep apnea (OSA). The results showed that adenotonsillectomy improved HRV indices, indicating improvements in cardiac autonomic function in children with OSA.
FRONTIERS IN PUBLIC HEALTH
(2023)
Review
Health Care Sciences & Services
Sy Duong-Quy, Hoang Nguyen-Huu, Dinh Hoang-Chau-Bao, Si Tran-Duc, Lien Nguyen-Thi-Hong, Thai Nguyen-Duy, Tram Tang-Thi-Thao, Chandat Phan, Khue Bui-Diem, Quan Vu-Tran-Thien, Thu Nguyen-Ngoc-Phuong, Vinh Nguyen-Nhu, Huong Le-Thi-Minh, Timothy Craig
Summary: Obstructive Sleep Apnea (OSA) is a common disease that is often underestimated and undertreated in all age groups. Personalized diagnosis and treatment approaches are necessary for clinical practice due to morphological differences, clinical phenotype diversity, and variations in diagnosis and treatment of OSA in children and adults. Treatment should be based on individual tolerance to sleep-quality-related parameters, the harmful effects of hypoxia on the cardiovascular system, and patients' comorbidities.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Review
Physiology
Fatima O. Martins, Silvia V. Conde
Summary: The relationship between obstructive sleep apnea (OSA) and endocrine and metabolic disease is bidirectional, with OSA contributing to and exacerbating obesity, metabolic syndrome, type 2 diabetes, and endocrine disturbances, while endocrine and metabolic diseases are also considered major risk factors for the development of OSA. Various factors including sympathetic activation, deregulation of the hypothalamus-pituitary axis, insulin resistance, and inflammation of adipose tissue are postulated to contribute to dysmetabolic states in OSA. Sex hormones and gender differences play a significant role in the link between OSA and dysmetabolism.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Medicine, General & Internal
Joanna Smardz, Mieszko Wieckiewicz, Anna Wojakowska, Monika Michalek-Zrabkowska, Rafal Poreba, Pawel Gac, Grzegorz Mazur, Helena Martynowicz
Summary: The relationship between sleep bruxism and obstructive sleep apnea is complex, with body position-related OSA phenotype associated with higher incidence of bruxism but the exact relationship is unclear. Further studies are needed to clarify the association between the two conditions.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Pediatrics
Hongru Wang, Liang Feng, Huan Zheng, Yibin Zeng, Bin Liu
Summary: The study found that heart rate recovery is closely associated with the severity of obstructive sleep apnea syndrome (OSAS) in children and adolescents, suggesting it might be a promising index for risk stratification and clinical management.
PEDIATRIC RESEARCH
(2021)
Article
Health Care Sciences & Services
Seung-Su Ha, Dong-Kyu Kim
Summary: The study proposes an ultra-short-term analysis method to assess the balance of autonomic nervous system (ANS) activity in patients with obstructive sleep apnea (OSA). The results show that this method is more effective in revealing the association between sympathetic overactivity and OSA severity, and it exhibits higher consistency compared to the traditional short-term analysis method.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Letter
Andrology
R. Uygur, M. Yagmurca, O. A. Alkoc, A. Genc, A. Songur, K. Ucok, O. A. Ozen
Correction
Andrology
R. Uygur, M. Yagmurca, O. A. Alkoc, A. Genc, A. Songur, K. Ucok, O. A. Ozen
Article
Psychiatry
Ahmet Hamdi Alpaslan, Kagan Ucok, Kerem Senol Coskun, Abdurrahman Genc, Hatice Karabacak, Halil Ibrahim Guzel
EATING AND WEIGHT DISORDERS-STUDIES ON ANOREXIA BULIMIA AND OBESITY
(2017)
Article
Andrology
R. Uygur, M. Yagmurca, O. A. Alkoc, A. Genc, A. Songur, K. Ucok, O. A. Ozen
Article
Gastroenterology & Hepatology
Cemil Celikagi, Abdurrahman Genc, Ahmet Bal, Kagan Ucok, Ozan Turamanlar, Z. Taner Ozkececi, Hatice Yalcinkaya, Necip F. Coban, Sueda Yorulmaz
EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY
(2014)
Article
Dermatology
Reha Demirel, Abdurrahman Genc, Kagan Ucok, Seval Dogruk Kacar, Pinar Ozuguz, Muhsin Toktas, Umit Sener, Hatice Karabacak, Semsettin Karaca
INTERNATIONAL JOURNAL OF DERMATOLOGY
(2013)
Article
Rheumatology
Umit Sener, Kagan Ucok, Alper M. Ulasli, Abdurrahman Genc, Hatice Karabacak, Necip F. Coban, Hasan Simsek, Halime Cevik
INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES
(2016)
Article
Rheumatology
Hatice Yalcinkaya, Kagan Ucok, Alper M. Ulasli, Necip F. Coban, Sedat Aydin, Idris Kaya, Gokhan Akkan, Tugba Tugrul Senay
INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES
(2017)
Article
Biochemistry & Molecular Biology
Mustafa Solak, Mujgan Ozdemir Erdogan, Saliha Handan Yildiz, Kagan Ucok, Seref Yuksel, Evrim Suna Arikan Terzi, Ahmet Bestepe
MOLECULAR BIOLOGY REPORTS
(2014)
Article
Clinical Neurology
Mehmet Yaman, Kagan Ucok, Hayri Demirbas, Abdurrahman Genc, Serdar Oruc, Hatice Karabacak, Gokhan Koyuncu
NEUROLOGICAL SCIENCES
(2013)
Article
Medicine, General & Internal
Abdurrahman Genc, Kagan Ucok, Umit Sener, Tulay Koyuncu, Olcay Akar, Sefa Celik, Mehmet Unlu
TURKISH JOURNAL OF MEDICAL SCIENCES
(2014)
Meeting Abstract
Ophthalmology
Umit Ubeyt Inan, Onur Polat, Sibel Inan, Tulay Koken, Mahmut Karadas, Mustafa Dogan, Kagan Ucok
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2015)
Meeting Abstract
Physiology
Abdurrahman Genc, Ahmet Ahsen, Yucel Gonul, Kasim Demir, Sezer Akcer, Mustafa Aldemir, Sefa Celik, Kagan Ucok
Article
Medicine, General & Internal
K. Ucok, H. Yalcinkaya, A. Acay, N. F. Coban, S. Aslanalp, G. Akkan, S. Aydin, C. Celikagi, A. Ahsen
NETHERLANDS JOURNAL OF MEDICINE
(2015)
Article
Pharmacology & Pharmacy
Y. Yavuz, H. Mollaoglu, Y. Yurumez, K. Ucok, L. Duran, K. Tunay, L. Akgun
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2013)