Article
Surgery
Ahmed AL-Bulushi, Issa Al Salmi, Fatma Al Rahbi, AbdulAziz Al Farsi, Suad Hannawi
Summary: This study investigated the epidemiology of patients with myasthenia gravis who underwent thymectomy at the Royal Hospital in Muscat, Oman over the past three decades. The results showed that post-thymectomy, most patients experienced significant clinical improvement, with a small percentage achieving complete clinical remission.
ASIAN JOURNAL OF SURGERY
(2021)
Article
Biochemistry & Molecular Biology
Mariela L. Paz, Francisco J. Barrantes
Summary: Myasthenia gravis is a disease that affects the signaling at the cholinergic neuromuscular junction, mainly caused by autoimmune diseases. Research also shows that cholesterol's rich content at the postsynaptic membrane is related to the modulation of nicotinic receptors, with discussions on the pathophysiology of myasthenia gravis affected by cholesterol.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2021)
Article
Clinical Neurology
Magne Solberg Nes, Mette Haugen, Hans Kristian Haugland, Nils Erik Gilhus, Christian Alexander Vedeler
Summary: Autoantibodies to the alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) and leucine-rich glioma-inactivated 1 (Lgi1) have been linked to autoimmune encephalitis. This single-case report describes a patient with myasthenia gravis and limbic encephalitis with antibodies to AMPAR and Lgi1, highlighting the persistence of these antibodies despite clinical recovery.
FRONTIERS IN NEUROLOGY
(2023)
Article
Clinical Neurology
Shahar Shelly, John R. Mills, Divyanshu Dubey, Andrew McKeon, Anastasia Zekeridou, Sean J. Pittock, C. Michel Harper, Elie Naddaf, Margherita Milone, Jay Mandrekar, Christopher J. Klein
Summary: The study demonstrates that striational antibodies are neither specific nor sensitive in predicting malignancy or neurologic phenotypes in patients, and their presence does not accurately identify these conditions.
Article
Clinical Neurology
Shahar Shelly, John R. Mills, Divyanshu Dubey, Andrew Mckeon, Anastasia Zekeridou, Sean J. Pittock, C. Michel Harper, Elie Naddaf, Margherita Milone, Jay Mandrekar, Christopher J. Klein
Summary: This study evaluates the clinical utility of StrAbs in paraneoplastic and myasthenia gravis (MG) serologic evaluations. Despite a statistically significant association with cancer, StrAbs are found to be neither specific nor sensitive in predicting malignancy or neurologic phenotypes.
Article
Multidisciplinary Sciences
Hiroaki Yoshikawa, Yumi Adachi, Yosikazu Nakamura, Nagato Kuriyama, Hiroyuki Murai, Yoshiko Nomura, Yasunari Sakai, Kazuo Iwasa, Yutaka Furukawa, Satoshi Kuwabara, Makoto Matsui
Summary: This study examined the prevalence and clinical features of myasthenia gravis (MG) in Japan in 2017. The results showed that the prevalence of MG had doubled compared to a previous study in 2006. The onset age of MG shifted towards the elderly, and the male-female ratio became almost equal. The study also categorized patients into four groups and found differences in clinical features and treatment approaches among them.
Review
Immunology
Ruksana Huda
Summary: Myasthenia gravis (MG) is a neuromuscular autoimmune disorder characterized by chronic but intermittent fatigue of the eye- and general body muscles. Muscle weakness is caused primarily by the binding of an autoantibody to the acetylcholine receptors, resulting in blockage of normal neuromuscular signal transmission. Research aims to identify unknown molecular pathways and novel targets involved in inflammation associated with MG and suggest the potential of targeting important inflammatory marker(s) along with current monoclonal antibody or antibody fragment based targeted therapies directed to a variety of cell surface receptors.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Clinical Neurology
Rodrigo Alvarez-Velasco, Gerardo Gutierrez-Gutierrez, Juan Carlos Trujillo, Elisabeth Martinez, Sonia Segovia, Marina Arribas-Velasco, Guillermo Fernandez, Carmen Paradas, Beatriz Velez-Gomez, Carlos Casasnovas, Velina Nedkova, Antonio Guerrero-Sola, Alba Ramos-Fransi, Alicia Martinez-Pineiro, Julio Pardo, Teresa Sevilla, Maria Teresa Gomez-Caravaca, Adolfo Lopez de Munain, Ivonne Jerico, Ana L. Pelayo-Negro, Maria Asuncion Martin, Yolanda Morgado, Maria Dolores Mendoza, Helena Perez-Perez, Ricard Rojas-Garcia, Janina Turon-Sans, Luis Querol, Eduard Gallardo, Isabel Illa, Elena Cortes-Vicente
Summary: The study on myasthenia gravis patients with thymoma found that they had more severe symptoms and worse prognosis compared to non-thymoma patients. Thymoma recurrence may lead to transient worsening, while patients with unresectable thymomas tend to present more severe forms of MG.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Review
Oncology
Mingbo Tang, Yifeng Shao, Junxue Dong, Xinliang Gao, Shixiong Wei, Jianzun Ma, Yang Hong, Zhiqin Li, Taiyu Bi, Yipeng Yin, Wenyu Zhang, Wei Liu
Summary: This study used a meta-analysis to examine the incidence of postoperative myasthenia gravis (PMG) and risk factors in patients with non-MG thymoma. The results showed that the incidence of PMG in preoperative patients with non-MG thymoma was 8%. Preoperative seropositive acetylcholine receptor antibody, open thymectomy, non-R0 resection, WHO type B, and postoperative inflammation were identified as risk factors for PMG.
FRONTIERS IN ONCOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Shruti M. Raja, Jeffrey T. Guptill, Alec McConnell, Hussein R. Al-Khalidi, Matthew G. Hartwig, Jacob A. Klapper
Summary: This study examines the perioperative complications of open and minimally invasive thymectomy techniques in autoimmune myasthenia gravis patients. The findings suggest that minimally invasive and trans cervical thymectomies have lower odds of perioperative complications compared to transthoracic thymectomies in nonthymomatous MG cases.
ANNALS OF THORACIC SURGERY
(2022)
Article
Medicine, Research & Experimental
Zhu Haoshuai, Zou Jianyong, Yang Lei, Zeng Bo, Jiefei Xiao, Xin Zhang, Zhenguang Chen, Su Chunhua
Summary: In patients with thymomatous MG undergoing thymectomy, it takes on average 6 months to achieve a 3 point reduction in QMGS and 30 months for another 3 point reduction. Older age (>=42 years) and higher Masaoka-Koga stage (>I) are associated with a lower probability of achieving a reduction in QMGS.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Review
Nutrition & Dietetics
Angel Yun-Kuan Thye, Jodi Woan-Fei Law, Loh Teng-Hern Tan, Sivakumar Thurairajasingam, Kok-Gan Chan, Vengadesh Letchumanan, Learn-Han Lee
Summary: The disruption of gut microbiota is associated with the pathogenesis of myasthenia gravis (MG). MG patients have altered gut microbiota composition compared to healthy individuals, and these changes are related to the severity of MG and gut inflammation. Alterations in gut microbiota can be used as a diagnostic tool for MG, and probiotics can modulate gut microbiota and help prevent and treat MG.
Review
Cell Biology
Cloe A. Payet, Axel You, Odessa-Maud Fayet, Nadine Dragin, Sonia Berrih-Aknin, Rozen Le Panse
Summary: Myasthenia gravis is a rare autoimmune disease associated with antibodies against components of the neuromuscular junction. An interferon type I signature is detected in the thymus of early-onset and thymoma-associated MG patients. IFN-I is normally produced in response to viral infection, but it is also present in some systemic autoimmune diseases known as interferonopathies.
Article
Clinical Neurology
Johanna Verwijst, Elisabet Westerberg, Anna Rostedt Punga
Summary: The study found that extrathymic cancers occurred mainly in patients with thymoma-associated MG and late-onset MG, and there was a significant correlation between the use of corticosteroid-sparing immunosuppressants (CSISs) and cancer risk.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Article
Oncology
Liu Chen, Yi Li, Xiaohua Dong, Guilong Tanzhu, Xianjing Chu, Fuxing Deng, Xiang Li, Jing Zhang, Bin Long, Di Jing, Lishui Niu, Haiqin Peng, Huan Yang, Rongrong Zhou
Summary: This study examined the impact of postoperative radiotherapy (PORT) on patients with thymoma associated with myasthenia gravis (MG). The results showed that PORT can improve MG symptoms and increase disease-free survival (DFS) and overall survival (OS) rates for these patients. The effect is particularly significant for patients with higher histologic subtype and Masaoka-Koga staging.
RADIOTHERAPY AND ONCOLOGY
(2023)
