Review
Infectious Diseases
Elie Haddad, Arnaud Fekkar, Sophie Bonnin, Natalia Shor, Danielle Seilhean, Isabelle Plu, Valerie Touitou, Veronique Leblond, Nicolas Weiss, Sophie Demeret, Valerie Pourcher
Summary: This study presents a case series of aggressive cerebral vasculitis caused by Aspergillus spp. infection in immunocompromised patients. The findings suggest that cerebral aspergillosis should be considered in immunocompromised individuals with suggestive lesions on imaging.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Clinical Neurology
Monique F. Stins, Agnes Mtaja, Evan Mulendele, Daniel W. Mwimbe, Gabriel Pinilla, Mable Mutengo, Carlos A. Pardo, James Chipeta
Summary: Neurological infections, such as cerebral malaria and meningitis, have high mortality rates and can cause persistent neurologic deficits, especially in young children. Inflammation in the brain plays a role in the development of these deficits. A study in Zambian children with neurological infections found high levels of markers for vascular inflammation in both plasma and cerebrospinal fluid (CSF). The levels of certain immune mediators, such as angiopoietins, differed between cerebral malaria and meningitis patients.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2023)
Article
Clinical Neurology
Fida Oukhai, Valerie Domigo, Joseph Benzakoun, Michel Wolff, Anne Ducros, Jean-Louis Mas, David Calvet
Summary: This article reports two cases of reversible cerebral vasoconstriction syndrome (RCVS) in patients with meningitis. Headache and artery irregularities resolved with the improvement of cerebrospinal fluid (CSF). These cases suggest that brain imaging should be performed to rule out RCVS when modifying or atypical headaches occur in the context of meningitis.
FRONTIERS IN NEUROLOGY
(2023)
Article
Multidisciplinary Sciences
Zhaobo Shi, Yong Sun, Hui Liu, Jun Zhang, Lili Ma
Summary: Cryptococcal meningoencephalitis (CM) is a highly fatal fungal infection that affects the central nervous system (CNS). It is mainly caused by Cryptococcus neoformans (C. neoformans) and can also occur in apparently immunocompetent patients. Complications such as cerebellar infarction and renal dysfunction may arise during the course of treatment, emphasizing the importance of close monitoring and timely intervention. In chronic hepatitis B virus (HBV) patients, CM may be a possible underlying pathogen, highlighting the need for awareness and appropriate management strategies.
Article
Neurosciences
Ying Wu, Sijin Yang, Zhi Zheng, Hong Pan, Yundong Jiang, Xue Bai, Tianzhu Liu, Shiyu Deng, Yaqin Li
Summary: The study demonstrated the crucial role of miR-191-5p in cerebral infarct angiogenesis by targeting BDNF, leading to reduced infarct volume and improved neurological deficits.
Article
Infectious Diseases
Susanne Dyckhoff-Shen, Jan P. Bewersdorf, Nina C. Teske, Stefanie Voelk, Hans-Walter Pfister, Uwe Koedel, Matthias Klein
Summary: This study aimed to classify patients with cerebrospinal fluid pleocytosis to differentiate bacterial meningitis (BM) from other causes. The study found that patients with BM had higher cerebrospinal fluid cell count, and the CHANCE score could effectively predict BM.
Article
Biochemistry & Molecular Biology
Julia Konovalova, Dmytro Gerasymchuk, Sergio Navarette Arroyo, Sven Kluske, Francesca Mastroianni, Alba Vargas Pereyra, Andrii Domanskyi
Summary: This study demonstrated for the first time the direct regulation of MANF and CDNF expression by specific miRNAs, revealing the mechanism and specificity of miRNAs in regulating these neurotrophic factors. The findings emphasize the complexity and importance of miRNA regulation of target genes, providing a new theoretical basis for further research on neuroprotective treatment strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Microbiology
Edwin Nuwagira, Kathy Huppler Hullsiek, Samuel Jjunju, Morris Rutakingirwa, John Kasibante, Kiiza Kandole Tadeo, Enock Kagimu, Lillian Tugume, Kenneth Ssebambulidde, Abdu K. Musubire, Ananta Bangdiwala, Conrad Muzoora, David B. Meya, David R. Boulware, Nathan C. Bahr, Fiona V. Creswell
Summary: This study evaluated the role of CSF lactate in diagnosing and predicting outcomes of TBM in HIV-positive individuals. High CSF lactate levels were found to be associated with the diagnosis of TBM, but not predictive of 2-week mortality. CSF lactate may be a useful tool in diagnosing TBM in the clinical setting.
MICROBIOLOGY SPECTRUM
(2022)
Article
Veterinary Sciences
Kosuke Kinoshita, Hidetaka Nishida, Ryoji Kanegi, Yuya Nakamoto, Toshiyuki Tanaka, Shunsuke Shimamura, Kazuhito Kusumoto, Hideo Akiyoshi
Summary: A 12-year-old Yorkshire terrier with epileptic seizures and nasal discharge was found to have cerebrospinal fluid (CSF) rhinorrhea based on clinical signs and MRI findings. Analysis of the glucose concentration and brain-type transferrin presence in nasal discharge could be useful for diagnosing CSF rhinorrhea.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Review
Medicine, General & Internal
Joan Siquier-Padilla, Guillermo Cuervo, Xabier Urra, Eduard Quintana, Marta Hernandez-Meneses, Elena Sandoval, Pau Lapena, Carles Falces, Carlos A. Mestres, Alfredo Paez-Carpio, Asuncion Moreno, Jose Maria Miro
Summary: This review aims to summarize the best evidence on the optimal timing for cardiac surgery in patients with infective endocarditis and neurological complications. The findings suggest that cardiac surgery can be performed without delay in cases of ischemic, infectious, or asymptomatic complications. In cases of intracranial hemorrhage, a delay of four weeks is recommended, although recent studies have suggested that early surgery within four weeks could be considered for selected cases.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Neurosciences
Olesja Bondarenko, Mart Saarma
Summary: Neurotrophic factors (NTFs) are essential for neuronal development and survival but face challenges in delivery to the brain due to the blood-brain barrier. Nanoparticles (NPs) show promise in stabilizing and transporting NTFs across the BBB, offering a potential solution to systemic delivery.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Medicine, General & Internal
Xin Cao, Qingluan Yang, Xian Zhou, Kun Lv, Zhe Zhou, Feng Sun, Qiaoling Ruan, Jun Zhang, Lingyun Shao, Daoying Geng
Summary: This study explored the relationship between MRI features and neurological deficits and prognosis in patients with tuberculous meningitis (TBM). The presence of acute cerebral infarction (ACI) or old cerebral infarctions (OCI) was associated with neurological deficits, and ACI, OCI, and hydrocephalus were considered poor prognostic predictors. Changes in Evan's ratio also affected the outcome.
Article
Multidisciplinary Sciences
Weifang Xing, Wensheng Zhang, Minzhen Zhu, Jinzhao He
Summary: This article reported a case of suppurative meningitis complicated with acute cerebral infarction caused by Streptococcus suis, providing reference for the diagnosis and treatment of Streptococcus suis infection. The clinical manifestations of this case were headache and fever, and the disease progressed rapidly. After effective anti-infection treatment, the patient's condition improved but with profound hearing impairment.
Article
Multidisciplinary Sciences
Pavlos Vlachogiannis, Lars Hillered, Per Enblad, Elisabeth Ronne-Engstrom
Summary: This study aims to investigate the role of chemokines, a relatively unexplored family of proteins, in the inflammatory pathophysiology of subarachnoid hemorrhage (SAH). Through analyzing the levels of 92 inflammation-related proteins in the cerebrospinal fluid of 29 SAH patients, the study found that higher levels of multiple chemokines at the late stage of SAH were associated with worse clinical outcome. The study also discovered correlations between certain chemokines and WFNS score, Fisher score, occurrence of DCI/DIND, and clinical outcome based on Glasgow score.
Article
Virology
Or Kriger, Merav Weil, Ilana S. Fratty, Eyal Leshem, Itai Gueta, Danit Sofer, Sharon Amit
Summary: This study aimed to assess the clinical significance of EV-PCR-positive CSF and stool, and found that compared to the EV CSF+/Stool+ group, the EV CSF-/Stool+ group frequently had other pathogens detected and a higher stool Ct-value. Clinically, EV CSF-/Stool+ patients had lower body temperature and more symptoms of lethargy and convulsions.
JOURNAL OF CLINICAL VIROLOGY
(2023)
Article
Clinical Neurology
Yujiro Higuchi, Akihiro Hashiguchi, Junhui Yuan, Akiko Yoshimura, Jun Mitsui, Hiroyuki Ishiura, Masaki Tanaka, Satoshi Ishihara, Hajime Tanabe, Satoshi Nozuma, Yuji Okamoto, Eiji Matsuura, Ryuichi Ohkubo, Saeko Inamizu, Wataru Shiraishi, Ryo Yamasaki, Yasumasa Ohyagi, Jun-ichi Kira, Yasushi Oya, Hayato Yabe, Noriko Nishikawa, Shinsuke Tobisawa, Nozomu Matsuda, Masayuki Masuda, Chiharu Kugimoto, Kazuhiro Fukushima, Satoshi Yano, Jun Yoshimura, Koichiro Doi, Masanori Nakagawa, Shinichi Morishita, Shoji Tsuji, Hiroshi Takashima
ANNALS OF NEUROLOGY
(2016)
Article
Neurosciences
Unsong Oh, Masahiro Fujita, Vasiliki N. Ikonomidou, Iordanis E. Evangelou, Eiji Matsuura, Erin Harberts, Joan Ohayon, Victor W. Pike, Yi Zhang, Sami S. Zoghbi, Robert B. Innis, Steven Jacobson
JOURNAL OF NEUROIMMUNE PHARMACOLOGY
(2011)
Review
Neurosciences
Eiji Matsuura, Yoshihisa Yamano, Steven Jacobson
JOURNAL OF NEUROIMMUNE PHARMACOLOGY
(2010)
Article
Clinical Neurology
Junhui Yuan, Yujiro Higuchi, Tatsui Nagado, Satoshi Nozuma, Tomonori Nakamura, Eiji Matsuura, Akihiro Hashiguchi, Yusuke Sakiyama, Akiko Yoshimura, Hiroshi Takashima
JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM
(2013)
Article
Biochemistry & Molecular Biology
Simone C. Wuest, Jehad H. Edwan, Jayne F. Martin, Sungpil Han, Justin S. A. Perry, Casandra M. Cartagena, Eiji Matsuura, Dragan Maric, Thomas A. Waldmann, Bibiana Bielekova
Article
Radiology, Nuclear Medicine & Medical Imaging
Bing Yao, Francesca Bagnato, Eiji Matsuura, Hellmut Merkle, Peter van Gelderen, Fredric K. Cantor, Jeff H. Duyn
Article
Virology
Yoshimi Enose-Akahata, Eiji Matsuura, Yuetsu Tanaka, Unsong Oh, Steven Jacobson
Article
Microbiology
Yoshimi Enose-Akahata, Eiji Matsuura, Unsong Oh, Steven Jacobson
Article
Clinical Neurology
Yusuke Sakiyama, Naoaki Kanda, Yujiro Higuchi, Michiyoshi Yoshimura, Hiroyuki Wakaguri, Yoshiharu Takata, Osamu Watanabe, Junhui Yuan, Yuichi Tashiro, Ryuji Saigo, Satoshi Nozuma, Akiko Yoshimura, Shiho Arishima, Kenichi Ikeda, Kazuya Shinohara, Hitoshi Arata, Kumiko Michizono, Keiko Higashi, Akihiro Hashiguchi, Yuji Okamoto, Ryuki Hirano, Tadafumi Shiraishi, Eiji Matsuura, Ryuichi Okubo, Itsuro Higuchi, Masamichi Goto, Hirofumi Hirano, Akira Sano, Takuya Iwasaki, Fumihiko Matsuda, Shuji Izumo, Hiroshi Takashima
NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION
(2015)
Meeting Abstract
Clinical Neurology
Eiji Matsuura, Ryuji Kubota, Yuetsu Tanaka, Hiroshi Takashima, Shuji Izumo
Meeting Abstract
Immunology
E. Matsuura, K. Yao, S. Jacobson, U. Oh, Y. Akahata, Y. Tanaka
AIDS RESEARCH AND HUMAN RETROVIRUSES
(2009)
Meeting Abstract
Immunology
Y. Akahata, E. Matsuura, S. Jacobson, U. Oh
AIDS RESEARCH AND HUMAN RETROVIRUSES
(2009)
Meeting Abstract
Immunology
Y. Akahata, E. Matsuura, S. Jacobson, U. Oh
AIDS RESEARCH AND HUMAN RETROVIRUSES
(2009)
Meeting Abstract
Clinical Neurology
H. M. Abdullah, I Higuchi, R. Kubota, E. Matsuura, A. Hashiguchi, N. H. Abdelbary, Y. Inamori, S. Izumo