Article
Allergy
Marta Krawiec, Suzana Radulovic, Ru-Xin Foong, Andreina Marques-Mejias, Irene Bartha, Matthew Kwok, Zainab Jama, Faye Harrison, Cristian Ricci, Gideon Lack, George Du Toit, Alexandra F. Santos
Summary: This study assessed the accuracy of current and new diagnostic tests compared to the gold standard DBPCFC, and found that BAT was the best diagnostic test in terms of accuracy and reduction in OFC.
Article
Allergy
Frederik Bloch Jessen, Charlotte G. Mortz, Esben Eller, Julie H. Gudichsen, Emil A. Baekdal, Carsten Bindslev-Jensen
Summary: This retrospective study compared the severity of symptoms and threshold values in children and adults with peanut allergy challenged in an open or double-blind, placebo-controlled protocol. The study found no difference in severity of symptoms or threshold values between the two challenge types, but a higher proportion of children experienced Grade 3 symptoms in the double-blind group. The findings suggest that open food challenges can be as effective as double-blind, placebo-controlled food challenges when strict objective stop criteria and trained staff are employed.
Article
Allergy
Julie Wang, Robert A. Wood, Samantha Raymond, Mayte Suarez-Farinas, Nan Yang, Scott H. Sicherer, Hugh A. Sampson, Xiu-Min Li
Summary: This study aimed to determine the safety and efficacy of enhanced, butanol purified Food Allergy Herbal Formula-2 (E-B-FAHF-2) for inducing remission in subjects undergoing omalizumab-facilitated multiallergen OIT (multi-OIT). The results showed that E-B-FAHF-2 did not improve the treatment outcomes.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2023)
Article
Allergy
Jennifer Dantzer, Joan Dunlop, Kevin J. Psoter, Corinne Keet, Robert Wood
Summary: Baked milk oral immunotherapy (BMOIT) has shown safety and efficacy in treating children with baked milk allergy. After 12 months of treatment, the majority of participants in the BMOIT group were able to tolerate higher doses of baked milk protein compared to the placebo group. Dose-related adverse reactions were common but mild. BMOIT increased cow's milk-sIgG4 levels and decreased casein IgE levels.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Article
Immunology
Piia Karisola, Kati Palosuo, Victoria Hinkkanen, Lukas Wisgrill, Terhi Savinko, Nanna Fyhrquist, Harri Alenius, Mika J. Makela
Summary: The study found that there were many changes in gene expression in children undergoing egg OIT, some of which were related to antigen recognition and signaling, while others were associated with humoral responses. Although most of the changes in gene expression were similar, desensitized and partially desensitized patients had different antibody responses, with partially desensitized patients showing slower changes and desensitized patients activating NK cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Haitao Zhu, Kaifa Tang, Guoqiang Chen, Zhongwei Liu
Summary: Food allergy is a global health problem, and effective treatment is needed. Oral immunotherapy has shown good efficacy and safety in most patients. Reliable biomarkers are needed for evaluating treatment effectiveness and predicting outcomes during oral immunotherapy.
JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B
(2022)
Article
Nutrition & Dietetics
Severina Terlouw, Frank E. van Boven, Monika Borsboom-van Zonneveld, Catharina de Graaf-in 't Veld, Marloes E. van Splunter, Paul L. A. van Daele, Maurits S. van Maaren, Marco W. J. Schreurs, Nicolette W. de Jong
Summary: The study compared the SPT results of homemade food allergen extracts with commercially available extracts, finding that homemade hazelnut and walnut extracts can be good alternatives in the absence of commercial extracts. The agreement between SPT results and food allergen-specific symptoms were comparable for homemade and commercial extracts, except for peach.
Article
Allergy
Na'ama Epstein-Rigbi, Michael B. Levy, Liat Nachshon, Yael Koren, Yitzhak Katz, Michael R. Goldberg, Arnon Elizur
Summary: Oral immunotherapy (OIT) is successful in desensitizing most adults with IgE-mediated food allergy. However, adults undergoing milk OIT are at increased risk for severe reactions and treatment failure.
Review
Nutrition & Dietetics
Kristina A. Malsagova, Arthur T. Kopylov, Alexandra A. Sinitsyna, Alexander A. Stepanov, Alexander A. Izotov, Tatyana V. Butkova, Konstantin Chingin, Mikhail S. Klyuchnikov, Anna L. Kaysheva
Summary: An athlete's diet is influenced by various factors, and it is important to follow recommendations from physicians and nutritionists before training and competition. Studying nutritional strategies and trends used by athletes can help optimize training outcomes and minimize negative symptoms associated with food consumption. Future clinical trials may be conducted to identify specific foods beneficial for athletes.
Article
Allergy
Mansi Kotwal, Ammara Ahmed, Jaqueline Isola, Jennifer A. Dantzer, Corinne Keet, Joan H. Dunlop, Robert A. Wood
Summary: Introduction of baked egg can accelerate the resolution of egg allergy, but there is limited long-term data on its safety and success in real-world settings. Lower egg white IgE levels and younger age were found to predict egg consumption in some form in the future. While most patients continued to consume some form of egg after the baked egg oral food challenges, many reverted to avoidance and adverse reactions were common.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2023)
Review
Food Science & Technology
Jin Wang, Zhaoyi He, Vijaya Raghavan
Summary: This review provides a detailed description of the pathogenesis, clinical characteristics, and diagnostic methods of soybean allergy, and summarizes the structures of major soybean allergens. The double-blind, placebo-controlled food challenge is recognized as the gold standard for diagnosing soybean allergy. Additionally, novel food processing techniques such as ultrasound and cold-plasma treatment show potential in reducing soybean allergenicity.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Nutrition & Dietetics
Sylvie Tagliati, Simona Barni, Mattia Giovannini, Giulia Liccioli, Lucrezia Sarti, Tatiana Alicandro, Erika Paladini, Giancarlo Perferi, Chiara Azzari, Elio Novembre, Francesca Mori
Summary: Nut allergies are increasingly common in Italian children, with hazelnuts and walnuts being common allergens. Clinical manifestations include anaphylaxis and gastrointestinal symptoms, with a majority of patients having a family history of allergy or concomitant allergic disorders.
Article
Allergy
Montserrat Fernandez-Rivas, Andrea Vereda, Brian P. Vickery, Vibha Sharma, Caroline Nilsson, Antonella Muraro, Jonathan O'b Hourihane, Audrey DunnGalvin, George Toit, Katharina Blumchen, Kirsten Beyer, Alex Smith, Robert Ryan, Daniel C. Adelman, Stacie M. Jones
Summary: The study demonstrates that daily treatment with PTAH for peanut allergies beyond 1 year leads to improved safety and tolerability, as well as sustained clinical and immunological responses.
Review
Pediatrics
Aysegul Akarsu, Giulia Brindisi, Alessandro Fiocchi, Anna Maria Zicari, Stefania Arasi
Summary: Oral allergen-specific immunotherapy (OIT) may increase reaction threshold and protect against severe reactions. However, safety issues, predictive biomarkers, and post-desensitization efficacy need further investigation. Omalizumab as an adjunct to OIT could reduce allergic reaction risk.
FRONTIERS IN PEDIATRICS
(2022)
Article
Medicine, General & Internal
Mincy Chakkalakal, Dawnica Nadora, Nimrit Gahoonia, Ashley Dumont, Waqas Burney, Adrianne Pan, Cindy J. Chambers, Raja K. Sivamani
Summary: This study demonstrates the beneficial effects of oral pomegranate extract supplementation on various aspects of skin health in healthy individuals, including improvements in biophysical properties, wrinkles, and the skin microbiome.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Allergy
R. Asero, S. Abbadessa, A. Aruanno, G. Barilaro, C. Barzaghi, D. Bignardi, M. B. Bilo, M. Borro, M. Bresciani, M. Busa, F. Buzzulini, C. Cavaliere, L. Cecchi, A. Ciccarelli, G. Cortellini, F. Cucinelli, G. Deleonardi, F. Emiliani, A. Farsi, E. Ferrarini, M. Franchini, A. Ingrassia, D. Lippolis, L. Losappio, A. M. Marra, M. Martini, S. Masieri, M. Mauro, M. Mazzolini, L. Muratore, F. Murzilli, E. Nucera, E. A. Pastorello, E. Pinter, B. R. Polillo, V Pravettoni, O. Quercia, A. Rizzi, M. Russello, C. Sacerdoti, E. Scala, G. Scala, A. Scarpa, J. Schroeder, C. G. Uasuf, D. Villalta, B. Yang, G. Mistrello, S. Amato, J. Lidholm
Summary: In Italian cypress pollen-allergic patients, monosensitization to peamaclein appears to be rare, with most patients reacting to peach, although other Rosaceae fruits and citrus fruits may also be offending foods. Aside from peamaclein, peach and cypress pollen likely share other cross-reacting allergens.
JOURNAL OF INVESTIGATIONAL ALLERGOLOGY AND CLINICAL IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Eleonora Nucera, Giuseppe Parrinello, Sebastiano Gangemi, Alessandro Buonomo, Arianna Aruanno, Franziska Michaela Lohmeyer, Riccardo Inchingolo, Angela Rizzi
Summary: This study compared hypersensitivity reactions to different types of contrast media and explored the possibility of new reactions in a long-term follow-up. It was found that patients with hypersensitivity reactions to gadolinium-based contrast media had a higher prevalence of asthma, food allergy, non-allergic drug hypersensitivity, and neurologic disease. Some patients reported new reactions despite negative skin test results.
Review
Pediatrics
Eleonora Nucera, Angela Rizzi, Chiara Agrosi, Franziska Michaela Lohmeyer, Riccardo Inchingolo
Summary: Asthma is a common chronic disease among children, but its impact on adolescents is still poorly understood. Poor adherence to treatments is a major management problem for asthmatic adolescents. Assessing respiratory function and understanding the impact on quality of life are key challenges in managing adolescent asthma. Telemedicine technologies have become an important tool in managing adolescent asthmatics during the COVID-19 pandemic.
Article
Nutrition & Dietetics
Sara Urbani, Arianna Aruanno, Antonio Gasbarrini, Alessandro Buonomo, Rossana Moroni, Caterina Sarnari, Angela Rizzi, Eleonora Nucera
Summary: Lipid transfer proteins (LTPs) are common allergens found in plant food and are the main cause of food allergies in adults in the Mediterranean basin. This study investigated the use of prescribed epinephrine auto-injectors in LTP patients and the appropriateness of their prescription. It also examined the occurrence of new food reactions, the need for emergency services, and possible predictive factors for further food reactions in these patients. The study found that most LTP patients experienced local symptoms in further reactions, with a small percentage requiring emergency care and only one patient using the epinephrine auto-injector. Patients with a history of anaphylaxis were more likely to seek emergency services during the follow-up period, and there was an association between platanus pollen sensitization and the severity of further reactions. The study also highlighted the need for follow-up to monitor patients over time and assess the actual use of prescribed epinephrine auto-injectors.
Article
Health Care Sciences & Services
Stefania Gallo, Paolo Castelnuovo, Luca Spirito, Marta Feduzi, Veronica Seccia, Dina Visca, Antonio Spanevello, Erica Statuti, Manuela Latorre, Claudio Montuori, Angela Rizzi, Cristina Boccabella, Matteo Bonini, Eugenio De Corso
Summary: This study evaluated the effectiveness of mepolizumab in treating comorbid CRSwNP and severe asthma. The results showed significant improvements in SNOT-22 score, NP score, and blood eosinophil count after 12 months of treatment. Some patients experienced improvements in both clinical and endoscopic outcomes. Responders had higher baseline SNOT-22 score compared to nonresponders. Further studies are needed to supplement these preliminary findings.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Letter
Allergy
Jessy Elst, Marie-Line M. van der Poorten, Alessandro Toscano, Athina L. Van Gasse, Christel Mertens, Michiel Beyens, Margo M. Hagendorens, Didier G. Ebo, Vito Sabato
Letter
Allergy
Didier G. Ebo, Jessy Elst, Christel Mertens, Marie-Line M. van der Poorten, Athina L. Van Gasse, Michel Van Houdt, Margo M. Hagendorens, Vito Sabato
CLINICAL AND EXPERIMENTAL ALLERGY
(2023)
Editorial Material
Allergy
Alessandro Buonomo, Stefano Pucci, Tiziana Maria Angela De Pasquale
CONTACT DERMATITIS
(2023)
Review
Medicine, General & Internal
Angela Rizzi, Luca Gammeri, Raffaele Cordiano, Mariagrazia Valentini, Michele Centrone, Sabino Marrone, Riccardo Inchingolo, Franziska Michaela Lohmeyer, Carlo Cavaliere, Francesco Ria, Gabriella Cadoni, Sebastiano Gangemi, Eleonora Nucera
Summary: Chronic rhinosinusitis with nasal polyps (CRSwNP) is the most bothersome phenotype of chronic rhinosinusitis, characterized by Type 2 inflammatory reaction, comorbidities, and high rates of nasal polyp recurrence. Effective management includes anti-inflammatory treatment with local corticosteroids.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Medicine, General & Internal
Angela Rizzi, Elena Lo Presti, Raffaella Chini, Luca Gammeri, Riccardo Inchingolo, Franziska Michaela Lohmeyer, Eleonora Nucera, Sebastiano Gangemi
Summary: Food allergies are immune reactions to ingested or contacted foods, and they are a widespread health issue. The role of inflammatory mediators in the pathogenesis of food allergies has been studied, and some of these mediators may serve as markers for the disease or response to therapy.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Cell Biology
Angela Rizzi, Mario Di Gioacchino, Luca Gammeri, Riccardo Inchingolo, Raffaella Chini, Francesca Santilli, Eleonora Nucera, Sebastiano Gangemi
Summary: Celiac disease is an intestinal disease triggered by gluten ingestion in genetically predisposed individuals. It is mediated by Th17, IL-21, and IL-17A lymphocytes, resulting in intestinal inflammation and altered mucosal architecture. B cells produce antibodies against tissue transglutaminase and deamidated gliadin. Besides the adaptive immune response, the role of innate immunity cells such as alarmins (DAMPs) is poorly understood. Our study aims to evaluate the evidence regarding the involvement of ILCs and alarmins in celiac disease and their potential diagnostic and therapeutic implications.
Review
Allergy
Cristobalina Mayorga, Adriana Ariza, Rosa Munoz-Cano, Vito Sabato, Inmaculada Dona, Maria J. Torres
Summary: Immediate drug hypersensitivity reactions (IDHRs) are burdensome and diagnosing the right phenotype and endotype at early stages is crucial due to the diverse mechanisms involved in drug-immune system interactions.
Article
Allergy
D. G. Ebo, H. P. Rihs, C. H. Mertens, A. L. Van Gasse, M. L. van Der Poorten, M. M. Hagendorens, V. Sabato, J. Elst
Article
Endocrinology & Metabolism
Giuseppe Parrinello, Sebastiano Gangemi, Angela Rizzi, Alessandro Buonomo, Mario Di Gioacchino, Arianna Aruanno, Eleonora Nucera
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2022)
Article
Immunology
Alessia Di Rienzo, Sara Urbani, David Longhino, Caterina Sarnari, Alessandro Buonomo, Angela Rizzi, Arianna Aruanno, Eleonora Nucera
Summary: During the COVID-19 pandemic, patients with latex allergy experienced adverse reactions. Continuous latex sublingual immunotherapy (SLIT) reduced the incidence of reactions and improved the quality of life of patients.
INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY
(2022)
