Review
Biochemistry & Molecular Biology
Klementina Ocskay, Peter Matrai, Peter Hegyi, Andrea Parniczky
Summary: This study analyzed randomized controlled trials and found that lactated Ringer's solution (LR) significantly reduces the risk of moderate-to-severe pancreatitis, mortality, and the need for intensive care compared to normal saline (NS). LR also reduces the risk of systemic and local complications in acute pancreatitis.
Article
Health Care Sciences & Services
Agnieszka Wiorek, Piotr K. Mazur, Elzbieta Zurawska, Lukasz J. Krzych
Summary: Prudent administration of fluids helps maintain hemodynamic stability, but may exacerbate existing coagulopathy. A study on healthy volunteers found that both balanced crystalloid and gelatine infusions resulted in decreased coagulation factors and fibrinogen concentration, impaired clot formation, and no effect on clot lysis. However, balanced crystalloid infusion caused less infusion-induced coagulopathy compared to gelatine.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Adriana R. Carrillo, Kirsten Elwood, Chris Werth, Jessica Mitchell, Preeyaporn Sarangarm
Summary: The use of Lactated Ringer's compared to normal saline as resuscitative fluid in diabetic ketoacidosis can reduce the incidence of iatrogenic hyperchloremia and support renal recovery.
ANNALS OF PHARMACOTHERAPY
(2022)
Article
Medicine, General & Internal
Agnieszka Wiorek, Piotr K. Mazur, Bozena Niemiec, Lukasz J. Krzych
Summary: Functional point-of-care tests have become valuable tools for diagnosing blood coagulation and fibrinolysis disorders. This study aimed to investigate the association between standard and functional parameters of coagulation and fibrinolysis during acute hemodilution caused by crystalloid or gelatine solutions. The results showed that ROTEM viscoelastic assays had moderate to strong correlations with conventional coagulation tests, regardless of the fluid type used. The strongest associations were found between ROTEM clot formation and clot strength and fibrinogen concentration and platelet count, as well as between ROTEM clotting time and APTT and PT.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Orthopedics
R. F. Trauzeddel, M. Leitner, L. Dehe, M. Nordine, S. K. Piper, M. Habicher, M. Sander, C. Perka, S. Treskatsch
Summary: This prospective study aimed to implement a goal-directed fluid therapy (GDFT) protocol using crystalloids in hip revision arthroplasty surgery. The results showed that GDFT using balanced crystalloids can reduce perioperative complications and is comparable to GDFT using colloids.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2023)
Article
Critical Care Medicine
Xuting Jin, Jiamei Li, Jiajia Ren, Ya Gao, Ruohan Li, Jingjing Zhang, Xiaochuang Wang, Gang Wang
Summary: This study assessed the effect of intravenous chloride load on prognosis in ICU patients with different initial serum chloride levels. High chloride load and increased serum chloride level were associated with poor outcomes in patients with normal or high initial chloride levels, but not in those with a low initial chloride level.
JOURNAL OF CRITICAL CARE
(2022)
Article
Veterinary Sciences
Alicia Inurria, Angelo Santana, Ana B. Casal, Pascual Calabuig, Alejandro Suarez-Perez, Jorge Oros
Summary: This study compares the efficacy and effects on acid-base and electrolyte status of four different crystalloids in stranded sea turtles, and finds that the combination of 0.9% NaCl and lactated Ringer's solutions is the most effective in resolving acid-base and electrolyte abnormalities.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Medicine, General & Internal
Simon Finfer, Sharon Micallef, Naomi Hammond, Leanlove Navarra, Rinaldo Bellomo, Laurent Billot, Anthony Delaney, Martin Gallagher, David Gattas, Qiang Li, M. Biostat, Diane Mackie, Jayanthi Mysore, Manoj Saxena, Colman Taylor, Paul Young, John Myburgh
Summary: There is no evidence that the use of balanced multielectrolyte solution (BMES) reduces the risk of death or acute kidney injury in critically ill patients compared to saline, according to a double-blind, randomized, controlled trial.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Review
Medicine, General & Internal
Guangjian Wang, Hongmin Zhang, Dawei Liu, Xiaoting Wang
Summary: Fluid resuscitation is crucial in critically ill patients, but the effects of different resuscitation fluids on glycocalyx integrity remain uncertain. Maintaining or restoring glycocalyx integrity may be a priority in therapeutic strategies, but the impact of various fluids on glycocalyx remains inconsistent.
CHINESE MEDICAL JOURNAL
(2022)
Review
Veterinary Sciences
Elke Rudloff, Kate Hopper
Summary: This manuscript reviews crystalloid and colloid fluids available for intravenous administration, focusing on their electrolyte, acid-base, colligative, and rheological effects and their implications in therapeutically treating animals with critical illness.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Urology & Nephrology
Natalja L. L. Stanski, Katja M. M. Gist, Kaci Pickett, John T. T. Brinton, Jennifer Sadlowski, Hector R. R. Wong, Peter Mourani, Danielle E. E. Soranno, Jessica Kendrick, Erin K. K. Stenson
Summary: This study aims to compare the effects of lactated ringers (LR) and 0.9% sodium chloride (0.9%NaCl) on electrolyte derangements in pediatric resuscitation. The results show that compared to the 0.9%NaCl group, the LR group had a lower incidence of extreme hyperkalemia and extreme acidosis.
Article
Medicine, General & Internal
Joseph Bledsoe, Ithan D. Peltan, R. J. Bunnell, Samuel M. Brown, Al Jephson, Danielle Groat, Nicholas M. Levin, Emily Wilson, Jon Newbold, Gabriel Fontaine, Joe Frandsen, David Hasleton, Paul Krakovitz, Kim Brunisholz, Todd Allen
Summary: In this comparative effectiveness study, an implementation program was associated with an increase in the proportion of fluids administered as lactated Ringer solution compared with normal saline and was associated with a reduction in MAKE30 events among patients treated in a large integrated health care system.
Article
Medicine, General & Internal
Michael G. Collins, Magid A. Fahim, Elaine M. Pascoe, Carmel M. Hawley, David W. Johnson, Julie Varghese, Laura E. Hickey, Philip A. Clayton, Kathryn B. Dansie, Rachael C. McConnochie, Liza A. Vergara, Charani Kiriwandeniya, Donna Reidlinger, Peter F. Mount, Laurence Weinberg, Colin J. McArthur, P. Toby Coates, Zoltan H. Endre, David Goodman, Kirsten Howard, Martin Howell, Jagadish S. Jamboti, John Kanellis, Jerome M. Laurence, Wai H. Lim, Steven J. McTaggart, Philip J. O'Connell, Helen L. Pilmore, Germaine Wong, Steven J. Chadban, Australasian Kidney Trials Network
Summary: In patients undergoing deceased donor kidney transplantation, intravenous fluid therapy with balanced crystalloid solution reduces the incidence of delayed graft function (DGF) compared to saline.
Article
Critical Care Medicine
Michael B. Weykamp, Katherine E. Stern, Scott C. Brakenridge, Bryce R. H. Robinson, Charles E. Wade, Erin E. Fox, John B. Holcomb, Grant E. O'Keefe
Summary: Although blood product resuscitation is favored, crystalloid resuscitation remains a common practice in prehospital care. This study investigated the relationship between prehospital crystalloid (PHC) volume and clinical outcomes, and found that higher PHC volume is associated with worse coagulopathy and increased risk of ARDS, but lower risk of AKI.
Article
Critical Care Medicine
Jonas Gmeiner, Bernhardt Bulach, Enzo Luesebrink, Leonhard Binzenhofer, Danny Kupka, Thomas Stocker, Kornelia Low, Ludwig Weckbach, Wolf-Stephan Rudi, Tobias Petzold, Stefan Kaab, Joerg Hausleiter, Christian Hagl, Steffen Massberg, Martin Orban, Clemens Scherer
Summary: This study aimed to compare the efficacy and safety of saline and balanced crystalloid solutions in fluid resuscitation for patients with cardiogenic shock. The results showed that there was no significant difference in 30-day mortality rate between patients treated with saline and balanced crystalloids, but the incidence of new onset renal replacement therapy was higher in the saline group. However, for patients with out-of-hospital cardiac arrest and a lactate level higher than 7.4 mmol/L, the mortality rate was significantly lower when treated with saline.
JOURNAL OF INTENSIVE CARE
(2023)
Article
Anesthesiology
Adam J. Kingeter, Karthik Raghunathan, Sibyl H. Munson, David K. Hayashida, Xuan Zhang, Sloka Iyengar, Martin Bunke, Andrew D. Shaw
CANADIAN JOURNAL OF ANESTHESIA-JOURNAL CANADIEN D ANESTHESIE
(2018)
Article
Critical Care Medicine
Kamal Maheshwari, Brian H. Nathanson, Sibyl H. Munson, Victor Khangulov, Mitali Stevens, Hussain Badani, Ashish K. Khanna, Daniel I. Sessler
INTENSIVE CARE MEDICINE
(2018)
Review
Cardiac & Cardiovascular Systems
Gurmeet Singh, Darren Hudson, Andrew Shaw
CANADIAN JOURNAL OF CARDIOLOGY
(2020)
Article
Multidisciplinary Sciences
Mitali Stevens, Apeksha V. Shenoy, Sibyl H. Munson, Halit O. Yapici, Boye L. A. Gricar, Xuan Zhang, Andrew D. Shaw
Article
Anesthesiology
David R. McIlroy, Bennett Roman, Frederic T. Billings, Bruce A. Bollen, Amanda Fox, Mariya Geube, Hong Liu, Linda Shore-Lesserson, Alexander Zarbock, Andrew D. Shaw
Summary: A survey of perioperative practice in adult patients undergoing cardiac surgery revealed that many strategies are believed to affect renal injury, with a focus on intraoperative target blood pressure and choice of vasopressor agent for potential renoprotection.
JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA
(2021)
Article
Anesthesiology
Rabail Chaudhry, Jonathan P. Wanderer, Talha Mubashir, Felix Kork, Jennifer Morse, Rida Waseem, John F. Zaki, Andrew D. Shaw, Holger K. Eltzschig, Yafen Liang
Summary: This retrospective cohort study aimed to determine the incidence and predictive factors of acute kidney injury (AKI) after off-pump lung transplantation. The study included 148 adult patients who underwent lung transplant without cardiopulmonary bypass or extracorporeal membrane oxygenator at the Vanderbilt University Medical Center between 2006 and 2016. The results showed that AKI is a common complication after off-pump lung transplantation, associated with increased hospital length of stay, and independently associated with younger age, unilateral lung transplant, and diagnosis of chronic obstructive pulmonary disease.
JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA
(2022)
Editorial Material
Anesthesiology
Andrew D. Shaw, Nicole R. Guinn, Jessica K. Brown, Rakesh C. Arora, Kevin W. Lobdell, Michael C. Grant, Tong J. Gan, Daniel T. Engelman
Summary: The advances in cardiac surgical techniques have improved outcomes, but have also led to complications and mortality outside of the operating room. To address this issue, a focus on evidence-based practice and standardized perioperative care is needed. The POQI and ERAS (R) Cardiac have identified significant evidence gaps in areas related to cardiac surgery, including patient blood management, goal-directed therapy, acute kidney injury, opioid analgesic reduction, and delirium.
PERIOPERATIVE MEDICINE
(2022)
Editorial Material
Critical Care Medicine
Marlies Ostermann, Andrew D. Shaw, Michael Joannidis
INTENSIVE CARE MEDICINE
(2023)
Article
Economics
Suzanne Laplante, Dilip U. Makhija, Sibyl H. Munson, Victor S. Khangulov, Fred W. Peyerl, Scott M. Paluszkiewicz, Aditi J. Ravindranath, Carol R. Schermer
PHARMACOECONOMICS-OPEN
(2018)
Article
Anesthesiology
Andrew D. Shaw, Michael G. Mythen, Douglas Shook, David K. Hayashida, Xuan Zhang, Jeffrey R. Skaar, Sloka S. Iyengar, Sibyl H. Munson
PERIOPERATIVE MEDICINE
(2018)
Article
Anesthesiology
Nadine Shehata, Richard Whitlock, Dean A. Fergusson, Kevin E. Thorpe, Charlie MacAdams, Hilary P. Grocott, Fraser Rubens, Stephen Fremes, Francois Lellouche, Sean Bagshaw, Alistair Royse, Peter M. Rosseel, Greg Hare, Etienne De Medicis, Christopher Hudson, Emilie Belley-Cote, Daniel Bainbridge, Blaine Kent, Andrew Shaw, Kelly Byrne, Summer Syed, Colin F. Royse, Shay McGuiness, Judith Hall, C. David Mazer
JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA
(2018)
Article
Cardiac & Cardiovascular Systems
Jason B. O'Neal, Frederic T. Billings, Xulei Liu, Matthew S. Shotwell, Yafen Liang, Ashish S. Shah, Jesse M. Ehrenfeld, Jonathan P. Wanderer, Andrew D. Shaw
AMERICAN JOURNAL OF CARDIOLOGY
(2017)
Article
Anesthesiology
Jason B. O'Neal, Frederic T. Billings, Xulei Liu, Matthew S. Shotwell, Yafen Liang, Ashish S. Shah, Jesse M. Ehrenfeld, Jonathan P. Wanderer, Andrew D. Shaw
CANADIAN JOURNAL OF ANESTHESIA-JOURNAL CANADIEN D ANESTHESIE
(2017)
Article
Critical Care Medicine
Matthew W. Semler, Jonathan P. Wanderer, Jesse M. Ehrenfeld, Joanna L. Stollings, Wesley H. Self, Edward D. Siew, Li Wang, Daniel W. Byrne, Andrew D. Shaw, Gordon R. Bernard, Todd W. Rice
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2017)