Article
Pediatrics
Jilei Lin, Yin Zhang, Meng Chen, Jihong Dai, Anchao Song, Jianchuan Chen, Xingping Tao
Summary: This study revealed that higher variability in electrolytes was associated with a higher risk of in-hospital mortality in critically ill children. There was also a linear relationship between the number of high variability parameters and in-hospital mortality. The variability of electrolytes may serve as a good predictor for in-hospital mortality in children admitted to ICUs.
FRONTIERS IN PEDIATRICS
(2021)
Article
Medicine, General & Internal
I-Chieh Mao, Pei-Ru Lin, Shin-Hwar Wu, Hsin-Hui Hsu, Pei-Shan Hung, Chew-Teng Kor
Summary: This study investigated the association between serum potassium levels and variability and ICU mortality in critically ill patients with acute kidney injury undergoing continuous renal replacement therapy (CRRT). The findings showed that patients with mean serum potassium levels between 3.0 and 4.0 mmol/L had the lowest mortality. Additionally, patients with higher variability in serum potassium levels had a significantly increased risk of in-hospital death.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Xiao Chen, Xiaofeng Zhu, Huichang Zhuo, Jiandong Lin, Xian Lin
Summary: This study reveals that the absence of basophils in ICU patients is strongly associated with poor prognosis and mortality. The findings suggest that basophil-mediated immunity may serve as a potential predictor for ICU patients' prognosis, and help identify patients who would benefit from intensified treatment and immunoenhancement therapy.
SCIENTIFIC REPORTS
(2023)
Article
Surgery
Tyler M. Loftus, Matthew Ruppert, Tezcan A. Ozrazgat-Baslanti, Jeremy Balch, Benjamin Shickel, Die A. Hu, Philip J. Efron, Patrick R. Tighe, William Hogan, Parisa R. Rashidi, Gilbert Upchurch Jr, Azra Bihorac
Summary: Objective: To test the hypothesis that postoperative ICU admission for low-acuity surgical patients is associated with lower value of care compared with ward admission. Methods: A longitudinal cohort study was conducted where postoperative ICU admissions were classified as overtriaged or appropriately triaged. Results: The results showed that overtriaged admissions had increased total costs, no improvements in outcomes, and received low-value care.
Article
Multidisciplinary Sciences
Bahar Kacmaz, Siran Keske, Uluman Sisman, Sena Tugana Ates, Mustafa Guldan, Yesim Besli, Erhan Palaoglu, Nahit Cakar, Onder Ergonul
Summary: We compared secondary bacterial infections (SBI) between COVID-19 patients and non-COVID-19 patients. A retrospective case-control study was conducted from January 01, 2020 to April 01, 2022, including adult patients who stayed in the intensive care unit (ICU) for 72 hours or longer. The study included a total of 405 patients, with 135 (33.3%) being COVID-19 patients, who had similar age and gender. COVID-19 patients had a higher rate of SBI, especially in cases of pneumonia, with gram-positive bacteria being more common in the COVID-19 group. Predictors of SBI included having COVID-19, intubation days, and being male. COVID-19, intubation days, active hematologic malignancy, active solid tumors, and coronary artery diseases were predictors of mortality. Methicillin-sensitive Staphylococcus aureus was the most common SBI in COVID-19 patients, while carbapenem-resistant Enterobacterales infections were not detected.
SCIENTIFIC REPORTS
(2023)
Article
Cardiac & Cardiovascular Systems
Mitchell Padkins, Alexander Fanaroff, Courtney Bennett, Brandon Wiley, Gregory Barsness, Sean van Diepen, Jason N. Katz, Jacob C. Jentzer
Summary: Readmission to the ICU after being discharged from the cardiac intensive care unit (CICU) is associated with poor outcomes. There is limited knowledge about critically ill patients with acute cardiovascular conditions in the CICU. This study aimed to investigate the incidence, risk factors, and outcomes of ICU readmissions in CICU survivors.
AMERICAN JOURNAL OF CARDIOLOGY
(2022)
Article
Medicine, General & Internal
Hani Karameh, Sharon Bruoha, Louay Taha, Meir Tabi, Rivka Farkash, Mohammad Karmi, Kamal Hamayel, Nimrod Perel, Yoed Steinmetz, David Marmor, Mohammed Manassra, Tomer Maller, Rafael Hitter, Itshak Amsalem, Michael Glikson, Elad Asher
Summary: This study aimed to assess the mortality rate and outcomes of patients treated with blood transfusion (BT) in a modern intensive cardiac care unit (ICCU). The study found that BT was associated with higher mortality rates in both the short and long term. Further consideration is needed to improve the strategy of BT administration in ICCU patients and develop guidelines for high-risk patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Fei Gao, Yun Zhang
Summary: The study revealed that inotropic administration in cardiogenic shock patients may increase mortality risk. Low-dose norepinephrine and milrinone were associated with lower hospital mortality in the inotrope group, while high-dose inotropes were linked to higher mortality risk.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Medicine, General & Internal
C. J. Crooks, J. West, J. R. Morling, M. Simmonds, I Juurlink, S. Briggs, S. Cruickshank, S. Hammond-Pears, D. Shaw, T. R. Card, A. W. Fogarty
Summary: This study suggests that patients with pigmented skin may have more severe illness at the time of transfer to intensive care units (ICUs) and lower oxygen saturations in Indian/Pakistani and Black/Mixed ethnic groups. These findings have implications for healthcare and health outcomes across ethnic groups globally.
QJM-AN INTERNATIONAL JOURNAL OF MEDICINE
(2023)
Article
Geriatrics & Gerontology
Eunki Chung, Kyung Soo Chung, Ah Young Leem, Ala Woo, Moo Suk Park, Young Sam Kim, Su Hwan Lee
Summary: Age does not affect acute mortality in critically ill patients, but surviving older age groups require more long-term care facilities.
Article
Multidisciplinary Sciences
Firas Khader, Jakob Nikolas Kather, Gustav Mueller-Franzes, Tianci Wang, Tianyu Han, Soroosh Tayebi Arasteh, Karim Hamesch, Keno Bressem, Christoph Haarburger, Johannes Stegmaier, Christiane Kuhl, Sven Nebelung, Daniel Truhn
Summary: This work proposes and evaluates a transformer-based neural network as a novel AI architecture that integrates multimodal patient data, i.e., imaging data (chest radiographs) and non-imaging data (clinical data). The performance of the model is evaluated in a retrospective study with 6,125 patients in intensive care. The results show that the combined model outperforms the radiographs-only model and the clinical data-only model in predicting in-hospital survival of patients.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Mome Mukherjee, Steve Cunningham, Mohammad Romel Bhuia, Tsz-Yan Milly Lo, Jasper Been, Aziz Sheikh
Summary: This study in the UK investigated the epidemiology and healthcare resource utilization of children with asthma in pediatric intensive care units (PICUs). The findings showed that children from more deprived neighborhoods had a higher percentage of asthma admissions, invasive ventilation, and deaths in PICU. This suggests that children experiencing socioeconomic deprivation could benefit from enhanced asthma support in the community.
SCIENTIFIC REPORTS
(2022)
Article
Critical Care Medicine
Joao Gabriel Rosa Ramos, Gabriel Machado Naus dos Santos, Marina Chetto Coutinho Bispo, Renata Cristina de Almeida Matos, Gil Mario Lopes Santos de Carvalho Jr, Rogerio da Hora Passos, Juliana Ribeiro Caldas, Andre Luiz Nunes Gobatto, Suzete Nascimento Farias da Guarda, Paulo Benigno Pena Batista
Summary: Unplanned transfers from the intermediate care unit to the intensive care unit were common among urgent admissions, associated with increased hospital mortality, and mostly due to deterioration in the condition that was the reason for admission.
AMERICAN JOURNAL OF CRITICAL CARE
(2021)
Article
Multidisciplinary Sciences
Frida Wilske, Paul Skorup, Katja Hanslin, Helena Janols, Anders Larsson, Miklos Lipcsey, Jan Sjolin
Summary: Early secondary sepsis (ESS), occurring after recent inflammatory activation, is associated with a reduced inflammatory response. This study aimed to investigate whether this attenuation also leads to decreased bacterial killing and a greater need for antibiotic efficacy compared to primary sepsis (PS). The results showed that attenuated inflammation in ESS is associated with enhanced antibacterial capacities in the spleen, and the blood bacterial count is related to splenic killing in ESS and blood bactericidal capacity in PS. These findings suggest that there is no increased need for synergistic antibiotic combinations in ESS.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Kazunao Mori, Yoko Tsukamoto, Satoshi Makino, Takuya Takabayashi, Masahiro Kurosawa, Wataru Ohashi, Masatoshi Okumura, Yoshihito Fujita, Yoshihiro Fujiwara
Summary: This study compared the outcomes of postoperative patients on mechanical ventilators before and after the participation of nurse practitioners in intensive care teams in Japan. The findings showed that patients who received care from nurse practitioners and physicians had significantly shorter stays in intensive care, and the other outcomes were similar to those who received care only from physicians. Multiple regression analysis suggested that the participation of nurse practitioners reduced the length of stay in the unit.
Article
Nutrition & Dietetics
Wouter Vankrunkelsven, Jan Gunst, Karin Amrein, Danielle E. Bear, Mette M. Berger, Kenneth B. Christopher, Valentin Fuhrmann, Michael Hiesmayr, Carole Ichai, Stephan M. Jakob, Sigismond Lasocki, Juan C. Montejo, Heleen M. Oudemans-van Straeten, Jean-Charles Preiser, Annika Reintam Blaser, Anne-Francoise Rousseau, Pierre Singer, Joel Starkopf, Arthur R. van Zanten, Steffen Weber-Carstens, Jan Wernerman, Alexander Wilmer, Michael P. Casaer
Summary: The survey revealed a wide variation in current practices of micronutrient, phosphate and magnesium measurement and parenteral administration, suggesting a risk of insufficient prevention, diagnosis and treatment of deficiencies. These results provide the context for future comparative studies, and identify areas for knowledge translation and recommendations.
CLINICAL NUTRITION
(2021)
Article
Urology & Nephrology
Ping Li, Shruti Gupta, Suraj S. Mothi, Helmut G. Rennke, David E. Leaf, Sushrut S. Waikar, Gearoid M. McMahon
Summary: The study used non-neoplastic tissue from nephrectomy specimens to examine the association between degree of histopathologic changes and eGFR, and found that greater degrees of glomerulosclerosis, interstitial fibrosis/tubular atrophy, and arterial sclerosis/arteriosclerosis were associated with lower eGFR. Although older individuals had a higher prevalence of severe histopathologic changes, the association between various histopathologic features and eGFR was not modified by age.
AMERICAN JOURNAL OF KIDNEY DISEASES
(2021)
Article
Nutrition & Dietetics
Karin Amrein, Jessica A. Lasky-Su, Harald Dobnig, Kenneth B. Christopher
Summary: The study found that in critically ill patients, an increase in 25-hydroxyvitamin D levels following high dose vitamin D3 intervention is associated with favorable changes in various metabolomic profiles, including those involved in endothelial protection, enhanced innate immunity, and improved mitochondrial function.
CLINICAL NUTRITION
(2021)
Article
Multidisciplinary Sciences
Sowmya Chary, Karin Amrein, Jessica A. Lasky-Su, Harald Dobnig, Kenneth B. Christopher
Summary: Our study found robust and coordinated sex-specific metabolite differences in early critical illness, with women showing significantly different changes in metabolites compared to men.
SCIENTIFIC REPORTS
(2021)
Article
Surgery
Gerdine C. von Meijenfeldt, Jessica E. Rydingsward, Maarten J. van der Laan, Clark J. Zeebregts, Kenneth B. Christopher
Summary: Functional status at discharge in non-cardiac vascular surgery patients is strongly associated with out-of-hospital mortality and readmission rates, with those having the lowest functional status facing a significantly higher risk. Further trials are needed to determine if improving functional status could help prevent adverse outcomes postoperatively.
ANNALS OF VASCULAR SURGERY
(2021)
Article
Physiology
Ofer Isakov, Bhanu K. Patibandla, Kenneth B. Christopher, Anil Chandraker, Tammy Hod
Summary: Posttransplant hypomagnesemia is significantly associated with long-term patient and allograft outcomes in kidney transplant recipients, even after accounting for other factors.
KIDNEY & BLOOD PRESSURE RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Sowmya Chary, Karin Amrein, Sherif H. Mahmoud, Jessica A. Lasky-Su, Kenneth B. Christopher
Summary: The metabolomics study revealed sex-specific differences in the metabolic response to high-dose oral vitamin D-3 intervention among critically ill patients. Women showed lower absorption of vitamin D-3 despite receiving higher doses, with distinct metabolite associations in females and males. These sex-specific pharmacometabolomics differences may have implications for personalized medicine.
Editorial Material
Nutrition & Dietetics
Kenneth B. B. Christopher
JOURNAL OF PARENTERAL AND ENTERAL NUTRITION
(2022)
Article
Urology & Nephrology
Iain C. Macdougall, Amy Mewborn Meadowcroft, Allison Blackorby, Borut Cizman, Alexander R. Cobitz, Sergio Godoy, Vivekanand Jha, Kirsten L. Johansen, Gearoid McMahon, Gregorio T. Obrador, Muh Geot Wong, Ajay K. Singh
Summary: This study explored the baseline characteristics and predictors of ESA hyporesponsiveness in chronic dialysis patients, finding that geographic region, lower baseline body mass index and transferrin saturation, younger age, lower albumin concentration, and a higher baseline IV iron dose were strongly associated with ESA hyporesponsiveness.
AMERICAN JOURNAL OF NEPHROLOGY
(2023)
Review
Nutrition & Dietetics
Ellen Dresen, Omy Naidoo, Aileen Hill, Gunnar Elke, Matthias Lindner, Joop Jonckheer, Elisabeth De Waele, Patrick Meybohm, Ranna Modir, Jayshil J. Patel, Kenneth B. Christopher, Christian Stoppe
Summary: Patients receiving ECMO may experience disease-associated metabolic, endocrinologic, and immunologic alterations, which along with the technical components of ECMO, can increase their risk for malnutrition. However, specific recommendations for medical nutrition therapy (MNT) in ECMO patients are limited and lack guidance. This article aims to provide evidence-based guidance for MNT in adult patients receiving ECMO to develop institutional protocols for clinical practice.
JOURNAL OF PARENTERAL AND ENTERAL NUTRITION
(2023)
Editorial Material
Nutrition & Dietetics
Kenneth B. Christopher
JOURNAL OF PARENTERAL AND ENTERAL NUTRITION
(2022)
Article
Surgery
Christian Stoppe, Bernard McDonald, Patrick Meybohm, Kenneth B. Christopher, Stephen Fremes, Richard Whitlock, Siamak Mohammadi, Dimitri Kalavrouziotis, Gunnar Elke, Rolf Rossaint, Philipp Helmer, Kai Zacharowski, Ulf Guenther, Matteo Parotto, Bernd Niemann, Andreas Boening, C. David Mazer, Philip M. Jones, Marion Ferner, Yoan Lamarche, Francois Lamontagne, Oliver J. Liakopoulos, Matthew Cameron, Matthias Mueller, Alexander Zarbock, Maria Wittmann, Andreas Goetzenich, Erich Kilger, Lutz Schomburg, Andrew G. Day, Daren K. Heyland
Summary: High-dose intravenous sodium selenite treatment did not reduce morbidity or mortality in high-risk cardiac surgery patients.
Article
Nutrition & Dietetics
Matthias Lindner, Martin Padar, Merli Mandul, Kenneth B. Christopher, Annika Reintam Blaser, Hans-Christoph Gratz, Gunnar Elke, Kaspar F. Bachmann
Summary: This study analyzed the current practice of gastric residual volume (GRV) measurement in critically ill patients and its association with clinical outcomes. The study found significant variability in GRV measurement techniques but this did not affect the amount of GRV. High GRV may serve as a marker of gastrointestinal dysfunction and disease severity, but it is not associated with mortality or number of ventilator-free days.
JOURNAL OF PARENTERAL AND ENTERAL NUTRITION
(2023)
Editorial Material
Nutrition & Dietetics
Kenneth B. Christopher
JOURNAL OF PARENTERAL AND ENTERAL NUTRITION
(2023)
Article
Critical Care Medicine
Martin Ingi Sigurdsson, Hirotada Kobayashi, Karin Amrein, Kiichi Nakahira, Angela J. Rogers, Mayra Pinilla-Vera, Rebecca M. Baron, Laura E. Fredenburgh, Jessica A. Lasky-Su, Kenneth B. Christopher
Summary: This study found that in critically ill patients, the level of N-formylmethionine in the blood is associated with changes in metabolites and an increase in 28-day mortality. Increased levels of N-formylmethionine lead to incomplete mitochondrial fatty acid oxidation, increased branched chain amino acid metabolism, and activation of the pentose phosphate pathway.