Article
Medicine, General & Internal
Kangha Jung, Sojin Kim, Byung Jun Kim, MiHye Park
Summary: In the study, it was found that ventilator-driven alveolar recruitment maneuver using the incrementally increasing positive end-expiratory pressure method during robotic prostatectomy led to greater improvements in lung function compared to using the incrementally increasing tidal volume method.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Health Care Sciences & Services
Kuan-Hsun Lin, Pei-Yi Chu, Zhanqi Zhao, Hung Chang, Po-Jen Yun, Tsai-Wang Huang
Summary: This study investigated the feasibility, ventilation distribution, and physiological effect of iatrogenic pneumothorax during nonintubated thoracoscopic surgery. The results showed that there was a difference in ventilation distribution between the operative and nonoperative lung, but it reached equilibrium after the surgery. Electrical impedance tomography is a safe and effective method for monitoring ventilation without adverse effects.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
John K. Peel, Duane J. Funk, Peter Slinger, Sadeesh Srinathan, Biniam Kidane
Summary: Low tidal volumes during 1-lung ventilation do not worsen oxygenation or compliance. A low tidal volume ventilation strategy during 1-lung ventilation was associated with a significant reduction in postoperative pulmonary complications.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2022)
Article
Medicine, General & Internal
Hong Ren, Li Xie, Zhulin Wang, Xiaoliao Tang, Botao Ning, Teng Teng, Juan Qian, Ying Wang, Lijun Fu, Zhanqi Zhao, Long Xiang
Summary: The study aims to compare the difference in positive end-expiratory pressure (PEEP) selection between chest electrical impedance tomography (EIT) and global dynamic respiratory system compliance (C-rs) in moderate-to-severe pediatric acute respiratory distress syndrome (pARDS). The results suggest that in moderate-to-severe pARDS, PEEP selected based on C-rs might not be inferior to EIT-guided regional ventilation.
FRONTIERS IN MEDICINE
(2022)
Article
Critical Care Medicine
Jefta van Dijk, Alette A. Koopman, Robert G. T. Blokpoel, Sandra Dijkstra, Dick G. Markhorst, Johannes G. M. Burgerhof, Martin C. J. Kneyber
Summary: The study found that allowing spontaneously breathing ventilated children in the recovery phase of respiratory failure did not negatively affect tidal volume (V-T) distribution or end-expiratory lung volume (EELV). This has important implications for estimating the impact of ventilatory support levels on V-T distribution and EELV.
Article
Critical Care Medicine
Vincent D. Gaertner, Andreas D. Waldmann, Peter G. Davis, Dirk Bassler, Laila Springer, Jessica Thomson, David G. Tingay, Christoph M. Ruegger
Summary: This study found that oscillatory volumes during noninvasive high-frequency oscillatory ventilation (nHFOV) can effectively be transmitted to the lungs in preterm infants. The oscillations were more likely to reach the right lung and non-gravity-dependent areas compared to spontaneous tidal breaths, providing insight into the physiological processes of nHFOV and potential for further refinement of this technique.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2021)
Article
Biophysics
Yen-Fen Ko, Kuo-Sheng Cheng
Summary: The study developed an automatic lung segmentation method for defining regions-of-interest in EIT images, facilitating the extraction and analysis of regional lung ventilation-dependent parameters.
PHYSIOLOGICAL MEASUREMENT
(2021)
Article
Multidisciplinary Sciences
Wei Zhang, Feifei Liu, Zhanqi Zhao, Chunqing Shao, Xin Xu, Jiajia Ma, Ruquan Han
Summary: This study found that driving pressure-guided positive end expiratory pressure (PEEP) can improve ventilation homogeneity, gas exchange, and respiratory compliance in patients undergoing gynecological laparoscopy.
SCIENTIFIC REPORTS
(2022)
Article
Critical Care Medicine
Tobias Becher, Valerie Buchholz, Daniel Hassel, Timo Meinel, Dirk Schaedler, Inez Frerichs, Norbert Weiler
Summary: The EIT-based protocol allows individualization of ventilator settings with improved oxygenation and reduced alveolar cycling without promoting global overdistension.
ANNALS OF INTENSIVE CARE
(2021)
Article
Biology
Lin Yang, Meng Dai, Shiqin Li, Hang Wang, Xinsheng Cao, Zhanqi Zhao
Summary: This study evaluated the feasibility of using electrical impedance tomography (EIT) to assess the performance of the anti-gravity straining maneuver (AGSM) and found that EIT could objectively characterize the maneuver details of AGSM. The differences in ventilation characteristics between teachers and students during AGSM implementation were significant, and there were significant reductions in rating scores with EIT compared to without EIT, both assessed by the professor and the students themselves.
COMPUTERS IN BIOLOGY AND MEDICINE
(2021)
Article
Veterinary Sciences
Shannon G. Beazley, Alex Focken, Rocio Fernandez-Parra, Keri L. Thomas, Andy Adler, Tanya Duke-Novakovski
Summary: This study aimed to investigate the effect of carbon dioxide insufflation on lung ventilation distribution in standing sedated horses. The results showed that there were no significant changes in lung ventilation distribution with increasing intra-abdominal pressure, but there was a significant decrease in tidal volume.
VETERINARY ANAESTHESIA AND ANALGESIA
(2022)
Article
Critical Care Medicine
Vincent Joussellin, Vincent Bonny, Savino Spadaro, Sebastien Clerc, Melodie Parfait, Martina Ferioli, Antonin Sieye, Yorschua Jalil, Vincent Janiak, Andrea Pinna, Martin Dres
Summary: This study found that patients who had extubation failure exhibited a loss of lung aeration before extubation, and this loss persisted after extubation, being associated with regional lung ventilation heterogeneity.
ANNALS OF INTENSIVE CARE
(2023)
Article
Pediatrics
Milena S. Nascimento, Cristiane do Prado, Eduardo L. Costa, Glasiele C. Alcala, Leticia C. Correa, Felipe S. Rossi, Marcelo B. P. Amato, Celso M. Rebello
Summary: This study evaluated the effects of high-flow nasal cannula (HFNC) at different flow rates on functional residual capacity (FRC) and pulmonary ventilation distribution. The results showed that the increase in end-expiratory lung volume (EELZ) at the highest flow rates was accompanied by decreased respiratory distress scores and improved oxygenation.
PEDIATRIC PULMONOLOGY
(2022)
Article
Critical Care Medicine
David G. Tingay, Olivia Farrell, Jessica Thomson, Elizabeth J. Perkins, Prue M. Pereira-Fantini, Andreas D. Waldmann, Christoph Ruegger, Andy Adler, Peter G. Davis, Inez Frerichs
Summary: This study investigated the spatial and temporal gas flow, aeration, and ventilation patterns within the lungs of term neonates during successful respiratory transition at birth. The results showed that ventilation within the lung was not uniform, with a unique volume pattern created by initial crying. Neonates naturally regulated expiratory flow to maintain functional residual capacity and redistribute gas to less aerated regions.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2021)
Review
Physiology
Hui Jiang, Yijiao Han, Xia Zheng, Qiang Fang
Summary: Lung transplantation is the preferred treatment for end-stage pulmonary disease, but factors like donor shortages and postoperative complications hinder its progress. Electrical impedance tomography (EIT) is a functional imaging tool that can evaluate lung ventilation and perfusion at the bedside. Its use in lung transplantation has gained interest from researchers, but physicians still lack knowledge about its potential applications.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Pediatrics
Vladimir L. Cousin, Hubert Colau, Francisca Barcos-Munoz, Peter C. Rimensberger, Angelo Polito
Summary: The study examined the perception of music therapy (MT) by parents of pediatric patients in a PICU. The majority of parents believed that MT helped their child's communication, reduced feelings of isolation, and helped them cope with stress during hospitalization. Parents also believed that MT contributed to physical recovery and alleviated anxiety. They suggested that MT should be offered as an outpatient service.
Article
Anesthesiology
Yingying Yang, Huaiwu He, Yun Long, Yi Chi, Siyi Yuan, Zhoutian Shen, Inez Frerichs, Zhanqi Zhao
Summary: This study evaluated the routine use of electrical impedance tomography (EIT) to diagnose pneumothorax (PTX) in mechanically ventilated patients in the intensive care unit (ICU). The study found that ventilation defect in the ventral regions and a high horizontal ventral ventilation index (HVVI) were observed in mechanically ventilated patients with PTX, which can be used as indicators to trigger further diagnostics.
JOURNAL OF CLINICAL MONITORING AND COMPUTING
(2023)
Article
Critical Care Medicine
Annemijn H. Jonkman, Glasiele C. Alcala, Bertrand Pavlovsky, Oriol Roca, Savino Spadaro, Gaetano Scaramuzzo, Lu Chen, Jose Dianti, Mayson L. de A. Sousa, Michael C. Sklar, Thomas Piraino, Huiqing Ge, Guang-Qiang Chen, Jian-Xin Zhou, Jie Li, Ewan C. Goligher, Eduardo Costa, Jordi Mancebo, Tommaso Mauri, Marcelo Amato, Laurent J. Brochard
Summary: This study used electrical impedance tomography (EIT) to quantify lung recruitability and proposed a method to select optimal positive end-expiratory pressure (PEEP) based on EIT. The researchers found that there is a wide variation in recruitability among COVID-19 patients, and EIT can help personalize PEEP setting to balance recruitability and overdistension.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Editorial Material
Critical Care Medicine
Long Xiang, Hong Ren, Ying Wang, Zhulin Wang, Inez Frerichs, Zhanqi Zhao
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Letter
Anesthesiology
Zhanqi Zhao, Inez Frerichs
Article
Medicine, General & Internal
H. He, N. Wang, M. Zhang, J. Jiang, N. Cui, I Frerichs, Y. Long, Z. Zhao
Summary: This study introduces a novel approach to detect right-to-left intracardiac shunt using electrical impedance tomography (EIT) based on the center of heart (CoH) parameter. The method involves identifying the timepoints when saline bolus enters the heart and lung regions, calculating the slope of the impedance-time curve in each pixel within a moving time window, and determining the CoH as the geometric center of these values. The results showed a significant difference in CoH between patients with intracardiac shunt and control patients. The findings suggest that saline bolus EIT may be used to identify right-to-left intracardiac shunt at the bedside.
QJM-AN INTERNATIONAL JOURNAL OF MEDICINE
(2023)
Article
Multidisciplinary Sciences
Lin Yang, Zhijun Gao, Xinsheng Cao, Feng Fu, Knut Moller, Inez Frerichs, Meng Dai, Zhanqi Zhao
Summary: The study aimed to examine the influence of gravity on regional ventilation measured by EIT with the standard electrode belt position during tilting from supine to sitting positions. Through observation of 30 healthy volunteers, it was found that as the upper body tilted to 90-degree position, ventilation distribution became more heterogeneous and moved towards dorsal regions, end-expiratory lung impedance increased, and tidal volume decreased. The study suggests that the standard electrode belt position should be reconsidered when comparing ventilation distribution between supine and sitting positions.
Article
Engineering, Biomedical
Carolin M. Geitner, Tobias Becher, Inez Frerichs, Norbert Weiler, Jason H. T. Bates, Wolfgang A. Wall
Summary: We propose a new approach to computationally model the lungs of diseased human using physics-based methods. Our model incorporates the dynamics of airway recruitment/derecruitment to accurately simulate the respiratory system mechanics, airway dimensions, and the properties of the lining fluid. This approach allows for more precise predictions of mechanical stress locations in the lungs, which play a crucial role in the development and propagation of injury. By matching the model to patient data and using medical CT images, we demonstrate the potential of the model to reveal underlying abnormalities in the specific case of acute respiratory distress syndrome (ARDS). The model accurately reproduces clinically measured quantities and exhibits physiologically reasonable lung recruitment dynamics, providing a valuable tool for personalized studies and optimized therapies.
INTERNATIONAL JOURNAL FOR NUMERICAL METHODS IN BIOMEDICAL ENGINEERING
(2023)
Letter
Pediatrics
Inez Frerichs, Claas Strodthoff, Barbara Vogt
PEDIATRIC PULMONOLOGY
(2023)
Article
Computer Science, Information Systems
N. Seifnaraghi, S. De Gelidi, I. Frerichs, M. Kallio, Md. E. Sorantin, A. Demosthenous, R. H. Bayford
Summary: This study investigates how the patient's recumbency positions affect the silent spaces parameter in chest electrical impedance tomography (EIT). The silent spaces parameter is a crucial factor in medical decision-making and interventions as it indicates the ventilation of each lung. The study shows that the assumptions made during the reconstruction stage and the region of interest (ROI) have a significant impact on the silent spaces parameter. By considering the internal organ movements caused by posture changes, the study demonstrates the importance of including the recumbency situation in chest EIT monitoring.
Letter
Critical Care Medicine
Zhanqi Zhao, Mei-Yun Chang, Chan-Ching Chu, Hou-Tai Chang, Knut Moller, Inez Frerichs, Yeong-Long Hsu
Article
Pediatrics
Svilen Atanasov, Constanze Dippel, Dupleix Takoulegha, Anita Windhorst, Rahel Schuler, Claas Strodthoff, Inez Frerichs, Jens Dreyhaupt, Markus Waitz, Keywan Sohrabi, Harald Ehrhardt
Summary: VLBW infants on NIV with frequent SpO(2) fluctuations benefit more from sNIPPV in maintaining the SpO(2) target and reducing FiO(2) exposure compared to nHFOV.
Letter
Critical Care Medicine
Qing Li, Yi Li, Guangyu Niu, Mingna Li, Jia Deng, Knut Moeller, Inez Frerichs, Jianing Xi, Hongying Jiang, Zhanqi Zhao
Article
Engineering, Biomedical
Carolin M. Geitner, Lea J. Koeglmeier, Inez Frerichs, Patrick Langguth, Matthias Lindner, Dirk Schaedler, Norbert Weiler, Tobias Becher, Wolfgang A. Wall
Summary: We present a novel computational model for simulating alveolar recruitment/derecruitment dynamics, which considers the characteristics observed in injured lungs and introduces patient-specific parameter determination. Applying this model to clinical data of mechanically ventilated patients allows for accurate estimation of individual tissue straining and cyclic derecruitment, contributing to the development of personalized protective ventilation strategies.
INTERNATIONAL JOURNAL FOR NUMERICAL METHODS IN BIOMEDICAL ENGINEERING
(2023)
Article
Engineering, Biomedical
Diogo Pessoa, Bruno Machado Rocha, Maria Gomes, Guilherme Rodrigues, Georgios Petmezas, Grigorios-Aris Cheimariotis, Nicos Maglaveras, Alda Marques, Inez Frerichs, Paulo de Carvalho, Rui Pedro Paiva
Summary: This study proposes a deep learning model to estimate respiratory airflow using only respiratory sound. The model performs well in various circumstances of different complexity, but its performance decreases when different devices are used.
BIOMEDICAL SIGNAL PROCESSING AND CONTROL
(2024)
