Review
Pediatrics
Jacob Karlsson, Per-Arne Lonnqvist
Summary: Hemodynamic monitoring in children is challenging due to technical limitations and lack of validation against reference methods. Accurate monitoring methods are needed for pediatric patients. The capnodynamic method, which calculates blood flow participating in gas exchange, allows for continuous monitoring of cardiac output and mixed venous oxygen saturation without additional equipment or calibration. This review will discuss the application, limitations, and future potential development of the capnodynamic method in pediatric patients.
FRONTIERS IN PEDIATRICS
(2023)
Article
Cardiac & Cardiovascular Systems
James A. Brown, Edgar Aranda-Michel, Arman Kilic, Derek Serna-Gallegos, Valentino Bianco, Floyd W. Thoma, Ibrahim Sultan
Summary: Objective of this study was to determine the impact of pulmonary artery catheter insertion on short-term postoperative outcomes in patients undergoing open cardiac surgery. The study found that pulmonary artery catheter use did not improve operative mortality in the overall cohort or in specific subgroups. Although there were longer intensive care unit stays and more red blood cell transfusions in the pulmonary artery catheterization group, the postoperative outcomes were otherwise similar.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2022)
Article
Anesthesiology
Yuefu Wang, Weiqin Huang, Jiange Han, Yu Tian, Chunrong Wang, Lihuan Li
Summary: This study conducted a multi-center clinical study in China to test the equivalence of cardiac output measured with the ClearSight system and the pulmonary artery catheter bolus thermodilution method. The results showed that the ClearSight system is equivalent to the pulmonary artery catheter bolus thermodilution method in measuring cardiac output in cardiac surgery patients.
PERIOPERATIVE MEDICINE
(2022)
Article
Anesthesiology
Akira Mukai, Koichi Suehiro, Aya Kimura, Katsuaki Tanaka, Tokuhiro Yamada, Takashi Mori, Kiyonobu Nishikawa
Summary: The study aimed to assess the impact of systemic vascular resistance on the reliability of the ClearSight system for measuring blood pressure and cardiac output. Results showed acceptable accuracy in measuring BP and tracking BP changes, but poor accuracy in CO measurement and its trending ability in different SVR states.
JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA
(2021)
Review
Critical Care Medicine
Virendra K. Arya, Waiel Al-Moustadi, Vikas Dutta
Summary: This article reviews various contemporary CO measurement technologies available and their utility in critically ill patients. Pulmonary artery catheter is the most accurate method, but its invasiveness may cause complications. Noninvasive devices predict CO via mathematical modeling, but are prone to errors in clinical situations. CCE provides CO and helps in differential diagnosis.
CURRENT OPINION IN CRITICAL CARE
(2022)
Article
Chemistry, Analytical
Thi Hang Dang, Geuk Young Jang, Kyounghun Lee, Tong In Oh
Summary: Electrical impedance tomography (EIT) can noninvasively monitor the hemodynamic state of conscious patients in real-time. However, the extracted cardiac volume signal (CVS) from EIT images is small and sensitive to motion artifacts (MAs). This study developed a new algorithm based on the source consistency between the electrocardiogram (ECG) and CVS to reduce MAs and improve heart rate (HR) and cardiac output (CO) monitoring accuracy in hemodialysis patients. The algorithm achieved higher correlation and precision compared to the conventional statistical algorithm, providing more reliable monitoring in high-motion environments.
Article
Cardiac & Cardiovascular Systems
Bernard S. Kadosh, David D. Berg, Erin A. Bohula, Jeong-Gun Park, Vivian M. Baird-Zars, Carlos Alviar, James Alzate, Christopher F. Barnett, Gregory W. Barsness, James Burke, Sunit-Preet Chaudhry, Lori B. Daniels, Andrew Defilippis, Anthony Delicce, Christopher B. Fordyce, Shahab Ghafghazi, Umesh Gidwani, Michael Goldfarb, Jason N. Katz, Ellen C. Keeley, Benjamin Kenigsberg, Michael C. Kontos, Patrick R. Lawler, Evan Leibner, Venu Menon, Thomas S. Metkus, Elliott Miller, Connor G. O'Brien, Alexander I. Papolos, Rajnish Prasad, Kevin S. Shah, Shashank S. Sinha, R. Jeffrey Snell, Derek So, Michael A. Solomon, Bradley W. Ternus, Jeffrey J. Teuteberg, Joseph Toole, Sean van Diepen, David A. Morrow, Robert O. Roswell
Summary: This study aimed to explore the current use of PACs in cardiac intensive care units and investigate the factors influencing their use. The study found that mechanical circulatory support and heart failure were the most influential patient-level factors for PAC use. There was significant variation in the proportion of PAC use among different study centers, and the use of PACs was associated with higher survival in cardiac patients with shock.
JACC-HEART FAILURE
(2023)
Article
Health Care Sciences & Services
Michal P. Pluta, Magdalena Dziech, Mateusz N. Zachura, Anna J. Szczepanska, Piotr F. Czempik, Piotr S. Liberski, Lukasz J. Krzych
Summary: The study aimed to assess the comparability between two arterial pressure cardiac output measurement methods, and the results showed that Capstesia(TM) smartphone software can serve as an alternative method for cardiac output assessment in patients with invasive arterial pressure monitoring with clearly discernible dicrotic notch, meeting the arterial pressure cardiac output evaluation criteria.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Yi-Hsin Hung, An-Li Yu, Chun-Kai Chen, Min-Tsun Liao, Mu-Yang Hsieh, Wen-Jone Chen
Summary: Wet beriberi, a rare but fatal disease, can present with nonspecific clinical manifestations and delay timely diagnosis. The use of a pulmonary artery catheter is crucial in rapidly deteriorating cases to confirm high cardiac output state. Prompt intravenous thiamine administration leads to dramatic recovery. Two cases of Shoshin beriberi were diagnosed in 2016 and 2022, both successfully reversed by thiamine supplementation through the use of a pulmonary artery catheter. A review of 19 wet beriberi cases reported between 2010 and 2022 was also conducted.
Article
Biochemistry & Molecular Biology
Gianfranco Piccirillo, Federica Moscucci, Andrea Corrao, Myriam Carnovale, Ilaria Di Diego, Ilaria Lospinuso, Cristina Caltabiano, Martina Mezzadri, Pietro Rossi, Damiano Magri
Summary: This study used bio-impedance and ECG data to compare HFrEF and HFpEF patients, and analyzed responders and non-responders to optimal medical therapy. The study found that these non-invasive parameters were able to highlight the differences between different types of heart failure patients and their response to medication.
Article
Anesthesiology
Ramakrishna Mukkamala, Benjamin A. Kohl, Aman Mahajan
Summary: The study compared the accuracy of two CO monitors using different pulse contour analysis methods in patients undergoing off-pump coronary artery bypass surgery, with the Argos device found to be more accurate than the Vigileo-FloTrac device in CO trending and absolute CO measurement.
BMC ANESTHESIOLOGY
(2021)
Article
Pediatrics
Armelle Bridier, Monisha Shcherbakova, Atsushi Kawaguchi, Nancy Poirier, Carla Said, Rita Noumeir, Philippe Jouvet
Summary: Infrared thermography and blood gas analysis were used to monitor children with low cardiac output syndrome, and a significant but weak correlation was found between the thermal gradient obtained by infrared thermography and the oxygen extraction ratio.
FRONTIERS IN PEDIATRICS
(2023)
Review
Critical Care Medicine
Martin Ruste, Matthias Jacquet-Lagreze, Jean-Luc Fellahi
Summary: Individualized hemodynamic optimization often requires cardiac output monitoring, which can be achieved through noninvasive technologies. Care providers need to be aware of the advantages and limitations of these technologies to ensure appropriate use for patient care.
CURRENT OPINION IN CRITICAL CARE
(2023)
Article
Sport Sciences
Brandon Pentz, Candela Diaz-Canestro, Arshia Sehgal, David Montero
Summary: This study investigated the effects of blood withdrawal on cardiac, hemodynamic, and pulmonary responses to submaximal exercise in females. The results showed that a 10% reduction in blood volume led to a decrease in cardiac filling, but compensatory chronotropic responses maintained cardiac output at a moderate submaximal workload. Blood pressure decreased while oxygen uptake remained unchanged. Therefore, blood volume determines the relative exercise intensity in this population.
JOURNAL OF SCIENCE AND MEDICINE IN SPORT
(2022)
Review
Critical Care Medicine
Julian Arias-Ortiz, Jean-Louis Vincent
Summary: Only a few acutely ill patients require a PAC, and the decision to insert it should be based on clinical context, availability of trained staff, and the potential benefits of measured variables in guiding therapy.
CURRENT OPINION IN CRITICAL CARE
(2023)
Article
Oncology
Vanessa Sitte, Barbara Burkhardt, Roland Weber, Oliver Kretschmar, Martin Hersberger, Eva Bergstrasser, Martin Christmann
Summary: This study aimed to evaluate sensitive parameters for cardiac damage in childhood cancer survivors. The results showed that strain imaging and new cardiac biomarkers in HFpEF were more sensitive than standard echo and laboratory parameters.
JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Marie Schafstedde, Sarah Nordmeyer, Anastasia Schleiger, Johannes Nordmeyer, Felix Berger, Peter Kramer, Stanislav Ovroutski
Summary: The prevalence of cyanosis remains significant in long-term follow-up after Fontan operation, and is associated with increased late mortality. Cyanosis is one of the strongest predictors for late mortality.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2022)
Article
Cardiac & Cardiovascular Systems
Vinzenz Boos, Felix Berger, Mi-Young Cho, Joachim Photiadis, Christoph Buehrer, Constanze Pfitzer
Summary: This study aimed to investigate the morbidity, long-term mortality, and neurodevelopmental outcomes in very low birthweight infants who underwent cardiac surgery for severe congenital heart defect within 1 year after birth. The findings revealed that survival rates decreased with increasing STAT mortality category of the surgical procedure, and the type of cardiac malformation may affect early- and long-term outcomes.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2022)
Article
Pediatrics
Rebecca Spillmann, Susanne Polentarutti, Melanie Ehrler, Oliver Kretschmar, Flavia M. Wehrle, Beatrice Latal
Summary: Children with congenital heart disease (CHD) are at risk for neurodevelopmental deficits, and this study investigated the impact of cognitive deficits on educational outcome and participation in leisure activities. The results showed that children with CHD had lower IQ and executive functions compared to norms, attended regular school and participated in leisure activities less frequently than the general population. These findings emphasized the importance of early detection of cognitive deficits and providing support for cognitive functioning in children with CHD.
PEDIATRIC RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Anna Krokovay, Martin Schweiger, Oliver Kretschmar, Rene Pretre
Summary: Anomalous origin of the left coronary artery from the pulmonary artery is a rare congenital anomaly, which can be corrected by reimplanting it into the aorta through surgery.
INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY
(2022)
Article
Cardiac & Cardiovascular Systems
Clara Stammnitz, Doerte Huscher, Ulrike M. M. Bauer, Aleksandra Urban, Johannes Nordmeyer, Stephan Schubert, Joachim Photiadis, Felix Berger, Sabine Klaassen
Summary: This study aimed to identify specific long-term risk factors for infective endocarditis (IE) in patients with congenital heart disease after pulmonary valve replacements. The study found that bovine jugular vein valves had the highest risk of IE, while Edwards Sapien and mechanical valves were used less frequently and remained without IE.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Cardiac & Cardiovascular Systems
A. Krokovay, R. Pretre, O. Kretschmar, W. Knirsch, E. Valsangiacomo Buechel, H. Dave
Summary: This study discussed the surgical reconstruction of non-sclerotic proximal coronary artery stenosis in children using autologous vein grafts, showing good medium- to long-term outcomes. The 100% survival rate and normal coronary artery patency and cardiac function post-reconstruction were observed.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2022)
Editorial Material
Cardiac & Cardiovascular Systems
Sven C. Weber, Friederike Danne, Moritz Kieslich, Annemarie Krauss, Felix Berger, Hannes Sallmon
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2022)
Article
Cardiac & Cardiovascular Systems
Marie Schafstedde, Johannes Nordmeyer, Felix Berger, Christoph Knosalla, Philipp Mertins, Matthias Ziehm, Marie-Luise Kirchner, Vera Regitz-Zagrosek, Titus Kuehne, Milena Kraus, Sarah Nordmeyer
Summary: Animal studies have shown the important role of dihydrotestosterone (DHT) in pressure overload-induced myocardial hypertrophy and dysfunction. This study aimed to evaluate the relationship between DHT levels and myocardial hypertrophy and protein expression in patients with severe aortic valve stenosis (AS). The findings suggest that DHT may be a target for preventing or attenuating adverse myocardial remodeling in patients with AS.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2022)
Article
Pediatrics
Celine Steger, Maria Feldmann, Julia Borns, Cornelia Hagmann, Beatrice Latal, Ulrike Held, Andras Jakab, Ruth O'Gorman Tuura, Walter Knirsch
Summary: Reduced white matter NAA/Cho ratios in neonates undergoing cardiac surgery for congenital heart defects may indicate delayed brain maturation. Further research is needed to understand the clinical impact of altered metabolites on brain development and outcome.
PEDIATRIC RESEARCH
(2023)
Article
Environmental Sciences
Regina Wespi, Alessia Callegari, Daniel Quandt, Jana Logoteta, Michael von Rhein, Oliver Kretschmar, Walter Knirsch
Summary: PDA stenting is a feasible and safe treatment option for patients with duct-dependent pulmonary perfusion. Interdisciplinary decision-making before the procedure and surgical backup afterwards are necessary. The procedure allows for adequate body and pulmonary vessel growth for subsequent surgical procedures.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Environmental Sciences
Alessia Callegari, Daniel Quandt, Achim Schmitz, Karin Klingel, Christian Balmer, Hitendu Dave, Oliver Kretschmar, Walter Knirsch
Summary: This study assessed the findings and outcomes in children with suspected cardiomyopathy or myocarditis undergoing cardiac catheterization. The study found that invasive hemodynamic data and histological/immunohistological findings provide important information for the clinical diagnosis and management of children with suspected CMP/myocarditis.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Biology
Antonio Amodeo, Milena Stojanovic, Hitendu Dave, Robert Cesnjevar, Alexander Konetzka, Tugba Erdil, Oliver Kretschmar, Martin Schweiger
Summary: This retrospective study evaluated the use and timing of V-A ECMO in pediatric patients and found that ventricular physiology and heart anatomy play important roles in the outcomes of children on ECMO.
Article
Surgery
Philipp Biedermann, Vanessa Sitte-Koch, Martin Schweiger, Anke Meinold, Daniel Quandt, Oliver Kretschmar, Christian Balmer, Walter Knirsch
Summary: Pulmonary hypertension is common before pediatric heart transplantation, but post-transplantation normalization of pulmonary hemodynamics starts immediately in cardiomyopathy patients and is delayed in congenital heart disease patients.
CLINICAL TRANSPLANTATION
(2023)
Article
Biotechnology & Applied Microbiology
Marvin Steitz, Sabra Zouhair, Mahamuda Badhon Khan, Alexander Breitenstein-Attach, Katharina Fritsch, Sugat Ratna Tuladhar, Dag Wulsten, Willem-Frederik Wolkers, Xiaolin Sun, Yimeng Hao, Jasper Emeis, Hans-E. Lange, Felix Berger, Boris Schmitt
Summary: A novel alternative crosslinking method was investigated for collagen-based biomaterials, showing improved thermal and enzymatic stability compared to glutaraldehyde, while maintaining similar biomechanical properties. The study suggests potential for the novel crosslinking agent in intraoperative processing of biomaterials, with further long-term studies required for assessing longevity and calcification.
BIOENGINEERING-BASEL
(2023)