Article
Neurosciences
Anouk Marsman, Anna Lind, Esben Thade Petersen, Mads Andersen, Vincent Oltman Boer
Summary: GABA and GSH play crucial roles in brain functioning and are involved in various neurodegenerative and psychiatric diseases. MRS is a unique non-invasive method to measure these neurometabolites, but motion stabilization is important, especially for specific patient groups. Spectral editing techniques are typically used for unambiguous detection of GABA and GSH, although they increase motion sensitivity.
Article
Food Science & Technology
Yuling Ma, Aixia Wang, Mei Yang, Shanshan Wang, Lili Wang, Sumei Zhou, Christophe Blecker
Summary: The study showed that black mung bean varieties with heat and relative humidity treatment had higher GABA content compared to green varieties. Soaking increased GABA content in mung beans, but a portion of it was distributed in the soaking solution. After cooking, the GABA content in heat and humidity treated mung beans slightly degraded, but remained higher than untreated mung beans.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2022)
Article
Neurosciences
Manoela V. Fogaca, Min Wu, Chan Li, Xiao-Yuan Li, Ronald S. Duman, Marina R. Picciotto
Summary: Alterations in glutamatergic and GABAergic function in the medial prefrontal cortex (mPFC) play a role in major depressive disorder. Scopolamine, a muscarinic receptor antagonist, has rapid antidepressant-like effects by targeting M1-type acetylcholine receptors (M1R). In this study, M1R deletion in SST interneurons in the mPFC attenuates the antidepressant-like effects of scopolamine and impairs GABAergic and glutamatergic function. These findings suggest that modulation of excitatory and inhibitory plasticity via M1R blockade in SST interneurons could be a promising strategy for developing antidepressants.
NEUROPSYCHOPHARMACOLOGY
(2023)
Review
Nutrition & Dietetics
David J. Nutt, Robin J. Tyacke, Meg Spriggs, Vanessa Jacoby, Alan D. Borthwick, Delia Belelli
Summary: Alcohol consumption is associated with health harms and governments worldwide are trying to reduce them. One approach is to reduce alcohol consumption, leading to the development of non-alcoholic drinks. However, non-alcoholic drinks do not provide the social interaction that alcohol does. Therefore, the alternative approach is to develop functional drinks that mimic the positive effects of alcohol without the harms.
Article
Multidisciplinary Sciences
Ateequr Rehman, Giulio Di Benedetto, Julia K. Bird, Valentina Dabene, Lisa Vadakumchery, Ali May, Ghislain Schyns, Wilbert Sybesma, Tim N. Mak
Summary: This study focused on the selection and optimization of a bacterial strain with high GABA production for probiotic supplement development. Two biosensors capable of detecting GABA were developed and tested in gut-like conditions. The results provide valuable insights for the development of probiotic supplements and monitoring of GABA in the digestive system.
SCIENTIFIC REPORTS
(2023)
Review
Immunology
Yu Shan, Jianan Zhao, Yixin Zheng, Shicheng Guo, Steven J. Schrodi, Dongyi He
Summary: Rheumatoid arthritis (RA) is a disabling autoimmune disease with a complex pathological process. The GABAergic system in the nervous system may have immunomodulatory effects and regulate abnormal pain response in RA patients.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Nutrition & Dietetics
Oliviero Bruni, Luigi Ferini-Strambi, Elena Giacomoni, Paolo Pellegrino
Summary: Sleep is crucial for physical and emotional wellbeing, but insomnia is a prevalent issue. The interest in using herbal medicines for treating or preventing insomnia has grown. Herbal extracts have been shown to improve sleep quality, potentially through interactions with GABA receptors in the brain.
Article
Agriculture, Dairy & Animal Science
Zhen Wu, Pengyu Wang, Daodong Pan, Xiaoqun Zeng, Yuxing Guo, Guangsheng Zhao
Summary: The study demonstrated that GABA-enriched adzuki bean sprout fermented milk may alleviate and even prevent mild depression symptoms in mice by enhancing social interaction and pleasure derived from movement. The research also highlighted the involvement of the GABA(B)-cAMP-PKA-CREB signaling pathway and increased neurotransmitter levels in the hippocampus after treatment. This suggests a potential dietary therapy for chronic social stress.
JOURNAL OF DAIRY SCIENCE
(2021)
Article
Behavioral Sciences
Simon Maier, Ansgard Lena Dueppers, Kimon Runge, Michael Dacko, Thomas Lange, Thomas Fangmeier, Andreas Riedel, Dieter Ebert, Dominique Endres, Katharina Domschke, Evgeniy Perlov, Kathrin Nickel, Ludger Tebartz van Elst
Summary: Adults with autism spectrum disorders have elevated levels of the inhibitory neurotransmitter GABA in the left dorsolateral prefrontal cortex. This finding supports the hypothesis of an imbalance between excitatory and inhibitory equilibrium in patients with autism spectrum disorders.
Article
Plant Sciences
Canying Li, Jie Zhu, Lei Sun, Yuan Cheng, Jiabao Hou, Yiting Fan, Yonghong Ge
Summary: The study demonstrates that exogenous GABA has significant effects on quality parameters, ethylene anabolism, polyamine metabolism, and GABA shunt in 'Golden Delicious' apples, helping to maintain fruit quality by suppressing unfavorable factors.
PLANT PHYSIOLOGY AND BIOCHEMISTRY
(2021)
Article
Clinical Neurology
Alice M. Fuller, Ana Luiz, Naxi Tian, Manuel Arcangeletti, Federico Iseppon, Jane E. Sexton, Queensta Millet, Sara Caxaria, Niloofar Ketabi, Petek Celik, John N. Wood, Shafaq Sikandar
Summary: Melzak and Wall's gate control theory suggests that innocuous input can inhibit pain-inducing nociceptive input. In this study, it is shown that proprioceptive parvalbumin-expressing sensory neurons tonically suppress nociceptor activation in the dorsal root ganglia. Deletion of these sensory neurons leads to increased nociceptor activity, enhanced input into spinal cord neurons, and increased pain behavior, as well as heightened innocuous sensation. These findings support the existence of peripheral gate control mechanisms within the dorsal root ganglia.
Article
Environmental Sciences
Qing Shan, Minghui Liu, Rui Li, Qinghua Shi, Yan Li, Biao Gong
Summary: In this study, we investigated the role of GABA in crops and found that exogenous application or endogenous regulation of GABA by gene-editing technology can promote pesticide detoxification and enhance crop tolerance. This is achieved by regulating the GABA shunt pathway and polyamine pathway in plants. Additionally, we unexpectedly discovered that GABA promotes stomatal closure, reducing pesticide absorption.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Biochemistry & Molecular Biology
Arnaud L. Lalive, Mauro Congiu, Christopher Lewis, Dominik Groos, Joseph A. Clerke, Anna Tchenio, Yuan Ge, Fritjof Helmchen, Manuel Mameli
Summary: Through experiments with mice, it was found that the activity of lateral habenula neurons decreases with the decrease of reward-related stimuli, and this phenomenon can guide reward-driven behavior through synaptic inhibition.
Review
Food Science & Technology
X. Y. Lee, J. S. Tan, L. H. Cheng
Summary: This mini review discusses the biosynthetic pathways of GABA in plants and its presence in foods. Compared to animal-based foods, plant-based foods generally have lower levels of GABA, although germination and fermentation can increase GABA content. However, there is limited research on the stability of GABA during processing and storage, its bioavailability, and clinical implications.
FOOD REVIEWS INTERNATIONAL
(2023)
Article
Neurosciences
Shigeru Ogata, Yuta Miyamoto, Naoki Shigematsu, Shigeyuki Esumi, Takaichi Fukuda
Summary: The study demonstrates the presence of a novel type of GABAergic neurons in the most caudal part of the striatum in male mice. These neurons have large somata and extend long dendrites towards adjoining regions, receiving inputs from MSNs in close proximity and facilitating prompt disinhibition in response to auditory stimuli.
JOURNAL OF NEUROSCIENCE
(2022)