Article
Oncology
Weiqian Guo, Xiaomin Zheng, Lei Hua, Xianbin Zheng, Yangyang Zhang, Bin Sun, Zhenchao Tao, Jin Gao
Summary: Differentiated expressed genes for nasopharyngeal carcinoma were identified and potential biomarkers were explored through bioinformatical analysis. The core genes screened may serve as prognostic and diagnostic biomarkers for NPC.
Article
Biology
Bokang Ko, Jeremy M. Van Raamsdonk
Summary: Gene expression studies provide valuable insights into biological processes, such as aging. This study shows that pooling individual RNA samples before sequencing can yield similar results as sequencing them individually, reducing the cost of experiments. Analysis of gene expression changes across the genome is a powerful and unbiased tool for understanding molecular mechanisms.
Article
Multidisciplinary Sciences
Changsheng Guo, Yuanqing Hua, Zuanhao Qian
Summary: This study identified differentially expressed lncRNAs and genes in Kawasaki disease (KD), as well as constructed ceRNA networks involving miRNAs and mRNAs. The study found specific lncRNAs (PSORS1C3, LINC00999, SNHG5) and genes (GATA3, SOD2, MAPK14, PPARG) that may play a key role in the pathogenesis and development of KD. Validation in a separate dataset showed that intravenous immunoglobulin treatment alleviated the deregulated RNA profiles in KD patients.
Article
Genetics & Heredity
Weitao Hu, Taiyong Fang, Xiaoqing Chen
Summary: This study identified DEGs associated with ulcerative colitis (UC) using bioinformatics analysis, providing potential diagnostic and therapeutic targets. The DEGs, hub genes and miRNAs identified may serve as biomarkers for UC, but further research is needed to understand their biological roles in the disease.
FRONTIERS IN GENETICS
(2022)
Article
Oncology
Reem Altaf, Umair Ilyas, Anmei Ma, Meiqi Shi
Summary: In this study, bioinformatics analysis was used to evaluate four datasets for differentially expressed genes (DEGs) associated with non-small cell lung cancer (NSCLC). Ten significant DEGs were identified and their expression was validated. Gene-gene and drug-gene network analysis revealed important interactions and potential drug targets. This study highlights the importance of systemic genetics in identifying potential targeted therapies for NSCLC.
FRONTIERS IN ONCOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Seung-Hoon Lee, Na Rae Park, Jung-Eun Kim
Summary: In this study, gene expression changes during megakaryocyte maturation were analyzed using the GeneChip microarray technology, and functional classification and protein interaction analysis of the differentially expressed genes were performed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Engineering, Chemical
Yuan-Shuo Hsueh, Hui Hua Chang, Shun-Yao Ko, Yi-Pai Lin, Wei-Yu Lin
Summary: Chronic partial bladder outlet obstruction (PBOO) can lead to bladder fibrosis, and gene expression alterations may play a significant role in its pathogenesis.
Article
Plant Sciences
Jing-xuan Wang, Bo Wang, Lu-bin Cui, Hao Xie, Run-zhi Li, Cheng Wang, Zhang-jie Nan, Yu-shu Liu, Jing-yu Ma, Yun-jin Sun, Wei-yu Li
Summary: This study identified key genes involved in aluminum resistance in soybeans, which are crucial for functions such as cell junction and phenylpropanoid biosynthesis, providing important information for breeding aluminum-resistant varieties.
PHYSIOLOGY AND MOLECULAR BIOLOGY OF PLANTS
(2021)
Article
Biochemistry & Molecular Biology
Evan Lloyd, Brittnee McDole, Martin Privat, James B. Jaggard, Erik R. Duboue, German Sumbre, Alex C. Keene
Summary: The Mexican cavefish Astyanax mexicanus provides an opportunity to study the evolutionary changes in sensory circuits in response to environmental perturbation. The study shows that the functional connectivity of the optic tectum in cavefish remains largely unchanged except for the loss of negatively correlated activity, indicating the resistance of positively correlated neural activity to the loss of input from the retina. Additionally, the changes in the tectum are found to be genetically distinct from the encoding of eye loss.
Article
Biochemical Research Methods
Lihong Zhao, Cong Yan, Shuzhen Kong, Tao Jia, Zhaowei Chu, Li Yang, Jian Wu, Songmei Geng, Kun Guo
Summary: CAP has more significant biological effects on melanoma cells than on HaCaT cells by inhibiting proliferation and promoting apoptosis. CAP can selectively kill melanoma cells and has good biosafety cytologically. Besides apoptosis, CAP can induce cell death via autophagy and necroptosis.
JOURNAL OF BIOPHOTONICS
(2022)
Article
Education, Scientific Disciplines
Zhongxiang Du, Xiajun Zhang, Weiya Gao, Jie Yang
Summary: This study analyzed differentially expressed genes in gastric cancer patients and identified three genes (PCCA, ECHS1, and HADH) with prognostic value. ECHS1 and HADH were significantly associated with disease-free survival, while PCCA was significantly correlated with overall survival rate. These genes may serve as new biomarkers for predicting the prognosis of gastric cancer.
Article
Dermatology
Li Deng, Yi Li, Qian Wu, QianWen Zeng, Yuanmin He, AiJun Chen
Summary: In this study, pathogenic genes related to ferroptosis in human skin after UVB radiation were identified through gene expression profile analysis. Functional annotation and pathway analysis revealed the significant roles of these genes in skin photodamage. These findings provide candidate genes and pathways for the development of new therapeutic targets for skin photodamage.
INTERNATIONAL JOURNAL OF DERMATOLOGY
(2023)
Article
Zoology
Yahui Zhao, Zushi Huang, Jinqing Huang, Chunguang Zhang, Fanwei Meng
Summary: The study found that eye-degenerated species in Sinocyclocheilus are polyphyletic, showing varying degrees of photoreceptor defects. While S. anophthalmus is classified as an eye-normal species, it exhibits high levels of eye degeneration and significant differences in eye-related gene expression compared to other eye-normal species.
INTEGRATIVE ZOOLOGY
(2021)
Article
Pharmacology & Pharmacy
Shun Ying Quah, Charng Choon Wong, Hui Chyn Wong, Kok Lian Ho, Nizar Abdul Manan, Pran Kishore Deb, Sreenivasa Rao Sagineedu, Johnson Stanslas
Summary: The study revealed that acquired chemoresistance to SRJ09 and SRJ23 in colon and prostate cancer cells may be attributed to alterations in the expression of genes related to the PI3K and autophagy pathways.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2021)
Article
Genetics & Heredity
Hengxing Ba, Min Chen, Chunyi Li
Summary: Antlers are an interesting model for basic research in regenerative biology. This study utilized genome and transcriptome data from four deer species to identify genes related to antler development. The results showed that the expression pattern of genes in the antlerogenic periosteum (AP) matched the antler phenotypes, suggesting their relevance in antler development. Upregulated genes in three-antlered deer were shown to be co-expressed and highly conserved, indicating their role in growth and antler development. In contrast, upregulated genes in antler-less deer were mainly involved in organismal death and growth failure, likely related to the loss of antlers during evolution. Overall, this study demonstrates the regulation of antler development by co-expressed genes in antlered deer.
FRONTIERS IN GENETICS
(2022)