Review
Biochemistry & Molecular Biology
Maria Magdalena Barreca, Riccardo Alessandro, Chiara Corrado
Summary: Flavonoids, phytochemical compounds found in plants, have various medicinal properties including anti-inflammatory, antioxidative, antiviral, and anticarcinogenic effects. They also offer neuroprotective and cardioprotective benefits. Recently, their effects have been shown to be mediated through the inhibition of the NF-κB signaling pathway. This review summarizes the effects of flavonoids on common diseases such as cancer, cardiovascular, and neurodegenerative diseases, with a focus on their action on the NF-κB pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Endocrinology & Metabolism
Yongjun Ye, Jianguo Zhou
Summary: Osteoarthritis (OA) is a joint disease associated with chronic inflammation. Inhibiting the NF-κB pathway, which plays a role in inflammation, can be a potential strategy for treating OA. Natural flavonoids, a type of polyphenol with anti-inflammatory properties, have shown protective activity against OA by inhibiting the NF-κB signaling pathway.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Pharmacology & Pharmacy
Tianrun Liu, Yingyu Li, Lumeng Wang, Xiaomeng Zhang, Yuxuan Zhang, Xuejie Gai, Li Chen, Lei Liu, Limin Yang, Baixin Wang
Summary: This study investigated the effects of mulberry leaf on enterovirus 71 (EV71) using network pharmacology, molecular docking, and in vitro experiments. The results revealed that quercetin, a major ingredient in mulberry leaf, exhibits potent anti-EV71 properties by inhibiting the NF-kappa B signaling pathway.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Medicine, Research & Experimental
Wenqing Li, Fubo Han, Kaifan Tang, Chengjie Ding, Fen Xiong, Yina Xiao, Chen Li, Qian Liang, Kwang Youl Lee, Ik-Soo Lee, Hongchang Gao
Summary: Demethylzeylasteral exhibits promising potential as a treatment for colon cancer by inhibiting S100A11 expression and directly interacting with it to attenuate cell proliferation. NF-kappa B acts as an upstream transcription factor regulating S100A11 expression.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Medicine, General & Internal
Shangwei Zhong, Changhao Huang, Zhikang Chen, Zihua Chen, Jun-Li Luo
Summary: Castration-resistant prostate cancer (CRPC) develops from the transformation of androgen-dependent (AD) prostate cancer (PCa) to androgen-independent (AI) PCa under androgen deprivation therapy (ADT). This forced evolutionary process allows AI PCa cells to selectively and dominantly proliferate, making PCa cells and the tumor microenvironment (TME) adapt and reprogram under ADT. Currently, there are no effective therapeutic methods available for the treatment of CRPC, highlighting the importance of targeting inflammatory signaling for the emergence and maintenance of CRPC.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Plant Sciences
Jin Kyeong Kim, Eunju Choi, Yo Han Hong, Haeyeop Kim, Young-Jin Jang, Jong Sub Lee, Eui Su Choung, Byoung Young Woo, Yong Deog Hong, Sarah Lee, Byoung-Hee Lee, Tran The Bach, Ji Hye Kim, Jong-Hoon Kim, Jae Youl Cho
Summary: The methanol extract of Melicope accedens (Ma-ME) demonstrated anti-inflammatory properties by targeting Syk in the NF-kappa B signaling pathway, containing various anti-inflammatory flavonoids.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Justyna Radzka, Zofia Lapinska, Urszula Szwedowicz, Agnieszka Gajewska-Naryniecka, Agnieszka Gizak, Julita Kulbacka
Summary: This review paper summarizes the current knowledge on the effects of natural compounds, including curcumin, resveratrol, quercetin, epigallocatechin-3-gallate, and berberine, on NF-κB signaling in muscle-derived cancers. These compounds have been shown to inhibit NF-κB signaling in rhabdomyosarcoma cells through various mechanisms. Natural compounds could be potential therapeutic agents for muscle-derived cancers, but more research is needed to fully understand their mechanisms of action and potential clinical applications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biotechnology & Applied Microbiology
Fangfang Gao, Xiaoqian Mu, Huijuan Wu, Lijuan Chen, Jie Liu, Yanqiu Zhao
Summary: Calreticulin (CALR) is aberrantly expressed in lung cancer, and its overexpression promotes proliferation of lung cancer cells, possibly through activation of the NF-kappa B signaling pathway.
Article
Biochemistry & Molecular Biology
Feng Tang, Hua Yu, Xia Wang, Jiageng Shi, Zhizhuang Chen, Hao Wang, Ziyu Wan, Qiqi Fu, Xuan Hu, Yisha Zuhaer, Tao Liu, Zhonghua Yang, Jianping Peng
Summary: NCAPG is overexpressed in bladder cancer, and its knockdown can inhibit cell proliferation through the inhibition of the NF-kappa B signaling pathway.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Biotechnology & Applied Microbiology
Dan Chen, Li Shi, Dingfu Zhong, Ying Nie, Yi Yang, Dong Liu
Summary: The role of circ_0002019 in gastric cancer (GC) was investigated in this study. It was found that circ_0002019 was highly expressed in GC tissues and cells. Silencing circ_0002019 suppressed the proliferation, migration, and invasion of GC cells. Mechanistically, circ_0002019 activated the NF-κB pathway by increasing the stability of TNFAIP6 mRNA through PTBP1. These findings indicate that circ_0002019 plays a critical regulatory role in the progression of GC.
Article
Chemistry, Multidisciplinary
Heba A. El Gizawy, Heba M. Abo-Salem, Ali A. Ali, Mohammed A. Hussein
Summary: The study showed that the active compounds in Parkia roxburghii have the ability to inhibit scopolamine-induced memory impairments, potentially serving as a more effective therapeutic agent for Alzheimer's disease. Molecular docking was used to determine the possible interactions of these compounds with various enzymes.
Article
Medicine, Research & Experimental
Jun Liu, Szu-Jung Chen, Ssu-Wei Hsu, Jun Zhang, Ji-Min Li, David C. Yang, Shenwen Gu, Kent E. Pinkerton, Ching-Hsien Chen
Summary: The study found that MARCKS was activated in response to cigarette smoke in human lung cancer cells, specimens, and non-human primate airway epithelium. By investigating its interaction with NF-kappa B-activating protein (NKAP), it revealed MARCKS as a novel NF-kappa B activator in smoke-mediated lung cancer progression.
Article
Integrative & Complementary Medicine
Shumeng Lin, Jing Wen, Xiao Xu, Jiamin Shi, Wen Zhang, Tiansheng Zheng, Yaqin Hou, Yanfei Zhang, Ziye Li, Kai Wang, Jing Jin, Liduo Yue, Baigenzhin Abay, Ming Li, Qingxi Yue, Lihong Fan
Summary: Amygdalin induces apoptosis of lung cancer cells through multiple mechanisms, including altered expression of apoptosis-related proteins, activation of NF kappa B-1 gene, and inhibition of NF kappa B signaling cascade. These findings reveal the potential of amygdalin as a therapeutic agent for lung cancer.
AMERICAN JOURNAL OF CHINESE MEDICINE
(2022)
Article
Food Science & Technology
Xiaoyi Huang, Xingjie Li, Yuanle Deng, Ting Zhou, Tao Chen, Shouxun Wu, Rui Xia, Yuhong Kang, Wenya Yin
Summary: Okra flower is a flavonoid-rich resource and its flavonoids (AFE) have potential in preventing colorectal cancer. This study found that AFE effectively alleviated intestinal inflammation and injury, maintained colon integrity, and involved gut microbiota in the protective effect. AFE also exhibited inhibitory effects on the NF-kappa B pathway and antioxidant effects through regulating Nrf2 signaling pathway.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Oncology
Qi Wu, Xiaoqing Zhou, Peng Li, Mao Ding, Shengjie You, Zhaoyu Xu, Junjie Ye, Xuedong Chen, Mingyue Tan, Jun Wang, Wei Wang, Jianxin Qiu
Summary: ROC1 is up-regulated in BCa tissues and cell lines, with high levels correlated with higher tumor grade, metastasis, and poor prognosis. It promotes BCa invasion and migration by activating NF-κB signaling through enhancing p-IκBα ubiquitination, leading to p65 nuclear translocation and transcription of metastasis-related genes.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)