期刊
INTEGRATIVE CANCER THERAPIES
卷 12, 期 2, 页码 165-173出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/1534735412442380
关键词
Lactobacillus casei; gastric cancer; KATO3; apoptosis; NF-kappa B; mTOR
资金
- Korea Basic Science Institute NAP [T3178B]
- Mid-career Researcher Program through an NRF
- MEST [No RO1-2008-000-20253-0]
Lactobacillus casei extract (LBX) has been reported to prevent gastric cancer, but the underlying mechanism remains unclear. The proliferation and cell death of gastric cancer KATO3 cells were examined after treatment with LBX for various times and at various doses. LBX inhibited the growth of gastric cancer cells and induced apoptosis by inactivating NF-kappa B promoter activity. Apoptosis induced by LBX, however, is not directly associated with the intrinsic mitochondrial pathway. Immunoblot analysis revealed that LBX decreased the expressions of NF-kappa B and I kappa B. The reduced NF-kappa B levels led to the decreased phosphorylation of mTOR signaling components, such as PI3K, Akt, and (p70)S6 kinase. These results showed for the first time that LBX induced apoptosis in gastric cancer cells by inhibiting NF-kappa B and mTOR-mediated signaling.
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