Article
Endocrinology & Metabolism
Martin Werdermann, Ilona Berger, Laura D. Scriba, Alice Santambrogio, Pia Schlinkert, Heike Brendel, Henning Morawietz, Andreas Schedl, Mirko Peitzsch, Aileen J. F. King, Cynthia L. Andoniadou, Stefan R. Bornstein, Charlotte Steenblock
Summary: This study investigated the impact of metabolic diseases on progenitor cells in the hypothalamic-pituitary-adrenal axis, showing that insulin enhances proliferation and differentiation of these cells, while chronic metabolic stress leads to hyperactivation of the axis. This suggests a potential link between early life stress and the development of metabolic syndrome in adulthood.
MOLECULAR METABOLISM
(2021)
Article
Cell Biology
Manxiu Ma, Alyssa A. Brunal, Kareem C. Clark, Carleigh Studtmann, Katelyn Stebbins, Shin-ichi Higashijima, Y. Albert Pan
Summary: The expression of corticotropin-releasing hormone (CRH) in the hypothalamus plays a critical role in regulating the hypothalamic-pituitary-adrenal (HPA) axis, which is involved in the stress response. Through studying zebrafish, researchers identified dscaml1 as an important factor in CRH neuron development and HPA axis function. Mutations in dscaml1 led to increased CRH expression and cell number in hypothalamic CRH neurons, as well as altered stress hormone levels and response to stressors. These findings suggest a role for dscaml1 in stress axis development and its potential contribution to neuropsychiatric disorders.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Endocrinology & Metabolism
Aleksandra S. S. Stojiljkovic, Zeljko Cupic, Stevan Macesic, Ana Ivanovic-Sasic, Ljiljana Kolar-Anic
Summary: This study investigates the mechanisms underlying the effects of arginine vasopressin (AVP) on the Hypothalamic-Pituitary-Adrenal (HPA) axis and reveals the influence of the synergistic action between AVP and corticotrophin-releasing hormone (CRH) on the ultradian dynamics of the HPA axis. The extended nonlinear network reaction model incorporates AVP into the HPA axis model and explores the conditions under which the HPA system transitions between oscillatory and stable states. The results demonstrate the importance of the synergy reaction rate constant and highlight the superior stimulatory effect of CRH compared to AVP on ACTH secretion in humans.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Christina Tatsi, Megan Neely, Chelsi Flippo, Maria-Eleni Bompou, Meg Keil, Constantine A. Stratakis
Summary: The recovery of adrenal function in pediatric patients with CD after TSS may not be influenced by most clinical and biochemical factors, except for an increase in urinary free cortisol which may prolong the recovery time. Patients who recover adrenal function earlier are at a higher risk for CD recurrence, highlighting the importance of close follow-up and counseling for these patients.
CLINICAL ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Wrivu N. Martin, Carol A. Wang, Stephen J. Lye, Stephen G. Matthews, Rebecca M. Reynolds, Carly E. McLaughlin, Roger Smith, Craig E. Pennell
Summary: A study found an inverse linear relationship between fetal growth and HPA-A function at the age of 18, which may be related to altered adrenal sensitivity.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Wrivu N. Martin, Carol A. Wang, Stephen J. Lye, Stephen G. Matthews, Rebecca M. Reynolds, Carly E. McLaughlin, Roger Smith, Craig E. Pennell
Summary: The study found an inverse linear relationship between fetal growth and HPA-A function at age 18, with no consistent quadratic relationships identified. Removal of anticipatory responders from the models substantially attenuated the observed relationships. This suggests altered adrenal sensitivity may underlie the relationship.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Review
Psychiatry
Felim Murphy, Anurag Nasa, Dearbhla Cullinane, Kesidha Raajakesary, Areej Gazzaz, Vitallia Sooknarine, Madeline Haines, Elena Roman, Linda Kelly, Aisling O'Neill, Mary Cannon, Darren William Roddy
Summary: Studies show that early life stress impacts developmental trajectories and can create vulnerability to psychological and psychiatric issues later in life. The mechanisms affecting the developing brain in children and the incorporation of adverse environmental stimuli into the adult brain are important areas of research focus.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Environmental Sciences
Jia Luo, Zheng Yan, Yao Shen, Denong Liu, Mingli Su, Jie Yang, Jiarong Xie, Hui Gao, Julin Yang, Aiming Liu
Summary: This study found that chronic low-intensity noise exposure exacerbated NAFLD in mice on a high-fat diet, affecting lipid metabolism and inflammation levels in the liver. Activation of the HPA axis played a critical role in the development of NAFLD, while depression played an intermediate role in exacerbating the condition.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Pediatrics
Cynthia R. Rovnaghi, Joseph Rigdon, Jean-Michel Roue, Monica O. Ruiz, Victor G. Carrion, Kanwaljeet J. S. Anand
Summary: This study aimed to identify children at risk for altered HPA-axis function due to early life stress by examining longitudinal trajectories of hair cortisol concentrations. The results revealed different classes of children with distinct HCC profiles, suggesting varying impacts of ELS on HPA-axis function.
FRONTIERS IN PEDIATRICS
(2021)
Article
Allergy
Wisdom Alemya Akurugu, Carel Jacobus Van Heerden, Nicola Mulder, Ekkehard Werner Zollner
Summary: This study found that some SNPs of the CRHR1 and NR3C1 genes are associated with HPAS in asthmatic children, with the C allele of rs41423247 potentially having a protective effect on HPAS, and the CC genotype being associated with the highest PMTP ACTH response.
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2021)
Review
Endocrinology & Metabolism
Jody A. Rusch, Brian T. Layden, Lara R. Dugas
Summary: Cognitive function in humans relies on the complex interplay between multiple body systems, including the HPA axis. The gut microbiota, which outnumbers human cells and has a greater genetic potential, plays a crucial role through the MGB axis, a bidirectional communication pathway. Stress can affect the MGB axis through the HPA axis and other pathways, and animal research has contributed to a paradigm shift in understanding the influence of microbiota on human health and disease. Preclinical and human trials are currently investigating the applicability of these findings in humans.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Pediatrics
Lekshmi Sambhu Hema, Prawin Kumar, Jagdish Prasad Goyal, Varuna Vyas, Kuldeep Singh
Summary: This study aims to assess the effect of long-term use of inhaled corticosteroids (ICS) on the hypothalamic-pituitary-adrenal (HPA) axis. By measuring cortisol levels and conducting adreno-corticotropic hormone (ACTH) stimulation tests, it was found that only a few asthmatic children using ICS showed HPA axis suppression, and there was no clinical evidence supporting this suppression.
INDIAN JOURNAL OF PEDIATRICS
(2023)
Review
Pharmacology & Pharmacy
Yudan Ding, Zirou Wei, Haohao Yan, Wenbin Guo
Summary: This meta-analysis found that HPA-targeting medications have certain efficacy for MDD patients, especially mifepristone and vasopressin V-1B receptor antagonist treatments are significantly effective, but with more adverse events reported.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Medicine, General & Internal
Jiawen Liu, Tianwei Meng, Chaojie Wang, Weiping Cheng, Qi Zhang, Guangyu Cheng
Summary: Depression is a prevalent psychiatric disorder with high morbidity and mortality rates. Traditional Chinese Medicine (TCM) natural products offer multi-target, multi-level, and multi-channel treatment modalities for depression. This study reviewed recent literature on depression and hypothalamic-pituitary-adrenal (HPA) axis dysregulation, and discussed the antidepressant mechanisms of natural medicines through various pathways.
Article
Biochemistry & Molecular Biology
Bei Zhou, Qilong Xu, Junjie Guo, Qinliang Chen, Qingqing Lv, Kan Xiao, Huiling Zhu, Jiangchao Zhao, Yulan Liu
Summary: This study investigates the role of necroptosis in the activation of the hypothalamic-pituitary-adrenal (HPA) axis in a stress model induced by Escherichia coli lipopolysaccharide (LPS). The findings indicate that necroptosis is present and contributes to HPA axis activation induced by LPS. Necroptosis may serve as a potential intervention target for alleviating HPA axis activation and stress responses.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cardiac & Cardiovascular Systems
Tienush Rassaf, Matthias Totzeck, Johannes Backs, Carsten Bokemeyer, Michael Hallek, Denise Hilfiker-Kleiner, Andreas Hochhaus, Diana Lueftner, Oliver J. Mueller, Ulrich Neudorf, Roman Pfister, Stephan von Haehling, Lorenz H. Lehmann, Johann Bauersachs
CLINICAL RESEARCH IN CARDIOLOGY
(2020)
Review
Obstetrics & Gynecology
Diana Lueftner, Andreas Schneeweiss, Andreas D. Hartkopf, Volkmar Mueller, Achim Woeckel, Wolfgang Janni, Johannes Ettl, Erik Belleville, Florian Schuetz, Marc Thill, Jens Huober, Peter A. Fasching, Hans-Christian Kolberg, Patrik Poeschke, Manfred Welslau, Friedrich Overkamp, Hans Tesch, Tanja N. Fehm, Michael P. Lux
GEBURTSHILFE UND FRAUENHEILKUNDE
(2020)
Review
Obstetrics & Gynecology
Michael Untch, Rachel Wuerstlein, Diana Lueftner, Renate Haidinger, Peter A. Fasching, Doris Augustin, Susanne Briest, Johannes Ettl, Frank Foerster, Christian M. Kurbacher, Hans-Joachim Lueck, Norbert Marschner, Lothar Mueller, Volkmar Mueller, Isabel Radke, Eugen Ruckhaeberle, Iris Scheffen, Eva Schumacher-Wulf, Moritz Schwoerer, Dieter Steinfeld-Birg, Katja Ziegler-Loehr, Christoph Thomssen, Nadia Harbeck
GEBURTSHILFE UND FRAUENHEILKUNDE
(2020)
Review
Oncology
Diana Luftner, Gary H. Lyman, Joao Goncalves, Xavier Pivot, Minji Seo
Article
Oncology
Andreas Schneeweiss, Johannes Ettl, Diana Lueftner, Matthias W. Beckmann, Erik Belleville, Peter A. Fasching, Tanja N. Fehm, Matthias Geberth, Lothar Haberle, Peyman Hadji, Andreas D. Hartkopf, Carsten Hielscher, Jens Huober, Eugen Ruckhaberle, Wolfgang Janni, Hans Christian Kolberg, Christian M. Kurbacher, Evelyn Klein, Michael P. Lux, Volkmar Mueller, Naiba Nabieva, Friedrich Overkamp, Hans Tesch, Elena Laakmann, Florin-Andrei Taran, Julia Seitz, Christoph Thomssen, Michael Untch, Pauline Wimberger, Rachel Wuerstlein, Bernhard Volz, Diethelm Wallwiener, Markus Wallwiener, Sara Y. Brucker
Review
Obstetrics & Gynecology
Nina Ditsch, Elmar Stickeler, Annika Behrens, Erik Belleville, Peter A. Fasching, Tanja N. Fehm, Andreas D. Hartkopf, Christian Jackisch, Wolfgang Janni, Cornelia Kolberg-Liedtke, Hans-Christian Kolberg, Diana Lueftner, Michael P. Lux, Volkmar Mueller, Andreas Schneeweiss, Florian Schuetz, Carla E. Schulmeyer, Hans Tesch, Christoph Thomssen, Christoph Uleer, Michael Untch, Manfred Welslau, Achim Woeckel, Lena A. Wurmthaler, Rachel Wuerstlein, Marc Thill, Bahriye Aktas
Summary: Recent studies have highlighted advancements in patient treatment and biomarkers in breast cancer, with new oral taxanes and clinical trial results for different molecular subtypes. Additionally, research on biomarkers for CDK4/6 inhibitors and the development of new substances for HER2+ breast cancer have shown promising progress.
GEBURTSHILFE UND FRAUENHEILKUNDE
(2021)
Review
Obstetrics & Gynecology
Elmar Stickeler, Bahriye Aktas, Annika Behrens, Erik Belleville, Nina Ditsch, Peter A. Fasching, Tanja N. Fehm, Andreas D. Hartkopf, Christian Jackisch, Wolfgang Janni, Cornelia Kolberg-Liedtke, Hans-Christian Kolberg, Diana Lueftner, Michael P. Lux, Volkmar Mueller, Andreas Schneeweiss, Florian Schuetz, Carla E. Schulmeyer, Hans Tesch, Christoph Thomssen, Christoph Uleer, Michael Untch, Manfred Welslau, Achim Woeckel, Lena A. Wurmthaler, Rachel Wuerstlein, Marc Thill
Summary: This review provides an overview of the latest evidence on breast cancer prevention and treatment for early-stage patients, including the significance of panel genes, endocrine efficacy, and adjuvant therapies such as CDK4/6 inhibitors. It also discusses the use of immune checkpoint inhibitors in improving pathologic complete response rates for TNBC patients, highlighting the importance of understanding quality of life and side effects in treatment decision-making.
GEBURTSHILFE UND FRAUENHEILKUNDE
(2021)
Review
Obstetrics & Gynecology
Michael P. Lux, Andreas Schneeweiss, Andreas D. Hartkopf, Volkmar Mueller, Wolfgang Janni, Erik Belleville, Elmar Stickeler, Marc Thill, Peter A. Fasching, Hans-Christian Kolberg, Michael Untch, Nadia Harbeck, Achim Woeckel, Christoph Thomssen, Carla E. Schulmeyer, Manfred Welslau, Friedrich Overkamp, Florian Schuetz, Diana Lueftner, Nina Ditsch
Summary: Recent years have seen significant progress in new therapeutic approaches to breast cancer, particularly in patients with HER2-positive and HER2-negative/HR+ breast cancer. Novel therapies, including targeted treatments and drug inhibitors, are showing promise in ongoing clinical trials.
GEBURTSHILFE UND FRAUENHEILKUNDE
(2021)
Article
Oncology
Peter A. Fasching, Siddhartha Yadav, Chunling Hu, Marius Wunderle, Lothar Haeberle, Steven N. Hart, Matthias Ruebner, Eric C. Polley, Kun Y. Lee, Rohan D. Gnanaolivu, Peyman Hadji, Hanna Huebner, Hans Tesch, Johannes Ettl, Friedrich Overkamp, Michael P. Lux, Arif B. Ekici, Bernhard Volz, Sabrina Uhrig, Diana Lueftner, Markus Wallwiener, Volkmar Mueller, Erik Belleville, Michael Untch, Hans-Christian Kolberg, Matthias W. Beckmann, Andre Reis, Arndt Hartmann, Wolfgang Janni, Pauline Wimberger, Florin-Andrei Taran, Tanja N. Fehm, Diethelm Wallwiener, Sara Y. Brucker, Andreas Schneeweiss, Andreas D. Hartkopf, Fergus J. Couch
Summary: Among patients with metastatic breast cancer, around 10.4% carry germline mutations in established breast cancer predisposition genes such as BRCA1 and BRCA2. While these mutations may impact tumor characteristics, they do not significantly affect progression-free survival or overall survival in patients with metastatic breast cancer.
JOURNAL OF CLINICAL ONCOLOGY
(2021)
Article
Oncology
Diana Lueftner, Hans Tesch, Marcus Schmidt, Andreas D. Hartkopf, Sarah Streicher, Anna Resch, Luca Genovese, Christian Rose, Roberta Valenti, Nadia Harbeck
Summary: Analyses from the ExteNET trial show that neratinib provides a significant disease-free survival advantage in hormone receptor-positive early breast cancer patients, supporting its use in extended adjuvant treatment.
EUROPEAN JOURNAL OF CANCER
(2021)
Article
Oncology
Sebastian Stintzing, Thomas Seufferlein, Christian Rose, Frank Reichenbach, Diana Lueftner
Summary: The German Health Technology Assessment (HTA) indicates that encorafenib + cetuximab has a significant additional benefit for patients with BRAFV600E-mutant mCRC and is considered the new standard of care for these patients.
CLINICAL COLORECTAL CANCER
(2022)
Editorial Material
Oncology
Diana Lueftner
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2022)
Review
Oncology
Diana Lueftner, Andreas D. Hartkopf, Michael P. Lux, Friedrich Overkamp, Hans Tesch, Adriana Titzmann, Patrik Poschke, Markus Wallwiener, Volkmar Muller, Matthias W. Beckmann, Erik Belleville, Wolfgang Janni, Tanja N. Fehm, Hans-Christian Kolberg, Johannes Ettl, Diethelm Wallwiener, Andreas Schneeweiss, Sara Y. Brucker, Peter A. Fasching
Summary: The PRAEGNANT Network aims to optimize oncological care for patients with metastatic breast cancer by systematically recording medical care, monitoring quality-of-life changes during therapy, and identifying patients eligible for clinical studies. It also allows targeted therapies based on the molecular structures of breast carcinomas.
Article
Obstetrics & Gynecology
Elena Laakmann, Julius Emons, Florin-Andrei Taran, Wolfgang Janni, Sabrina Uhrig, Friedrich Overkamp, Hans-Christian Kolberg, Peyman Hadji, Hans Tesch, Lothar Haeberle, Johannes Ettl, Diana Lueftner, Markus Wallwiener, Carla Schulmeyer, Volkmar Mueller, Matthias W. Beckmann, Erik Belleville, Pauline Wimberger, Carsten Hielscher, Christian Kurbacher, Rachel Wuerstlein, Christoph Thomssen, Michael Untch, Bernhard Volz, Peter A. Fasching, Tanja N. Fehm, Diethelm Wallwiener, Sara Y. Brucker, Andreas Schneeweiss, Andreas D. Hartkopf
GEBURTSHILFE UND FRAUENHEILKUNDE
(2020)
Review
Obstetrics & Gynecology
Jens Huober, Andreas Schneeweiss, Andreas D. Hartkopf, Volkmar Mueller, Michael P. Lux, Wolfgang Janni, Johannes Ettl, Erik Belleville, Marc Thill, Peter A. Fasching, Hans-Christian Kolberg, Carla E. Schulmeyer, Manfred Welslau, Friedrich Overkamp, Hans Tesch, Tanja N. Fehm, Diana Lueftner, Florian Schuetz, Achim Woeckel
GEBURTSHILFE UND FRAUENHEILKUNDE
(2020)