Article
Biochemistry & Molecular Biology
Abdullah A. Alamoudi, Paula A. Mendez, David Workman, Andreas G. Schatzlein, Ijeoma F. Uchegbu
Summary: Therapeutic gene silencing in the brain can be achieved through intranasal administration of siRNA-poly(ethylene glycol) based polyplexes. These polyplexes have low toxicity and can effectively silence specific genes in brain cells.
Article
Chemistry, Multidisciplinary
Hongmei Liu, Chongyi Liu, Li Ye, Ding Ma, Xiaozhen He, Qianyun Tang, Xue Zhao, Hanbing Zou, Xiaojing Chen, Peifeng Liu
Summary: A novel PEG modification strategy was proposed in this study, forming PEG/G5PBA/siRNA nanoassemblies through reversible boronate esters, which significantly improved siRNA delivery efficiency under both serum-free and serum-containing conditions.
ADVANCED MATERIALS
(2021)
Article
Polymer Science
Yasuhiro Nakagawa, Kotaro Ushidome, Keita Masuda, Kazunori Igarashi, Yu Matsumoto, Tatsuya Yamasoba, Yasutaka Anraku, Madoka Takai, Horacio Cabral
Summary: Multi-arm star-shaped block copolymers consisting of poly(furfuryl glycidol) (PFG) and poly(ethylene glycol) (PEG) were developed for drug delivery. The block copolymers showed controlled sizes and effectively loaded and released model drugs. When injected intravenously, they exhibited prolonged blood circulation, indicating their potential as long-circulating nanocarriers.
Article
Biochemistry & Molecular Biology
Jaroslav Malina, Hana Kostrhunova, Vojtech Novohradsky, Peter Scott, Viktor Brabec
Summary: The design of efficient and safe gene delivery vehicles remains a major challenge for gene therapy. Metal complexes with high affinity for nucleic acids are emerging as an attractive option for gene delivery systems. Certain metallohelices have been discovered to act as nonviral DNA delivery vectors capable of mediating efficient gene transfection, forming globular DNA particles that protect the DNA from degradation, and successfully being processed by cells.
NUCLEIC ACIDS RESEARCH
(2022)
Article
Chemistry, Multidisciplinary
Jun Ma, Keke Mao, Jingxiang Low, Zihao Wang, Dawei Xi, Wenqing Zhang, Huanxin Ju, Zeming Qi, Ran Long, Xiaojun Wu, Li Song, Yujie Xiong
Summary: The optimization of the reactivity of hydroxyl radicals on WO3 via facet tuning led to efficient production of ethylene glycol from PEC methane conversion. The surface-bound (OH)-O-. on {010} facets showed the highest reactivity, resulting in superior PEC methane conversion efficiency for WO3 with the highest {010} facet ratio. Methanol was confirmed as the main intermediate for ethylene glycol production through reactive (OH)-O-. attack.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Engineering, Electrical & Electronic
Tan Li, Linqi Song
Summary: This paper investigates the privacy-preserving communication-efficient algorithm in federated multi-armed bandit problems and explores the relationship between privacy, communication, and learning performance. By designing learning algorithms and communication protocols, protecting privacy and reducing communication costs, we obtain theoretical and empirical results.
IEEE JOURNAL ON SELECTED AREAS IN COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Zhaoyuan Zhu, Li Zhang, Ruilong Sheng, Jian Chen
Summary: A novel cationic cholesterol lipid derivative (CEL) was developed as a non-viral siRNA delivery carrier. Well-organized CEL/siRNA nanocomplexes were prepared using microfluidic-assisted assembly and exhibited good stability, low cytotoxicity, high siRNA delivery efficiency, and rapid cellular uptake through caveolae/lipid raft-mediated endocytosis pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Polymer Science
Masaaki Okihara, Kohei Okuma, Akifumi Kawamura, Takashi Miyata
Summary: In this study, a photoresponsive tetra-PEG gel that undergoes a phase transition from a sol to a gel state in response to light is reported. The gelation of the tetra-PEG containing photodimerization groups was investigated by varying the polymer concentration and light irradiation time, showing that the elastic modulus of the gel increases with the increase in light irradiation time.
Article
Chemistry, Multidisciplinary
Zerui Su, Jian Zhang, Shiyao Lu, Feng-Shou Xiao
Summary: In this study, Nb-modified anatase-supported Pt nanoparticles were synthesized for efficient cellulose conversion to light bioalcohols. Characterization confirmed the presence of SMSIs in the catalysts, providing adjacent hydrogenation sites, Bronsted and Lewis acid sites. Treating the catalysts in humid air enhanced the acidic concentration, accelerating the key step during the reaction.
CHEMICAL COMMUNICATIONS
(2022)
Article
Chemistry, Physical
Jing-Xiao Tang, Liang-Ping Xiao, Chi Xiao, Na Tian, Zhi-You Zhou, Shi-Gang Sun
Summary: In this study, alloy tetrahexahedral (THH) PdRh nanocrystals with tunable composition enclosed by {11 4 0} facets were successfully prepared by an electrochemical square-wave potential method. The as-prepared PdRh nanocrystals exhibit high catalytic activity for ethylene glycol electrooxidation, with Pd86.9Rh13.1 NCs showing the highest catalytic activity. The introduction of Rh in the high-index facets enhances the capability of cleaving the C-C bond, demonstrating the promising potential of high-index facets with alloy electronic structure for the preparation of high performance electrocatalysts.
JOURNAL OF MATERIALS CHEMISTRY A
(2021)
Article
Chemistry, Physical
Jinglin Tan, Yue-Fei Zhang
Summary: Cationic trisiloxane surfactants based on PEG were synthesized and their micellization behavior in aqueous solution was studied. The introduction of ethylene glycol segments resulted in lower CMC values and larger surface tension compared to permethyltrisiloxane surfactants, forming spherical aggregates driven by enthalpy.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2022)
Article
Chemistry, Multidisciplinary
Oana Dobre, Mariana A. G. Oliva, Giuseppe Ciccone, Sara Trujillo, Aleixandre Rodrigo-Navarro, Douglas Cormac Venters, Virginia Llopis-Hernandez, Massimo Vassalli, Cristina Gonzalez-Garcia, Matthew J. Dalby, Manuel Salmeron-Sanchez
Summary: Laminins are crucial structural proteins in the ECM that bind growth factors and play tissue-specific roles. A new LM-PEG hydrogel platform inspired by Matrigel offers controlled stiffness and degradability, enabling specific targeting of tissues through GFs presented at ultralow doses. This platform demonstrates the potential to induce stem cell differentiation and promote neural cell growth in a synthetic, reproducible 3D microenvironment mimicking the native ECM.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Chemistry, Physical
Usman Saeed, Asim Laeeq Khan, Mazhar Amjad Gilani, Muhammad Roil Bilad, Asad Ullah Khan
Summary: Impregnation of deep eutectic solvents (DES) into polymer supports allows for efficient separation of CO2 from CH4, with permeability and selectivity varying based on the type of hydrogen bond donors used, providing a promising pathway for future material design.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Article
Chemistry, Physical
Balasingh Thangadurai Jebaslinhepzybai, Thamodaran Partheeban, Deepak S. Gavali, Ranjit Thapa, Manickam Sasidharan
Summary: A facile one-pot ethyleneglycol-mediated solvothermal synthesis of orthorhombic Co2P with particle size around 20-30 nm was reported as an efficient catalyst for both HER and OER. Co2P showed low overpotentials and long-term stability in acidic and alkaline medium for HER, as well as an overpotential of 364 mV at 10 mA cm(-2) current density for OER. XPS analysis confirmed the formation of amorphous cobalt oxyhydroxide (CoOOH) as an intermediate during the OER process.
INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
(2021)
Article
Engineering, Chemical
Zengyue Chen, Yunfeng Li, Fei Tian, Xin Chen, Zhansheng Wu
Summary: In this study, a green reaction route for the preparation of BiVO4/g-C3N4 composite was constructed using an acetic acid and reusable ethylene glycol system combined with the microwave method. The prepared photocatalyst exhibited high performance in removing pesticides and dyes from agricultural and urban runoff. The establishment of the ethylene glycol and acetic acid system provides a new perspective for the replacement of strong acids in the preparation of BiVO4-based photocatalysts.
SEPARATION AND PURIFICATION TECHNOLOGY
(2022)
Article
Nursing
Wai Tong Chien, David R. Thompson, Sau Fong Leung, Daniel Bressington
Summary: This study found that social relationship-related quality of life is low among Asian inpatients with severe mental illness pre-discharge, and there is a weak correlation between functioning, quality of life, and symptoms. The study suggests that interventions beyond traditional focus on psychiatric symptoms, targeting social relationships, employment status, and physical health problems, may be needed to improve functioning levels in recently discharged individuals with severe mental illness.
JOURNAL OF PSYCHIATRIC AND MENTAL HEALTH NURSING
(2022)
Article
Public, Environmental & Occupational Health
Tina Habota, Jan Cameron, David R. Thompson, Chantal F. Ski
Summary: The study revealed significant prospective memory deficits in patients with chronic heart failure, but no significant differences were found in background cognitive tasks between groups. These PM impairments may impact patient engagement in HF self-care behaviors.
PSYCHOLOGY HEALTH & MEDICINE
(2022)
Article
Polymer Science
Estefania Gonzalez Solveyra, David H. Thompson, Igal Szleifer
Summary: Protein adsorption onto nanomaterials is controlled by functionalizing their surface with polymers, and the efficiency depends on design parameters, surface curvature, and solution conditions. A comprehensive study analyzing the effect of these factors was conducted using molecular theory calculations.
Article
Education & Educational Research
Brittany M. Williams, David J. Thompson
Summary: This article examines the issues faced by higher education researchers and practitioners in addressing HIV/AIDS in the college context in the United States. The study finds limited focus on HIV/AIDS in college environments and an overemphasis on quantitative research methods. Additionally, researchers rarely discuss identity nuances and tend to focus on individual choices rather than systemic structures.
JOURNAL OF DIVERSITY IN HIGHER EDUCATION
(2022)
Article
Biochemistry & Molecular Biology
Zachary J. Struzik, Shruti Biyani, Tim Grotzer, Judith Storch, David H. Thompson
Summary: In this study, a robust pathway to optically pure PG is presented, utilizing triethyl ammonium H-phosphonate salt, instead of the currently unavailable commercially available optically pure material. The challenges in purification during the process have been addressed.
Article
Chemistry, Applied
Shruti A. Biyani, Corryn Lytle, Seok-Hee Hyun, Michael A. McGuire, Ranya Pendyala, David H. Thompson
Summary: This article presents a novel 5-step continuous flow synthesis for lorazepam, a widely used sedative. Each step was optimized and translated to continuous flow, resulting in over 99% pure lorazepam.
ORGANIC PROCESS RESEARCH & DEVELOPMENT
(2022)
Article
Cardiac & Cardiovascular Systems
Chantal F. Ski, Susie Cartledge, Dan Foldager, David R. Thompson, Suzanne Fredericks, Inger Ekman, Jeroen M. Hendriks
Summary: In a rapidly changing health and care landscape, it is important to acknowledge the need for integrated care with a patient-centered approach. Unfortunately, care systems are often fragmented and focused on the condition rather than the patient. To address this issue, the Science Committee of the Association of Cardiovascular Nursing and Allied Professions of the European Society of Cardiology has issued a statement on integrated care for those with cardiovascular disease. This statement outlines the evidence, challenges, and recommendations for practice, education, and research.
EUROPEAN JOURNAL OF CARDIOVASCULAR NURSING
(2023)
Article
Multidisciplinary Sciences
Shayak Samaddar, Debosreeta Bose, Bradley P. Loren, Joseph L. Skulsky, Olga Ilnytska, Zachary J. Struzik, Judith Storch, David H. Thompson
Summary: This study explores a new approach for treating Niemann-Pick Type C (NPC) using polyrotaxanes containing 2-Hydroxypropyl-β-cyclodextrin (HP-β-CD). The study found that polyrotaxanes can remove cholesterol from NPC patient cells, and the endcapping and threading efficiency of polyrotaxanes are directly related to cholesterol mobilization. Additionally, improving the solubility of the compounds can significantly enhance cholesterol mobilization.
Article
Toxicology
Giselle R. M. Bellia, Robert A. A. Bilott, Ning Sun, David Thompson, Vasilis Vasiliou
Summary: Current literature suggests that PFAS carbon chain length may affect its toxicity, and statistical modeling can be used to predict toxicity and improve the efficiency of PFAS regulation development. In this study, data analysis and predictive modeling were conducted, showing significant differences in mean values for 11 out of 15 health outcomes. Simple linear regressions were used for two health outcomes, yielding statistically significant results. Comparison between the results of an actual dataset and a theoretically generated dataset indicated no significant differences in the mean values of the two health outcomes. Therefore, predictive statistical modeling can be used to predict health outcomes for PFAS exposure.
TOXICOLOGY MECHANISMS AND METHODS
(2023)
Article
Biophysics
Shawn M. Sternisha, Abraham D. Wilson, Emilie Bouda, Akash Bhattacharya, Ross VerHeul
Summary: Accurate characterization of capsid species is crucial for viral vector-based gene therapies and vaccines. The current standard method, sedimentation velocity analytical ultracentrifugation (SV-AUC), is often size-limited and requires specialized software for analysis. The density gradient equilibrium AUC (DGE-AUC) provides a simplified and high-resolution method for separating biologics of different densities. It offers improvements in sensitivity and can be used with larger viral particles. This serotype-agnostic method enables intuitive interpretation and analysis without the need for specialized software.
EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS
(2023)
Article
Acoustics
Eduardo Latorre Iglesias, David Thompson, Jorge Munoz Paniagua, Javier Garcia Garcia
Summary: At speeds above 300 km/h, aerodynamic noise from the bogie area in high-speed trains becomes significant. Component-based models are attractive for predicting aerodynamic noise due to their fast and cheap calculations. This study evaluates the feasibility of applying these models to predict the aerodynamic noise from bogies and adjusts the empirical constants using measurements in a wind tunnel.
Article
Pharmacology & Pharmacy
Klaus Richter, Christine Wurm, Kim Strasser, Jana Bauer, Maria Bakou, Ross VerHeul, Shawn Sternisha, Andrea Hawe, Michael Salomon, Tim Menzen, Akash Bhattacharya
Summary: The development and manufacturing of AAV-based vectors for gene therapy require suitable analytical methods. In this study, we compared different biophysical methods to assess the quality of AAV formulations. The results showed that selected orthogonal methods can deliver consistent information on empty/filled contents, as well as other critical quality attributes.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2023)
Article
Engineering, Mechanical
Luis Baeza, Juan Giner-Navarro, Christopher Knuth, David J. Thompson
Summary: The study develops a wheelset model that considers both flexibility and rotation, and provides a global modeling method applicable to any coordinate system. Linear equations are derived in axisymmetric coordinates, allowing the calculation of natural frequencies in both fixed and rotating frames. The model is also applied to simulate the response of strain gauges in load-measuring wheelsets.
MECHANICAL SYSTEMS AND SIGNAL PROCESSING
(2023)
Article
Engineering, Civil
Jiawei Wang, David Thompson, Giacomo Squicciarini
Summary: The study presents a semi-analytical model of railway track that accounts for vertical, lateral, and axial dynamics as well as the discrete supports provided by sleepers. The model includes torsion and warping effects on rail behavior and is validated through comparison with measurements. The results show that torsion and warping have a significant impact on the lateral behavior of the track.
PROCEEDINGS OF THE INSTITUTION OF MECHANICAL ENGINEERS PART F-JOURNAL OF RAIL AND RAPID TRANSIT
(2023)
Article
Biochemistry & Molecular Biology
Giulia Murbach-Oliveira, Kalpita Banerjee, Marcelo M. Nociari, David H. Thompson
Summary: A2E, a lipid bisretinoid, leads to vision impairment in eye diseases. Interaction between ethanolamine, acetic acid, and ATR plays a crucial role in high-yield A2E formation, with imine formation being a key step in the reaction. By optimizing reaction conditions, the yield and quality of A2E were significantly improved.
ACS BIO & MED CHEM AU
(2022)
