Review
Genetics & Heredity
Giovanna Civitate Bastos, Giovanna Cantini Tolezano, Ana Cristina Victorino Krepischi
Summary: Macrocephaly often occurs in single-gene disorders affecting the PI3K-AKT-MTOR pathway, but epigenetic mutations, mosaicism, and copy number variations (CNVs) are also relevant causative factors. By studying CNVs and genomic loci, candidate genes and genomic regions linked to macrocephaly can be identified.
Article
Dentistry, Oral Surgery & Medicine
Adrian Ujin Yap, Carolina Marpaung
Summary: This study examined the relationship between severity of temporomandibular disorders (TMDs), emotional distress, and eudaimonic well-being. The findings revealed that young adults with mild and moderate-to-severe TMD experience higher emotional distress and lower eudaimonic well-being compared to those without TMD. The study suggests that positive psychological interventions may be beneficial for managing TMD-related psychosocial disabilities.
Article
Biology
Lyubov Getmantseva, Maria Kolosova, Faridun Bakoev, Anna Zimina, Siroj Bakoev
Summary: This study identified 70 SNPs associated with capped hock in pigs and determined overlapping regions with QTLs linked to health traits and meat characteristics, identifying a total of 31 genes related to the condition.
Article
Biochemical Research Methods
Elham Kazemi, Javaad Zargooshi, Marzieh Kaboudi, Parviz Heidari, Danial Kahrizi, Behzad Mahaki, Youkhabeh Mohammadian, Habibolah Khazaei, Kawsar Ahmed
Summary: In this study, the gene expression profiles of normal and ED samples were investigated to identify 17 genes associated with ED. These genes were found to be involved in pathways related to human diseases and had diverse physicochemical properties and functions. Furthermore, interactions with the insulin pathway and identification of common cis-regulatory elements in the promoter sites of selected genes were also discussed. Additionally, conserved motifs and binding sites of miR-29-3p were identified in the upstream and untranslated regions of genes related to ED.
BRIEFINGS IN BIOINFORMATICS
(2021)
Article
Plant Sciences
Mingwei Guan, Xiangtian Shi, Si Chen, Yuanyuan Wan, Yunshan Tang, Tian Zhao, Lei Gao, Fujun Sun, Nengwen Yin, Huiyan Zhao, Kun Lu, Jiana Li, Cunmin Qu
Summary: Yellow seed coat in rapeseed is a desirable trait and understanding the genetic mechanism behind it can improve the quality of this oilseed crop. Through transcriptome profiling, differentially expressed genes related to seed development were identified and enriched in processes like carbohydrate and lipid metabolism, photosynthesis, and embryo development. Furthermore, candidate genes involved in seed coat color were discovered and 25 transcription factors were identified to potentially regulate the synthesis of flavonoids and phenylpropanoids, thus influencing seed color formation. These findings provide valuable insights into candidate gene function in seed development and lay the foundation for further research on the yellow-seeded trait in rapeseed.
FRONTIERS IN PLANT SCIENCE
(2023)
Article
Neurosciences
Yi Zhang, Tao Wang, Yan Wang, Kun Xia, Jinchen Li, Zhongsheng Sun
Summary: This study conducted genetic sequencing on 1102 Chinese patients with NDDs, identifying novel gene variants and prioritizing 212 candidate genes for further validation and genetic counseling. The interactions between these novel candidate genes and known genes form a functional network involved in known pathways.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Medicine, General & Internal
Deepa L. Sekhar, Eric W. Schaefer, James G. Waxmonsky, Leslie R. Walker-Harding, Krista L. Pattison, Alissa Molinari, Perri Rosen, Jennifer L. Kraschnewski
Summary: Universal school-based MDD screening successfully increased identification of MDD symptoms and treatment initiation among adolescents, confirming the value of this approach to address this rising public health concern.
Article
Multidisciplinary Sciences
Valerie Poulin, Delase Amesefe, Emmanuel Gonzalez, Hermine Alexandre, Simon Joly
Summary: This study aims to identify candidate genes involved in corolla shape variation between two closely related species of the Rhytidophyllum genus. By conducting a comparative transcriptome sequence analysis and QTL mapping, three genes (RADIALIS, GLOBOSA, and JAGGED) were found to be strongly associated with corolla shape variation. These findings provide a first step towards understanding the genetic basis of reproductive isolation and speciation in this genus.
Article
Psychiatry
Annica J. Rasmusson, Maike Gallwitz, Bardia Soltanabadi, Diana M. Ciuculete, Jonas Mengel-From, Kaare Christensen, Marianne Nygaard, Mette Soerensen, Adrian E. Bostrom, Robert Fredriksson, Eva Freyhult, Jessica Mwinyi, Darina Czamara, Elisabeth B. Binder, Helgi B. Schioth, Janet L. Cunningham
Summary: This study found an inverse correlation between depressive symptoms in young Scandinavian adults and the methylation level of TLR4, as well as a correlation with the plasma levels of the inflammatory protein MIP-1 beta.
TRANSLATIONAL PSYCHIATRY
(2021)
Article
Multidisciplinary Sciences
Shani Hadar, Anatoly Meller, Naseeb Saida, Reut Shalgi
Summary: Exposure to certain stresses leads to readthrough transcription, which has an important impact on cellular stress response. This study found that readthrough transcription can extend into downstream genes, and these read-in genes have common genomic characteristics, such as GC-richness and short length. Moreover, read-in genes show significant intron retention, which is not solely related to their intron length and GC content. Additionally, H3K36me3 is enriched upstream of read-in genes.
Article
Genetics & Heredity
Minjie Sheng, Haiying Cai, Qin Yang, Jing Li, Jian Zhang, Lihua Liu
Summary: Lymphoma is a serious and relatively rare type of cancer that affects adolescents and elder adults, with genetic factors playing a significant role in its initiation and progression. Identifying lymphoma-associated genes is crucial for understanding the pathogenesis of lymphoma.
FRONTIERS IN GENETICS
(2021)
Article
Plant Sciences
Luca Dondini, Cecilia Domenichini, Yonghui Dong, Fabio Gennari, Daniele Bassi, Stefano Foschi, Martina Lama, Marco Adami, Paolo De Franceschi, Claudia Cervellati, Lorenzo Bergonzoni, Sara Alessandri, Stefano Tartarini
Summary: This study investigates the genetic basis of fruit acidity in apricots through molecular markers and genomics analysis. Major QTLs related to fruit acidity traits were identified and candidate genes were identified in specific genomic regions.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Computer Science, Artificial Intelligence
Zhi-An Huang, Jia Zhang, Zexuan Zhu, Edmond Q. Wu, Kay Chen Tan
Summary: A new multilabel classification model is proposed in this study to identify autistic risk genes and toxic chemicals on a large-scale data set. Through simulation experiments and manual validation, it is confirmed that the model demonstrates superior classification performance and has the potential to provide better support for therapeutic decisions regarding ASD.
IEEE TRANSACTIONS ON NEURAL NETWORKS AND LEARNING SYSTEMS
(2021)
Article
Microbiology
Jenna J. Guthmiller, Olivia Stovicek, Jiaolong Wang, Siriruk Changrob, Lei Li, Peter Halfmann, Nai-Ying Zheng, Henry Utset, Christopher T. Stamper, Haley L. Dugan, William D. Miller, Min Huang, Ya-Nan Dai, Christopher A. Nelson, Paige D. Hall, Maud Jansen, Kumaran Shanmugarajah, Jessica S. Donington, Florian Krammer, Daved H. Fremont, Andrzej Joachimiak, Yoshihiro Kawaoka, Vera Tesic, Maria Lucia Madariaga, Patrick C. Wilson
Summary: The study reveals that individuals with more severe SARS-CoV-2 infection have a stronger overall antibody response to the spike and nucleocapsid proteins, and a larger memory B cell response against the spike. Additionally, these individuals develop antibodies that cross-react with other viral antigens, suggesting potential protection against reinfection.
Article
Multidisciplinary Sciences
John E. Bowers, Haibao Tang, John M. Burke, Andrew H. Paterson
Summary: The frequency of G and C nucleotides in genomes varies among species, with monocot grasses showing a bimodal distribution of genic GC content absent in dicots. Syntenic genes have higher GC content than non-syntenic genes at their 5'-end in the third position within codons in all species. Biased GC content in genes can be caused by mutation of methylated C to T and gene conversion from A to G.
Article
Clinical Neurology
Siddhartha Datta, Sudipta Sarkar, Sumit Chakraborty, Sai Krishna Mulpuru, Swadhapriya Basu, Basant K. Tiwary, Nilkanta Chakrabarti, Prasun Kumar Roy
Correction
Clinical Neurology
Siddhartha Datta, Sudipta Sarkar, Sumit Chakraborty, Sai Krishna Mulpuru, Swadhapriya Basu, Basant K. Tiwary, Nilkanta Chakrabarti, Prasun Kumar Roy
Article
Microbiology
Amit Kumar, Pragna Lakshmi Thotakura, Basant Kumar Tiwary, Ramadas Krishna
Article
Biochemistry & Molecular Biology
Amit Kumar, Rajagopalan Saranathan, K. Prashanth, Basant K. Tiwary, Ramadas Krishna
MOLECULAR BIOSYSTEMS
(2017)
Article
Cardiac & Cardiovascular Systems
Suvendu Giri, Jagadesh Chandra Bose, Ajay Chandrasekar, Basant K. Tiwary, Palanivel Gajalakshmi, Suvro Chatterjee
CARDIOVASCULAR TOXICOLOGY
(2019)
Article
Endocrinology & Metabolism
Basant K. Tiwary
NEUROENDOCRINOLOGY
(2013)
Article
Biochemical Research Methods
Basant K. Tiwary
BRIEFINGS IN BIOINFORMATICS
(2020)
Article
Oncology
H. Lalremmawia, Basant K. Tiwary
Article
Behavioral Sciences
Siddhartha Datta, Diptaman Samanta, Basant Tiwary, Alok Ghosh Chaudhuri, Nilkanta Chakrabarti
BEHAVIOURAL BRAIN RESEARCH
(2019)
Article
Biotechnology & Applied Microbiology
Basant K. Tiwary
Article
Medicine, Research & Experimental
Suvojit Hazra, Alok Ghosh Chaudhuri, Basant K. Tiwary, Nilkanta Chakrabarti
Letter
Psychiatry
T. Sayamsmruti Panda, H. Lalremmawia, Basant K. Tiwary
ASIAN JOURNAL OF PSYCHIATRY
(2021)
Article
Oncology
Karamveer, Basant K. Tiwary
Summary: A machine learning model, called CarcinoHPVPred, has been developed to predict the carcinogenic nature of newly discovered HPV based on their genomic composition. This model achieved a high accuracy rate (94-100%) and can assist in accurate prediction of HPV-induced cancer samples in clinical genetic testing.
Article
Multidisciplinary Sciences
Suvojit Hazra, Alok Ghosh Chaudhuri, Basant K. Tiwary, Nilkanta Chakrabarti
Summary: By constructing tripartite and combined gene networks, candidate genes related to neurological manifestations of COVID-19 were identified. The analysis revealed that specific genes have influences on neurological phenotypes such as neurodegenerative diseases, neurodevelopmental diseases, tumor/cancer, cellular signaling, behavioral/cognitive, and motor dysfunctions.
SCIENTIFIC REPORTS
(2022)
Article
Genetics & Heredity
Arunagiri Kuha Deva Magendhra Rao, Mayakannan Manikandan, Ganesan Arunkumar, Sundaramoorthy Revathidevi, Vilvanathan Vinothkumar, Kanagaraj Arun, Basant K. Tiwary, Kottayasamy Seenivasagam Rajkumar, Ramamurthy Rajaraman, Arasambattu Kannan Munirajan