Review
Oncology
Hany E. Marei, Asmaa Althani, Nahla Afifi, Anwarul Hasan, Thomas Caceci, Giacomo Pozzoli, Andrea Morrione, Antonio Giordano, Carlo Cenciarelli
Summary: The p53 protein, known as the guardian of the genome, plays a critical role in preserving genomic integrity, and mutations in the TP53 gene can lead to uncontrolled cell proliferation and cancer formation. With p53 deficiency being common in human cancer, restoring p53 function may be an effective approach for cancer treatment.
CANCER CELL INTERNATIONAL
(2021)
Article
Cell Biology
Ting Zhuang, Beibei Wang, Xiaojing Tan, Le Wu, Xin Li, Zhongbo Li, Yuqing Cai, Rongrong Fan, Xiao Yang, Chenmiao Zhang, Yan Xia, Zhiguo Niu, Bingtian Liu, Qi Cao, Yinlu Ding, Zhipeng Zhou, Qingsong Huang, Huijie Yang
Summary: In this study, the researchers found that TRIM3, an E3 ligase, promotes ER alpha signaling activity and breast cancer progression. Depletion of TRIM3 inhibits breast cancer cell proliferation and migration, and unbiased RNA sequencing data showed that TRIM3 is crucial for estrogen signaling activity on a genome-wide scale. The researchers also demonstrated that TRIM3 associates with ER alpha and promotes its stability by inducing a specific ubiquitin modification. These findings provide a novel posttranslational mechanism in estrogen signaling and suggest that modulation of TRIM3 expression or function could be a promising approach for breast cancer treatment.
CELL COMMUNICATION AND SIGNALING
(2022)
Review
Oncology
Anshika Goenka, Fatima Khan, Bhupender Verma, Priyanka Sinha, Crismita C. Dmello, Manasi P. Jogalekar, Prakash Gangadaran, Byeong-Cheol Ahn
Summary: Tumor development and metastasis are influenced by the complex interactions between cancer cells and their microenvironment, which includes stromal cells and extracellular matrix components. Understanding the signaling pathways involved in these interactions is crucial for developing effective intervention strategies. This review provides a comprehensive analysis of the diverse signaling pathways in the tumor microenvironment, highlighting the latest preclinical and clinical studies and their underlying biology.
CANCER COMMUNICATIONS
(2023)
Article
Multidisciplinary Sciences
Zixiang Wang, Shourong Wang, Junchao Qin, Xiyu Zhang, Gang Lu, Hongbin Liu, Haiyang Guo, Ligang Wu, Victoria O. Shender, Changshun Shao, Beihua Kong, Zhaojian Liu
Summary: This study reveals that altered expression of splicing factor BUD31 can enhance ovarian cancer progression by promoting exon inclusion in the anti-apoptotic BCL2 family member, BCL2L12. The findings highlight the critical role of BUD31-regulated exon inclusion in ovarian cancer cell survival and cancer progression.
NATURE COMMUNICATIONS
(2022)
Article
Medicine, Research & Experimental
Fabiola Lili Sarmiento-Salinas, Andrea Perez-Gonzalez, Adilene Acosta-Casique, Adrian Ix-Ballote, Alfonso Diaz, Samuel Trevino, Nora Hilda Rosas-Murrieta, Lourdes Millan-Perez-Pena, Paola Maycotte
Summary: Cancer is a major global cause of death, with the role of reactive oxygen species (ROS) in cancer development and progression being extensively studied. However, conflicting evidence exists regarding the specific impact of ROS on cancer, which may vary depending on the type of cancer and stage of tumorigenesis. Recent research has focused on exploring the diverse aspects of ROS interaction with cancer at different stages of cancer progression.
Article
Genetics & Heredity
Sulaiman Mohammed Alnasser
Summary: Stem cell therapy is a method used to treat damaged tissues, especially in cancer cases. This paper discusses the main advantages of using different types of cells in the treatment of various cancerous diseases and analyzes the results of cell therapy worldwide over the past twenty years. Additionally, the challenges of funded cancer care and the future of current treatment methods are also discussed.
Article
Biochemistry & Molecular Biology
Penghe Yang, Xiao Yang, Dehai Wang, Huijie Yang, Zhongbo Li, Chenmiao Zhang, Shuqing Zhang, Jian Zhu, Xin Li, Peng Su, Ting Zhuang
Summary: In this study, we identified a novel positive feedback loop between PSMD14 and ER alpha signaling in breast cancer progression, and found that blockade of PSMD14 could be a plausible strategy for luminal breast cancer.
Article
Cell Biology
Anna-Christina Rambow, Insa Aschenbach, Sofie Hagelund, Doaa Tawfik, Jan-Paul Gundlach, Sebastian Weisse, Nicolai Maass, Anna Trauzold
Summary: Binding of TRAIL to its death domain-containing receptors TRAIL-R1 and TRAIL-R2 can induce cell death and/or pro-inflammatory signaling. The importance of TRAIL and TRAIL-R1/R2 in tumor immune surveillance and cancer biology has meanwhile been well documented. TRAIL also binds to TRAIL-R3 and TRAIL-R4, which have regulatory functions in apoptotic and non-apoptotic signaling pathways. Knockdown of TRAIL-R4 affects the activation of apoptotic and non-apoptotic pathways in cancer cells, showing opposing effects on cell death and clonogenic survival. TRAIL-R4 also regulates the expression of anti-apoptotic proteins and affects the activity of AKT, ERK, p38 and NF-kappa B. This study provides evidence for the important role of endogenous TRAIL-R4 in cancer cells and improves the understanding of the complex TRAIL/TRAIL-R system in humans.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Medicine, Research & Experimental
Qi Wang, Jiaju Xu, Zhiyong Xiong, Tianbo Xu, Jingchong Liu, Yuenan Liu, Jiaping Chen, Jian Shi, Yi Shou, Changjie Yue, Di Liu, Huageng Liang, Hongmei Yang, Xiong Yang, Xiaoping Zhang
Summary: This research identified that several CENP family members, especially CENPA, are highly expressed in ccRCC tissues and can serve as biomarkers for the disease. Overexpression of CENPA was found to promote ccRCC proliferation and metastasis by accelerating the cell cycle and activating the Wnt/beta-catenin signaling pathway. Targeting CENPA with selective drugs may be a promising direction for cancer treatment.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Chun-Yi Chuang, Chiao-Wen Lin, Chun-Wen Su, Yi-Tzu Chen, Wei-En Yang, Shun-Fa Yang, Shih-Chi Su
Summary: Deoxyshikonin (DSK) has been found to halt cell cycle progression and induce cell apoptosis in tongue cancer cell lines. The apoptotic protein regulation by DSK is p38 kinase-dependent, suggesting its potential therapeutic implications for the management of oral squamous cell carcinoma (OSCC).
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Jiayu Zou, Li Wang, Hailin Tang, Xiuxiu Liu, Fu Peng, Cheng Peng
Summary: Ferroptosis plays a significant role in inhibiting tumor progression in non-small cell lung cancer by regulating the GPX4 signaling pathway and also has a GSH-independent preventive mechanism. It has the potential to become a novel strategy for overcoming therapy resistance in NSCLC, highlighting its therapeutic potential.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Jordan F. Hastings, Sharissa L. Latham, Alvin Kamili, Madeleine S. Wheatley, Jeremy Z. R. Han, Marie Wong-Erasmus, Monica Phimmachanh, Max Nobis, Chiara Pantarelli, Antonia L. Cadell, Yolande E. I. O'Donnell, King Ho Leong, Sophie Lynn, Fan-Suo Geng, Lujing Cui, Sabrina Yan, Joanna Achinger-Kawecka, Clare Stirzaker, Murray D. Norris, Michelle Haber, Toby N. Trahair, Frank Speleman, Katleen De Preter, Mark J. Cowley, Ozren Bogdanovic, Paul Timpson, Thomas R. Cox, Walter Kolch, Jamie I. Fletcher, Dirk Fey, David R. Croucher
Summary: Gene expression noise promotes stochastic drug resistance in rare cancer cells. However, when integrated across multiple components of an apoptotic signaling network, the influence of noise leads to a higher frequency of chemoresistant neuroblastoma cells. These cells are characterized by JNK impairment and retain a memory of their resistant state even after chemotherapy treatment.
Article
Medicine, Research & Experimental
Wei Zhang, Xianhui Ruan, Yaoshuang Li, Jingtai Zhi, Linfei Hu, Xiukun Hou, Xianle Shi, Xin Wang, Jinpeng Wang, Weike Ma, Pengfei Gu, Xiangqian Zheng, Ming Gao
Summary: The study reveals that KDM1A regulates the stemness of thyroid cancer and promotes cancer progression through the Wnt/beta-catenin pathway. Inhibiting KDM1A can significantly inhibit thyroid cancer progression and enhance sensitivity to chemotherapy.
Article
Biochemistry & Molecular Biology
Qiurong Yang, Maoye Wang, Jing Xu, Dan Yu, Yixin Li, Yanke Chen, Xiaoxin Zhang, Jiahui Zhang, Jianmei Gu, Xu Zhang
Summary: In this study, a new lncRNA (LINC02159) was identified as upregulated in tumor tissues and serum of NSCLC patients. Knockdown of LINC02159 inhibited NSCLC cell proliferation, migration, and invasion, while overexpression led to the opposite effect. It was found that LINC02159 enhanced the stability of YAP1 mRNA through m(5)C modification by binding to ALYREF, resulting in the activation of Hippo and β-catenin signaling pathways. The findings suggest that LINC02159 plays an oncogenic role in NSCLC and has potential as a diagnostic marker and therapeutic target for the disease.
Review
Biochemistry & Molecular Biology
Ling Wu, Weidong Lian, Liang Zhao
Summary: The ancient Greek saying 'everything flows' is true for all living things, demonstrating the importance of calcium signaling in cellular activities. Recent research has highlighted the significant roles calcium signaling plays in cancer progression, prompting further exploration into its potential as a target for improving cancer therapies.
Article
Multidisciplinary Sciences
Octavian Bucur, Gabriel Gaidos, Achani Yatawara, Bodvael Pennarun, Chamila Rupasinghe, Jeremie Roux, Stefan Andrei, Bingqian Guo, Alexandra Panaitiu, Maria Pellegrini, Dale F. Mierke, Roya Khosravi-Far
SCIENTIFIC REPORTS
(2015)
Article
Biotechnology & Applied Microbiology
Eun-Yeong Oh, Stephen M. Christensen, Sindhu Ghanta, Jong Cheol Jeong, Octavian Bucur, Benjamin Glass, Laleh Montaser-Kouhsari, Nicholas W. Knoblauch, Nicholas Bertos, Sadiq M. I. Saleh, Benjamin Haibe-Kains, Morag Park, Andrew H. Beck
Article
Oncology
Manoj K. Bhasin, Kenneth Ndebele, Octavian Bucur, Eric U. Yee, Hasan H. Otu, Jessica Plati, Andrea Bullock, Xuesong Gu, Eduardo Castan, Peng Zhang, Robert Najarian, Maria S. Muraru, Rebecca Miksad, Roya Khosravi-Far, Towia A. Libermann
Article
Biotechnology & Applied Microbiology
Yongxin Zhao, Octavian Bucur, Humayun Irshad, Fei Chen, Astrid Weins, Andreea L. Stancu, Eun-Young Oh, Marcello DiStasio, Vanda Torous, Benjamin Glass, Isaac E. Stillman, Stuart J. Schnitt, Andrew H. Beck, Edward S. Boyden
NATURE BIOTECHNOLOGY
(2017)
Article
Biochemistry & Molecular Biology
Barbara L. Hopkins, Monica Nadler, John J. Skoko, Thierry Bertomeu, Andrea Pelosi, Parisa Mousavi Shafaei, Kevin Levine, Anja Schempf, Bodvael Pennarun, Bo Yang, Dipak Datta, Octavian Bucur, Kenneth Ndebele, Steffi Oesterreich, Da Yang, Maria Giulia Rizzo, Roya Khosravi-Far, Carola A. Neumann
ANTIOXIDANTS & REDOX SIGNALING
(2018)
Article
Biochemistry & Molecular Biology
Octavian Bucur, Bodvael Pennarun, Andreea Lucia Stancu, Monica Nadler, Maria Sinziana Muraru, Thierry Bertomeu, Roya Khosravi-Far
Editorial Material
Cardiac & Cardiovascular Systems
Elisa A. Liehn, Octavian Bucur, Christian Weber
CIRCULATION RESEARCH
(2012)
Article
Multidisciplinary Sciences
Octavian Bucur, Andreea Lucia Stancu, Ioana Goganau, Stefana Maria Petrescu, Bodvael Pennarun, Thierry Bertomeu, Rajan Dewar, Roya Khosravi-Far
Editorial Material
Cell Biology
O. Bucur, A. L. Stancu, R. Khosravi-Far, A. Almasan
CELL DEATH & DISEASE
(2012)
Article
Cell Biology
B. Pennarun, G. Gaidos, O. Bucur, A. Tinari, C. Rupasinghe, T. Jin, R. Dewar, K. Song, M. T. Santos, W. Malorni, D. Mierke, R. Khosravi-Far
CELL DEATH & DISEASE
(2013)
Article
Cell Biology
V. Gunda, O. Bucur, J. Varnau, P. Vanden Borre, M. J. Bernasconi, R. Khosravi-Far, S. Parangi
CELL DEATH & DISEASE
(2014)
Article
Multidisciplinary Sciences
Aleksandra Klimas, Octavian Bucur, Brigdet Njeri, Yongxin Zhao
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2019)
Article
Biochemical Research Methods
Octavian Bucur, Feifei Fu, Mike Calderon, Geetha H. Mylvaganam, Ngoc L. Ly, Jimmy Day, Simon Watkin, Bruce D. Walker, Edward S. Boyden, Yongxin Zhao
Article
Medicine, General & Internal
Octavian Bucur, Yongxin Zhao
FRONTIERS IN MEDICINE
(2018)