Article
Multidisciplinary Sciences
Sebastian Schindler, Jan Querengaesser, Maximilian Bruchmann, Nele Johanna Boegemann, Robert Moeck, Thomas Straube
Summary: Studying the relationship between personality traits and the anchoring effect did not show a clear correlation. The susceptibility to anchoring effects might be influenced by specific designs, restricted to certain cognitive domains, or reflect unreliable individual cognitive phenomena.
SCIENTIFIC REPORTS
(2021)
Review
Biology
Emma Hart, Leni K. Le Goff
Summary: This article investigates how learning can enhance evolutionary approaches to optimizing the performance of robots. By studying the interaction between the evolution of the body and brain, and individual and cultural learning mechanisms, it explores how the 'evolution plus learning' pattern influences the diversity, performance, and rate of improvement of robotic systems.
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2022)
Article
Infectious Diseases
Daniel Golparian, Leonor Sanchez-Buso, Michelle Cole, Magnus Unemo
Summary: NG-STAR CCs are a useful method for monitoring AMR in N. gonorrhoeae, accurately defining and predicting resistance lineages, with simplicity, reproducibility, and portability.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2021)
Article
Multidisciplinary Sciences
Maria Escala-Garcia, Sander Canisius, Renske Keeman, Jonathan Beesley, Hoda Anton-Culver, Volker Arndt, Annelie Augustinsson, Heiko Becher, Matthias W. Beckmann, Sabine Behrens, Marina Bermisheva, Stig E. Bojesen, Manjeet K. Bolla, Hermann Brenner, Federico Canzian, Jose E. Castelao, Jenny Chang-Claude, Stephen J. Chanock, Fergus J. Couch, Kamila Czene, Mary B. Daly, Joe Dennis, Peter Devilee, Thilo Dork, Alison M. Dunning, Douglas F. Easton, Arif B. Ekici, A. Heather Eliassen, Peter A. Fasching, Henrik Flyger, Manuela Gago-Dominguez, Montserrat Garcia-Closas, Jose A. Garcia-Saenz, Juergen Geisler, Graham G. Giles, Mervi Grip, Melanie Guendert, Eric Hahnen, Christopher A. Haiman, Niclas Hakansson, Per Hall, Ute Hamann, Jaana M. Hartikainen, Bernadette A. M. Heemskerk-Gerritsen, Antoinette Hollestelle, Reiner Hoppe, John L. Hopper, David J. Hunter, William Jacot, Anna Jakubowska, Esther M. John, Audrey Y. Jung, Rudolf Kaaks, Elza Khusnutdinova, Linetta B. Koppert, Peter Kraft, Vessela N. Kristensen, Allison W. Kurian, Diether Lambrechts, Loic Le Marchand, Annika Lindblom, Robert N. Luben, Jan Lubinski, Arto Mannermaa, Mehdi Manoochehri, Sara Margolin, Dimitrios Mavroudis, Taru A. Muranen, Heli Nevanlinna, Andrew F. Olshan, Hakan Olsson, Tjoung-Won Park-Simon, Alpa V. Patel, Paolo Peterlongo, Paul D. P. Pharoah, Kevin Punie, Paolo Radice, Gad Rennert, Hedy S. Rennert, Atocha Romero, Rebecca Roylance, Thomas Ruediger, Matthias Ruebner, Emmanouil Saloustros, Elinor J. Sawyer, Rita K. Schmutzler, Minouk J. Schoemaker, Christopher Scott, Melissa C. Southey, Harald Surowy, Anthony J. Swerdlow, Rulla M. Tamimi, Lauren R. Teras, Emilie Thomas, Ian Tomlinson, Melissa A. Troester, Celine M. Vachon, Qin Wang, Robert Winqvist, Alicja Wolk, Argyrios Ziogas, Kyriaki Michailidou, Georgia Chenevix-Trench, Thomas Bachelot, Marjanka K. Schmidt
Summary: Two germline variants on chromosome 1 were significantly associated with breast cancer-specific survival, however, validation in a smaller replication dataset was not successful. Larger replication studies are needed to confirm the identified associations.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Claudia Ojeda-Granados, Paolo Abondio, Alice Setti, Stefania Sarno, Guido Alberto Gnecchi-Ruscone, Eduardo Gonzalez-Orozco, Sara De Fanti, Andres Jimenez-Kaufmann, Hector Rangel-Villalobos, Andres Moreno-Estrada, Marco Sazzini
Summary: The genetic ancestry of Native Americans is linked to increased risk of health issues in Mexican populations due to recent environmental, dietary, and cultural changes. Indigenous Mexican groups may have retained the highest proportions of genetic components shaped by ancient environments, impacting biological traits and disease risk patterns. Adaptive variants evolved in response to local conditions may play a role in modulating susceptibility to certain diseases in present-day Native and Mestizo Mexican populations.
MOLECULAR BIOLOGY AND EVOLUTION
(2022)
Article
Multidisciplinary Sciences
Ernest Diez Benavente, Emilia Manko, Jody Phelan, Monica Campos, Debbie Nolder, Diana Fernandez, Gabriel Velez-Tobon, Alberto Tobon Castano, Jamille G. Dombrowski, Claudio R. F. Marinho, Anna Caroline C. Aguiar, Dhelio Batista Pereira, Kanlaya Sriprawat, Francois Nosten, Robert Moon, Colin J. Sutherland, Susana Campino, Taane G. Clark
Summary: The genetic diversity of Plasmodium vivax strains in South Asia isn't well described, with South Asian isolates found to be distinct from East African and South East Asian isolates. Genetic markers associated with drug resistance were identified, along with shared genetic regions with parasites from India and Ethiopia.
NATURE COMMUNICATIONS
(2021)
Article
Astronomy & Astrophysics
P. Serra, F. M. Maccagni, D. Kleiner, D. Molnar, M. Ramatsoku, A. Loni, F. Loi, W. J. G. de Blok, G. L. Bryan, R. J. Dettmar, B. S. Frank, J. H. van Gorkom, F. Govoni, E. Iodice, G. I. G. Jozsa, P. Kamphuis, R. Kraan-Korteweg, S. I. Loubser, M. Murgia, T. A. Oosterloo, R. Peletier, D. J. Pisano, M. W. L. Smith, S. C. Trager, M. A. W. Verheijen
Summary: The MeerKAT Fornax Survey employs the MeerKAT telescope to map the distribution and kinematics of atomic neutral hydrogen gas (H I) in the nearby Fornax galaxy cluster. The survey covers the central region of the cluster up to R-vir and extends southwest to include the NGC 1316 galaxy group. The study reveals evidence of ram pressure shaping the distribution of H I in the Fornax cluster through the presence of long, one-sided, starless H I tails with measurable internal velocity gradients.
ASTRONOMY & ASTROPHYSICS
(2023)
Article
Infectious Diseases
J. Machuca, E. Recacha, B. Gallego-Mesa, S. Diaz-Diaz, G. Rojas-Granado, A. Garcia-Duque, F. Docobo-Perez, J. Blazquez, A. Rodriguez-Rojas, A. Pascual, J. M. Rodriguez-Martinez
Summary: RecA inactivation leads to decreased fluoroquinolone resistance in Escherichia coli clinical isolates, especially in high-risk clone ST131. Inactivation of the SOS system results in a survival disadvantage for E. coli, reducing the development of quinolone resistance.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2021)
Article
Astronomy & Astrophysics
Nikki Zabel, Timothy A. Davis, Matthew W. L. Smith, Marc Sarzi, Alessandro Loni, Paolo Serra, Maritza A. Lara-Lopez, Phil Cigan, Maarten Baes, George J. Bendo, Ilse De Looze, Enrichetta Iodice, Dane Kleiner, Barbel S. Koribalski, Reynier Peletier, Francesca Pinna, P. Tim de Zeeuw
Summary: Observations from various telescopes were used to study gas-to-dust ratios in Fornax cluster galaxies, showing that these ratios are lower compared to field galaxies at similar stellar mass/metallicity. The presence of a large fraction of metals locked up in dust in these systems suggests altered chemical evolution in the dense environment. Additionally, low ratios are driven not only by Hi deficiencies, but also by decreased H-2-to-dust ratios.
MONTHLY NOTICES OF THE ROYAL ASTRONOMICAL SOCIETY
(2021)
Article
Medicine, General & Internal
Xuechen Chen, Hengjing Li, Marko Mandic, Michael Hoffmeister, Hermann Brenner
Summary: This study explores the association between body mass index (BMI), polygenic risk, and colorectal cancer (CRC), finding that excess weight is associated with CRC regardless of genetic risk, and having a BMI within the reference range may offset the increased genetic risk for CRC.
Article
Astronomy & Astrophysics
Nicolas O. L. de Oliveira, Yolanda Jimenez-Teja, Renato Dupke
Summary: In this study, we analysed the contribution of intracluster light (ICL) to the total luminosity of two massive galaxy clusters observed by the Hubble Space Telescope. We developed an algorithm called CICLE to separate the ICL from the light of galaxies and measure the ICL fraction. The results showed that the ICL fraction varied between 7-25% for Abell 370 and 3-22% for Abell S1063, consistent with theoretical predictions. We also found an enhanced ICL fraction in the intermediate filter F606W, indicating the presence of younger/lower metallicity stars in the ICL compared to the cluster galaxies. Based on these findings, we concluded that both Abell 370 and Abell S1063 are merging systems.
MONTHLY NOTICES OF THE ROYAL ASTRONOMICAL SOCIETY
(2022)
Review
Computer Science, Interdisciplinary Applications
Nana Tian, Phil Lopes, Ronan Boulic
Summary: Cybersickness remains a significant challenge for the widespread usage of virtual reality, with inconsistent results and little attention to individual susceptibility in the research field.
Article
Evolutionary Biology
Luca Ermini, Jeffrey C. Francis, Gabriel S. Rosa, Alexandra J. Rose, Jian Ning, Mel Greaves, Amanda Swain
Summary: Variants in the MLPH gene have undergone positive selection in Caucasian populations, potentially influencing prostate cancer risk. Depletion of MLPH function in prostate organoid cultures may impact cancer risk.
EVOLUTION MEDICINE AND PUBLIC HEALTH
(2021)
Article
Astronomy & Astrophysics
Elena A. Balakina, Maria Pruzhinskaya, Alexander S. Moskvitin, Sergei Blinnikov, Xiaofeng Wang, Danfeng Xiang, Han Lin, Liming Rui, Huijuan Wang
Summary: The study presents the photometric and spectroscopic observations of type IIb supernova 2017gpn, with numerical modeling to determine its properties. Additionally, the supernova's location and potential origin pose new challenges to current understanding of type IIb supernovae.
MONTHLY NOTICES OF THE ROYAL ASTRONOMICAL SOCIETY
(2021)
Article
Veterinary Sciences
Aroa Suarez-Vega, Beatriz Gutierrez-Gil, Pablo G. Toral, Pilar Frutos, Juan J. Loor, Juan-Jose Arranz, Gonzalo Hervas
Summary: Dietary supplementation with marine lipids can improve the fatty acid profile of ruminant milk, but it can also cause milk fat depression. There is significant individual variation in susceptibility to diet-induced milk fat depression. This study used gene expression profiles to investigate the mechanisms underlying milk fat depression in goats and individual variation in its extent. The results identified differentially expressed genes and regulatory pathways associated with milk fat depression in goats.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Cell Biology
Binbin Yuan, Chengfei Jiang, Lingyan Chen, Lihui Wen, Jinlong Cui, Min Chen, Shu Zhang, Lin Zhou, Yimeng Cai, Jian-Hua Mao, Xiaoping Zou, Bo Hang, Pin Wang
Summary: Through evaluating the DNA repair gene signature in gastric cancer patients, this study found that patients with high scores had better therapeutic outcomes with immune checkpoint blockade therapy. These high DRGS score patients exhibited higher levels of anti-tumor lymphocyte infiltration, tumor mutation burden, PD-L1 expression, and longer overall survival.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Engineering, Environmental
Xiaochen Tang, Neal Benowitz, Lara Gundel, Bo Hang, Christopher M. Havel, Eunha Hoh, Peyton Jacob, Jian-Hua Mao, Manuela Martins-Green, Georg E. Matt, Penelope J. E. Quintana, Marion L. Russell, Altaf Sarker, Suzaynn F. Schick, Antoine M. Snijders, Hugo Destaillats
Summary: Tobacco-specific nitrosamines (TSNAs) may pose long-term health risks to nonsmokers, especially in homes contaminated with thirdhand smoke.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2022)
Article
Oncology
Xiao-Ping Liu, Xiaoqing Jin, Saman Seyed Ahmadian, Xu Yang, Su-Fang Tian, Yu-Xiang Cai, Kuldeep Chawla, Antoine M. Snijders, Yankai Xia, Paul J. van Diest, William A. Weiss, Jian-Hua Mao, Zhi-Qiang Li, Hannes Vogel, Hang Chang
Summary: By developing and validating cellular morphometric subtypes (CMS), personalized diagnosis and therapy for LGG patients can be achieved. These subtypes can predict patient prognosis and treatment response based on molecular alterations and immune microenvironment, and also have translational impact on glioblastoma.
Article
Biology
Polly Y. Chang, James Bakke, Chris J. Rosen, Kathleen A. Bjornstad, Jian-Hua Mao, Eleanor A. Blakely
Summary: This study aimed to investigate the dose-response relationship of lung tumorigenesis after exposure to different ion beams in mice. Results showed a non-linear relationship between lung tumor prevalence and dose, suggesting potential threshold doses depending on the LET of the beams.
Article
Oncology
Xuan-Yu Mao, Jesus Perez-Losada, Mar Abad, Marta Rodriguez-Gonzalez, Cesar A. Rodriguez, Jian-Hua Mao, Hang Chang
Summary: This study utilizes artificial intelligence to analyze cellular morphometric, gene, and microbiome data of breast cancer patients and establishes a scoring system for risk stratification. The scoring system can predict the overall survival and progress-free survival of patients more accurately than clinical factors and biomarkers alone.
WORLD JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Veterinary Sciences
Libette J. Roman, Antoine M. Snijders, Hang Chang, Jian-Hua Mao, Kristina J. A. Jones, Gregory W. Lawson
Summary: This study examines the effect of different barrier practices on the fecal microbiome of breeding C57Bl/6J mice. The results show that differences in barrier husbandry practices can affect fecal microbiome divergence in both the parental and filial generations of different breeding colonies.
JOURNAL OF THE AMERICAN ASSOCIATION FOR LABORATORY ANIMAL SCIENCE
(2023)
Article
Environmental Sciences
Hui Yang, Xinzhi Wang, Pin Wang, Li He, Suzyann F. Schick, Peyton Jacob, Neal Benowitz, Lara A. Gundel, Chi Zhu, Yankai Xia, Jamie L. Inman, Hang Chang, Antoine M. Snijders, Jian-Hua Mao, Bo Hang
Summary: Increasing evidence suggests that thirdhand smoke (THS) exposure has adverse health effects and may increase cancer risk. This study used the Collaborative Cross (CC) mouse population-based model system to assess the effects of THS exposure on cancer risk and found an increased incidence and burden of tumors in THS-treated mice. Lung and liver tissues were particularly susceptible to tumorigenesis after THS exposure. The study also highlighted the importance of host genetic background in individual susceptibility to THS-induced tumorigenesis and emphasized the need to consider genetic factors when determining cancer risk in humans exposed to THS.
ENVIRONMENT INTERNATIONAL
(2023)
Article
Substance Abuse
Georg E. Matt, Lydia Greiner, Rachael A. Record, Heather Wipfli, Jamie Long, Nathan G. Dodder, Eunha Hoh, Nicolas Lopez Galvez, Thomas E. Novotny, Penelope J. E. Quintana, Hugo Destaillats, Xiaochen Tang, Antoine M. Snijders, Jian-Hua Mao, Bo Hang, Suzaynn Schick, Peyton Jacob, Prue Talbot, E. Melinda Mahabee-Gittens, Ashley L. Merianos, Thomas F. Northrup, Lara Gundel, Neal L. Benowitz
Summary: Since the 1970s, policies prohibiting smoking indoors have saved numerous lives and reduced healthcare expenditure. However, these policies do not fully protect the public from the long-lasting toxic residues of tobacco smoke, known as thirdhand smoke. This article discusses the differences between secondhand and thirdhand smoke exposure and proposes four policy considerations to better protect the public and remediate thirdhand smoke.
Article
Endocrinology & Metabolism
Lijuan Chen, Lin Guo, Susu Feng, Congcong Wang, Zhicheng Cui, Sijing Wang, Qingmiao Lu, Hang Chang, Bo Hang, Antoine M. Snijders, Jian-Hua Mao, Yibing Lu, Dafa Ding
Summary: This study confirms the effectiveness of FMT in treating patients with T2DM and demonstrates its positive impact on gut microbiome, serum metabolites, intestinal epithelial barrier, inflammation, and circulating immune cells.
BMJ OPEN DIABETES RESEARCH & CARE
(2023)
Review
Oncology
Manuel Jesus Perez-Baena, Francisco Josue Cordero-Perez, Jesus Perez-Losada, Marina Holgado-Madruga
Summary: GAB1 is a pleckstrin homology domain-containing protein that plays a crucial role in cellular transformation and cancer progression, activating various signaling pathways and modulating resistance to anticancer therapies. Its deficiency leads to developmental abnormalities, while its dysregulation is associated with worse prognosis in multiple cancer types. Understanding the mechanisms of GAB1 in cancer could provide insights for future anticancer strategies.
Article
Cell Biology
Aurora Gomez-Vecino, Roberto Corchado-Cobos, Adrian Blanco-Gomez, Natalia Garcia-Sancha, Sonia Castillo-Lluva, Ana Martin-Garcia, Marina Mendiburu-Elicabe, Carlos Prieto, Sara Ruiz-Pinto, Guillermo Pita, Alejandro Velasco-Ruiz, Carmen Patino-Alonso, Purificacion Galindo-Villardon, Maria Linarejos Vera-Pedrosa, Jose Jalife, Jian-Hua Mao, Guillermo Macias de Plasencia, Andres Castellanos-Martin, Maria del Mar Saez-Freire, Susana Fraile-Martin, Telmo Rodrigues-Teixeira, Carmen Garcia-Macias, Julie Milena Galvis-Jimenez, Asuncion Garcia-Sanchez, Maria Isidoro-Garcia, Manuel Fuentes, Maria Begona Garcia-Cenador, Francisco Javier Garcia-Criado, Juan Luis Garcia-Hernandez, Maria Angeles Hernandez-Garcia, Juan Jesus Cruz-Hernandez, Cesar Augusto Rodriguez-Sanchez, Alejandro Martin Garcia-Sancho, Estefania Perez-Lopez, Antonio Perez-Martinez, Federico Gutierrez-Larraya, Antonio J. Carton, Jose Angel Garcia-Saenz, Ana Patino-Garcia, Miguel Martin, Teresa Alonso-Gordoa, Christof Vulsteke, Lieselot Croes, Sigrid Hatse, Thomas Van Brussel, Diether Lambrechts, Hans Wildiers, Hang Chang, Marina Holgado-Madruga, Anna Gonzalez-Neira, Pedro L. Sanchez, Jesu Perez Losada
Summary: Cardiotoxicity due to anthracyclines (CDA) affects cancer patients, and identifying individuals at risk is challenging. In this study, the authors investigated intermediate molecular phenotypes (IMPs) associated with myocardial damage to determine CDA susceptibility. By analyzing a mouse cohort treated with doxorubicin and docetaxel, they identified genetic markers linked to IMPs and CDA. These markers were also found to be associated with CDA in cancer patients, highlighting their potential as predictive factors. Additionally, genetic risk scores were generated using machine-learning regression to personalize patient management.
Article
Oncology
Xuanyu Mao, Yimeng Cai, Sarah Long, Jesus Perez-Losada, Jian-Hua Mao, Hang Chang
Summary: Increased mitotic activity is associated with the genesis and aggressiveness of many cancers. The mitotic network activity index (MNAI) constructed based on a 54-gene mitotic apparatus network has been evaluated as a potential prognostic biomarker in a pan-cancer study. The study confirmed the significant association of MNAI with overall survival, progression-free survival, and other prognostic endpoints in multiple cancer types, and also revealed its association with genetic instability and treatment response.
FRONTIERS IN ONCOLOGY
(2023)
Article
Microbiology
Kenneth H. H. Wan, Soo Park, Benjamin W. W. Booth, Ella C. C. Brydon, Joanne Eichenberger, Jamie L. L. Inman, Jian-Hua Mao, Antoine M. M. Snijders, Susan E. E. Celniker
Summary: Microbacterium sp. BDGP8 is a facultative anaerobic gram-positive bacterium belonging to the family Microbacteriaceae. Its complete genome consists of a single circular chromosome of 3,293,567 bp with a G + C content of 69.84% and two plasmids of 49,365 bp and 32,884 bp.
MICROBIOLOGY RESOURCE ANNOUNCEMENTS
(2023)