Article
Plant Sciences
Yufei Wang, Gang Wang, Yingping Liu, Fangyu Yang, Hongshuo Zhang, Ying Kong
Summary: This study found that icaritin can inhibit the proliferation, migration, and invasion of endometrial cancer cells by inhibiting aberrant O-GlcNAc modification of FOXC1. This finding provides important theoretical basis for the use of icaritin in the treatment of endometrial cancer.
Review
Immunology
Paul Stewart, Shivani Patel, Andrew Comer, Shafi Muneer, Uzma Nawaz, Violet Quann, Mira Bansal, Vishwanath Venketaraman
Summary: Historically, research on the immunologic response to M. tb infection has mainly focused on T cells and macrophages, disregarding the role of B cells. However, recent studies have shown that B cells play varying roles during different stages of mycobacterial infection. A better understanding of the role of B cells in defense against TB could contribute to the development of effective vaccines and therapies to reduce the burden of disease.
Article
Biochemistry & Molecular Biology
Jing Wang, Pupu Ge, Zehui Lei, Zhe Lu, Lihua Qiang, Qiyao Chai, Yong Zhang, Dongdong Zhao, Bingxi Li, Jiaqi Su, Ruchao Peng, Yu Pang, Yi Shi, Yu Zhang, George Fu Gao, Xiao-Bo Qiu, Cui Hua Liu
Summary: The study reveals that PknG acts as both a ubiquitin-activating enzyme and ligase, promoting the degradation of key components of the immune system and inhibiting NF-kappa B signaling, providing a potential target for tuberculosis treatment.
Article
Food Science & Technology
Tong-Tong Tang, Li Jiang, Qian Zhong, Zhi-Jing Ni, Kiran Thakur, Mohammad Rizwan Khan, Zhao -Jun Wei
Summary: Saikosaponin D (SSD) shows cytotoxicity and induces apoptosis in human endometrial cancer Ishikawa cells, while being non-toxic to normal human cells. It also inhibits cell migration and invasion, potentially through the MAPK cascade pathway. These findings suggest that SSD could be a natural secondary metabolite with potential benefits in preventing and treating endometrial carcinoma.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Article
Food Science & Technology
Yancui Liang, Qian Zhong, Runhui Ma, Zhijing Ni, Kiran Thakur, Jianguo Zhang, Zhaojun Wei
Summary: Apigenin, a natural flavonoid, has been found to inhibit the growth and spread of endometrial cancer cells by promoting autophagy and ferroptosis. It increases iron and lipid oxidation, depletes glutathione, and regulates the expression of relevant genes and proteins. Additionally, apigenin promotes autophagy by upregulating certain proteins and downregulating others. Finally, it inhibits tumor tissue proliferation and growth through ferroptosis.
FOOD SCIENCE AND HUMAN WELLNESS
(2023)
Article
Food Science & Technology
Lei Ye, Run-Hui Ma, Xiu-Xiu Zhang, Kiran Thakur, Jian-Guo Zhang, Mohammad Rizwan Khan, Rosa Busquets, Zhao-Jun Wei
Summary: Isorhamnetin has shown potential as a promising medicinal material for the treatment of endometrial cancer, as it can induce apoptosis and inhibit metastasis through multiple pathways.
Article
Immunology
Ying Luo, Ying Xue, Liyan Mao, Qun Lin, Guoxing Tang, Huijuan Song, Wei Liu, Shutao Tong, Hongyan Hou, Min Huang, Renren Ouyang, Feng Wang, Ziyong Sun
Summary: The study demonstrated that HLA-DR on MTB-specific cells is a potentially useful biomarker for accurately discriminating between ATB and LTBI individuals.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Microbiology
Yongwei Qin, Qinglan Wang, Jiahai Shi
Summary: The down-regulated expression of immune-activating receptors and enhanced expression of immune-inhibitory receptors play a role in chronic infectious diseases and cancer. However, the impact of Mycobacterium tuberculosis infection on the expression of immune checkpoint molecules on natural killer (NK) cells and their functions has been poorly studied. Understanding the function of NK cells during Mtb infection is crucial for a comprehensive understanding of the immune mechanism and evaluation of immunotherapies for treating tuberculosis.
MICROBIOLOGICAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Subhashree Subhasmita Nayak, Guneswar Sethi, Krishna Ramadas
Summary: Tuberculosis is a global airborne transmissible disease caused by Mycobacterium tuberculosis. The current vaccine, BCG, is ineffective in preventing adult pulmonary TB and latent tuberculosis. In this study, a new multi-epitope vaccine was designed using subtractive proteomics and immunoinformatics techniques. The designed vaccine showed promising binding modes with immunogenic receptors and demonstrated stability in molecular dynamics simulations. In silico cloning successfully expressed the designed vaccine, and immune simulation predicted a significant immune response. However, experimental validation in animal models is needed for effectiveness and safety.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Microbiology
Xi Chen, Xiaojian Cao, Yingying Lei, Aikebaier Reheman, Wei Zhou, Bing Yang, Weipan Zhang, Weize Xu, Shuang Dong, Rohit Tyagi, Zhen F. Fu, Gang Cao
Summary: Mycobacterium tuberculosis can inhibit lysosome acidification in certain cell lines, but in others, it is targeted to acidified phagolysosomes. The gene profile analysis identified the role of ITGB3 in promoting M. tuberculosis clearance in endothelial cells, suggesting a new defense mechanism against the pathogen.
Review
Biochemistry & Molecular Biology
Andre G. Loxton, Ilana C. van Rensburg
Summary: Tuberculosis is a major health crisis, with patients ranging from latent infection to active disease. B-cells play a significant role in TB by expressing regulatory functions, including FasL.
JOURNAL OF MOLECULAR BIOLOGY
(2021)
Article
Immunology
Mohammed Asaad, Md Kaisar Ali, M. A. Abo-kadoum, Nzungize Lambert, Zhen Gong, Hao Wang, Moure Uae, Stech A. E. Nazou, Zhongmei Kuang, Jianping Xie
Summary: PPE10 plays a significant role in host-pathogen interaction by enhancing Mycobacterium tuberculosis's resistance to stress conditions and regulating host cell apoptosis through the expression of apoptosis-related proteins. The study provides novel insights into the mechanism of action of the PPE gene family.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Immunology
Jing Wei, Fangzheng Guo, Yamin Song, Kun Xu, Feiyang Lin, Kangsheng Li, Baiqing Li, Zhongqing Qian, Xiaojing Wang, Hongtao Wang, Tao Xu
Summary: In this study, RNA sequencing of Mtb-Ag-stimulated and control samples identified differentially expressed genes related to immune function. These genes are primarily involved in cellular pathways associated with immune function, revealing the immune response mechanism triggered by Mtb-Ag stimulation.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Immunology
Ying Luo, Ying Xue, Guoxing Tang, Qun Lin, Huijuan Song, Wei Liu, Botao Yin, Jin Huang, Wei Wei, Liyan Mao, Feng Wang, Ziyong Sun
Summary: The combination of HLA-DR on MTB-specific cells and TBAg/PHA ratio can effectively discriminate between active TB and latent TB infection, with a high accuracy rate of 93.7%.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Jane Alexandra Shaw, Stephanus T. Malherbe, Gerhard Walzl, Nelita du Plessis
Summary: Epidemiologic data indicate that both current and previous tuberculosis (TB) increase the risk of in-hospital mortality from COVID-19, and a similar trend is observed for poor outcomes from Mtb infection after recent SARS-CoV-2. Dysregulation of immunity explains the dual risk posed by co-infection, with a dysfunctional innate immune response observed in COVID-19. Myeloid-derived suppressor cells (MDSC) play a crucial role in this process by becoming immunosuppressive and impairing pathogen clearance. MDSC are enriched in severe COVID-19 patients and are associated with higher levels of inflammatory cytokines.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Meenu Subrahmanian, Jeya Marimuthu, Thiagarajan Sairam, Ramalingam Sankaran
BIOTECHNOLOGY LETTERS
(2020)
Article
Toxicology
Ankit Choraria, Rajeswari Somasundaram, Mrinmoy Gautam, Muthiah Ramanathan, Bilal Ahmad Paray, Mohammad K. Al-Sadoon, A. Michael
Summary: In this study, antibodies against the venoms of Daboia russelii and Echis carinatus snakes were generated and compared with commercial antivenom. The results showed that the generated antivenoms effectively neutralized the injected venoms, suggesting the potential for further screening and evaluation of IgY antivenoms.
Article
Biochemistry & Molecular Biology
S. Meenu, B. Pradeep, Sudha Ramalingam, Thiagarajan Sairam, Reena Rai, Ramalingam Sankaran
MOLECULAR BIOLOGY REPORTS
(2020)
Article
Environmental Sciences
R. Narayanan, S. Muthusamy, S. Lakshmi, K. Ramaraju, G. Balasubramaniam, R. Sankaran
Summary: The development of whole-body inhalational chambers for rodent acute toxicity risk assessment is crucial for clinical and occupational hazard evaluations. The study aimed to design and validate an inhalational chamber for risk assessment of Aroclor 1232, showing reproducibility of behavioral scores and deriving a benchmark dose for further studies. The chamber can be used to assess occupational hazards and mixtures of pollutants, maintaining acceptable environmental parameters for rodents during experimental procedures.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL SCIENCE AND TECHNOLOGY
(2022)
Review
Toxicology
Ankit Choraria, Rajeswari Somasundaram, S. Janani, Selvakumar Rajendran, Naoual Oukkache, A. Michael
Summary: Research has shown that chicken egg yolk (IgY) antibodies have the potential to be used as an alternative to mammalian antibodies for treating snakebites. There is currently a debate surrounding the use of IgY in snakebite therapy.
Article
Genetics & Heredity
Pratul Kumar Jain, Shashank Jayappa, Thiagarajan Sairam, Anupam Mittal, Sayan Paul, Vinay J. Rao, Harshil Chittora, Deepak K. Kashyap, Dasaradhi Palakodeti, Kumarasamy Thangaraj, Jayaprakash Shenthar, Rakesh Koranchery, Ranjith Rajendran, Haghighi Alireza, Kurukkanparampil Sreedharan Mohanan, Andiappan Rathinavel, Perundurai S. Dhandapany
Summary: This study identified variants in the S6K1 gene associated with HCM and showed a gain-of-function effect of mutated proteins in cellular models. Early detection of S6K1 variant carriers can help identify family members at risk and implement preventive measures. Further screening in patients with HCM of different ethnic populations will establish the specificity and frequency of S6K1 gene variants.
JOURNAL OF MEDICAL GENETICS
(2022)
Review
Biotechnology & Applied Microbiology
Xiaoying Zhang, Brindha Chelliappan, Michael Antonysamy, S. Rajeswari
Summary: Eggs are a highly nutritious food with various pharmacological properties and industrial applications, playing an important role in disease prevention and treatment.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Pediatrics
Bharathi Elangovan, N. T. Rajesh, Meenu Subrahmanian
Summary: This study aimed to investigate APOE gene polymorphism and lipid profile in IUGR and AGA neonates, showing a lower frequency of the ε4 allele in the IUGR group and no increase in the ε4 allele associated with adult-onset diseases. Neonates with the ε4 allele exhibited abnormal lipid profiles in both groups, suggesting a possible association.
JOURNAL OF PEDIATRIC GENETICS
(2022)
Article
Medicine, General & Internal
Volga Harikrishnan, Shantha Kumari, Subramaniam Ramkumar, Ramalingam Sankaran, Sudha Ramalingam, Thiagarajan Sairam
Summary: The study aimed to assess the incidence of the BRAF V600E mutation in thyroid neoplasms at a tertiary care center and its association with various phenotypic features. Results showed that in the cases, 31% of papillary thyroid carcinoma (PTC) and 18.72% of follicular neoplasms expressed the BRAF V600E mutation, displaying characteristic nuclear features.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2021)
Article
Zoology
Shikun Ge, Yanli Yang, Brindha Chelliappan, Antonysamy Michael, Fagang Zhong, Xiaoying Zhang
PAKISTAN JOURNAL OF ZOOLOGY
(2020)
Article
Obstetrics & Gynecology
S. Meenu, Sudha Ramalingam, Thiagarajan Sairam, Arati Appinabhavi, Seetha Panicker, Seema Oommen, Ramalingam Sankaran
JOURNAL OF OBSTETRICS AND GYNECOLOGY OF INDIA
(2020)