Article
Biochemistry & Molecular Biology
Deblina Roy, Mohammad Anas, Ashan Manhas, Satyen Saha, Niti Kumar, Gautam Panda
Summary: In this study, a series of quinoline-imidazole hybrid compounds were synthesized and evaluated for their blood-stage antimalarial activity against Plasmodium falciparum. The results showed that one of the compounds exhibited significant antimalarial efficacy with low cytotoxicity and high selectivity. Furthermore, the study revealed the influence of substituents on the quinoline ring and the role of stereochemistry in the inhibitory activity.
BIOORGANIC CHEMISTRY
(2022)
Article
Chemistry, Physical
Gokay Cetiner, Ulviye Acar Cevik, Ismail Celik, Hayrani Eren Bostanci, Yusuf Ozkay, Zafer Asim Kaplancikli
Summary: In this study, a series of imidazole derivatives were synthesized and evaluated for their biological activity against MCF7 breast cancer cells. The compounds showed higher efficacy than the reference drug cisplatin and exhibited low toxicity on L929 fibroblast cells, indicating good selectivity. Moreover, the compounds demonstrated similar effects to the reference drug letrozole on both MCF7 cells and aromatase enzyme. Molecular docking analysis further revealed their potential as non-steroidal aromatase inhibitors. Additionally, computational ADME-Tox studies suggested favorable drug profiles for these compounds.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Biochemistry & Molecular Biology
R. Reshma, R. Selwin Joseyphus, D. Arish, R. Jaya Reshmi Jaya, J. Johnson
Summary: A novel Schiff base was synthesized by condensation of imidazole-2-carboxaldehyde with l-histidine, which was then complexed with a series of 3-d metal(II) ions. The complexes exhibited excellent antibacterial and antifungal activities in vitro, with electronic spectra and magnetic moment data indicating an octahedral geometry for most complexes.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2022)
Article
Crystallography
Abdulrahman A. A. Almehizia, Mohamed A. A. Al-Omar, Ahmed M. M. Naglah, Mashooq A. A. Bhat, Razan Eskandrani, Fatimah A. A. Alotaibi, Moamen S. S. Refat, Abdel Majid A. Adam
Summary: Lomefloxacin (F1) and pefloxacin (F2) form metal-based complexes with Mg(II), Ca(II), Zn(II), and Fe(III) metal ions, which exhibit broad spectrum antimicrobial activities. The complexes were characterized using various physicochemical methods and their structures were determined. The Fe(III)-F1 complex showed remarkable inhibitory activity against gram-positive and gram-negative bacterial and fungal species.
Article
Chemistry, Inorganic & Nuclear
Haseeba Sadaf, Imtiaz-ud-Din, Mohammed Fettouhi, Wiktor Zierkiewicz, Mariusz Michalczyk, Ihsan-ul-Haq, Tayyaba Ahmad, Saeed Ahmad
Summary: Six palladium(II) complexes containing 2-phenylimidazole and 1,2-dimethylimidazole were synthesized and characterized in this study. The crystal structure of one of the complexes was determined. DFT calculations were used to predict the structures of the complexes. The complexes exhibited moderate antimicrobial activities and excellent anti-diabetic effects, but were not effective as antioxidants.
Article
Chemistry, Physical
Hong-Ru Dong, Jian-Guo Wu, Guo-Yong Huo
Summary: A series of new triazole compounds were designed and synthesized, and characterized in this study. The experimental results showed that one of the compounds exhibited weaker inhibitory activity against HIV-1 protease and relatively weaker antimicrobial activity.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Polymer Science
Kunxiang Shi, Yucai Shen, Yunxu Yang, Tingwei Wang
Summary: A series of latent curing agents were developed by replacing the hydrogen atom on secondary amine in imidazole with methoxy polyethylene glycol maleate diesters via Michael addition reaction. These modified systems showed good latent properties and could cure quickly at high temperatures, while remaining stable over long periods of time.
JOURNAL OF APPLIED POLYMER SCIENCE
(2021)
Article
Chemistry, Physical
Salem El -t. Ashoor, Rania A. Abokhater, Lotfi Belkhiri, Suad Abd. Gadir
Summary: This study presents experimental and computational investigations into the molecular structure and spectroscopic assignments of chromium (III) complexes. Two complexes, [Cr (GLU) (HQ)] and [Cr (FRU) (QH)], were synthesized and their possible structures were determined based on elemental and mass analyses. Powder X-ray diffraction (XRD) provided information on the molecular structures. UV-Vis techniques were used to examine the complexes' spectroscopic properties. Theoretical calculations were performed to determine the geometric parameters and vibrational assignments.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Chemistry, Inorganic & Nuclear
Soumyadip Patra, Hemanta Deka, Sanjay K. Singh
Summary: A series of half sandwich arene-ruthenium complexes containing bis-imidazole methane-based ligands were synthesized and tested for hydrogen production from formic acid in aqueous medium. Among the complexes investigated, Ru(II) coordinated with a 4-methoxyphenyl substituted bis-imidazole methane ligand exhibited the highest catalytic turnover and efficiency for formic acid dehydrogenation in water.
INORGANIC CHEMISTRY
(2021)
Article
Chemistry, Physical
Michael Tapera, Emin Saripinar, Hueseyin Kekecmuhammed, Murat Dogan, Burak Tuezuen, Uemit M. Kocyigit, Feyza Nur Cetin
Summary: A series of compounds containing imidazole and hydrazone structural frameworks were synthesized and evaluated as antiproliferative agents and inhibitors of human carbonic anhydrase. Some of these compounds showed remarkable antiproliferative activity, low cytotoxicity to healthy cells, and significant inhibition of the target enzymes. The results of computational studies and molecular docking provided insights into the binding modes and reactive sites of the compounds. In silico predictions suggested that these compounds have good oral bioavailability.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Optics
Aziza Sarwar, Siti Munirah Saharin, Hadariah Bahron, Yatimah Alias
Summary: A set of three novel dinuclear Ir(III) azomethine complexes were successfully synthesized and characterized in this study, showing significant photoluminescence activities and promising potential in antibacterial applications.
JOURNAL OF LUMINESCENCE
(2021)
Article
Chemistry, Medicinal
Lima Rodrigues, Santosh G. Tilve, Mahesh S. Majik
Summary: Thiolane-based bioactive organic compounds, inspired by bioactive natural products, exhibit a variety of astonishing biological activities, making them excellent candidates for drug discovery. This review highlights the development of important thiolane-based therapeutics and aims to inspire chemists and biochemists to take up the challenges in synthesizing and developing thiolane-based drugs.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Ceyhun Kucuk, Senay Yurdakul, Belgin Erdem
Summary: This study analyzed the vibrational wavenumbers and molecular orbital energy values of 1-(4-methoxyphenyl)-1H-imidazole using FT-IR, Raman, and DFT calculations. The stability and reactivity of the molecule were determined based on the HOMO-LUMO energy gap. The compound showed significant antibacterial activity and exhibited important nonlinear optical properties.
Article
Chemistry, Organic
Jamelah S. Al-Otaibi, Y. Sheena Mary, Renjith Thomas, B. Narayana
Summary: In this study, four compounds were synthesized and their vibrational wavenumbers and electronic properties were investigated. These compounds showed good light absorption properties in dye-sensitized solar cells and exhibited promising nonlinear optical activity. Molecular docking experiments revealed that these compounds may serve as potential candidates for anticancer drugs.
POLYCYCLIC AROMATIC COMPOUNDS
(2022)
Article
Biochemistry & Molecular Biology
Huseyin Kekecmuhammed, Michael Tapera, Ekrem Aydogdu, Emin Saripinar, Elanur Aydin Karatas, Eda Mehtap Uc, Mesut Akyuz, Burak Tuzun, Ilhami Gulcin, Rifat Emin Bora, Ilhan Ozer Ilhan
Summary: A new series of hybrid compounds incorporating imidazole ring and hydrazone moiety were synthesized and their structures were determined using various spectral techniques. Some of these compounds showed significant anticancer and carbonic anhydrase inhibitory activity. The drug-likeness qualities of these bioactive molecules were calculated and their drug properties were examined using ADME/T analysis.
CHEMISTRY & BIODIVERSITY
(2023)
Article
Chemistry, Inorganic & Nuclear
Amina A. Soayed
INORGANICA CHIMICA ACTA
(2015)
Article
Chemistry, Physical
Amina A. Soayed, Amel F. El-Husseiny
JOURNAL OF MOLECULAR LIQUIDS
(2015)
Article
Chemistry, Multidisciplinary
Amina A. Soayed, Heba M. Refaat, Leena Sinha
JOURNAL OF SAUDI CHEMICAL SOCIETY
(2015)
Article
Crystallography
Mohamed A. Makhyoun, Rex A. Palmer, Amina A. Soayed, Heba M. Refaat, Dina E. Basher
JOURNAL OF CHEMICAL CRYSTALLOGRAPHY
(2016)
Article
Chemistry, Multidisciplinary
Mamdouh S. Masoud, Ahmed M. Ramadan, Amina A. Soayed, Sherif M. S. Ammar
JOURNAL OF THE IRANIAN CHEMICAL SOCIETY
(2016)
Article
Thermodynamics
Mamdouh S. Masoud, Ahmed M. Hindawy, Amina A. Soayed, Marwa Y. Abd El-Kaway
FLUID PHASE EQUILIBRIA
(2011)
Article
Chemistry, Inorganic & Nuclear
Amina A. Soayed, Heba M. Refaat, Doaa A. Noor El-Din
INORGANICA CHIMICA ACTA
(2013)
Article
Chemistry, Analytical
Mamdouh S. Masoud, Amina A. Soayed, Ahmed S. Elkholany
JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
(2012)
Article
Spectroscopy
Mamdouh S. Masoud, Marwa Y. Abd El-Kaway, Ahmed M. Hindawy, Amina A. Soayed
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2012)
Article
Spectroscopy
Mamdouh S. Masoud, Amina A. Soayed, Amel F. El-Husseiny
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2012)
Article
Chemistry, Multidisciplinary
Amina A. Soayed, Heba M. Refaat
JOURNAL OF THE CHILEAN CHEMICAL SOCIETY
(2013)
Article
Spectroscopy
MS Masoud, AA Soayed, AE Ali
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2004)
Article
Chemistry, Analytical
ME Mahmoud, AA Soayed, OF Hafez
Article
Chemistry, Inorganic & Nuclear
MS Masoud, AA Soayed, AE Ali, OK Sharsherh
JOURNAL OF COORDINATION CHEMISTRY
(2003)
Article
Chemistry, Inorganic & Nuclear
Angela Lis, Viorica Gladchi, Gheorghe Duca, Sergey Travin
Summary: This work presents studies on the photochemical transformations of TU and Cys with the addition of Cu(II) or Fe(III) ions. The results show that the oxidation rate of the thiols increases significantly when Cu(II) or Fe(III) ions are added to the system. It has also been found that TU and Cys can form stable complex compounds with the studied metal ions. The oxidation rates of the thiols are found to depend on the radiation intensity and emission spectrum of the irradiation sources.
INORGANICA CHIMICA ACTA
(2024)
Article
Chemistry, Inorganic & Nuclear
Cristiane F. A. Teixeira, Estefane I. Teixeira, J. P. C. Nascimento, M. Amilcar Junior, L. M. C. Pinto, Anderson R. L. Caires, G. B. Alcantara, Ana C. Micheletti, Victor M. Deflon, Davi F. Back, Heveline Silva, Lucas Pizzuti, Gleison Antonio Casagrande
Summary: Novel binuclear heteroleptic copper(I) complexes based on mixed DPPE/thiocarbamoyl-pyrazoline ligands were synthesized and structurally characterized. These complexes exhibited similar structural behavior around the Copper(I) atoms and showed promising antimicrobial and anticancer activities.
INORGANICA CHIMICA ACTA
(2024)
Article
Chemistry, Inorganic & Nuclear
Chen Chen, Li Liu, Xin-Xin Zhong, Fa-Bao Li, Hai-Mei Qin
Summary: Thermally activated delayed fluorescent (TADF) Cu(I) halide complexes with short lifetimes and intense emissions were synthesized and characterized. These complexes exhibit intense green to yellow-green delayed fluorescence and are suitable for OLED devices.
INORGANICA CHIMICA ACTA
(2024)
Article
Chemistry, Inorganic & Nuclear
Tian-Yu Zhang, Xue-Qian Wu, Heng-Yu Ruan, Yi Yuan, Le Wang, Ya-Pan Wu, Qing-Wen Han, Ruan Chi, Dong-Sheng Li
Summary: In this study, a novel Ni(II)-based metal-organic framework with good electrocatalytic oxidation performance was successfully synthesized, showing potential for direct alcohol fuel cells.
INORGANICA CHIMICA ACTA
(2024)
Article
Chemistry, Inorganic & Nuclear
Susanta Das Baishnab, R. N. Dutta Purkayastha, Waldemar Maniukiewicz, Rosa M. Gomila, Antonio Frontera
Summary: The synthesis, structure, and DNA binding ability of three decavanadate complexes containing cationic organic moieties were reported. The complexes were characterized by various techniques and their solid-state structures were analyzed. The complexes showed interesting assembly patterns and exhibited moderately strong intercalative binding with CTDNA. Additionally, their micellization behavior in the presence of the surfactant CTAB was studied.
INORGANICA CHIMICA ACTA
(2024)
Review
Chemistry, Inorganic & Nuclear
Jubaraj B. Baruah
Summary: Isomorphous series are generated by replacing atoms or molecules to form materials with similar compositions. They allow modulation of structure and properties, and generate equivalent compositions with novel material properties. The study of stereo-electronic aspects of different equivalent compositions can improve the utility of the original composition.
INORGANICA CHIMICA ACTA
(2024)
Article
Chemistry, Inorganic & Nuclear
Kamelah S. Al-Rashdi, Bandar A. Babgi, Ehab M. M. Ali, Bambar Davaasuren, Abdul-Hamid M. Emwas, Mariusz Jaremko, Mark G. Humphrey, Mostafa A. Hussien
Summary: Tridentate ligands were used to synthesize a set of palladium complexes, which were characterized and found to have DNA and BSA binding abilities. The complexes also showed differences in anticancer activities.
INORGANICA CHIMICA ACTA
(2024)
Article
Chemistry, Inorganic & Nuclear
Diane Isaacs, Chandler Cox, Mark A. Bezpalko, W. Scott Kassel, William G. Dougherty
Summary: The structure and electrochemical properties of zinc(II) complexes with a face-capping ligand have been investigated, revealing the effect of the ligand on bound semiquinonate (SQ) radicals. The substitution pattern of the SQ ring plays a crucial role in determining the fate of the bound SQ radicals. Additionally, the protective pocket formed by the ligand's phenyl substituents is unable to prevent decomposition of SQ radicals with minimal steric bulk, suggesting that substitution of the SQ ring is the main contributor to their stabilization.
INORGANICA CHIMICA ACTA
(2024)
Article
Chemistry, Inorganic & Nuclear
Xingliang Chen, Zhiqiang Jiang
Summary: Here, a series of zinc tetrahedral tetrazolate frameworks (Zn-TTFs) are presented, and it is demonstrated that rotation of carboxyl group can generate structural diversity. Compound 3 exhibits a unique zeolite-like structure, while compound 4 shows both super acid and alkali resistance.
INORGANICA CHIMICA ACTA
(2024)
Article
Chemistry, Inorganic & Nuclear
Ankita Puri, Allison Mcaninch, Sheng Shu, Khashayar Rajabimoghadam, Maxime A. Siegler, Marcel Swart, Isaac Garcia-Bosch
Summary: In this article, the synthesis and characterization of copper, nickel, and palladium complexes bound by bidentate ligands derived from ortho-phenylenediamine are described. The complexes contain tunable H-bond donors and their crystal structures reveal intramolecular H-bonding interactions between the ligand scaffolds. Variations in the coordination sphere led to the isolation of the complexes in square-planar or twisted pseudo-tetrahedral geometries. Structural analysis showed that intramolecular H-bonding interactions can be altered by disrupting the bonds between countercations, solvent of crystallization, and ligand scaffold, resulting in changes in the geometry of the complexes. DFT calculations confirmed that Cu complexes prefer twisted geometries while Ni and Pd complexes favor square-planar geometries.
INORGANICA CHIMICA ACTA
(2024)
Article
Chemistry, Inorganic & Nuclear
Laiane dos Santos Oliveira, Pedro Henrique de Souza Guarda, Leticia Bazilio Rosa, Gustavo Clauss Rodrigues, Daniele Daiane Affonso, Joao Ernesto de Carvalho, Igor Andrade Santos, Mark Harris, Douglas Hideki Nakahata, Jose Ricardo Sabino, Danilo Ciccone Miguel, Ana Lucia Tasca Gois Ruiz, Ana Carolina Gomes Jardim, Camilla Abbehausen
Summary: Chalcones are chemical precursors of flavonoids that have various biological properties. In this study, novel copper(II)-2'-hydroxy-4-benzyloxychalcone complexes were synthesized and evaluated for their antileishmanial, antiproliferative, and antiviral activities. The results demonstrated that these complexes showed potential effects against tumor cells, leishmania parasites, and SARS-CoV-2 virus. The study also highlighted the influence of ligand structure on biological activity.
INORGANICA CHIMICA ACTA
(2024)
Review
Chemistry, Inorganic & Nuclear
Archana Thakur, Harpreet Kaur, Vishal Tyagi
Summary: This review article discusses the findings of research on the 13C NMR spectra of di- and tri-butyltin carboxylates, highlighting the importance of 13C NMR chemical shifts in determining the chemical surroundings of carbon nuclei and their role in structure elucidation.
INORGANICA CHIMICA ACTA
(2024)
Article
Chemistry, Inorganic & Nuclear
Qiang Zhao, Qi-Yang Li, Zhi Shen, Guo Zang, Wen-Jun Lv
Summary: In this study, five metal complexes were synthesized using a solvothermal reaction and their structures were analyzed by single crystal X-ray diffraction. Fluorescence and magnetic properties of some complexes were also investigated.
INORGANICA CHIMICA ACTA
(2024)
Article
Chemistry, Inorganic & Nuclear
Jeremy Erb, Darcy Setter, Jake Swavey, Frederick Willits, Shawn Swavey
Summary: Three BODIPY-Ru(II) complexes were synthesized by coordinating [Ru(bpy)2Cl]+ complexes to BODIPY ligands. The spectroscopic and electrochemical properties of the complexes were characterized. The complexes exhibited intense absorption peaks due to the pi pi* transitions localized on the BODIPY core, and additional charge transfer transitions associated with the metal center. The complexes showed significant singlet oxygen generation and were able to induce photo-nicking of DNA.
INORGANICA CHIMICA ACTA
(2024)
Article
Chemistry, Inorganic & Nuclear
Sahin Reja, Dilip Sarkar, Kaushik Sarkar, Deboshmita Mukherjee, T. K. S. Fayaz, Palash Sanphui, Rajesh Kumar Das
Summary: A promising bioinspired metallocatalyst has been produced and characterized, showing high catalytic activity in oxygen dependant enzymatic radical pathway. The catalyst also exhibits inter and intra molecular H-bonding and C-H-pi interactions.
INORGANICA CHIMICA ACTA
(2024)