Article
Chemistry, Inorganic & Nuclear
Shaista Ramzan, Shaukat Shujah, Katherine B. Holt, Zia-ur Rehman, Syed Tasleem Hussain, Jeremy Karl Cockcroft, Naila Malkani, Niaz Muhammad, Aneela Kauser
Summary: Five new organotin(IV) complexes were synthesized and their structures were determined by FT-IR, 1H-NMR, 13C-NMR spectroscopy and single-crystal X-ray analysis. DNA interaction studies indicated an intercalative mode of interaction between the complexes and SS-DNA. The complexes exhibited significant cytotoxic activity against human breast cancer cell line MDA-MB-231.
JOURNAL OF ORGANOMETALLIC CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Qiang Guo, Ru-Fen Zhang, Xue-Wen Hua, Qian-Li Li, Xiu-Mei Du, Jing Ru, Chun-Lin Ma
Summary: Four organotin(IV) complexes were synthesized and evaluated for their cytostatic and antifungal activities. The results showed that two complexes exhibited high cytostatic and antifungal activities. Morphological and ultrastructural studies indicated that one of the complexes may act on the vacuoles of cells and ultimately lead to cell death.
NEW JOURNAL OF CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Karol Sikora, Marta Bauer, Sylwia Bartoszewska, Damian Neubauer, Wojciech Kamysz
Summary: This study investigates the effect of glycosylation on the biological activity of ultrashort cationic lipopeptides (USCLs). It shows that glycosylation does not necessarily enhance antimicrobial activity or decrease hemolytic and cytotoxic activities, but in some cases, glycosylated USCLs (gUSCLs) exhibit superior activity compared to their unmodified counterparts (USCLs).
Article
Chemistry, Inorganic & Nuclear
Sushree Aradhana Patra, Gurunath Sahu, Deepika Mohapatra, Pratikshya Das Pattanayak, Rupam Dinda
Summary: Three luminescent mixed ligand diorganotin(IV) complexes were synthesized and characterized. The complexes exhibited stability in aqueous/biological media and showed interaction with DNA and bovine serum albumin. They also demonstrated cytotoxic potential against cancer cells and induced apoptosis.
Article
Chemistry, Inorganic & Nuclear
Naresh Kumar, Sonika Asija, Yogesh Deswal, Deepak Kumar, Deepak Kumar Jindal, Lokender Kumar, Sandeep Kumar, Jai Devi
Summary: In this study, a series of diorganotin(IV) complexes with the general formula R2SnL1-4 were synthesized by reacting R2SnCl2 (R = Me, Et, Bu, and Ph) with hydrazone ligands (H2L1-4). Various analytical techniques were used to determine the structures of the synthesized compounds. The compounds showed better antimicrobial activity than the free ligands, with complexes 8, 12, and 20 exhibiting the highest activity. Additionally, the synthesized compounds showed significant anticancer activity against three cancer cell lines, with complexes 5, 6, and 8 being the most active.
INORGANIC CHEMISTRY COMMUNICATIONS
(2023)
Article
Chemistry, Medicinal
Liuliu Zheng, Tingting Gao, Zhiwei Ge, Zhongjun Ma, Jinzhong Xu, Wanjing Ding, Li Shen
Summary: A series of glycosylated derivatives of lamellarin D were designed and synthesized, showing potent inhibition of human Topo I activity and anticancer effects. Among them, ZL-3 exhibited the best activity with IC50 values of 3 nM, 10 nM, and 15 nM against different cancer cell lines, demonstrating the potential of glycosylation as a strategy to optimize lamellarin D derivatives as anticancer agents.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Pharmacology & Pharmacy
Anife Ahmedova, Rositsa Mihaylova, Silviya Stoykova, Veronika Mihaylova, Nikola Burdzhiev, Viktoria Elincheva, Georgi Momekov, Denitsa Momekova
Summary: Pt(IV) complexes formed by linking pyrene butyric acid with cisplatin exhibit high anticancer potency against leukemia cells and multidrug-resistant derivatives, while showing low toxicity to healthy cells. The larger bis-pyrene complex is found to potentially be trapped in the cytoskeleton, limiting its cytotoxicity to adherent cells.
Article
Pharmacology & Pharmacy
Aleen Khoury, Jennette A. Sakoff, Jayne Gilbert, Kieran F. Scott, Shawan Karan, Christopher P. Gordon, Janice R. Aldrich-Wright
Summary: Platinum(IV) prodrugs showed outstanding activity against various cancer cell lines, with nanomolar activities observed. Cellular accumulation of the complexes was correlated with increased cytotoxicity. COX inhibition or lipophilicity did not solely determine the cytotoxicity of these prodrugs.
Article
Biochemistry & Molecular Biology
Joanna Palion-Gazda, Andre Luz, Luis R. Raposo, Katarzyna Choroba, Jacek E. Nycz, Alina Bienko, Agnieszka Lewinska, Karol Erfurt, Pedro V. Baptista, Barbara Machura, Alexandra R. Fernandes, Lidia S. Shul'pina, Nikolay S. Ikonnikov, Georgiy B. Shul'pin
Summary: Methyl-substituted 8-hydroxyquinolines were used to synthesize five-coordinated oxovanadium(IV) complexes, which showed high catalytic activity in the oxidation of hydrocarbons with H2O2 in acetonitrile. The reaction led to the formation of cyclohexyl hydroperoxide, cyclohexanol, and cyclohexanone. Complexes 1 and 2 exhibited cytotoxic effects on colorectal and ovarian carcinoma cell lines, while complex 3 showed higher cytotoxicity in colorectal carcinoma cells, lower cytotoxicity in normal dermal fibroblasts, and no effect in ovarian carcinoma cells.
Article
Chemistry, Inorganic & Nuclear
Tushar S. Basu Baul, M. F. atima C. Guedes da Silva, Maheswara Rao Addepalli, Bietlaichhai Hlychho, Antonin Lycka, Praseeda Vamadevan, Shashank Saurav, Sunil K. Manna
Summary: This study expands an attractive coordination chemistry scaffold by introducing alkyl groups of different steric hindrance into O,N,S-tris-chelating ligands. Six novel compounds were synthesized and characterized, and their properties were evaluated through NMR analysis and cell experiments. Compounds 4-6 demonstrated good cytotoxic activity in human histiocytic lymphoma U-937 cells.
INORGANICA CHIMICA ACTA
(2022)
Article
Biochemistry & Molecular Biology
Adriana Corina Hangan, Roxana Liana Lucaciu, Alexandru Turza, Lucia Dican, Bogdan Sevastre, Emoeke Pall, Luminita Simona Oprean, Gheorghe Borodi
Summary: The discovery of new non-toxic metal complexes with biological activity is an active area of research. Two Cu+2 complexes with new ligands were synthesized and characterized by X-ray crystallography. Both complexes showed in vitro biological activities, with complex C2 being more active. The complexes exhibited distorted square pyramidal square-planar geometries and were characterized by FT-IR and UV-Vis spectroscopy. The antibacterial activity of the complexes against four Gram-positive and two Gram-negative bacteria was determined using the microdilution method, and cytotoxicity studies were carried out on tumor cell lines and a normal cell line. Flow cytometric assessment of apoptosis induced by the complexes was also performed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Medicinal
Cao Van Anh, Jong Soon Kang, Hwa-Sun Lee, Phan Thi Hoai Trinh, Chang-Su Heo, Hee Jae Shin
Summary: In this study, three new glycosylated secondary metabolites and three known compounds were isolated from two marine-derived bacterial strains. The structures of the new compounds were determined through extensive analysis and comparison of their spectroscopic data. The cytotoxicity assay showed that one of the new compounds exhibited moderate activity against multiple cancer cell lines.
Article
Biochemistry & Molecular Biology
Wujiu Jiang, Qiqi Qin, Xiyuan Xiao, Yuxing Tan
Summary: In this study, eight new diorganotin(IV) complexes were synthesized and their structures were characterized. The antiproliferative activity of the complexes was tested, and complex 1c showed stronger antitumor activity, inducing cell apoptosis and DNA damage.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Naresh Kumar, Sonika Asija, Yogesh Deswal, Sonia Saroya, Ashwani Kumar
Summary: The present study synthesized new diorganotin(IV) complexes and found that the Ph2SnL1 complex exhibited the most active antimicrobial activity against microbes. Additionally, molecular docking study showed that compound Ph2SnL1 effectively inhibits microbes and could be a potential candidate for treating various infections.
RESEARCH ON CHEMICAL INTERMEDIATES
(2022)
Article
Chemistry, Multidisciplinary
Pinki Barwa, Sonika Asija, Yogesh Deswal, Naresh Kumar, Ashwani Kumar, Jai Devi
Summary: In this study, sixteen new diorganotin(IV) complexes were synthesized and characterized. The synthesized compounds exhibited good antioxidant and antimicrobial activities, with complex 20 being the most effective against Escherichia coli and Candida albicans. Molecular docking studies were performed to investigate the binding modes of complex 20 in the active sites of enzymes, and in silico studies suggested that the compounds have the potential to be used as orally active drugs.
RESEARCH ON CHEMICAL INTERMEDIATES
(2023)
Article
Chemistry, Multidisciplinary
Shipra Yadav, Imtiyaz Yousuf, Mohammad Usman, Musheer Ahmad, Farukh Arjmanda, Sartaj Tabassum
Article
Chemistry, Inorganic & Nuclear
Said S. Al-Jaroudi, Muhammad Altaf, Adam A. Seliman, Shipra Yadav, Farukh Arjmand, Ali Alhoshani, Hesham M. Korashy, Saeed Ahmad, Anvarhusein A. Isab
INORGANICA CHIMICA ACTA
(2017)
Article
Chemistry, Inorganic & Nuclear
Rais Ahmad Khan, Shipra Yadav, Zahid Hussain, Farukh Arjmand, Sartaj Tabassum
DALTON TRANSACTIONS
(2014)
Article
Chemistry, Inorganic & Nuclear
Sartaj Tabassum, Shipra Yadav
INORGANICA CHIMICA ACTA
(2014)
Article
Biochemistry & Molecular Biology
Shipra Yadav, Jai Deo Singh
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2019)
Article
Chemistry, Inorganic & Nuclear
Sartaj Tabassum, Shipra Yadav, Farukh Arjmand
JOURNAL OF ORGANOMETALLIC CHEMISTRY
(2013)
Article
Chemistry, Inorganic & Nuclear
Sartaj Tabassum, Shipra Yadav, Iqbal Ahmad
JOURNAL OF ORGANOMETALLIC CHEMISTRY
(2014)
Article
Biochemistry & Molecular Biology
Manal Shamsi, Shipra Yadav, Farukh Arjmand
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
(2014)
Article
Chemistry, Inorganic & Nuclear
Angela Lis, Viorica Gladchi, Gheorghe Duca, Sergey Travin
Summary: This work presents studies on the photochemical transformations of TU and Cys with the addition of Cu(II) or Fe(III) ions. The results show that the oxidation rate of the thiols increases significantly when Cu(II) or Fe(III) ions are added to the system. It has also been found that TU and Cys can form stable complex compounds with the studied metal ions. The oxidation rates of the thiols are found to depend on the radiation intensity and emission spectrum of the irradiation sources.
INORGANICA CHIMICA ACTA
(2024)
Article
Chemistry, Inorganic & Nuclear
Cristiane F. A. Teixeira, Estefane I. Teixeira, J. P. C. Nascimento, M. Amilcar Junior, L. M. C. Pinto, Anderson R. L. Caires, G. B. Alcantara, Ana C. Micheletti, Victor M. Deflon, Davi F. Back, Heveline Silva, Lucas Pizzuti, Gleison Antonio Casagrande
Summary: Novel binuclear heteroleptic copper(I) complexes based on mixed DPPE/thiocarbamoyl-pyrazoline ligands were synthesized and structurally characterized. These complexes exhibited similar structural behavior around the Copper(I) atoms and showed promising antimicrobial and anticancer activities.
INORGANICA CHIMICA ACTA
(2024)
Article
Chemistry, Inorganic & Nuclear
Chen Chen, Li Liu, Xin-Xin Zhong, Fa-Bao Li, Hai-Mei Qin
Summary: Thermally activated delayed fluorescent (TADF) Cu(I) halide complexes with short lifetimes and intense emissions were synthesized and characterized. These complexes exhibit intense green to yellow-green delayed fluorescence and are suitable for OLED devices.
INORGANICA CHIMICA ACTA
(2024)
Article
Chemistry, Inorganic & Nuclear
Tian-Yu Zhang, Xue-Qian Wu, Heng-Yu Ruan, Yi Yuan, Le Wang, Ya-Pan Wu, Qing-Wen Han, Ruan Chi, Dong-Sheng Li
Summary: In this study, a novel Ni(II)-based metal-organic framework with good electrocatalytic oxidation performance was successfully synthesized, showing potential for direct alcohol fuel cells.
INORGANICA CHIMICA ACTA
(2024)
Article
Chemistry, Inorganic & Nuclear
Susanta Das Baishnab, R. N. Dutta Purkayastha, Waldemar Maniukiewicz, Rosa M. Gomila, Antonio Frontera
Summary: The synthesis, structure, and DNA binding ability of three decavanadate complexes containing cationic organic moieties were reported. The complexes were characterized by various techniques and their solid-state structures were analyzed. The complexes showed interesting assembly patterns and exhibited moderately strong intercalative binding with CTDNA. Additionally, their micellization behavior in the presence of the surfactant CTAB was studied.
INORGANICA CHIMICA ACTA
(2024)
Review
Chemistry, Inorganic & Nuclear
Jubaraj B. Baruah
Summary: Isomorphous series are generated by replacing atoms or molecules to form materials with similar compositions. They allow modulation of structure and properties, and generate equivalent compositions with novel material properties. The study of stereo-electronic aspects of different equivalent compositions can improve the utility of the original composition.
INORGANICA CHIMICA ACTA
(2024)
Article
Chemistry, Inorganic & Nuclear
Kamelah S. Al-Rashdi, Bandar A. Babgi, Ehab M. M. Ali, Bambar Davaasuren, Abdul-Hamid M. Emwas, Mariusz Jaremko, Mark G. Humphrey, Mostafa A. Hussien
Summary: Tridentate ligands were used to synthesize a set of palladium complexes, which were characterized and found to have DNA and BSA binding abilities. The complexes also showed differences in anticancer activities.
INORGANICA CHIMICA ACTA
(2024)
Article
Chemistry, Inorganic & Nuclear
Diane Isaacs, Chandler Cox, Mark A. Bezpalko, W. Scott Kassel, William G. Dougherty
Summary: The structure and electrochemical properties of zinc(II) complexes with a face-capping ligand have been investigated, revealing the effect of the ligand on bound semiquinonate (SQ) radicals. The substitution pattern of the SQ ring plays a crucial role in determining the fate of the bound SQ radicals. Additionally, the protective pocket formed by the ligand's phenyl substituents is unable to prevent decomposition of SQ radicals with minimal steric bulk, suggesting that substitution of the SQ ring is the main contributor to their stabilization.
INORGANICA CHIMICA ACTA
(2024)
Article
Chemistry, Inorganic & Nuclear
Xingliang Chen, Zhiqiang Jiang
Summary: Here, a series of zinc tetrahedral tetrazolate frameworks (Zn-TTFs) are presented, and it is demonstrated that rotation of carboxyl group can generate structural diversity. Compound 3 exhibits a unique zeolite-like structure, while compound 4 shows both super acid and alkali resistance.
INORGANICA CHIMICA ACTA
(2024)
Article
Chemistry, Inorganic & Nuclear
Ankita Puri, Allison Mcaninch, Sheng Shu, Khashayar Rajabimoghadam, Maxime A. Siegler, Marcel Swart, Isaac Garcia-Bosch
Summary: In this article, the synthesis and characterization of copper, nickel, and palladium complexes bound by bidentate ligands derived from ortho-phenylenediamine are described. The complexes contain tunable H-bond donors and their crystal structures reveal intramolecular H-bonding interactions between the ligand scaffolds. Variations in the coordination sphere led to the isolation of the complexes in square-planar or twisted pseudo-tetrahedral geometries. Structural analysis showed that intramolecular H-bonding interactions can be altered by disrupting the bonds between countercations, solvent of crystallization, and ligand scaffold, resulting in changes in the geometry of the complexes. DFT calculations confirmed that Cu complexes prefer twisted geometries while Ni and Pd complexes favor square-planar geometries.
INORGANICA CHIMICA ACTA
(2024)
Article
Chemistry, Inorganic & Nuclear
Laiane dos Santos Oliveira, Pedro Henrique de Souza Guarda, Leticia Bazilio Rosa, Gustavo Clauss Rodrigues, Daniele Daiane Affonso, Joao Ernesto de Carvalho, Igor Andrade Santos, Mark Harris, Douglas Hideki Nakahata, Jose Ricardo Sabino, Danilo Ciccone Miguel, Ana Lucia Tasca Gois Ruiz, Ana Carolina Gomes Jardim, Camilla Abbehausen
Summary: Chalcones are chemical precursors of flavonoids that have various biological properties. In this study, novel copper(II)-2'-hydroxy-4-benzyloxychalcone complexes were synthesized and evaluated for their antileishmanial, antiproliferative, and antiviral activities. The results demonstrated that these complexes showed potential effects against tumor cells, leishmania parasites, and SARS-CoV-2 virus. The study also highlighted the influence of ligand structure on biological activity.
INORGANICA CHIMICA ACTA
(2024)
Review
Chemistry, Inorganic & Nuclear
Archana Thakur, Harpreet Kaur, Vishal Tyagi
Summary: This review article discusses the findings of research on the 13C NMR spectra of di- and tri-butyltin carboxylates, highlighting the importance of 13C NMR chemical shifts in determining the chemical surroundings of carbon nuclei and their role in structure elucidation.
INORGANICA CHIMICA ACTA
(2024)
Article
Chemistry, Inorganic & Nuclear
Qiang Zhao, Qi-Yang Li, Zhi Shen, Guo Zang, Wen-Jun Lv
Summary: In this study, five metal complexes were synthesized using a solvothermal reaction and their structures were analyzed by single crystal X-ray diffraction. Fluorescence and magnetic properties of some complexes were also investigated.
INORGANICA CHIMICA ACTA
(2024)
Article
Chemistry, Inorganic & Nuclear
Jeremy Erb, Darcy Setter, Jake Swavey, Frederick Willits, Shawn Swavey
Summary: Three BODIPY-Ru(II) complexes were synthesized by coordinating [Ru(bpy)2Cl]+ complexes to BODIPY ligands. The spectroscopic and electrochemical properties of the complexes were characterized. The complexes exhibited intense absorption peaks due to the pi pi* transitions localized on the BODIPY core, and additional charge transfer transitions associated with the metal center. The complexes showed significant singlet oxygen generation and were able to induce photo-nicking of DNA.
INORGANICA CHIMICA ACTA
(2024)
Article
Chemistry, Inorganic & Nuclear
Sahin Reja, Dilip Sarkar, Kaushik Sarkar, Deboshmita Mukherjee, T. K. S. Fayaz, Palash Sanphui, Rajesh Kumar Das
Summary: A promising bioinspired metallocatalyst has been produced and characterized, showing high catalytic activity in oxygen dependant enzymatic radical pathway. The catalyst also exhibits inter and intra molecular H-bonding and C-H-pi interactions.
INORGANICA CHIMICA ACTA
(2024)