Article
Chemistry, Multidisciplinary
Sean J. Steinke, Sayak Gupta, Eric J. Piechota, Curtis E. Moore, Jeremy J. Kodanko, Claudia Turro
Summary: This paper reports two new tris-heteroleptic Ru(II) complexes with triphenylphosphine coordination, which show suitable photochemical properties for photochemotherapeutic applications. The study reveals that under visible light irradiation, the complexes exhibit increased activity due to the photoinduced substitution reaction of PPh3 ligand in the excited state. These complexes represent a new design motif for the selective release of PPh3 and CH3CN for use in photochemotherapy.
Article
Chemistry, Inorganic & Nuclear
Lorcan Holden, Karmel S. Gkika, Christopher S. Burke, Conor Long, Tia E. Keyes
Summary: This study reports a Ru(II) complex (Ru-PDC3) that combines the light switch capability of a Ru(II) dipyridylphenazine complex with the well-known G4-selective ligand Phen-DC3 into a single structure. The complex exhibits the expected light switch effect and strong affinity for G4 structures, while also possessing a powerful G4 disrupting capability. Additionally, the complex is fully water-soluble and readily permeable to live cells.
INORGANIC CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Luca Conti, Alessio Mengoni, Gina Elena Giacomazzo, Lorenzo Mari, Mauro Perfetti, Camilla Fagorzi, Lorenzo Sorace, Barbara Valtancoli, Claudia Giorgi
Summary: The antimicrobial potential of two ruthenium(II) polypyridyl complexes, containing specific polyamine frameworks, was investigated in this study. The complexes showed promising singlet oxygen sensitizing capacities and phototoxicity against gram-positive bacteria, highlighting a versatile tool for enhanced antibacterial strategies.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2021)
Article
Chemistry, Physical
Yanhong Nie, Zhongming Dai, Fozia, Guangyao Zhao, Jianrong Jiang, Xu Xu, Ming Ying, Yu Wang, Zhangli Hu, Hong Xu
Summary: A pair of ruthenium(II) complex enantiomers were designed and synthesized, and their binding behaviors to CT-DNA were studied. Experimental results showed that both enantiomers bound to CT-DNA through van der Waals force or hydrogen bond, with Delta-[Ru(bpy)(2)MBIP](2+) having deeper insertion and better photocleavage ability. Molecular simulation further revealed the difference in binding modes. These findings are important for understanding the mechanism of metal complex-DNA binding and designing antitumor drugs.
JOURNAL OF PHYSICAL CHEMISTRY B
(2022)
Article
Chemistry, Inorganic & Nuclear
Hashini N. K. Herath, Austin L. L. MacRae, Angel Ugrinov, Glenn R. R. Morello, Alexander R. R. Parent
Summary: Two phosphorus-containing ruthenium complexes were synthesized and characterized spectroscopically and electrochemically. Both complexes exhibited proton-coupled electron transfer (PCET) behavior. A Ru(V/IV) couple was detected at 1.4 V vs. NHE for [Ru(bpyPO(3)H(2))(bpy)Cl]Cl. The complexes were tested for their ability to catalyze C-H bond oxidation and it was found that [Ru(bpyPO(3)H(2))(bpy)Cl]Cl can oxidize secondary C-H bonds using NaIO4 as the primary oxidant under aqueous conditions.
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Raphael T. Ryan, Austin C. Hachey, Kimberly Stevens, Sean R. Parkin, Richard J. Mitchell, John P. Selegue, David K. Heidary, Edith C. Glazer
Summary: A systematic study was conducted to alter metal-ligand bond lengths, angles, and intraligand distortion by changing the chelate ring size and introducing a linker atom or group. This study lays the foundation for creating photoactive systems using alternative types of distortion to enhance photosubstitution reactions.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2023)
Article
Biochemical Research Methods
Navaneetha Nambigari, Aruna Kodipaka, Ravi Kumar Vuradi, Praveen Kumar Airva, Satyanarayana Sirasani
Summary: In this study, mononuclear Ru(II) polypyridyl complexes were synthesized and their antibacterial activity and interaction with DNA were investigated. The complexes were found to bind to DNA predominantly through intercalation, with the ancillary ligand playing a significant role in determining their specificity for DNA binding. Furthermore, the complexes showed significant antibacterial activity against both Gram-negative and Gram-positive bacteria.
JOURNAL OF FLUORESCENCE
(2022)
Article
Chemistry, Inorganic & Nuclear
Sinval F. Sousa, Mehmed Z. Ertem, Leandro A. Faustino, Antonio Eduardo H. Machado, Javier J. Concepcion, Pedro I. S. Maia, Antonio Otavio T. Patrocinio
Summary: A new ruthenium polypyridyl complex was synthesized and characterized, showing instability and oxidation under aerobic conditions. The reaction provides insights into C-H activation with important implications for catalysis. Theoretical and experimental investigations suggest a two-step aerobic oxidative transformation with the formation of a diruthenium mu-peroxo intermediate as an alternative pathway for C-H activation.
DALTON TRANSACTIONS
(2021)
Article
Multidisciplinary Sciences
P. Anithabanu, Surabhya Balasubramanian, P. David Dayanidhi, T. Nandhini, V. G. Vaidyanathan
Summary: The conjugation of a Ru(II) polypyridyl complex with collagen was successfully achieved in this study, and its luminescence behavior was found to be similar to that of FITC-labeled collagen. This is the first report on the conjugation of a Ru(II) complex with collagen, providing an alternative to FITC-collagen.
Article
Biochemistry & Molecular Biology
Xi-Juan Chao, Chun-Hua Huang, Miao Tang, Zhu-Ying Yan, Rong Huang, Yan Li, Ben-Zhan Zhu
Summary: Targeted and enantioselective delivery of chiral diagnostic-probes and therapeutics into specific compartments inside cells is crucial for disease detection and treatment improvement. The cationic [Ru(DIP)(2)(dppz)](2+) is found to be redirected into live-cell nucleus through ion-pairing with suitable weak acid counter-anions, maintaining its original DNA recognition characteristics. Interestingly, only the Delta-enantiomer is selectively translocated into the nucleus, inducing DNA damage and cell apoptosis upon prolonged visible-light irradiation. This opens new opportunities for more effective enantioselective cancer treatment.
NUCLEIC ACIDS RESEARCH
(2023)
Article
Chemistry, Multidisciplinary
Yao Jian, Zhihui Jin, Shuang Qi, Xuwen Da, Zhanhua Wang, Xuesong Wang, Qianxiong Zhou
Summary: In this study, a Ru2 drug was constructed that specifically labeled the surface of Gram-positive bacteria through bio-orthogonal click reaction, achieving specific and effective photo-inactivation against Staphylococcus aureus and methicillin-resistant Staphylococcus aureus without affecting mammalian cells.
CHEMISTRY-A EUROPEAN JOURNAL
(2022)
Article
Chemistry, Inorganic & Nuclear
Suffora Akhter, Mohammad Usman, Farukh Arjmand, Sartaj Tabassum
Summary: In this study, a half-sandwich Ru(II) complex containing an aminoquinoline ligand was synthesized and characterized. The complex showed strong binding affinity towards DNA and induced DNA cleavage through an oxidative pathway. Additionally, the complex exhibited fluorescence quenching of proteins and low cytotoxicity against human cancer cell lines.
Article
Biochemistry & Molecular Biology
Sushma B. Singh, Avinash S. Kumbhar, Gulshan Walke, Prasad P. Kulkarni
Summary: The binuclear Ru(II) polypyridyl complexes were synthesized and their interactions with CT-DNA were studied, showing their ability to condense DNA by reducing DNA viscosity, forming nanosized globular aggregates, and inducing the formation of orderly particles in supercoiled plasmid DNA. The complexes exhibited moderate cytotoxicity against MCF-7 cells.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2022)
Article
Electrochemistry
Jeanet Conradie
Summary: This mini review briefly discusses the developments on the application of polypyridyl-based copper complexes in dye-sensitized solar cells (DSSCs). Copper complexes can be used as dye sensitizers and/or as redox mediators in DSSCs. The abundance and low cost of copper make it a cheaper and non-toxic alternative to the commonly used iodide/triiodide electrolyte redox couple and the expensive and rare ruthenium-based dyes.
ELECTROCHEMISTRY COMMUNICATIONS
(2022)
Article
Chemistry, Multidisciplinary
Le Tu, Chonglu Li, Chang Liu, Suya Bai, Jingfang Yang, Xian Zhang, Liying Xu, Xiaoxing Xiong, Yao Sun
Summary: In this study, we synthesized a series of Ru(ii) metallacycles with multimodal chemo-phototherapeutic properties, which showed higher anticancer activity and better cancer-cell selectivity compared to cisplatin. The antitumor mechanism was attributed to the activation of caspase 3/7 and subsequent apoptosis. These findings suggest new potential applications of Ru(ii) metallacycles in biomedicine.
CHEMICAL COMMUNICATIONS
(2022)
Article
Chemistry, Inorganic & Nuclear
Angela Lis, Viorica Gladchi, Gheorghe Duca, Sergey Travin
Summary: This work presents studies on the photochemical transformations of TU and Cys with the addition of Cu(II) or Fe(III) ions. The results show that the oxidation rate of the thiols increases significantly when Cu(II) or Fe(III) ions are added to the system. It has also been found that TU and Cys can form stable complex compounds with the studied metal ions. The oxidation rates of the thiols are found to depend on the radiation intensity and emission spectrum of the irradiation sources.
INORGANICA CHIMICA ACTA
(2024)
Article
Chemistry, Inorganic & Nuclear
Cristiane F. A. Teixeira, Estefane I. Teixeira, J. P. C. Nascimento, M. Amilcar Junior, L. M. C. Pinto, Anderson R. L. Caires, G. B. Alcantara, Ana C. Micheletti, Victor M. Deflon, Davi F. Back, Heveline Silva, Lucas Pizzuti, Gleison Antonio Casagrande
Summary: Novel binuclear heteroleptic copper(I) complexes based on mixed DPPE/thiocarbamoyl-pyrazoline ligands were synthesized and structurally characterized. These complexes exhibited similar structural behavior around the Copper(I) atoms and showed promising antimicrobial and anticancer activities.
INORGANICA CHIMICA ACTA
(2024)
Article
Chemistry, Inorganic & Nuclear
Chen Chen, Li Liu, Xin-Xin Zhong, Fa-Bao Li, Hai-Mei Qin
Summary: Thermally activated delayed fluorescent (TADF) Cu(I) halide complexes with short lifetimes and intense emissions were synthesized and characterized. These complexes exhibit intense green to yellow-green delayed fluorescence and are suitable for OLED devices.
INORGANICA CHIMICA ACTA
(2024)
Article
Chemistry, Inorganic & Nuclear
Tian-Yu Zhang, Xue-Qian Wu, Heng-Yu Ruan, Yi Yuan, Le Wang, Ya-Pan Wu, Qing-Wen Han, Ruan Chi, Dong-Sheng Li
Summary: In this study, a novel Ni(II)-based metal-organic framework with good electrocatalytic oxidation performance was successfully synthesized, showing potential for direct alcohol fuel cells.
INORGANICA CHIMICA ACTA
(2024)
Article
Chemistry, Inorganic & Nuclear
Susanta Das Baishnab, R. N. Dutta Purkayastha, Waldemar Maniukiewicz, Rosa M. Gomila, Antonio Frontera
Summary: The synthesis, structure, and DNA binding ability of three decavanadate complexes containing cationic organic moieties were reported. The complexes were characterized by various techniques and their solid-state structures were analyzed. The complexes showed interesting assembly patterns and exhibited moderately strong intercalative binding with CTDNA. Additionally, their micellization behavior in the presence of the surfactant CTAB was studied.
INORGANICA CHIMICA ACTA
(2024)
Review
Chemistry, Inorganic & Nuclear
Jubaraj B. Baruah
Summary: Isomorphous series are generated by replacing atoms or molecules to form materials with similar compositions. They allow modulation of structure and properties, and generate equivalent compositions with novel material properties. The study of stereo-electronic aspects of different equivalent compositions can improve the utility of the original composition.
INORGANICA CHIMICA ACTA
(2024)
Article
Chemistry, Inorganic & Nuclear
Kamelah S. Al-Rashdi, Bandar A. Babgi, Ehab M. M. Ali, Bambar Davaasuren, Abdul-Hamid M. Emwas, Mariusz Jaremko, Mark G. Humphrey, Mostafa A. Hussien
Summary: Tridentate ligands were used to synthesize a set of palladium complexes, which were characterized and found to have DNA and BSA binding abilities. The complexes also showed differences in anticancer activities.
INORGANICA CHIMICA ACTA
(2024)
Article
Chemistry, Inorganic & Nuclear
Diane Isaacs, Chandler Cox, Mark A. Bezpalko, W. Scott Kassel, William G. Dougherty
Summary: The structure and electrochemical properties of zinc(II) complexes with a face-capping ligand have been investigated, revealing the effect of the ligand on bound semiquinonate (SQ) radicals. The substitution pattern of the SQ ring plays a crucial role in determining the fate of the bound SQ radicals. Additionally, the protective pocket formed by the ligand's phenyl substituents is unable to prevent decomposition of SQ radicals with minimal steric bulk, suggesting that substitution of the SQ ring is the main contributor to their stabilization.
INORGANICA CHIMICA ACTA
(2024)
Article
Chemistry, Inorganic & Nuclear
Xingliang Chen, Zhiqiang Jiang
Summary: Here, a series of zinc tetrahedral tetrazolate frameworks (Zn-TTFs) are presented, and it is demonstrated that rotation of carboxyl group can generate structural diversity. Compound 3 exhibits a unique zeolite-like structure, while compound 4 shows both super acid and alkali resistance.
INORGANICA CHIMICA ACTA
(2024)
Article
Chemistry, Inorganic & Nuclear
Ankita Puri, Allison Mcaninch, Sheng Shu, Khashayar Rajabimoghadam, Maxime A. Siegler, Marcel Swart, Isaac Garcia-Bosch
Summary: In this article, the synthesis and characterization of copper, nickel, and palladium complexes bound by bidentate ligands derived from ortho-phenylenediamine are described. The complexes contain tunable H-bond donors and their crystal structures reveal intramolecular H-bonding interactions between the ligand scaffolds. Variations in the coordination sphere led to the isolation of the complexes in square-planar or twisted pseudo-tetrahedral geometries. Structural analysis showed that intramolecular H-bonding interactions can be altered by disrupting the bonds between countercations, solvent of crystallization, and ligand scaffold, resulting in changes in the geometry of the complexes. DFT calculations confirmed that Cu complexes prefer twisted geometries while Ni and Pd complexes favor square-planar geometries.
INORGANICA CHIMICA ACTA
(2024)
Article
Chemistry, Inorganic & Nuclear
Laiane dos Santos Oliveira, Pedro Henrique de Souza Guarda, Leticia Bazilio Rosa, Gustavo Clauss Rodrigues, Daniele Daiane Affonso, Joao Ernesto de Carvalho, Igor Andrade Santos, Mark Harris, Douglas Hideki Nakahata, Jose Ricardo Sabino, Danilo Ciccone Miguel, Ana Lucia Tasca Gois Ruiz, Ana Carolina Gomes Jardim, Camilla Abbehausen
Summary: Chalcones are chemical precursors of flavonoids that have various biological properties. In this study, novel copper(II)-2'-hydroxy-4-benzyloxychalcone complexes were synthesized and evaluated for their antileishmanial, antiproliferative, and antiviral activities. The results demonstrated that these complexes showed potential effects against tumor cells, leishmania parasites, and SARS-CoV-2 virus. The study also highlighted the influence of ligand structure on biological activity.
INORGANICA CHIMICA ACTA
(2024)
Review
Chemistry, Inorganic & Nuclear
Archana Thakur, Harpreet Kaur, Vishal Tyagi
Summary: This review article discusses the findings of research on the 13C NMR spectra of di- and tri-butyltin carboxylates, highlighting the importance of 13C NMR chemical shifts in determining the chemical surroundings of carbon nuclei and their role in structure elucidation.
INORGANICA CHIMICA ACTA
(2024)
Article
Chemistry, Inorganic & Nuclear
Qiang Zhao, Qi-Yang Li, Zhi Shen, Guo Zang, Wen-Jun Lv
Summary: In this study, five metal complexes were synthesized using a solvothermal reaction and their structures were analyzed by single crystal X-ray diffraction. Fluorescence and magnetic properties of some complexes were also investigated.
INORGANICA CHIMICA ACTA
(2024)
Article
Chemistry, Inorganic & Nuclear
Jeremy Erb, Darcy Setter, Jake Swavey, Frederick Willits, Shawn Swavey
Summary: Three BODIPY-Ru(II) complexes were synthesized by coordinating [Ru(bpy)2Cl]+ complexes to BODIPY ligands. The spectroscopic and electrochemical properties of the complexes were characterized. The complexes exhibited intense absorption peaks due to the pi pi* transitions localized on the BODIPY core, and additional charge transfer transitions associated with the metal center. The complexes showed significant singlet oxygen generation and were able to induce photo-nicking of DNA.
INORGANICA CHIMICA ACTA
(2024)
Article
Chemistry, Inorganic & Nuclear
Sahin Reja, Dilip Sarkar, Kaushik Sarkar, Deboshmita Mukherjee, T. K. S. Fayaz, Palash Sanphui, Rajesh Kumar Das
Summary: A promising bioinspired metallocatalyst has been produced and characterized, showing high catalytic activity in oxygen dependant enzymatic radical pathway. The catalyst also exhibits inter and intra molecular H-bonding and C-H-pi interactions.
INORGANICA CHIMICA ACTA
(2024)