Article
Chemistry, Medicinal
Molhm Nassir, Avinoam Isaak, Bilha Fischer
Summary: This study provided insights into the hydrolytic stability of thiophosphate and dithiophosphate monoester isostere families, filling a gap in the research on their chemical stability. The findings explain the different stability of PS or PS2 moieties at different positions of the nucleotide phosphate chain.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Jane M. Donnelly, Frederik Lermyte, Juliusz A. Wolny, Marc Walker, Ben G. Breeze, Russell J. Needham, Christina S. Muller, Peter B. O'Connor, Volker Schunemann, Joanna F. Collingwood, Peter J. Sadler
Summary: A stable square-planar Cu(iii) complex, [bis(toluene-3,4-dithiolato)copper(iii)][NEt3H], has been synthesised and characterised using various analytical techniques. Interestingly, a unique [(toluene-3,4-dithiolato)Cu(iii)(peroxide)](-) complex is formed when the complex is fragmented in FTICR-MS upon reaction with oxygen. Additionally, natural 1,2-dithiolenes known to bind molybdenum may play a role in stabilising Cu(iii) in vivo.
CHEMICAL COMMUNICATIONS
(2021)
Article
Chemistry, Inorganic & Nuclear
Tukki Sarkar, Arun Kumar, Somarupa Sahoo, Akhtar Hussain
Summary: The bioessential nature of cobalt and the rich photochemistry of its coordination complexes have been utilized to develop six novel mixed-ligand cobalt(III) complexes for studying their light-triggered cytotoxicity in cancer cells, with one of the complexes showing remarkable visible-light-triggered cytotoxicity against cancer cells.
INORGANIC CHEMISTRY
(2021)
Article
Chemistry, Inorganic & Nuclear
Yating Chen, Zhilin Ke, Lingyu Yuan, Meixiang Liang, Shuhua Zhang
Summary: We synthesized and analyzed nine unique copper(II) hydrazylpyridine salicylaldehyde and 1,10-phenanthroline complexes. It was found that these complexes exhibited higher anticancer activity and lower cytotoxicity towards normal cells compared to other substances. Specifically, Cugdupt1 and Cugdupt8 induced cell death through ATP depletion and activation of mitophagy pathways.
DALTON TRANSACTIONS
(2023)
Article
Chemistry, Physical
Neyen Romano, Nicholas M. Hein, Kevin Basemann, Youngran Seo, Michel R. Gagne
Summary: This study reports the use of a bis-oxazoline Cu2+ catalyst for the selective azidation of sugars. Experimental and computational results suggest that the catalyst activates azide through a silylium transfer mechanism, leading to the azidation of sugars.
Article
Chemistry, Physical
Kaiming Zhang, Qin Zhang, Xiuyang Wang, Jian Yue, Tong Ni, Bin Xu, Xiaoqiang Liu, Weidong Jiang
Summary: Three new copper (II) complexes were synthesized and characterized, and their catalytic activities in the hydrolysis reactions were investigated. The results showed that these complexes can significantly accelerate the hydrolysis of nitrophenyl esters under certain conditions.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2022)
Article
Chemistry, Inorganic & Nuclear
Yuiko Tasaki-Handa, Shiori Tsuda, Masami Shibukawa, Shingo Saito
Summary: This study investigates the ion exchange behavior of the CeL3 coordination polymer (CP) and elucidates its mechanism. It is found that the limit of Ln(3+)-to-Ce3+ mixing (x(lim)) in the crystal is an important factor for the feasibility of structural transition. When the mixing ratio (x) of Ln(3+) is above x(lim), the crystal structure tends to transition and the exchange of Ce3+ for Ln(3+) is facilitated.
INORGANIC CHEMISTRY COMMUNICATIONS
(2022)
Review
Agriculture, Dairy & Animal Science
Charlotte M. E. Heyer, Neil W. Jaworski, Greg Page, Ruurd T. Zijlstra
Summary: This review focuses on the interaction between fermentable substrates and selected minerals in nutrient digestion and absorption to determine nutritional solutions for maximizing animal performance. However, there is currently no standardized method to assess in vitro mineral digestion. The total tract digestibility of phosphorus might be underestimated in diets with fermentable ingredients, and further research is needed to calculate the true total tract digestibility of phosphorus. The quantification of fiber type, composition, and its influence on digestion kinetics and nutrient solubility should be considered in diet formulation.
Article
Chemistry, Inorganic & Nuclear
Alan Le Goff, Deborah Brazzolotto, Yannig Nedellec, Christian Philouze, Michael Holzinger, Fabrice Thomas
Summary: A new ligand and complex were designed and immobilized on multiwalled carbon nanotube electrodes. These complexes exhibit strong autoreduction tendencies and interact strongly with the sidewalls of the nanotubes. Additionally, they demonstrate good catalytic performance in oxygen reduction reactions.
INORGANIC CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Marielle Drommi, Clement Rulmont, Charlene Esmieu, Christelle Hureau
Summary: This study reports the synthesis of three new hybrid ligands designed to capture copper from amyloid-beta peptides and prevent the formation of reactive oxygen species. The research investigated the copper complexes formed with the ligands and their ability to remove copper from A beta, highlighting the importance of the reduced state of copper (Cu(I) in preventing and inhibiting reactive oxygen species.
Article
Chemistry, Multidisciplinary
Irina V. Krylova, Liliya D. Labutskaya, Mariya O. Markova, Victoriya A. Balycheva, Pavel G. Shangin, Anna Ya. Akyeva, Victoriya V. Golovina, Mikhail E. Minyaev, Andrey V. Lalov, Valery M. Pechennikov, Vasiliy T. Novikov, Mikhail P. Egorov, Mikhail A. Syroeshkin
Summary: Tin coordination derivatives have notable advantages in terms of availability, safety, and stability, making them promising for applications in medicine and materials science. The location and gap between frontier molecular orbitals are crucial factors in determining their properties. In this study, new penta-, hexa-, and hepta-coordinated tin(iv) derivatives were synthesized and characterized. The influence of hypercoordination and bond formation with N-donor ligands on the control and tuning of HOMO and LUMO levels was demonstrated through spectroscopic and electrochemical analyses.
NEW JOURNAL OF CHEMISTRY
(2023)
Article
Electrochemistry
Jeanet Conradie
Summary: A density functional theory study was conducted to determine the properties of a series of [Cu(phen)(2)](n+) complexes, which are favorable for use as dyes in DSSCs.
ELECTROCHIMICA ACTA
(2022)
Article
Crystallography
Xingman Xu, Renqiang Sun
Summary: This passage describes the structure and crystallographic parameters of a compound.
ZEITSCHRIFT FUR KRISTALLOGRAPHIE-NEW CRYSTAL STRUCTURES
(2022)
Article
Chemistry, Organic
Juliano M. Fernandes, Rafael N. Soek, Thalita C. do Nascimento, Leociley R. A. Menezes, Guilherme L. Sassaki, Renan B. Campos
Summary: This study investigates the degradation of organophosphate pesticides promoted by 1,2,4-triazole through kinetic studies, NMR analyses, and theoretical calculations. The results show that TAZ(-) enhances the degradation of OPs in alkaline conditions, with potential for the design of novel catalysts.
JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Chemistry, Physical
Elena Martsinko, Olha Buchko, Elena Chebanenko, Inna Seifullina, Viktoriya Dyakonenko, Svitlana Shishkina
Summary: The study successfully synthesized three different types of complexes and revealed the important role of hydrogen atoms in intermolecular interactions.
JOURNAL OF MOLECULAR STRUCTURE
(2021)
Review
Biochemistry & Molecular Biology
Joel Costoya, Bapurao Surnar, Akil A. Kalathil, Nagesh Kolishetti, Shanta Dhar
Summary: In order to combat cancer, researchers are developing more efficient chemotherapeutic drugs and suitable delivery vehicles using controlled-release nanomaterials, which can reduce side-effects and improve efficacy.
MOLECULAR ASPECTS OF MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Nagesh Kolishetti, Arti Vashist, Adriana Yndart Arias, Venkata Atluri, Shanta Dhar, Madhavan Nair
Summary: Magneto-electric nanomaterials with core-shell architecture have emerged as promising tools in biomedical fields, offering controlled on-demand cargo transport and release. They show coupling of magnetic and electric properties and have been successfully utilized for therapeutic delivery, sensing, and neuromodulation.
MOLECULAR ASPECTS OF MEDICINE
(2022)
Article
Chemistry, Inorganic & Nuclear
Dulal Musib, Vanitha Ramu, Md Kausar Raza, Aarti Upadhyay, Maynak Pal, Amit Kunwar, Mithun Roy
Summary: Red light-activatable transition metal complexes have shown remarkable photodynamic activity in this study, with the La(iii)-curcumin-functionalized gold nanocomposite demonstrating high photosensitivity and inducing apoptosis in adenocarcinomic cells through red light-induced generation of singlet oxygen.
INORGANIC CHEMISTRY FRONTIERS
(2022)
Review
Chemistry, Organic
Arup K. Kabi, Maynak Pal, Raghuram Gujjarappa, Chandi C. Malakar, Mithun Roy
Summary: This article provides an overview of the potential therapeutic agents remdesivir and hydroxychloroquine in drug repositioning strategy for the treatment of COVID-19, as well as their pharmacokinetics and possible mechanisms of action against SARS-CoV-2.
JOURNAL OF HETEROCYCLIC CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Suzana Hamdan, Bapurao Surnar, Alexia L. Kafkoutsou, Luciano Magurno, Sapna K. Deo, Dushyantha T. Jayaweera, Shanta Dhar, Sylvia Daunert
Summary: Improved techniques were used to create dimensional nanostructures, doped nanovesicles, which effectively addressed the issues of insolubility and low bioavailability of highly potent pharmaceutical drugs. These nanovesicles provide a powerful tool for treating medical conditions and emerging pathogens.
Article
Engineering, Biomedical
Andrew J. Ciciriello, Bapurao Surnar, Giovanni D. Medy, Xiaoyu Su, Shanta Dhar, Courtney M. Dumont
Summary: Drug delivery requires precision in timing, location, and dosage. To address the challenges in achieving therapeutic benefits, researchers have developed the BEACON platform, which utilizes an implantable biomaterial as a target for systemically delivered nanoparticles (NPs). The BEACON system has demonstrated temporal dexterity, decreased off-target accumulation, and retention of NPs in the target biomaterial, showing its broad applicability in improving targeted drug delivery.
ACTA BIOMATERIALIA
(2022)
Article
Chemistry, Inorganic & Nuclear
Bhabatosh Banik, Akash Ashokan, Joshua H. H. Choi, Bapurao Surnar, Shanta Dhar
Summary: Cisplatin, a key player in chemotherapy, has been improved by developing new platinum-based prodrugs with active ligands. Platin-C, a platinum(iv)-based prodrug tethered to curcumin, showed enhanced chemotherapeutic efficacy and targeted mitochondria of cancer cells. It also demonstrated the ability to attenuate cellular inflammation.
DALTON TRANSACTIONS
(2023)
Review
Biochemistry & Molecular Biology
Abhishek Panwar, Maynak Pal, Mithun Roy
Summary: Iron is an important trace element that is being studied for its medicinal and diagnostic applications. The photo-activated states of iron complexes, which exhibit various reactions and energy transfers, have attracted global attention for their potential applications in photo-chemotherapy. Significant advancements have been made in the development of iron-based complexes for photo-chemotherapeutic applications.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2023)
Article
Biochemical Research Methods
Xiao Zhang, Shrita Sarkar, Akash Ashokan, Bapurao Surnar, Nagesh Kolishetti, Shanta Dhar
Summary: The metabolic preference of cells toward glycolysis often indicates a diseased state ranging from cancer to other dysfunctions. When a particular cell type utilizes glycolysis as a major energy production pathway, their mitochondria become impaired resulting in a cascade of events which eventually contributes to resistance towards therapies to tackle such diseases. In abnormal tissues such as seen in the tumor microenvironment, when cancer cells utilize glycolysis, other cell types such as the immune cells switch their metabolism and prefer such glycolysis.
BIOCONJUGATE CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Dulal Musib, Aarti Upadhyay, Maynak Pal, Md Kausar Raza, Indranil Saha, Amit Kunwar, Mithun Roy
Summary: We synthesized and characterized a red-light activable gold nanoparticle functionalized with biotinylated copper(II) complex. This nanoconjugate exhibited photodynamic activity against biotin positive cancer cells under red light irradiation, resulting in mitochondrial membrane damage and apoptosis. The nanocomposite has potential as a next generation PDT agent.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2023)
Correction
Chemistry, Multidisciplinary
Akil A. Kalathil, Subham Guin, Akash Ashokan, Uttara Basu, Bapurao Surnar, Katiana S. Delma, Leonor M. Lima, Oleksandr N. Kryvenko, Shanta Dhar
ACS CENTRAL SCIENCE
(2023)
Article
Chemistry, Multidisciplinary
Akil A. Kalathil, Subham Guin, Akash Ashokan, Uttara Basu, Bapurao Surnar, Katiana S. Delma, Leonor M. Lima, Oleksandr N. Kryvenko, Shanta Dhar
Summary: Tumor cells develop resistance to multimodal cancer therapy, including cisplatin, by relying on fatty acid oxidation (FAO). In this study, we validated the expression of an important enzyme, CPT1A, in patient biopsies and discovered that the cisplatin prodrug, Platin-L, can inhibit FAO by interacting with CPT1A. We further synthesized cisplatin-based prodrugs and found that the presence of a carboxylic acid group near the fatty acid linker is crucial for CPT1A binding. By disrupting fat metabolism with Platin-L, prostate cancer cells transition to a glucose-dependent chemosensitive state. We incorporated Platin-L into a nanocarrier for targeted delivery to the tumor microenvironment and demonstrated its efficacy and safety.
ACS CENTRAL SCIENCE
(2023)
Article
Chemistry, Inorganic & Nuclear
Dulal Musib, Moubani Mukherjee, Mithun Roy
Summary: Lanthanides have unique coordination chemistry, magnetic and optical properties, and photophysical or photochemical characteristics, making them potential tools for medicinal and diagnostic applications. Lanthanum(III) ion has been studied as an efficient modulator for singlet oxygen generation by different photosensitizers in photodynamic therapy. The development of La(III)-based nanocomposites activated by UV-visible light or X-rays has shown significant progress in photodynamic applications. This article provides a micro review of the recent development of La(III)-based compounds as PDT agents.
INORGANICA CHIMICA ACTA
(2023)
Article
Chemistry, Organic
Maynak Pal, Dulal Musib, Mithun Roy
Summary: The study found that compound 1 is a potential therapeutic agent for COVID-19, inhibiting viral proteins and modulating inflammatory signaling cascades.
INDIAN JOURNAL OF CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Anuj S. Shah, Bapurao Surnar, Nagesh Kolishetti, Shanta Dhar
Summary: Since its discovery, cisplatin has been widely used in cancer therapies. However, its side effects and limitations have led to the development of platinum-based prodrugs. Additionally, nanomedicine plays a crucial role in improving the efficacy of cisplatin prodrugs by delivering them with precision and targeting specific cancers. The intersection between inorganic medicinal chemistry and nanotechnology has great potential in advancing cancer treatment.
ACCOUNTS OF MATERIALS RESEARCH
(2022)
Article
Chemistry, Inorganic & Nuclear
Angela Lis, Viorica Gladchi, Gheorghe Duca, Sergey Travin
Summary: This work presents studies on the photochemical transformations of TU and Cys with the addition of Cu(II) or Fe(III) ions. The results show that the oxidation rate of the thiols increases significantly when Cu(II) or Fe(III) ions are added to the system. It has also been found that TU and Cys can form stable complex compounds with the studied metal ions. The oxidation rates of the thiols are found to depend on the radiation intensity and emission spectrum of the irradiation sources.
INORGANICA CHIMICA ACTA
(2024)
Article
Chemistry, Inorganic & Nuclear
Cristiane F. A. Teixeira, Estefane I. Teixeira, J. P. C. Nascimento, M. Amilcar Junior, L. M. C. Pinto, Anderson R. L. Caires, G. B. Alcantara, Ana C. Micheletti, Victor M. Deflon, Davi F. Back, Heveline Silva, Lucas Pizzuti, Gleison Antonio Casagrande
Summary: Novel binuclear heteroleptic copper(I) complexes based on mixed DPPE/thiocarbamoyl-pyrazoline ligands were synthesized and structurally characterized. These complexes exhibited similar structural behavior around the Copper(I) atoms and showed promising antimicrobial and anticancer activities.
INORGANICA CHIMICA ACTA
(2024)
Article
Chemistry, Inorganic & Nuclear
Chen Chen, Li Liu, Xin-Xin Zhong, Fa-Bao Li, Hai-Mei Qin
Summary: Thermally activated delayed fluorescent (TADF) Cu(I) halide complexes with short lifetimes and intense emissions were synthesized and characterized. These complexes exhibit intense green to yellow-green delayed fluorescence and are suitable for OLED devices.
INORGANICA CHIMICA ACTA
(2024)
Article
Chemistry, Inorganic & Nuclear
Tian-Yu Zhang, Xue-Qian Wu, Heng-Yu Ruan, Yi Yuan, Le Wang, Ya-Pan Wu, Qing-Wen Han, Ruan Chi, Dong-Sheng Li
Summary: In this study, a novel Ni(II)-based metal-organic framework with good electrocatalytic oxidation performance was successfully synthesized, showing potential for direct alcohol fuel cells.
INORGANICA CHIMICA ACTA
(2024)
Article
Chemistry, Inorganic & Nuclear
Susanta Das Baishnab, R. N. Dutta Purkayastha, Waldemar Maniukiewicz, Rosa M. Gomila, Antonio Frontera
Summary: The synthesis, structure, and DNA binding ability of three decavanadate complexes containing cationic organic moieties were reported. The complexes were characterized by various techniques and their solid-state structures were analyzed. The complexes showed interesting assembly patterns and exhibited moderately strong intercalative binding with CTDNA. Additionally, their micellization behavior in the presence of the surfactant CTAB was studied.
INORGANICA CHIMICA ACTA
(2024)
Review
Chemistry, Inorganic & Nuclear
Jubaraj B. Baruah
Summary: Isomorphous series are generated by replacing atoms or molecules to form materials with similar compositions. They allow modulation of structure and properties, and generate equivalent compositions with novel material properties. The study of stereo-electronic aspects of different equivalent compositions can improve the utility of the original composition.
INORGANICA CHIMICA ACTA
(2024)
Article
Chemistry, Inorganic & Nuclear
Kamelah S. Al-Rashdi, Bandar A. Babgi, Ehab M. M. Ali, Bambar Davaasuren, Abdul-Hamid M. Emwas, Mariusz Jaremko, Mark G. Humphrey, Mostafa A. Hussien
Summary: Tridentate ligands were used to synthesize a set of palladium complexes, which were characterized and found to have DNA and BSA binding abilities. The complexes also showed differences in anticancer activities.
INORGANICA CHIMICA ACTA
(2024)
Article
Chemistry, Inorganic & Nuclear
Diane Isaacs, Chandler Cox, Mark A. Bezpalko, W. Scott Kassel, William G. Dougherty
Summary: The structure and electrochemical properties of zinc(II) complexes with a face-capping ligand have been investigated, revealing the effect of the ligand on bound semiquinonate (SQ) radicals. The substitution pattern of the SQ ring plays a crucial role in determining the fate of the bound SQ radicals. Additionally, the protective pocket formed by the ligand's phenyl substituents is unable to prevent decomposition of SQ radicals with minimal steric bulk, suggesting that substitution of the SQ ring is the main contributor to their stabilization.
INORGANICA CHIMICA ACTA
(2024)
Article
Chemistry, Inorganic & Nuclear
Xingliang Chen, Zhiqiang Jiang
Summary: Here, a series of zinc tetrahedral tetrazolate frameworks (Zn-TTFs) are presented, and it is demonstrated that rotation of carboxyl group can generate structural diversity. Compound 3 exhibits a unique zeolite-like structure, while compound 4 shows both super acid and alkali resistance.
INORGANICA CHIMICA ACTA
(2024)
Article
Chemistry, Inorganic & Nuclear
Ankita Puri, Allison Mcaninch, Sheng Shu, Khashayar Rajabimoghadam, Maxime A. Siegler, Marcel Swart, Isaac Garcia-Bosch
Summary: In this article, the synthesis and characterization of copper, nickel, and palladium complexes bound by bidentate ligands derived from ortho-phenylenediamine are described. The complexes contain tunable H-bond donors and their crystal structures reveal intramolecular H-bonding interactions between the ligand scaffolds. Variations in the coordination sphere led to the isolation of the complexes in square-planar or twisted pseudo-tetrahedral geometries. Structural analysis showed that intramolecular H-bonding interactions can be altered by disrupting the bonds between countercations, solvent of crystallization, and ligand scaffold, resulting in changes in the geometry of the complexes. DFT calculations confirmed that Cu complexes prefer twisted geometries while Ni and Pd complexes favor square-planar geometries.
INORGANICA CHIMICA ACTA
(2024)
Article
Chemistry, Inorganic & Nuclear
Laiane dos Santos Oliveira, Pedro Henrique de Souza Guarda, Leticia Bazilio Rosa, Gustavo Clauss Rodrigues, Daniele Daiane Affonso, Joao Ernesto de Carvalho, Igor Andrade Santos, Mark Harris, Douglas Hideki Nakahata, Jose Ricardo Sabino, Danilo Ciccone Miguel, Ana Lucia Tasca Gois Ruiz, Ana Carolina Gomes Jardim, Camilla Abbehausen
Summary: Chalcones are chemical precursors of flavonoids that have various biological properties. In this study, novel copper(II)-2'-hydroxy-4-benzyloxychalcone complexes were synthesized and evaluated for their antileishmanial, antiproliferative, and antiviral activities. The results demonstrated that these complexes showed potential effects against tumor cells, leishmania parasites, and SARS-CoV-2 virus. The study also highlighted the influence of ligand structure on biological activity.
INORGANICA CHIMICA ACTA
(2024)
Review
Chemistry, Inorganic & Nuclear
Archana Thakur, Harpreet Kaur, Vishal Tyagi
Summary: This review article discusses the findings of research on the 13C NMR spectra of di- and tri-butyltin carboxylates, highlighting the importance of 13C NMR chemical shifts in determining the chemical surroundings of carbon nuclei and their role in structure elucidation.
INORGANICA CHIMICA ACTA
(2024)
Article
Chemistry, Inorganic & Nuclear
Qiang Zhao, Qi-Yang Li, Zhi Shen, Guo Zang, Wen-Jun Lv
Summary: In this study, five metal complexes were synthesized using a solvothermal reaction and their structures were analyzed by single crystal X-ray diffraction. Fluorescence and magnetic properties of some complexes were also investigated.
INORGANICA CHIMICA ACTA
(2024)
Article
Chemistry, Inorganic & Nuclear
Jeremy Erb, Darcy Setter, Jake Swavey, Frederick Willits, Shawn Swavey
Summary: Three BODIPY-Ru(II) complexes were synthesized by coordinating [Ru(bpy)2Cl]+ complexes to BODIPY ligands. The spectroscopic and electrochemical properties of the complexes were characterized. The complexes exhibited intense absorption peaks due to the pi pi* transitions localized on the BODIPY core, and additional charge transfer transitions associated with the metal center. The complexes showed significant singlet oxygen generation and were able to induce photo-nicking of DNA.
INORGANICA CHIMICA ACTA
(2024)
Article
Chemistry, Inorganic & Nuclear
Sahin Reja, Dilip Sarkar, Kaushik Sarkar, Deboshmita Mukherjee, T. K. S. Fayaz, Palash Sanphui, Rajesh Kumar Das
Summary: A promising bioinspired metallocatalyst has been produced and characterized, showing high catalytic activity in oxygen dependant enzymatic radical pathway. The catalyst also exhibits inter and intra molecular H-bonding and C-H-pi interactions.
INORGANICA CHIMICA ACTA
(2024)
